The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in...

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Bibliographic Details
Published inCell reports (Cambridge) Vol. 30; no. 1; pp. 112 - 123.e4
Main Authors Katsuyama, Eri, Suarez-Fueyo, Abel, Bradley, Sean J., Mizui, Masayuki, Marin, Ana V., Mulki, Lama, Krishfield, Suzanne, Malavasi, Fabio, Yoon, Joon, Sui, Shannan J. Ho, Kyttaris, Vasileios C., Tsokos, George C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 07.01.2020
Elsevier
Subjects
ADP-ribosyl Cyclase 1 - metabolism
Adult
CD38
CD8 T cell
CD8-Positive T-Lymphocytes - immunology
Cell Line
cytotoxicity
Enhancer of Zeste Homolog 2 Protein - metabolism
EZH2
Female
Humans
infection
Infections - immunology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - microbiology
Male
NAD - metabolism
nicotinamide adenine dinucleotide
patients
Sirtuin 1 - metabolism
Sirtuin1
systemic lupus erythematosus
T-Lymphocytes, Cytotoxic - immunology
Transcription Factors - metabolism
nicotinamide adenine dinucleotide
systemic lupus erythematosus
infection
CD8 T cell
patients
CD38
cytotoxicity
Sirtuin1
EZH2
Online AccessGet full text
ISSN2211-1247
2211-1247
DOI10.1016/j.celrep.2019.12.014

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Abstract Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a subgroup of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically. [Display omitted] •Expanded CD8CD38high T cells in SLE patients identify patients with infections•CD8CD38high T cells express decreased amounts of cytotoxic molecules•CD38 decreases NAD+ and SIRT1 activity and releases the activity of EZH2•Inhibition of EZH2 restores the degranulation capacity of CD8CD38high T cells Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.
AbstractList Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a subgroup of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically. [Display omitted] •Expanded CD8CD38high T cells in SLE patients identify patients with infections•CD8CD38high T cells express decreased amounts of cytotoxic molecules•CD38 decreases NAD+ and SIRT1 activity and releases the activity of EZH2•Inhibition of EZH2 restores the degranulation capacity of CD8CD38high T cells Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.
Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38 T cell subset in a subgroup of patients with increased rates of infections. CD8CD38 T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38 T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically.
Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a subgroup of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically. : Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE. Keywords: systemic lupus erythematosus, patients, CD8 T cell, CD38, cytotoxicity, infection, nicotinamide adenine dinucleotide, Sirtuin1, EZH2
Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a subgroup of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically.Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a subgroup of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically.
Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely unknown. We find an expanded CD8CD38high T cell subset in a sub-group of patients with increased rates of infections. CD8CD38high T cells from healthy subjects and patients with SLE display decreased cytotoxic capacity, degranulation, and expression of granzymes A and B and perforin. The key cytotoxicity-related transcription factors T-bet, RUNX3, and EOMES are decreased in CD8CD38high T cells. CD38 leads to increased acetylated EZH2 through inhibition of the deacetylase Sirtuin1. Acetylated EZH2 represses RUNX3 expression, whereas inhibition of EZH2 restores CD8 T cell cytotoxic responses. We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically. Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.
Author Katsuyama, Eri
Yoon, Joon
Tsokos, George C.
Marin, Ana V.
Suarez-Fueyo, Abel
Mizui, Masayuki
Malavasi, Fabio
Sui, Shannan J. Ho
Krishfield, Suzanne
Kyttaris, Vasileios C.
Mulki, Lama
Bradley, Sean J.
AuthorAffiliation 2 Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, and Fondazione Ricerca Molinette, Torino, Italy
4 Lead Contact
1 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
3 Harvard Chan Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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– name: 3 Harvard Chan Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
– name: 4 Lead Contact
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31914379$$D View this record in MEDLINE/PubMed
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Cites_doi 10.4049/jimmunol.131.4.1797
10.1084/jem.20081242
10.1586/erv.10.49
10.4049/jimmunol.172.2.1287
10.1038/s41467-018-04125-8
10.1002/art.1780251101
10.1073/pnas.1714717115
10.1371/journal.ppat.1004251
10.1177/0961203319827646
10.1179/1945577115Y.0000000005
10.1002/art.39410
10.1186/gb-2008-9-9-r137
10.1038/nature11606
10.3389/fgene.2014.00075
10.1084/jem.20161066
10.1093/bioinformatics/btv098
10.1093/rheumatology/ker178
10.1073/pnas.1303628110
10.7717/peerj.3720
10.1038/s41467-017-02187-8
10.1124/pr.110.003905
10.1093/annonc/mdw141
10.1016/S0049-0172(96)80018-7
10.1371/journal.ppat.1002328
10.1007/BF02591400
10.1016/j.cmet.2015.05.023
10.1002/art.1780380408
10.1038/nature14468
10.1074/jbc.270.51.30327
10.1016/j.cmet.2017.10.006
10.1002/art.40038
10.1016/j.molimm.2005.05.002
10.1146/annurev.biochem.74.082803.133500
10.1038/nmeth.4396
10.1007/s11926-016-0571-2
10.1186/s13059-014-0550-8
10.1152/physrev.00035.2007
10.1097/00002030-200006160-00004
10.1074/jbc.M800224200
10.1165/rcmb.2004-0243OC
10.1126/science.1065543
10.1177/096120339700600905
10.1016/0896-8411(91)90056-I
10.1093/rheumatology/key418
10.1016/j.celrep.2017.01.007
10.3389/fimmu.2018.02981
10.1371/journal.pone.0183357
10.1016/j.cell.2006.02.041
10.1038/nbt.1754
10.1002/art.1780350606
10.1126/science.1090148
10.1038/nrrheum.2013.147
10.1016/j.ijid.2012.07.008
10.1093/nar/gkv238
10.1016/j.cyto.2013.02.023
10.3389/fimmu.2019.00760
10.1016/j.clim.2019.108276
10.3109/10428190109097682
10.1371/journal.pone.0101920
10.1155/2019/4278658
10.1038/ni.3773
10.1016/S0022-1759(03)00265-5
10.18632/oncotarget.4693
10.4049/jimmunol.1302943
10.1155/2018/7019398
10.1371/journal.pone.0141171
10.2174/138161209787185788
10.1093/nar/gku365
10.1016/j.bbrc.2006.05.042
10.1128/mBio.01141-17
10.1002/art.40931
10.1097/QAD.0000000000002068
10.1046/j.1365-2249.2003.02219.x
10.1093/bioinformatics/btp352
10.1186/gb-2009-10-3-r25
10.1371/journal.pone.0111382
10.1046/j.1365-2249.2002.01809.x
10.1016/j.immuni.2009.11.009
10.1177/0961203313493032
10.1016/S1074-7613(04)00048-2
10.1038/nm1101-1209
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Issue 1
Keywords nicotinamide adenine dinucleotide
systemic lupus erythematosus
infection
CD8 T cell
patients
CD38
cytotoxicity
Sirtuin1
EZH2
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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content type line 23
Conceptualization, E.K., A.S.-F., S.J.B., and G.C.T.; Methodology, E.K., A.S.-F., S.J.B., V.C.K., F.M., and G.C.T.; Investigation, E.K., A.S.-F., S.J.B., V.C.K., M.M., L.M., A.V.M., and S.K.; Formal Analysis, E.K., A.S.-F., S.J.B., V.C.K., J.Y., and S.J.H.S.; Writing—Original Draft, E.K., A.S.-F., and G.C.T.; Writing—Review & Editing, E.K., V.C.K., F.M., H.S.S., and G.C.T.; Funding Acquisition, G.C.T.; Resources, F.M.; Supervision, G.C.T.
