Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of d-amphetamine and SKF-82958, and their augmentation by food restriction in rat
Rationale Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK sign...
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| Published in | Psychopharmacologia Vol. 201; no. 4; pp. 495 - 506 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer-Verlag
01.01.2009
Springer Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0033-3158 1432-2072 |
| DOI | 10.1007/s00213-008-1313-6 |
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| Abstract | Rationale
Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs.
Objectives
The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR.
Materials and methods
Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of
d
-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958.
Results
FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of
d
-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups.
Conclusions
These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. |
|---|---|
| AbstractList | Rationale
Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs.
Objectives
The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR.
Materials and methods
Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of
d
-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958.
Results
FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of
d
-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups.
Conclusions
These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs. The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR. Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of d-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958. FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of d-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups. These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. [PUBLICATION ABSTRACT] Abstract; Rationale; Objectives; Materials and methods; Results; Conclusions Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs. The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR. Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of d-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958. FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of d-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups. These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs. The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR. Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of D-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958. FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of D-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups. These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs.RATIONALEFood restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role has been established for ERK signaling in drug-mediated associative learning, it is not clear whether ERK regulates unconditioned behavioral effects of abused drugs.The purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR.OBJECTIVESThe purpose of this study was to determine whether blockade of ERK signaling, using the brain-penetrant MEK inhibitor, SL-327, decreases behavioral or NAc cellular responses to acute drug treatment and their augmentation by FR.Separate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of D-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958.MATERIALS AND METHODSSeparate experiments assessed the effects of SL-327 (50 mg/kg, intraperitoneally) on (1) the reward-potentiating effect of D-amphetamine in an intracranial self-stimulation protocol, (2) the locomotor-activating effect of the D-1 agonist, SKF-82958, and (3) Fos-immunostaining induced in the NAc by SKF-82958.FR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of