Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction - Bige, Naïke; Shweke, Nasim; Benhassine, Safa; Jouanneau, Chantal; Vandermeersch, Sophie; Dussaule, Jean-Claude; Chatziantoniou, Christos; Ronco, Pierre; Boffa, Jean-Jacques (Kidney international, 2012)
Keywords: Animals; Apoptosis; Atrophy; Biochemistry, Molecular Biology; Biological and medical sciences; Capillaries; Capillaries - metabolism; Capillaries - pathology; Cell Proliferation; Chemokine CCL2; Chemokine CCL2 - metabolism; Chronic Disease; Collagen Type III; Collagen Type III - metabolism; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Genomics; Inflammation Mediators; Inflammation Mediators - metabolism; Kidney; Kidney - blood supply; Kidney - metabolism; Kidney - pathology; Kidney Diseases; Kidney Diseases - etiology; Kidney Diseases - genetics; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidneys; Life Sciences; Male; Medical sciences; Mice; Mice, Knockout; Nephrectomy; Nephritis; Nephritis - etiology; Nephritis - genetics; Nephritis - metabolism; Nephritis - pathology; Nephritis - prevention & control; Nephrology. Urinary tract diseases; Rats; Rats, Sprague-Dawley; renal fibrosis; renal progression; Signal Transduction; TGF-β; Thrombospondin 1; Thrombospondin 1 - deficiency; Thrombospondin 1 - genetics; Thrombospondin 1 - metabolism; Time Factors; Transforming Growth Factor beta1; Transforming Growth Factor beta1 - metabolism; Ureteral Obstruction; Ureteral Obstruction - complications; Ureteral Obstruction - genetics; Ureteral Obstruction - metabolism; Ureteral Obstruction - pathology; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor A - metabolism; renal fibrosis; TGF-β; renal progression; Kidney disease; Nephrology; Urinary system disease; Prognosis; Transforming growth factor β; Renal fibrosis; Ureteral obstruction; Ureteral disease; Inflammation; Urinary tract disease; Thrombospondin 1; Kidney; Urology; Urinary system; Evolution; Antiangiogenic agent