AUTHOR CONTRIBUTIONS
ORCID 0000-0002-8696-0197
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References Morandi, Morandi, Horenstein, Chillemi, Quarona, Zaccarello, Carrega, Ferlazzo, Mingari, Moretta (bib51) 2015; 6
Rodrigues, Medeiros, Weckx, Bonnez, Salomão, Kallas (bib65) 2002; 128
Scharer, Barwick, Guo, Bally, Boss (bib69) 2018; 9
Erkeller-Yuksel, Lydyard, Isenberg (bib26) 1997; 6
Malavasi, Deaglio, Funaro, Ferrero, Horenstein, Ortolan, Vaisitti, Aydin (bib47) 2008; 88
Malavasi, Funaro, Alessio, DeMonte, Ausiello, Dianzani, Lanza, Magrini, Momo, Roggero (bib46) 1992; 22
Bernstein, Mikkelsen, Xie, Kamal, Huebert, Cuff, Fry, Meissner, Wernig, Plath (bib6) 2006; 125
Horenstein, Bracci, Morandi, Malavasi (bib32) 2019; 10
Iliopoulos, Tsokos (bib34) 1996; 25
Naidoo, Page, Li, Connell, Schindler, Lacouture, Postow, Wolchok (bib54) 2016; 27
Jeng, Hull, Fei, Kwon, Tsou, Kasler, Ng, Gordon, Johnson, Krogan (bib35) 2018; 215
Ospina, Echeverri, Zambrano, Suso, Martínez-Blanco, Cañas, Tobón (bib55) 2017; 56
Matalonga, Glaria, Bresque, Escande, Carbó, Kiefer, Vicente, León, Beceiro, Pascual-García (bib48) 2017; 18
Larsen, Sauce, Deback, Arnaud, Mathian, Miyara, Boutolleau, Parizot, Dorgham, Papagno (bib40) 2011; 7
Love, Huber, Anders (bib45) 2014; 15
Tarasov, Vilella, Cuppen, Nijman, Prins (bib76) 2015; 31
Leu, Hsu, Kuo, Lai, Liu, Chen, Chang, Tsai, Chen (bib41) 2019; 58
Tan, Cohen, Fries, Masi, McShane, Rothfield, Schaller, Talal, Winchester (bib75) 1982; 25
Ramírez, Dündar, Diehl, Grüning, Manke (bib63) 2014; 42
Tong, He, Xie, Mochizuki, Liu, Mochizuki, Meng, Sun, Zhang, Guo (bib77) 2014; 192
D’Arena, Musto, Cascavilla, Dell’Olio, Di Renzo, Perla, Savino, Carotenuto (bib21) 2001; 42
Kis-Toth, Comte, Karampetsou, Kyttaris, Kannan, Terhorst, Tsokos (bib37) 2016; 68
Buggert, Tauriainen, Yamamoto, Frederiksen, Ivarsson, Michaëlsson, Lund, Hejdeman, Jansson, Sönnerborg (bib12) 2014; 10
Didion, Martin, Collins (bib25) 2017; 5
Danza, Ruiz-Irastorza (bib22) 2013; 22
Betts, Brenchley, Price, De Rosa, Douek, Roederer, Koup (bib7) 2003; 281
Viegas, Silva, Monteiro, do Carmo, Martins (bib79) 2011; 50
Kono, Yoshida, Maeda, Tsokos (bib38) 2018; 115
You, Wu, Wu, Wei, Wang, Jiang, Yu, Zhang, Wang, Tang (bib81) 2012; 16
Corces, Trevino, Hamilton, Greenside, Sinnott-Armstrong, Vesuna, Satpathy, Rubin, Montine, Wu (bib19) 2017; 14
Feng, Zhang, Liang, Wang, Zhao, Gao, Guo, Luo (bib27) 2019; 28
Stohl (bib73) 1995; 38
Pavón, Muñoz, Navarro, Raya-Alvarez, Callejas-Rubio, Navarro-Pelayo, Ortego-Centeno, Sancho, Zubiaur (bib59) 2006; 43
Chatterjee, Daenthanasanmak, Chakraborty, Wyatt, Dhar, Selvam, Fu, Zhang, Nguyen, Kang (bib16) 2018; 27
Chini (bib17) 2009; 15
Dentone, Fenoglio, Schenone, Cenderello, Prinapori, Signori, Parodi, Kalli, Battaglia, Feasi (bib23) 2015; 16
Cantó, Menzies, Auwerx (bib14) 2015; 22
Li, He, Hao, Ni, Dong (bib43) 2018; 9
Shan, Zeng, Xing, Li, Hartwig, Gullicksrud, Kurup, Van Braeckel-Budimir, Su, Martin (bib70) 2017; 18
Zidovec Lepej, Vince, Dakovic Rode, Remenar, Jeren (bib84) 2003; 133
Li, Handsaker, Wysoker, Fennell, Ruan, Homer, Marth, Abecasis, Durbin (bib42) 2009; 25
Blair, Noreña, Flores-Borja, Rawlings, Isenberg, Ehrenstein, Mauri (bib8) 2010; 32
Arbuckle, Gardina, Gordon, Hickman, Yewdell, Pierson, Myers, Kristie (bib5) 2017; 8
Langmead, Trapnell, Pop, Salzberg (bib39) 2009; 10
Lieberman, Tsokos (bib44) 2014; 9
Aksoy, White, Thompson, Chini (bib2) 2006; 345
Szabo, Sullivan, Stemmann, Satoskar, Sleckman, Glimcher (bib74) 2002; 295
Partida-Sánchez, Goodrich, Kusser, Oppenheimer, Randall, Lund (bib58) 2004; 20
Alcocer-Varela, Alarcón-Riquelme, Laffón, Sánchez-Madrid, Alarcón-Segovia (bib3) 1991; 4
Wan, Zhan, Li, Ma, Xu, Liu, Xue, Xie, Fang, Chin, Zhang (bib80) 2015; 43
Pannus, Adams, Willems, Heyndrickx, Florence, Rutsaert, De Spiegelaere, Vandekerckhove, Seguin-Devaux, Vanham (bib56) 2019; 33
Perl (bib62) 2013; 9
Zaritskaya, Shurin, Sayers, Malyguine (bib82) 2010; 9
Deshpande, White, Guedes, Milla, Walseth, Lund, Kannan (bib24) 2005; 32
Sauve, Wolberger, Schramm, Boeke (bib67) 2006; 75
Carroll, Liang, Salama, Stark, de Santiago (bib15) 2014; 5
Kang, Quan, Nolasco, Park, Hong, Crouch, Pamer, Howe, Craft (bib36) 2004; 172
Pearce, Mullen, Martins, Krawczyk, Hutchins, Zediak, Banica, DiCioccio, Gross, Mao (bib61) 2003; 302
Zhang, Liu, Meyer, Eeckhoute, Johnson, Bernstein, Nusbaum, Myers, Brown, Li, Liu (bib83) 2008; 9
Murphy, Bhamidiphati, Rubin, Kipp, Robinson, Lanz (bib53) 2019; 209
Rohraff, He, Farkash, Schonfeld, Tsou, Sawalha (bib66) 2019; 71
Bombardier, Gladman, Urowitz, Caron, Chang (bib9) 1992; 35
Aarhus, Graeff, Dickey, Walseth, Lee (bib1) 1995; 270
Shrishrimal, Kosmacek, Oberley-Deegan (bib71) 2019; 2019
