RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure
The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of...
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| Published in | Molecular cell Vol. 62; no. 3; pp. 327 - 334 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
05.05.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-2765 1097-4164 |
| DOI | 10.1016/j.molcel.2016.03.034 |
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| Abstract | The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases.
In this Perspective, Pannunzio and Lieber discuss recent findings linking topological tension generated from transcription to genome rearrangements, framing the work in the historical context of research spanning the previous four decades. |
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| AbstractList | The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases. The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription, but arrived at different conclusions as to which is more detrimental and why. The issue turns on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases? The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases. In this Perspective, Pannunzio and Lieber discuss recent findings linking topological tension generated from transcription to genome rearrangements, framing the work in the historical context of research spanning the previous four decades. |
| Author | Pannunzio, Nicholas R. Lieber, Michael R. |
| AuthorAffiliation | 1 USC Norris Comprehensive Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Rm. 5428, Los Angeles, CA 90089, USA |
| AuthorAffiliation_xml | – name: 1 USC Norris Comprehensive Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Rm. 5428, Los Angeles, CA 90089, USA |
| Author_xml | – sequence: 1 givenname: Nicholas R. surname: Pannunzio fullname: Pannunzio, Nicholas R. organization: USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 5428, Los Angeles, CA 90089, USA – sequence: 2 givenname: Michael R. surname: Lieber fullname: Lieber, Michael R. email: lieber@usc.edu organization: USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, Room 5428, Los Angeles, CA 90089, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27153532$$D View this record in MEDLINE/PubMed |
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| Snippet | The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models... |
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| SubjectTerms | Animals Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Chromosomal Instability DNA DNA - chemistry DNA - metabolism DNA Damage DNA, Bacterial - chemistry DNA, Bacterial - metabolism DNA, Fungal - chemistry DNA, Fungal - metabolism DNA-directed RNA polymerase DNA-Directed RNA Polymerases - metabolism Humans mice Models, Genetic molecular biology Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Nucleic Acid Conformation RNA transcription (genetics) Transcription, Genetic turbulent flow |
| Title | RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure |
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