D-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups.RESULTSFR rats displayed enhanced responses to drug treatment on all measures. SL-327 had no effect on sensitivity to rewarding brain stimulation or the reward-potentiating effect of D-amphetamine. The MEK inhibitor, U0126, microinjected into the NAc was also without effect. The locomotor-activating effect of SKF-82958 was unaffected by SL-327. In contrast, SL-327 decreased NAc Fos-immunostaining and abolished the difference between feeding groups.These results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects.CONCLUSIONSThese results support the conclusion that ERK signaling does not mediate unlearned behavioral responses to drug treatment. However, the upregulation of ERK and downstream transcriptional responses to acute drug treatment may underlie the reported enhancement of reward-related learning in FR subjects. |
| Author | Chau, Lily S. Sun, Yanjie de Vaca, Soledad Cabeza Dela Cruz, Julie Pan, Yan Carr, Kenneth D. |
| AuthorAffiliation | 2 Department of Pharmacology, New York University School of Medicine 550 First Avenue, New York, New York 10016, USA 1 Department of Psychiatry, New York University School of Medicine 550 First Avenue, New York, New York 10016, USA |
| AuthorAffiliation_xml | – name: 1 Department of Psychiatry, New York University School of Medicine 550 First Avenue, New York, New York 10016, USA – name: 2 Department of Pharmacology, New York University School of Medicine 550 First Avenue, New York, New York 10016, USA |
| Author_xml | – sequence: 1 givenname: Kenneth D. surname: Carr fullname: Carr, Kenneth D. email: kc16@nyu.edu organization: Department of Psychiatry, School of Medicine, New York University, Department of Pharmacology, School of Medicine, New York University – sequence: 2 givenname: Soledad Cabeza surname: de Vaca fullname: de Vaca, Soledad Cabeza organization: Department of Psychiatry, School of Medicine, New York University – sequence: 3 givenname: Yanjie surname: Sun fullname: Sun, Yanjie organization: Department of Psychiatry, School of Medicine, New York University – sequence: 4 givenname: Lily S. surname: Chau fullname: Chau, Lily S. organization: Department of Psychiatry, School of Medicine, New York University – sequence: 5 givenname: Yan surname: Pan fullname: Pan, Yan organization: Department of Psychiatry, School of Medicine, New York University – sequence: 6 givenname: Julie surname: Dela Cruz fullname: Dela Cruz, Julie organization: Department of Psychiatry, School of Medicine, New York University |
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| Cites_doi | 10.1038/nprot.2007.441 10.1046/j.1460-9568.2003.02694.x 10.1016/j.tins.2006.10.005 10.1037/0735-7044.118.4.740 10.1016/j.coph.2005.12.003 10.1016/S0006-8993(00)02018-7 10.1037/h0037217 10.1016/j.neuropharm.2004.07.006 10.1016/j.neuron.2007.03.021 10.1016/S0896-6273(00)81056-9 10.1126/science.287.5461.2262 10.1016/j.neuron.2005.08.006 10.1002/(SICI)1098-2396(199703)25:3<227::AID-SYN1>3.0.CO;2-D 10.1111/j.1471-4159.2004.02712.x 10.1111/j.1460-9568.2004.03278.x 10.1016/0031-9384(86)90388-4 10.1111/j.1471-4159.2006.04208.x 10.1016/j.neuroscience.2005.12.024 10.1016/j.appet.2006.02.009 10.1038/nn1452 10.1038/sj.npp.1301014 10.1038/nrn1346 10.1186/1471-2202-7-20 10.1046/j.1471-4159.2001.00054.x 10.1016/j.neuroscience.2004.01.037 10.1038/nn1383 10.1016/S0893-133X(00)00238-4 10.1046/j.0953-816x.2001.01652.x 10.1016/0167-4943(87)90014-8 10.1007/s002130050258 10.1016/S0306-4522(03)00227-6 10.1016/j.tins.2007.03.008 10.1097/00001756-199212000-00013 10.1016/0899-3289(92)90041-U 10.1126/science.289.5478.463 10.1016/j.tins.2005.06.005 10.1016/j.neuroscience.2005.02.006 10.1046/j.1471-4159.2003.02067.x 10.1007/s002130000523 10.1016/0306-4603(95)00062-3 10.1016/0197-4580(89)90003-1 10.1146/annurev.neuro.29.051605.113009 10.1016/j.conb.2004.03.004 10.1038/sj.bjp.0705506 10.1146/annurev.ne.19.030196.001535 10.1016/B978-0-12-004704-8.50008-0 10.1523/JNEUROSCI.22-12-05042.2002 10.1523/JNEUROSCI.22-12-04860.2002 10.1523/JNEUROSCI.22-09-03306.2002 10.1523/JNEUROSCI.16-13-04231.1996 10.1016/j.molbrainres.2005.08.001 10.1523/JNEUROSCI.18-18-07502.1998 10.1128/MCB.19.1.136 10.1523/JNEUROSCI.20-23-08701.2000 10.1152/jn.2001.85.1.117 10.1523/JNEUROSCI.18-24-10297.1998 10.1093/geronj/42.1.78 |