Cruz-Guilloty, Pipkin, Djuretic, Levanon, Lotem, Lichtenheld, Groner, Rao (bib20) 2009; 206
Savarino, Bottarel, Malavasi, Dianzani (bib68) 2000; 14
Hua, Lécuroux, Sáez-Cirión, Pancino, Girault, Versmisse, Boufassa, Taulera, Sinet, Lambotte, Venet (bib33) 2014; 9
Fujii, Ito, Ito, Ochiai (bib29) 2008; 283
He, Liu, Meng, Sun, Wang, Ji, Purushe, Chen, Li, Madzo (bib31) 2017; 8
Stark, Brown (bib72) 2011
Bradley, Suarez-Fueyo, Moss, Kyttaris, Tsokos (bib11) 2015; 10
Comte, Karampetsou, Yoshida, Kis-Toth, Kyttaris, Tsokos (bib18) 2017; 69
Tsokos, Magrath, Balow (bib78) 1983; 131
Gertz, Fischer, Nguyen, Lakshminarasimhan, Schutkowski, Weyand, Steegborn (bib30) 2013; 110
Andrews (bib4) 2010
Fors Nieves, Izmirly (bib28) 2016; 18
McKinney, Lee, Jayne, Lyons, Smith (bib50) 2015; 523
McCabe, Ott, Ganji, Korenchuk, Thompson, Van Aller, Liu, Graves, Della Pietra, Diaz (bib49) 2012; 492
Robinson, Thorvaldsdóttir, Winckler, Guttman, Lander, Getz, Mesirov (bib64) 2011; 29
Booiman, Wit, Girigorie, Maurer, De Francesco, Sabin, Harskamp, Prins, Franceschi, Deeks (bib10) 2017; 12
Morandi, Horenstein, Rizzo, Malavasi (bib52) 2018; 2018
Pavón, Zumaquero, Rosal-Vela, Khoo, Cerezo-Wallis, García-Rodríguez, Carrascal, Abian, Graeff, Callejas-Rubio (bib60) 2013; 62
Cantó, Auwerx (bib13) 2012; 64
Partida-Sánchez, Cockayne, Monard, Jacobson, Oppenheimer, Garvy, Kusser, Goodrich, Howard, Harmsen (bib57) 2001; 7
Andrews (10.1016/j.celrep.2019.12.014_bib4) 2010
Booiman (10.1016/j.celrep.2019.12.014_bib10) 2017; 12
Murphy (10.1016/j.celrep.2019.12.014_bib53) 2019; 209
Partida-Sánchez (10.1016/j.celrep.2019.12.014_bib57) 2001; 7
Tong (10.1016/j.celrep.2019.12.014_bib77) 2014; 192
Aarhus (10.1016/j.celrep.2019.12.014_bib1) 1995; 270
Horenstein (10.1016/j.celrep.2019.12.014_bib32) 2019; 10
Wan (10.1016/j.celrep.2019.12.014_bib80) 2015; 43
Bombardier (10.1016/j.celrep.2019.12.014_bib9) 1992; 35
Kang (10.1016/j.celrep.2019.12.014_bib36) 2004; 172
Malavasi (10.1016/j.celrep.2019.12.014_bib47) 2008; 88
Cruz-Guilloty (10.1016/j.celrep.2019.12.014_bib20) 2009; 206
Fujii (10.1016/j.celrep.2019.12.014_bib29) 2008; 283
Cantó (10.1016/j.celrep.2019.12.014_bib13) 2012; 64
Danza (10.1016/j.celrep.2019.12.014_bib22) 2013; 22
Li (10.1016/j.celrep.2019.12.014_bib42) 2009; 25
Robinson (10.1016/j.celrep.2019.12.014_bib64) 2011; 29
McCabe (10.1016/j.celrep.2019.12.014_bib49) 2012; 492
Partida-Sánchez (10.1016/j.celrep.2019.12.014_bib58) 2004; 20
Jeng (10.1016/j.celrep.2019.12.014_bib35) 2018; 215
Pannus (10.1016/j.celrep.2019.12.014_bib56) 2019; 33
Cantó (10.1016/j.celrep.2019.12.014_bib14) 2015; 22
Li (10.1016/j.celrep.2019.12.014_bib43) 2018; 9
Zidovec Lepej (10.1016/j.celrep.2019.12.014_bib84) 2003; 133
Ramírez (10.1016/j.celrep.2019.12.014_bib63) 2014; 42
Pavón (10.1016/j.celrep.2019.12.014_bib59) 2006; 43
Carroll (10.1016/j.celrep.2019.12.014_bib15) 2014; 5
Blair (10.1016/j.celrep.2019.12.014_bib8) 2010; 32
Malavasi (10.1016/j.celrep.2019.12.014_bib46) 1992; 22
D’Arena (10.1016/j.celrep.2019.12.014_bib21) 2001; 42
Fors Nieves (10.1016/j.celrep.2019.12.014_bib28) 2016; 18
Stark (10.1016/j.celrep.2019.12.014_bib72)
Dentone (10.1016/j.celrep.2019.12.014_bib23) 2015; 16
Arbuckle (10.1016/j.celrep.2019.12.014_bib5) 2017; 8
Langmead (10.1016/j.celrep.2019.12.014_bib39) 2009; 10
Tarasov (10.1016/j.celrep.2019.12.014_bib76) 2015; 31
Scharer (10.1016/j.celrep.2019.12.014_bib69) 2018; 9
Leu (10.1016/j.celrep.2019.12.014_bib41) 2019; 58
Erkeller-Yuksel (10.1016/j.celrep.2019.12.014_bib26) 1997; 6
Iliopoulos (10.1016/j.celrep.2019.12.014_bib34) 1996; 25
Aksoy (10.1016/j.celrep.2019.12.014_bib2) 2006; 345
Feng (10.1016/j.celrep.2019.12.014_bib27) 2019; 28
Rohraff (10.1016/j.celrep.2019.12.014_bib66) 2019; 71
Bernstein (10.1016/j.celrep.2019.12.014_bib6) 2006; 125
Buggert (10.1016/j.celrep.2019.12.014_bib12) 2014; 10
He (10.1016/j.celrep.2019.12.014_bib31) 2017; 8
Hua (10.1016/j.celrep.2019.12.014_bib33) 2014; 9
You (10.1016/j.celrep.2019.12.014_bib81) 2012; 16
Corces (10.1016/j.celrep.2019.12.014_bib19) 2017; 14
Betts (10.1016/j.celrep.2019.12.014_bib7) 2003; 281
Deshpande (10.1016/j.celrep.2019.12.014_bib24) 2005; 32
Bradley (10.1016/j.celrep.2019.12.014_bib11) 2015; 10
Chini (10.1016/j.celrep.2019.12.014_bib17) 2009; 15
McKinney (10.1016/j.celrep.2019.12.014_bib50) 2015; 523
Viegas (10.1016/j.celrep.2019.12.014_bib79) 2011; 50
Larsen (10.1016/j.celrep.2019.12.014_bib40) 2011; 7
Savarino (10.1016/j.celrep.2019.12.014_bib68) 2000; 14
Tan (10.1016/j.celrep.2019.12.014_bib75) 1982; 25
Chatterjee (10.1016/j.celrep.2019.12.014_bib16) 2018; 27
Stohl (10.1016/j.celrep.2019.12.014_bib73) 1995; 38
Ospina (10.1016/j.celrep.2019.12.014_bib55) 2017; 56
Sauve (10.1016/j.celrep.2019.12.014_bib67) 2006; 75
Didion (10.1016/j.celrep.2019.12.014_bib25) 2017; 5
