Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia - Tasian, Sarah K.; Teachey, David T.; Li, Yong; Shen, Feng; Harvey, Richard C.; Chen, I-Ming; Ryan, Theresa; Vincent, Tiffaney L.; Willman, Cheryl L.; Perl, Alexander E.; Hunger, Stephen P.; Loh, Mignon L.; et al. (Blood, 2017)
Keywords: Animals; Antineoplastic Agents - pharmacology; Cell Proliferation - drug effects; Humans; Janus Kinases - antagonists & inhibitors; Lymphoid Neoplasia; Mice; Phosphoinositide-3 Kinase Inhibitors; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins c-abl - antagonists & inhibitors; Random Allocation; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - antagonists & inhibitors; Xenograft Model Antitumor Assays