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| Keywords | SKF-82958 SL-327 c amphetamine ERK 1/2 Self-stimulation Reward Food restriction U0126 Amphetamine derivatives Food restriction . Reward Extracellular signal-regulated protein kinase Rat Psychotropic D-amphetamine Protooncogene CNS stimulant Enzyme Transferases fos Gene Rodentia Mitogen-activated protein kinase In vitro Feeding Vertebrata Mammalia Animal C-Onc gene Self stimulation Dexamfetamine Inhibitor c-fos . ERK 1/2 . SL-327 . U0126 Restricted diet Immediate early gene |
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| References | Wise (CR57) 1996; 19 Crombag, Badiani, Chan, Dell’Orco, Dineen, Robinson (CR13) 2001; 24 Konradi, Leveque, We (CR33) 1996; 16 Carroll, Meisch (CR11) 1984; 4 Krahn, Kurth, Demitrack, Drewnowski (CR34) 1992; 4 Surmeier, Ding, Day, Wang, Shen (CR45) 2007; 30 Valjent, Corvol, Pages, Besson, Maldonado, Caboche (CR48) 2000; 20 Goldin, Segal (CR22) 2003; 17 Cardinal, Everitt (CR5) 2004; 14 Wiederman, Pryor (CR55) 1996; 21 Haberny, Carr (CR24) 2005; 141 Lu, Hope, Dempsey, Liu, Bossert, Shaham (CR35) 2005; 8 Carlezon, Duman, Nestler (CR7) 2005; 28 Gerfen, Miyachi, Paletzki, Brown (CR20) 2002; 22 Miller, Marshall (CR38) 2005; 47 Hyman, Malenka, Nestler (CR28) 2006; 29 Sweatt (CR46) 2001; 76 Valjent, Corvol, Trzaskos, Girault, Herve (CR51) 2006; 7 Cabeza de Vaca, Carr (CR3) 1998; 18 Paxinos, Watson (CR39) 1998 Carr, Kim, Cabeza de Vaca (CR9) 2000; 152 Wang, Fibuch, Mao (CR54) 2007; 100 Ferguson, Fasano, Yang, Brambilla, Robinson (CR18) 2006; 31 Valjent, Pages, Rogard, Besson, Maldonado, Caboche (CR49) 2001; 14 Berke, Hyman (CR2) 2000; 25 Lu, Koya, Zhai, Hope, Shaham (CR36) 2006; 29 Gerdjikov, Ross, Beninger (CR19) 2004; 118 Carr, Kutchukhidze (CR8) 2000; 861 Wilson, Fairburn, Wilson (CR56) 1993 Shi, McGinty (CR42) 2006; 138 Wolf, Sun, Mangiavacchi, Chao (CR58) 2004; 47 Carr, Tsimberg, Berman, Yamamoto (CR10) 2003; 119 Ferguson, Robinson (CR17) 2004; 91 Valjent, Pages, Herve, Girault, Caboche (CR50) 2004; 19 Vanhoutte, Barnier, Guibert, Pages, Besson, Hipskind, Caboche (CR52) 1999; 19 Thomas, Huganir (CR47) 2004; 5 Kelley, Berridge (CR31) 2002; 22 Stewart, Mitchell, Kalant (CR44) 1989; 10 Dudman, Eaton, Rajadhyaksha, Macias, Taher, Barczak, Kameyama, Huganir, Konradi (CR15) 2003; 87 Volkow, Wise (CR53) 2005; 8 Cheer, Aragona, Heien, Seipel, Carelli, Wightman (CR12) 2007; 54 Girault, Valjent, Caboche, Herve (CR21) 2006; 6 Ingram, Weindruch, Spangler, Freeman, Walford (CR30) 1987; 42 Hayashi, Shi, Esteban, Piccini, Poncer, Malinow (CR26) 2000; 287 Yuan, Adams, Swank, Sweatt, Johnston (CR59) 2002; 22 Bell, Stewart, Thompson, Meisch (CR1) 1997; 131 Polivy, Herman (CR40) 2006; 47 Carlezon, Chartoff (CR6) 2007; 2 Kerr, Wickens (CR32) 2001; 85 Snyder, Fienberg, Huganir, Greengard (CR43) 1998; 18 Haberny, Berman, Meller, Carr (CR25) 2004; 125 Idobro, Nandy, Mostofsky, Blatt, Nandy (CR29) 1987; 6 Das, Grunert, Williams, Vincent (CR14) 1997; 25 Edmonds, Gallistel (CR16) 1974; 87 Hori, Hirotsu, Davis, Carpenter (CR27) 1992; 3 Salzmann, Marie-Claire, Le Guen, Roques, Noble (CR41) 2003; 140 Haberny, Carr (CR23) 2005; 132 Cabib, Orsini, Le Moal, Piazza (CR4) 2000; 289 Miliaressis, Rompre, Laviolette, Philippe, Coulombe (CR37) 1986; 37 JT Dudman (1313_CR15) 2003; 87 DE Edmonds (1313_CR16) 1974; 87 HS Crombag (1313_CR13) 2001; 24 LL Yuan (1313_CR59) 2002; 22 P Vanhoutte (1313_CR52) 1999; 19 SL Haberny (1313_CR24) 2005; 141 SM Ferguson (1313_CR17) 2004; 91 SL Haberny (1313_CR25) 2004; 125 E Miliaressis (1313_CR37) 1986; 37 E Valjent (1313_CR49) 2001; 14 C Konradi (1313_CR33) 1996; 16 D Krahn (1313_CR34) 1992; 4 CA Miller (1313_CR38) 2005; 47 DK Ingram (1313_CR30) 1987; 42 JF Cheer (1313_CR12) 2007; 54 AE Kelley (1313_CR31) 2002; 22 JD Sweatt (1313_CR46) 2001; 76 SM Ferguson (1313_CR18) 2006; 31 S Cabeza de Vaca (1313_CR3) 1998; 18 ND Volkow (1313_CR53) 2005; 8 J Salzmann (1313_CR41) 2003; 140 ME Wolf (1313_CR58) 2004; 47 L Lu (1313_CR36) 2006; 29 E Valjent (1313_CR48) 2000; 20 S Das (1313_CR14) 1997; 25 RA Wise (1313_CR57) 1996; 19 CR Gerfen (1313_CR20) 2002; 22 F Idobro (1313_CR29) 1987; 6 DJ Surmeier (1313_CR45) 2007; 30 M Goldin (1313_CR22) 2003; 17 RN Cardinal (1313_CR5) 2004; 14 GT Wilson (1313_CR56) 1993 SE Hyman (1313_CR28) 2006; 29 J Stewart (1313_CR44) 1989; 10 TV Gerdjikov (1313_CR19) 2004; 118 L Lu (1313_CR35) 2005; 8 KD Carr (1313_CR8) 2000; 861 E Valjent (1313_CR51) 2006; 7 S Cabib (1313_CR4) 2000; 289 SM Bell (1313_CR1) 1997; 131 SL Haberny (1313_CR23) 2005; 132 E Valjent (1313_CR50) 2004; 19 KD Carr (1313_CR9) 2000; 152 J-A Girault (1313_CR21) 2006; 6 N Hori (1313_CR27) 1992; 3 X Shi (1313_CR42) 2006; 138 JN Kerr (1313_CR32) 2001; 85 GM Thomas (1313_CR47) 2004; 5 GL Snyder (1313_CR43) 1998; 18 J Polivy (1313_CR40) 2006; 47 WA Carlezon (1313_CR6) 2007; 2 JQ Wang (1313_CR54) 2007; 100 KD Carr (1313_CR10) 2003; 119 ME Carroll (1313_CR11) 1984; 4 G Paxinos (1313_CR39) 1998 WA Carlezon (1313_CR7) 2005; 28 Y Hayashi (1313_CR26) 2000; 287 JD Berke (1313_CR2) 2000; 25 MW Wiederman (1313_CR55) 1996; 21 |
| References_xml | – volume: 2 start-page: 2987 year: 2007 end-page: 2995 ident: CR6 article-title: Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation publication-title: Nat Protoc doi: 10.1038/nprot.2007.441 – start-page: 97 year: 1993 end-page: 120 ident: CR56 article-title: Binge eating and addictive disorders publication-title: Binge eating: nature, assessment, and treatment – volume: 17 start-page: 2529 year: 2003 end-page: 2539 ident: CR22 article-title: Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2003.02694.x – volume: 141 start-page: 121 year: 2005 end-page: 127 ident: CR24 article-title: Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate–putamen and nucleus accumbens of ad libitum fed and food-restricted rats publication-title: Brain Res Mol Brain Res – volume: 29 start-page: 695 year: 2006 end-page: 703 ident: CR36 article-title: Role of ERK in cocaine addiction publication-title: Trends Neurosci doi: 10.1016/j.tins.2006.10.005 – volume: 118 start-page: 740 year: 2004 end-page: 750 ident: CR19 article-title: Place preference induced by nucleus accumbens amphetamine is impaired by antagonists of ERK or p38 MAP kinases in rats publication-title: Behav Neurosci doi: 10.1037/0735-7044.118.4.740 – volume: 6 start-page: 1 year: 2006 end-page: 9 ident: CR21 article-title: ERK2: a logical AND gate critical for drug-induced plasticity? publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2005.12.003 – volume: 861 start-page: 88 year: 2000 end-page: 96 ident: CR8 article-title: Chronic food restriction increases fos-like immunoreactivity induced in rat forebrain by intraventricular amphetamine publication-title: Brain Res doi: 10.1016/S0006-8993(00)02018-7 – volume: 20 start-page: 8701 year: 2000 end-page: 8709 ident: CR48 article-title: Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties publication-title: J Neurosci – volume: 87 start-page: 876 year: 1974 end-page: 884 ident: CR16 article-title: Parametric analysis of brain stimulation reward in the rat: III Effect of performance variables on the reward summation function publication-title: J Comp Physiol Psychol doi: 