Kis-Toth (10.1016/j.celrep.2019.12.014_bib37) 2016; 68
Tsokos (10.1016/j.celrep.2019.12.014_bib78) 1983; 131
Pearce (10.1016/j.celrep.2019.12.014_bib61) 2003; 302
Morandi (10.1016/j.celrep.2019.12.014_bib52) 2018; 2018
Kono (10.1016/j.celrep.2019.12.014_bib38) 2018; 115
Comte (10.1016/j.celrep.2019.12.014_bib18) 2017; 69
Gertz (10.1016/j.celrep.2019.12.014_bib30) 2013; 110
Pavón (10.1016/j.celrep.2019.12.014_bib60) 2013; 62
Shrishrimal (10.1016/j.celrep.2019.12.014_bib71) 2019; 2019
Shan (10.1016/j.celrep.2019.12.014_bib70) 2017; 18
Zhang (10.1016/j.celrep.2019.12.014_bib83) 2008; 9
Naidoo (10.1016/j.celrep.2019.12.014_bib54) 2016; 27
Morandi (10.1016/j.celrep.2019.12.014_bib51) 2015; 6
Rodrigues (10.1016/j.celrep.2019.12.014_bib65) 2002; 128
Love (10.1016/j.celrep.2019.12.014_bib45) 2014; 15
Lieberman (10.1016/j.celrep.2019.12.014_bib44) 2014; 9
Perl (10.1016/j.celrep.2019.12.014_bib62) 2013; 9
Szabo (10.1016/j.celrep.2019.12.014_bib74) 2002; 295
Zaritskaya (10.1016/j.celrep.2019.12.014_bib82) 2010; 9
Alcocer-Varela (10.1016/j.celrep.2019.12.014_bib3) 1991; 4
Matalonga (10.1016/j.celrep.2019.12.014_bib48) 2017; 18
32061543 - Trends Immunol. 2020 Mar;41(3):187-189
References_xml – volume: 283
  start-page: 17324
  year: 2008
  end-page: 17332
  ident: bib29
  article-title: Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation
  publication-title: J. Biol. Chem.
– volume: 7
  start-page: e1002328
  year: 2011
  ident: bib40
  article-title: Exhausted cytotoxic control of Epstein-Barr virus in human lupus
  publication-title: PLoS Pathog.
– volume: 22
  start-page: 1286
  year: 2013
  end-page: 1294
  ident: bib22
  article-title: Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies
  publication-title: Lupus
– volume: 115
  start-page: 2478
  year: 2018
  end-page: 2483
  ident: bib38
  article-title: Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 42
  start-page: 109
  year: 2001
  end-page: 114
  ident: bib21
  article-title: CD38 expression correlates with adverse biological features and predicts poor clinical outcome in B-cell chronic lymphocytic leukemia
  publication-title: Leuk. Lymphoma
– volume: 43
  start-page: 1029
  year: 2006
  end-page: 1039
  ident: bib59
  article-title: Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells
  publication-title: Mol. Immunol.
– volume: 32
  start-page: 129
  year: 2010
  end-page: 140
  ident: bib8
  article-title: CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
  publication-title: Immunity
– volume: 12
  start-page: e0183357
  year: 2017
  ident: bib10
  article-title: Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls
  publication-title: PLoS ONE
– volume: 31
  start-page: 2032
  year: 2015
  end-page: 2034
  ident: bib76
  article-title: Sambamba: fast processing of NGS alignment formats
  publication-title: Bioinformatics
– volume: 10
  start-page: R25
  year: 2009
  ident: bib39
  article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
  publication-title: Genome Biol.
– volume: 10
  start-page: 760
  year: 2019
  ident: bib32
  article-title: CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy
  publication-title: Front. Immunol.
– volume: 68
  start-page: 164
  year: 2016
  end-page: 173
  ident: bib37
  article-title: Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus
  publication-title: Arthritis Rheumatol.
– volume: 64
  start-page: 166
  year: 2012
  end-page: 187
  ident: bib13
  article-title: Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
  publication-title: Pharmacol. Rev.
– volume: 192
  start-page: 5012
  year: 2014
  end-page: 5022
  ident: bib77
  article-title: Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice
  publication-title: J. Immunol.
– volume: 6
  start-page: 25602
  year: 2015
  end-page: 25618
  ident: bib51
  article-title: A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation
  publication-title: Oncotarget
– volume: 14
  start-page: 1079
  year: 2000
  end-page: 1089
  ident: bib68
  article-title: Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions?
  publication-title: AIDS
– volume: 10
  start-page: e0141171
  year: 2015
  ident: bib11
  article-title: T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus
  publication-title: PLoS ONE
– volume: 9
  start-page: R137
  year: 2008
  ident: bib83
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
– volume: 5
  start-page: 75
  year: 2014
  ident: bib15
  article-title: Impact of artifact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data
  publication-title: Front. Genet.
– volume: 206
  start-page: 51
  year: 2009
  end-page: 59
  ident: bib20
  article-title: Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
  publication-title: J. Exp. Med.
– volume: 302
  start-page: 1041
  year: 2003
  end-page: 1043
  ident: bib61
  article-title: Control of effector CD8+ T cell function by the transcription factor Eomesodermin
  publication-title: Science
– volume: 128
  start-page: 149
  year: 2002
  end-page: 154
  ident: bib65
  article-title: Immunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculosis infection and disease
  publication-title: Clin. Exp. Immunol.
– volume: 133
  start-page: 384
  year: 2003
  end-page: 390
  ident: bib84
  article-title: Increased numbers of CD38 molecules on bright CD8+ T lymphocytes in infectious mononucleosis caused by Epstein-Barr virus infection
  publication-title: Clin. Exp. Immunol.
– volume: 215
  start-page: 51
  year: 2018
  end-page: 62
  ident: bib35
  article-title: Metabolic reprogramming of human CD8
  publication-title: J. Exp. Med.
– volume: 6
  start-page: 708
  year: 1997
  end-page: 712
  ident: bib26
  article-title: Lack of NK cells in lupus patients with renal involvement
  publication-title: Lupus
– volume: 18
  start-page: 21
  year: 2016
  ident: bib28
  article-title: Mortality in Systemic Lupus Erythematosus: an Updated Review
  publication-title: Curr. Rheumatol. Rep.
– volume: 209
  start-page: 108276
  year: 2019
  ident: bib53
  article-title: Immunomodulatory receptors are differentially expressed in B and T cells subsets relevant to autoimmune disease
  publication-title: Clin. Immunol.
– volume: 295
  start-page: 338
  year: 2002
  end-page: 342
  ident: bib74
  article-title: Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
  publication-title: Science
– volume: 75
  start-page: 435
  year: 2006
  end-page: 465
  ident: bib67
  article-title: The biochemistry of sirtuins
  publication-title: Annu. Rev. Biochem.
– volume: 56
  start-page: i46
  year: 2017
  end-page: i54
  ident: bib55
  article-title: Distinguishing infections vs flares in patients with systemic lupus erythematosus
  publication-title: Rheumatology (Oxford)
– volume: 20
  start-page: 279
  year: 2004
  end-page: 291
  ident: bib58
  article-title: Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity
  publication-title: Immunity
– volume: 172
  start-page: 1287
  year: 2004
  end-page: 1294
  ident: bib36
  article-title: Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
  publication-title: J. Immunol.
– volume: 492
  start-page: 108
  year: 2012
  end-page: 112
  ident: bib49
  article-title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
  publication-title: Nature
– volume: 110
  start-page: E2772
  year: 2013
  end-page: E2781
  ident: bib30
  article-title: Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 2019
  start-page: 4278658
  year: 2019
  ident: bib71
  article-title: Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
  publication-title: Oxid. Med. Cell. Longev.
– volume: 35
  start-page: 630
  year: 1992
  end-page: 640
  ident: bib9
  article-title: Derivation of the SLEDAI. A disease activity index for lupus patients
  publication-title: Arthritis Rheum.
– volume: 18
  start-page: 1241
  year: 2017
  end-page: 1255
  ident: bib48
  article-title: The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism
  publication-title: Cell Rep.
– volume: 9
  start-page: 674
  year: 2013
  end-page: 686
  ident: bib62
  article-title: Oxidative stress in the pathology and treatment of systemic lupus erythematosus
  publication-title: Nat. Rev. Rheumatol.
– volume: 69
  start-page: 1035
  year: 2017
  end-page: 1044
  ident: bib18
  article-title: Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus
  publication-title: Arthritis Rheumatol.
– volume: 281
  start-page: 65
  year: 2003
  end-page: 78
  ident: bib7
  article-title: Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
  publication-title: J. Immunol. Methods
– volume: 88
  start-page: 841
  year: 2008
  end-page: 886
  ident: bib47
  article-title: Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
  publication-title: Physiol. Rev.
– volume: 71
  start-page: 1681
  year: 2019
  end-page: 1690
  ident: bib66
  article-title: Inhibition of EZH2 Ameliorates Lupus-Like Disease in MRL/lpr Mice
  publication-title: Arthritis Rheumatol
– volume: 9
  start-page: 2981
  year: 2018
  ident: bib43
  article-title: High Levels of Eomes Promote Exhaustion of Anti-tumor CD8
  publication-title: Front. Immunol.
– volume: 125
  start-page: 315
  year: 2006
  end-page: 326
  ident: bib6
  article-title: A bivalent chromatin structure marks key developmental genes in embryonic stem cells
  publication-title: Cell
– year: 2011
  ident: bib72
  article-title: DiffBind: differential binding analysis of ChIP-Seq peak data
– volume: 15
  start-page: 57
  year: 2009
  end-page: 63
  ident: bib17
  article-title: CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions
  publication-title: Curr. Pharm. Des.
– volume: 29
  start-page: 24
  year: 2011
  end-page: 26
  ident: bib64
  article-title: Integrative genomics viewer
  publication-title: Nat. Biotechnol.
– volume: 16
  start-page: e816
  year: 2012
  end-page: e825
  ident: bib81
  article-title: Immunogenicity and protective efficacy of heterologous prime-boost regimens with mycobacterial vaccines and recombinant adenovirus- and poxvirus-vectored vaccines against murine tuberculosis
  publication-title: Int. J. Infect. Dis.
– volume: 33
  start-page: 387
  year: 2019
  end-page: 398
  ident: bib56
  article-title: In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients
  publication-title: AIDS
– volume: 43
  start-page: 3591
  year: 2015
  end-page: 3604
  ident: bib80
  article-title: PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression
  publication-title: Nucleic Acids Res.
– volume: 4
  start-page: 935
  year: 1991
  end-page: 945
  ident: bib3
  article-title: Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2
  publication-title: J. Autoimmun.
– volume: 14
  start-page: 959
  year: 2017
  end-page: 962
  ident: bib19
  article-title: An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
  publication-title: Nat. Methods
– volume: 32
  start-page: 149
  year: 2005
  end-page: 156
  ident: bib24
  article-title: Altered airway responsiveness in CD38-deficient mice
  publication-title: Am. J. Respir. Cell Mol. Biol.
– volume: 25
  start-page: 2078
  year: 2009
  end-page: 2079
  ident: bib42
  article-title: The Sequence Alignment/Map format and SAMtools
  publication-title: Bioinformatics
– volume: 2018
  start-page: 7019398
  year: 2018
  ident: bib52
  article-title: The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases
  publication-title: Mediators Inflamm.
– volume: 345
  start-page: 1386
  year: 2006
  end-page: 1392
  ident: bib2
  article-title: Regulation of intracellular levels of NAD: a novel role for CD38
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 38
  start-page: 506
  year: 1995
  end-page: 516
  ident: bib73
  article-title: Impaired polyclonal T cell cytolytic activity. A possible risk factor for systemic lupus erythematosus
  publication-title: Arthritis Rheum.