10.1037/h0037217 – volume: 42 start-page: 78 year: 1987 end-page: 81 ident: CR30 article-title: Dietary restriction benefits learning and motor performance of aged mice publication-title: J Gerontol – volume: 47 start-page: 61 year: 2004 end-page: 79 ident: CR58 article-title: Psychomotor stimulants and neuronal plasticity publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2004.07.006 – volume: 54 start-page: 237 year: 2007 end-page: 244 ident: CR12 article-title: Coordinated accumbal dopamine release and neural activity drive goal-directed behavior publication-title: Neuron doi: 10.1016/j.neuron.2007.03.021 – volume: 25 start-page: 515 year: 2000 end-page: 532 ident: CR2 article-title: Addiction, dopamine, and the molecular mechanisms of memory publication-title: Neuron doi: 10.1016/S0896-6273(00)81056-9 – volume: 287 start-page: 2262 year: 2000 end-page: 2267 ident: CR26 article-title: Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction publication-title: Science doi: 10.1126/science.287.5461.2262 – volume: 47 start-page: 873 year: 2005 end-page: 884 ident: CR38 article-title: Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory publication-title: Neuron doi: 10.1016/j.neuron.2005.08.006 – year: 1998 ident: CR39 publication-title: The rat brain in stereotaxic coordinates – volume: 25 start-page: 227 year: 1997 end-page: 233 ident: CR14 article-title: NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c- in striatal neurons in primary culture publication-title: Synapse doi: 10.1002/(SICI)1098-2396(199703)25:3<227::AID-SYN1>3.0.CO;2-D – volume: 91 start-page: 337 year: 2004 end-page: 348 ident: CR17 article-title: Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascade publication-title: J Neurochem doi: 10.1111/j.1471-4159.2004.02712.x – volume: 19 start-page: 1826 year: 2004 end-page: 1836 ident: CR50 article-title: Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2004.03278.x – volume: 37 start-page: 85 year: 1986 end-page: 91 ident: CR37 article-title: The curve–shift paradigm in self-stimulation publication-title: Physiol Behav doi: 10.1016/0031-9384(86)90388-4 – volume: 100 start-page: 1 year: 2007 end-page: 11 ident: CR54 article-title: Regulation of mitogen-activated protein kinases by glutamate receptors publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04208.x – volume: 22 start-page: 3306 year: 2002 end-page: 3311 ident: CR31 article-title: The neuroscience of natural rewards: relevance to addictive drugs publication-title: J Neurosci – volume: 19 start-page: 136 year: 1999 end-page: 146 ident: CR52 article-title: Glutamate induces phosphorylation of elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices publication-title: Mol Cell Biol – volume: 138 start-page: 1289 year: 2006 end-page: 1298 ident: CR42 article-title: Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.12.024 – volume: 47 start-page: 30 year: 2006 end-page: 35 ident: CR40 article-title: An evolutionary perspective on dieting publication-title: Appetite doi: 10.1016/j.appet.2006.02.009 – volume: 8 start-page: 555 year: 2005 end-page: 560 ident: CR53 article-title: How can drug addiction help us understand obesity? publication-title: Nat Neurosci doi: 10.1038/nn1452 – volume: 31 start-page: 2660 year: 2006 end-page: 2668 ident: CR18 article-title: Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301014 – volume: 5 start-page: 173 year: 2004 end-page: 183 ident: CR47 article-title: MAPK cascade signaling and synaptic plasticity publication-title: Nat Rev Neurosci doi: 10.1038/nrn1346 – volume: 7 start-page: 20 year: 2006 ident: CR51 article-title: Role of the ERK pathway in psychostimulant-induced locomotor sensitization publication-title: BMC Neurosci doi: 10.1186/1471-2202-7-20 – volume: 85 start-page: 117 year: 2001 end-page: 124 ident: CR32 