– volume: 270
  start-page: 30327
  year: 1995
  end-page: 30333
  ident: bib1
  article-title: ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP
  publication-title: J. Biol. Chem.
– volume: 15
  start-page: 550
  year: 2014
  ident: bib45
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
– volume: 16
  start-page: 190
  year: 2015
  end-page: 196
  ident: bib23
  article-title: Increased CD38 expression on T lymphocytes as a marker of HIV dissemination into the central nervous system
  publication-title: HIV Clin. Trials
– volume: 9
  start-page: e111382
  year: 2014
  ident: bib44
  article-title: Lupus-prone mice fail to raise antigen-specific T cell responses to intracellular infection
  publication-title: PLoS ONE
– volume: 18
  start-page: 931
  year: 2017
  end-page: 939
  ident: bib70
  article-title: The transcription factor Runx3 guards cytotoxic CD8
  publication-title: Nat. Immunol.
– volume: 5
  start-page: e3720
  year: 2017
  ident: bib25
  article-title: Atropos: specific, sensitive, and speedy trimming of sequencing reads
  publication-title: PeerJ
– volume: 25
  start-page: 1271
  year: 1982
  end-page: 1277
  ident: bib75
  article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum.
– volume: 9
  start-page: 601
  year: 2010
  end-page: 616
  ident: bib82
  article-title: New flow cytometric assays for monitoring cell-mediated cytotoxicity
  publication-title: Expert Rev. Vaccines
– year: 2010
  ident: bib4
  article-title: FastQC: a quality control tool for high throughput sequence data. Available online
– volume: 8
  year: 2017
  ident: bib5
  article-title: Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
  publication-title: MBio
– volume: 9
  start-page: 1698
  year: 2018
  ident: bib69
  article-title: Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
  publication-title: Nat. Commun.
– volume: 22
  start-page: 31
  year: 2015
  end-page: 53
  ident: bib14
  article-title: NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
  publication-title: Cell Metab.
– volume: 27
  start-page: 1362
  year: 2016
  ident: bib54
  article-title: Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
  publication-title: Ann. Oncol.
– volume: 523
  start-page: 612
  year: 2015
  end-page: 616
  ident: bib50
  article-title: T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
  publication-title: Nature
– volume: 28
  start-page: 304
  year: 2019
  end-page: 316
  ident: bib27
  article-title: Peripheral neutrophil CD64 index combined with complement, CRP, WBC count and B cells improves the ability of diagnosing bacterial infection in SLE
  publication-title: Lupus
– volume: 58
  start-page: 719
  year: 2019
  end-page: 728
  ident: bib41
  article-title: Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus
  publication-title: Rheumatology (Oxford)
– volume: 50
  start-page: 1569
  year: 2011
  end-page: 1577
  ident: bib79
  article-title: Knocking out of CD38 accelerates development of a lupus-like disease in lpr mice
  publication-title: Rheumatology (Oxford)
– volume: 27
  start-page: 85
  year: 2018
  end-page: 100
  ident: bib16
  article-title: CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
  publication-title: Cell Metab
– volume: 42
  start-page: W187
  year: 2014
  end-page: W191
  ident: bib63
  article-title: deepTools: a flexible platform for exploring deep-sequencing data
  publication-title: Nucleic Acids Res.
– volume: 10
  start-page: e1004251
  year: 2014
  ident: bib12
  article-title: T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
  publication-title: PLoS Pathog.
– volume: 8
  start-page: 2125
  year: 2017
  ident: bib31
  article-title: Ezh2 phosphorylation state determines its capacity to maintain CD8
  publication-title: Nat. Commun.
– volume: 22
  start-page: 73
  year: 1992
  end-page: 80
  ident: bib46
  article-title: CD38: a multi-lineage cell activation molecule with a split personality
  publication-title: Int. J. Clin. Lab. Res.
– volume: 9
  start-page: e101920
  year: 2014
  ident: bib33
  article-title: Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers
  publication-title: PLoS ONE
– volume: 7
  start-page: 1209
  year: 2001
  end-page: 1216
  ident: bib57
  article-title: Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
  publication-title: Nat. Med.
– volume: 62
  start-page: 232
  year: 2013
  end-page: 243
  ident: bib60
  article-title: Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients
  publication-title: Cytokine
– volume: 25
  start-page: 318
  year: 1996
  end-page: 336
  ident: bib34
  article-title: Immunopathogenesis and spectrum of infections in systemic lupus erythematosus
  publication-title: Semin. Arthritis Rheum.
– volume: 131
  start-page: 1797
  year: 1983
  end-page: 1801
  ident: bib78
  article-title: Epstein-Barr virus induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus
  publication-title: J. Immunol.
– volume: 131
  start-page: 1797
  year: 1983
  ident: 10.1016/j.celrep.2019.12.014_bib78
  article-title: Epstein-Barr virus induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.131.4.1797
– volume: 206
  start-page: 51
  year: 2009
  ident: 10.1016/j.celrep.2019.12.014_bib20
  article-title: Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20081242
– volume: 9
  start-page: 601
  year: 2010
  ident: 10.1016/j.celrep.2019.12.014_bib82
  article-title: New flow cytometric assays for monitoring cell-mediated cytotoxicity
  publication-title: Expert Rev. Vaccines
  doi: 10.1586/erv.10.49
– volume: 172
  start-page: 1287
  year: 2004
  ident: 10.1016/j.celrep.2019.12.014_bib36
  article-title: Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.172.2.1287
– volume: 9
  start-page: 1698
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib69
  article-title: Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04125-8
– volume: 25
  start-page: 1271
  year: 1982
  ident: 10.1016/j.celrep.2019.12.014_bib75
  article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780251101
– volume: 115
  start-page: 2478
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib38
  article-title: Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1714717115
– volume: 10
  start-page: e1004251
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib12
  article-title: T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1004251
– volume: 28
  start-page: 304
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib27
  article-title: Peripheral neutrophil CD64 index combined with complement, CRP, WBC count and B cells improves the ability of diagnosing bacterial infection in SLE
  publication-title: Lupus
  doi: 10.1177/0961203319827646
– volume: 16
  start-page: 190
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib23
  article-title: Increased CD38 expression on T lymphocytes as a marker of HIV dissemination into the central nervous system
  publication-title: HIV Clin. Trials
  doi: 10.1179/1945577115Y.0000000005
– volume: 68
  start-page: 164
  year: 2016
  ident: 10.1016/j.celrep.2019.12.014_bib37
  article-title: Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.39410
– volume: 9
  start-page: R137
  year: 2008
  ident: 10.1016/j.celrep.2019.12.014_bib83
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 492
  start-page: 108
  year: 2012
  ident: 10.1016/j.celrep.2019.12.014_bib49
  article-title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
  publication-title: Nature
  doi: 10.1038/nature11606
– volume: 5
  start-page: 75
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib15
  article-title: Impact of artifact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2014.00075
– volume: 215
  start-page: 51
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib35
  article-title: Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20161066
– volume: 31
  start-page: 2032
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib76
  article-title: Sambamba: fast processing of NGS alignment formats
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv098
– volume: 50
  start-page: 1569
  year: 2011
  ident: 10.1016/j.celrep.2019.12.014_bib79
  article-title: Knocking out of CD38 accelerates development of a lupus-like disease in lpr mice
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ker178
– volume: 110
  start-page: E2772
  year: 2013
  ident: 10.1016/j.celrep.2019.12.014_bib30
  article-title: Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1303628110
– volume: 5
  start-page: e3720
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib25
  article-title: Atropos: specific, sensitive, and speedy trimming of sequencing reads
  publication-title: PeerJ
  doi: 10.7717/peerj.3720
– volume: 8
  start-page: 2125
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib31
  article-title: Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-02187-8
– volume: 64
  start-page: 166
  year: 2012
  ident: 10.1016/j.celrep.2019.12.014_bib13
  article-title: Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
  publication-title: Pharmacol. Rev.
  doi: 10.1124/pr.110.003905
– volume: 27
  start-page: 1362
  year: 2016
  ident: 10.1016/j.celrep.2019.12.014_bib54
  article-title: Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdw141
– volume: 25
  start-page: 318
  year: 1996
  ident: 10.1016/j.celrep.2019.12.014_bib34
  article-title: Immunopathogenesis and spectrum of infections in systemic lupus erythematosus
  publication-title: Semin. Arthritis Rheum.
  doi: 10.1016/S0049-0172(96)80018-7
– volume: 7
  start-page: e1002328
  year: 2011
  ident: 10.1016/j.celrep.2019.12.014_bib40
  article-title: Exhausted cytotoxic control of Epstein-Barr virus in human lupus
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002328
– volume: 22
  start-page: 73
  year: 1992
  ident: 10.1016/j.celrep.2019.12.014_bib46
  article-title: CD38: a multi-lineage cell activation molecule with a split personality
  publication-title: Int. J. Clin. Lab. Res.
  doi: 10.1007/BF02591400
– volume: 22
  start-page: 31
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib14
  article-title: NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.05.023
– volume: 38
  start-page: 506
  year: 1995
  ident: 10.1016/j.celrep.2019.12.014_bib73
  article-title: Impaired polyclonal T cell cytolytic activity. A possible risk factor for systemic lupus erythematosus
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780380408
– volume: 523
  start-page: 612
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib50
  article-title: T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
  publication-title: Nature
  doi: 10.1038/nature14468
– volume: 270
  start-page: 30327
  year: 1995
  ident: 10.1016/j.celrep.2019.12.014_bib1
  article-title: ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.51.30327
– volume: 27
  start-page: 85
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib16
  article-title: CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2017.10.006
– volume: 69
  start-page: 1035
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib18
  article-title: Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.40038
– volume: 43
  start-page: 1029
  year: 2006
  ident: 10.1016/j.celrep.2019.12.014_bib59
  article-title: Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2005.05.002
– volume: 75
  start-page: 435
  year: 2006
  ident: 10.1016/j.celrep.2019.12.014_bib67
  article-title: The biochemistry of sirtuins
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.74.082803.133500
– volume: 14
  start-page: 959
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib19
  article-title: An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4396
– volume: 18
  start-page: 21
  year: 2016
  ident: 10.1016/j.celrep.2019.12.014_bib28
  article-title: Mortality in Systemic Lupus Erythematosus: an Updated Review
  publication-title: Curr. Rheumatol. Rep.
  doi: 10.1007/s11926-016-0571-2
– volume: 15
  start-page: 550
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib45
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 88
  start-page: 841
  year: 2008
  ident: 10.1016/j.celrep.2019.12.014_bib47
  article-title: Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00035.2007
– volume: 14
  start-page: 1079
  year: 2000
  ident: 10.1016/j.celrep.2019.12.014_bib68
  article-title: Role of CD38 in HIV-1 infection: an epiphenomenon of T-cell activation or an active player in virus/host interactions?
  publication-title: AIDS
  doi: 10.1097/00002030-200006160-00004
– volume: 283
  start-page: 17324
  year: 2008
  ident: 10.1016/j.celrep.2019.12.014_bib29
  article-title: Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M800224200
– volume: 32
  start-page: 149
  year: 2005
  ident: 10.1016/j.celrep.2019.12.014_bib24
  article-title: Altered airway responsiveness in CD38-deficient mice
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2004-0243OC
– volume: 295
  start-page: 338
  year: 2002
  ident: 10.1016/j.celrep.2019.12.014_bib74
  article-title: Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
  publication-title: Science
  doi: 10.1126/science.1065543
– volume: 6
  start-page: 708
  year: 1997
  ident: 10.1016/j.celrep.2019.12.014_bib26
  article-title: Lack of NK cells in lupus patients with renal involvement
  publication-title: Lupus
  doi: 10.1177/096120339700600905
– volume: 4
  start-page: 935
  year: 1991
  ident: 10.1016/j.celrep.2019.12.014_bib3
  article-title: Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2
  publication-title: J. Autoimmun.
  doi: 10.1016/0896-8411(91)90056-I
– volume: 58
  start-page: 719
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib41
  article-title: Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/key418
– volume: 18
  start-page: 1241
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib48
  article-title: The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.007
– volume: 9
  start-page: 2981
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib43
  article-title: High Levels of Eomes Promote Exhaustion of Anti-tumor CD8+ T Cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02981
– ident: 10.1016/j.celrep.2019.12.014_bib72
– volume: 12
  start-page: e0183357
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib10
  article-title: Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0183357
– volume: 125
  start-page: 315
  year: 2006
  ident: 10.1016/j.celrep.2019.12.014_bib6
  article-title: A bivalent chromatin structure marks key developmental genes in embryonic stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.041
– volume: 29
  start-page: 24
  year: 2011
  ident: 10.1016/j.celrep.2019.12.014_bib64
  article-title: Integrative genomics viewer
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1754
– volume: 35
  start-page: 630
  year: 1992
  ident: 10.1016/j.celrep.2019.12.014_bib9
  article-title: Derivation of the SLEDAI. A disease activity index for lupus patients
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.1780350606
– volume: 302
  start-page: 1041
  year: 2003
  ident: 10.1016/j.celrep.2019.12.014_bib61
  article-title: Control of effector CD8+ T cell function by the transcription factor Eomesodermin
  publication-title: Science
  doi: 10.1126/science.1090148
– volume: 9
  start-page: 674
  year: 2013
  ident: 10.1016/j.celrep.2019.12.014_bib62
  article-title: Oxidative stress in the pathology and treatment of systemic lupus erythematosus
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2013.147
– volume: 16
  start-page: e816
  year: 2012
  ident: 10.1016/j.celrep.2019.12.014_bib81
  article-title: Immunogenicity and protective efficacy of heterologous prime-boost regimens with mycobacterial vaccines and recombinant adenovirus- and poxvirus-vectored vaccines against murine tuberculosis
  publication-title: Int. J. Infect. Dis.