article-title: Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro publication-title: J Neurophysiol – volume: 76 start-page: 1 year: 2001 end-page: 10 ident: CR46 article-title: The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory publication-title: J Neurochem doi: 10.1046/j.1471-4159.2001.00054.x – volume: 125 start-page: 289 year: 2004 end-page: 298 ident: CR25 article-title: Chronic food restriction increases D-1 dopamine receptor agonist-induced ERK1/2 MAP Kinase and CREB phosphorylation in caudate–putamen and nucleus accumbens publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.01.037 – volume: 22 start-page: 5042 year: 2002 end-page: 5054 ident: CR20 article-title: D1 dopamine receptor supersensitivity in the dopamine-depleted striatum results from a switch in the regulation of ERK1/2 MAP kinase publication-title: J Neurosci – volume: 8 start-page: 212 year: 2005 end-page: 219 ident: CR35 article-title: Central amygdale ERK signaling pathway is critical to incubation of cocaine craving publication-title: Nat Neurosci doi: 10.1038/nn1383 – volume: 24 start-page: 680 year: 2001 end-page: 690 ident: CR13 article-title: The ability of environmental context to facilitate psychomotor sensitization to amphetamine can be dissociated from its effect on acute drug responsiveness and on conditioned responding publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00238-4 – volume: 14 start-page: 342 year: 2001 end-page: 352 ident: CR49 article-title: Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission publication-title: Eur J Neurosci doi: 10.1046/j.0953-816x.2001.01652.x – volume: 6 start-page: 355 year: 1987 end-page: 362 ident: CR29 article-title: Dietary restriction: effects on radial maze learning and lipofuscin pogment deposition in the hippocampus and frontal cortex publication-title: Arch Gerontol Geriat doi: 10.1016/0167-4943(87)90014-8 – volume: 18 start-page: 10297 year: 1998 end-page: 10303 ident: CR43 article-title: A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (M, 32kDa) protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor publication-title: J Neurosci – volume: 131 start-page: 1 year: 1997 end-page: 8 ident: CR1 article-title: Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats publication-title: Psychopharmacology doi: 10.1007/s002130050258 – volume: 119 start-page: 1157 year: 2003 end-page: 1167 ident: CR10 article-title: Evidence of increased dopamine receptor signaling in food-restricted rats publication-title: Neuroscience doi: 10.1016/S0306-4522(03)00227-6 – volume: 30 start-page: 228 year: 2007 end-page: 235 ident: CR45 article-title: D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons publication-title: Trends Neurosci doi: 10.1016/j.tins.2007.03.008 – volume: 3 start-page: 1085 year: 1992 end-page: 1088 ident: CR27 article-title: Long-term potentiation is lost in aged rats but preserved by calorie restriction publication-title: NeuroReport doi: 10.1097/00001756-199212000-00013 – volume: 4 start-page: 341 year: 1992 end-page: 353 ident: CR34 article-title: The relationship of dieting severity and bulimic behaviors to alcohol and other drug use in young women publication-title: J Subst Abuse doi: 10.1016/0899-3289(92)90041-U – volume: 289 start-page: 463 year: 2000 end-page: 465 ident: CR4 article-title: Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience publication-title: Science doi: 10.1126/science.289.5478.463 – volume: 22 start-page: 4860 year: 2002 end-page: 4868 ident: CR59 article-title: Protein kinase modulation of dendritic K channels in hippocampus involves a mitogen-activated protein kinase pathway publication-title: J Neurosci – volume: 28 start-page: 436 year: 2005 end-page: 445 ident: CR7 article-title: The many faces of CREB publication-title: Trends Neurosci doi: 10.1016/j.tins.2005.06.005 – volume: 