  doi: 10.1016/j.ijid.2012.07.008
– volume: 43
  start-page: 3591
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib80
  article-title: PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv238
– volume: 62
  start-page: 232
  year: 2013
  ident: 10.1016/j.celrep.2019.12.014_bib60
  article-title: Increased CD38 expression in T cells and circulating anti-CD38 IgG autoantibodies differentially correlate with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2013.02.023
– volume: 10
  start-page: 760
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib32
  article-title: CD38 in Adenosinergic Pathways and Metabolic Re-programming in Human Multiple Myeloma Cells: In-tandem Insights From Basic Science to Therapy
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00760
– year: 2010
  ident: 10.1016/j.celrep.2019.12.014_bib4
– volume: 209
  start-page: 108276
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib53
  article-title: Immunomodulatory receptors are differentially expressed in B and T cells subsets relevant to autoimmune disease
  publication-title: Clin. Immunol.
  doi: 10.1016/j.clim.2019.108276
– volume: 42
  start-page: 109
  year: 2001
  ident: 10.1016/j.celrep.2019.12.014_bib21
  article-title: CD38 expression correlates with adverse biological features and predicts poor clinical outcome in B-cell chronic lymphocytic leukemia
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428190109097682
– volume: 9
  start-page: e101920
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib33
  article-title: Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0101920
– volume: 2019
  start-page: 4278658
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib71
  article-title: Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2019/4278658
– volume: 18
  start-page: 931
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib70
  article-title: The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3773
– volume: 281
  start-page: 65
  year: 2003
  ident: 10.1016/j.celrep.2019.12.014_bib7
  article-title: Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
  publication-title: J. Immunol. Methods
  doi: 10.1016/S0022-1759(03)00265-5
– volume: 6
  start-page: 25602
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib51
  article-title: A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4693
– volume: 192
  start-page: 5012
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib77
  article-title: Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1302943
– volume: 2018
  start-page: 7019398
  year: 2018
  ident: 10.1016/j.celrep.2019.12.014_bib52
  article-title: The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases
  publication-title: Mediators Inflamm.
  doi: 10.1155/2018/7019398
– volume: 10
  start-page: e0141171
  year: 2015
  ident: 10.1016/j.celrep.2019.12.014_bib11
  article-title: T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0141171
– volume: 15
  start-page: 57
  year: 2009
  ident: 10.1016/j.celrep.2019.12.014_bib17
  article-title: CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/138161209787185788
– volume: 56
  start-page: i46
  issue: suppl_1
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib55
  article-title: Distinguishing infections vs flares in patients with systemic lupus erythematosus
  publication-title: Rheumatology (Oxford)
– volume: 42
  start-page: W187
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib63
  article-title: deepTools: a flexible platform for exploring deep-sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku365
– volume: 345
  start-page: 1386
  year: 2006
  ident: 10.1016/j.celrep.2019.12.014_bib2
  article-title: Regulation of intracellular levels of NAD: a novel role for CD38
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2006.05.042
– volume: 8
  year: 2017
  ident: 10.1016/j.celrep.2019.12.014_bib5
  article-title: Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens
  publication-title: MBio
  doi: 10.1128/mBio.01141-17
– volume: 71
  start-page: 1681
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib66
  article-title: Inhibition of EZH2 Ameliorates Lupus-Like Disease in MRL/lpr Mice
  publication-title: Arthritis Rheumatol
  doi: 10.1002/art.40931
– volume: 33
  start-page: 387
  year: 2019
  ident: 10.1016/j.celrep.2019.12.014_bib56
  article-title: In-vitro viral suppressive capacity correlates with immune checkpoint marker expression on peripheral CD8+ T cells in treated HIV-positive patients
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000002068
– volume: 133
  start-page: 384
  year: 2003
  ident: 10.1016/j.celrep.2019.12.014_bib84
  article-title: Increased numbers of CD38 molecules on bright CD8+ T lymphocytes in infectious mononucleosis caused by Epstein-Barr virus infection
  publication-title: Clin. Exp. Immunol.
  doi: 10.1046/j.1365-2249.2003.02219.x
– volume: 25
  start-page: 2078
  year: 2009
  ident: 10.1016/j.celrep.2019.12.014_bib42
  article-title: The Sequence Alignment/Map format and SAMtools
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp352
– volume: 10
  start-page: R25
  year: 2009
  ident: 10.1016/j.celrep.2019.12.014_bib39
  article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
  publication-title: Genome Biol.
  doi: 10.1186/gb-2009-10-3-r25
– volume: 9
  start-page: e111382
  year: 2014
  ident: 10.1016/j.celrep.2019.12.014_bib44
  article-title: Lupus-prone mice fail to raise antigen-specific T cell responses to intracellular infection
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0111382
– volume: 128
  start-page: 149
  year: 2002
  ident: 10.1016/j.celrep.2019.12.014_bib65
  article-title: Immunophenotypic characterization of peripheral T lymphocytes in Mycobacterium tuberculosis infection and disease
  publication-title: Clin. Exp. Immunol.
  doi: 10.1046/j.1365-2249.2002.01809.x
– volume: 32
  start-page: 129
  year: 2010
  ident: 10.1016/j.celrep.2019.12.014_bib8
  article-title: CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
  publication-title: Immunity
  doi: 10.1016/j.immuni.2009.11.009
– volume: 22
  start-page: 1286
  year: 2013
  ident: 10.1016/j.celrep.2019.12.014_bib22
  article-title: Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies
  publication-title: Lupus
  doi: 10.1177/0961203313493032
– volume: 20
  start-page: 279
  year: 2004
  ident: 10.1016/j.celrep.2019.12.014_bib58
  article-title: Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity
  publication-title: Immunity
  doi: 10.1016/S1074-7613(04)00048-2
– volume: 7
  start-page: 1209
  year: 2001
  ident: 10.1016/j.celrep.2019.12.014_bib57
  article-title: Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
  publication-title: Nat. Med.
  doi: 10.1038/nm1101-1209
– reference: 32061543 - Trends Immunol. 2020 Mar;41(3):187-189
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Snippet Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses...
Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses...
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SubjectTerms ADP-ribosyl Cyclase 1 - metabolism
Adult
CD38
CD8 T cell
CD8-Positive T-Lymphocytes - immunology
Cell Line
cytotoxicity
Enhancer of Zeste Homolog 2 Protein - metabolism
EZH2
Female
Humans
infection
Infections - immunology
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - microbiology
Male
NAD - metabolism
nicotinamide adenine dinucleotide
patients
Sirtuin 1 - metabolism
Sirtuin1
systemic lupus erythematosus
T-Lymphocytes, Cytotoxic - immunology
Transcription Factors - metabolism
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Title The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections
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