132 start-page: 1035 year: 2005 end-page: 1043 ident: CR23 article-title: Food restriction increases NMDA receptor-mediated CaMK II and NMDA receptor/ERK 1/2-mediated CREB phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.02.006 – volume: 87 start-page: 922 year: 2003 end-page: 934 ident: CR15 article-title: Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1 publication-title: J Neurochem doi: 10.1046/j.1471-4159.2003.02067.x – volume: 18 start-page: 7502 year: 1998 end-page: 7510 ident: CR3 article-title: Food restriction enhances the central rewarding effect of abused drugs publication-title: J Neurosci – volume: 152 start-page: 200 year: 2000 end-page: 207 ident: CR9 article-title: Chronic food restriction augments the central rewarding effect of cocaine and the δ-1 opioid agonist, DPDPE, but not the δ-2 agonist, deltorphin-II publication-title: Psychopharmacology doi: 10.1007/s002130000523 – volume: 16 start-page: 4231 year: 1996 end-page: 4239 ident: CR33 article-title: Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium publication-title: J Neurosci – volume: 21 start-page: 269 year: 1996 end-page: 272 ident: CR55 article-title: Substance abuse and impulsive behaviors among adolescents with eating disorders publication-title: Addict Behav doi: 10.1016/0306-4603(95)00062-3 – volume: 10 start-page: 669 year: 1989 end-page: 675 ident: CR44 article-title: The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes publication-title: Neurobiol Aging doi: 10.1016/0197-4580(89)90003-1 – volume: 29 start-page: 565 year: 2006 end-page: 598 ident: CR28 article-title: Neural mechanisms of addiction: the role of reward-related learning and memory publication-title: Annu Rev Neurosci doi: 10.1146/annurev.neuro.29.051605.113009 – volume: 14 start-page: 156 year: 2004 end-page: 162 ident: CR5 article-title: Neural and psychological mechanisms underlying appetitive learning: links to drug addiction publication-title: Curr Opin Neurobiol doi: 10.1016/j.conb.2004.03.004 – volume: 4 start-page: 47 year: 1984 end-page: 88 ident: CR11 article-title: Increased drug-reinforced behavior due to food deprivation publication-title: Adv Behav Pharmacol – volume: 140 start-page: 831 year: 2003 end-page: 838 ident: CR41 article-title: Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0705506 – volume: 19 start-page: 319 year: 1996 end-page: 340 ident: CR57 article-title: Addictive drugs and brain stimulation reward publication-title: Annu Rev Neurosci doi: 10.1146/annurev.ne.19.030196.001535 – volume: 4 start-page: 47 year: 1984 ident: 1313_CR11 publication-title: Adv Behav Pharmacol doi: 10.1016/B978-0-12-004704-8.50008-0 – start-page: 97 volume-title: Binge eating: nature, assessment, and treatment year: 1993 ident: 1313_CR56 – volume: 22 start-page: 5042 year: 2002 ident: 1313_CR20 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.22-12-05042.2002 – volume: 5 start-page: 173 year: 2004 ident: 1313_CR47 publication-title: Nat Rev Neurosci doi: 10.1038/nrn1346 – volume: 91 start-page: 337 year: 2004 ident: 1313_CR17 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2004.02712.x – volume: 28 start-page: 436 year: 2005 ident: 1313_CR7 publication-title: Trends Neurosci doi: 10.1016/j.tins.2005.06.005 – volume: 152 start-page: 200 year: 2000 ident: 1313_CR9 publication-title: Psychopharmacology doi: 10.1007/s002130000523 – volume: 47 start-page: 61 year: 2004 ident: 1313_CR58 publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2004.07.006 – volume: 22 start-page: 4860 year: 2002 ident: 1313_CR59 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.22-12-04860.2002 – volume: 22 start-page: 3306 year: 2002 ident: 1313_CR31 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.22-09-03306.2002 – volume: 16 start-page: 4231 year: 1996 ident: 1313_CR33 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.16-13-04231.1996 – volume: 6 start-page: 1 year: 2006 ident: 1313_CR21 publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2005.12.003 – volume: 100 start-page: 1 year: 2007 ident: 1313_CR54 publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.04208.x – volume: 141 start-page: 121 year: 2005 ident: 1313_CR24 publication-title: Brain Res Mol Brain Res doi: 10.1016/j.molbrainres.2005.08.001 – volume: 21 start-page: 269 year: 1996 ident: 1313_CR55 publication-title: Addict Behav doi: 10.1016/0306-4603(95)00062-3 – volume: 119 start-page: 1157 year: 2003 ident: 1313_CR10 publication-title: Neuroscience doi: 10.1016/S0306-4522(03)00227-6 – volume: 87 start-page: 876 year: 1974 ident: 1313_CR16 publication-title: J Comp Physiol Psychol doi: 10.1037/h0037217 – volume: 54 start-page: 237 year: 2007 ident: 1313_CR12 publication-title: Neuron doi: 10.1016/j.neuron.2007.03.021 – volume: 8 start-page: 555 year: 2005 ident: 1313_CR53 publication-title: Nat Neurosci doi: 10.1038/nn1452 – volume: 14 start-page: 156 year: 2004 ident: 1313_CR5 publication-title: Curr Opin Neurobiol doi: 10.1016/j.conb.2004.03.004 – volume: 87 start-page: 922 year: 2003 ident: 1313_CR15 publication-title: J Neurochem doi: 10.1046/j.1471-4159.2003.02067.x – volume: 29 start-page: 695 year: 2006 ident: 1313_CR36 publication-title: Trends Neurosci doi: 10.1016/j.tins.2006.10.005 – volume: 18 start-page: 7502 year: 1998 ident: 1313_CR3 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-18-07502.1998 – volume: 47 start-page: 30 year: 2006 ident: 1313_CR40 publication-title: Appetite doi: 10.1016/j.appet.2006.02.009 – volume: 131 start-page: 1 year: 1997 ident: 1313_CR1 publication-title: Psychopharmacology doi: 10.1007/s002130050258 – volume: 25 start-page: 515 year: 2000 ident: 1313_CR2 publication-title: Neuron doi: 10.1016/S0896-6273(00)81056-9 – volume: 19 start-page: 136 year: 1999 ident: 1313_CR52 publication-title: Mol Cell Biol doi: 10.1128/MCB.19.1.136 – volume: 76 start-page: 1 year: 2001 ident: 1313_CR46 publication-title: J Neurochem doi: 10.1046/j.1471-4159.2001.00054.x – volume: 7 start-page: 20 year: 2006 ident: 1313_CR51 publication-title: BMC Neurosci doi: 10.1186/1471-2202-7-20 – volume: 289 start-page: 463 year: 2000 ident: 1313_CR4 publication-title: Science doi: 10.1126/science.289.5478.463 – volume: 24 start-page: 680 year: 2001 ident: 1313_CR13 publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(00)00238-4 – volume: 37 start-page: 85 year: 1986 ident: 1313_CR37 publication-title: Physiol Behav doi: 10.1016/0031-9384(86)90388-4 – volume: 17 start-page: 2529 year: 2003 ident: 1313_CR22 publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2003.02694.x – volume: 3 start-page: 1085 year: 1992 ident: 1313_CR27 publication-title: NeuroReport doi: 10.1097/00001756-199212000-00013 – volume: 861 start-page: 88 year: 2000 ident: 1313_CR8 publication-title: Brain Res doi: 10.1016/S0006-8993(00)02018-7 – volume: 287 start-page: 2262 year: 2000 ident: 1313_CR26 publication-title: Science doi: 10.1126/science.287.5461.2262 – volume: 20 start-page: 8701 year: 2000 ident: 1313_CR48 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.20-23-08701.2000 – volume: 30 start-page: 228 year: 2007 ident: 1313_CR45 publication-title: Trends Neurosci doi: 10.1016/j.tins.2007.03.008 – volume: 138 start-page: 1289 year: 2006 ident: 1313_CR42 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.12.024 – volume: 8 start-page: 212 year: 2005 ident: 1313_CR35 publication-title: Nat Neurosci doi: 10.1038/nn1383 – volume: 2 start-page: 2987 year: 2007 ident: 1313_CR6 publication-title: Nat Protoc doi: 10.1038/nprot.2007.441 – volume: 125 start-page: 289 year: 2004 ident: 1313_CR25 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.01.037 – volume-title: The rat brain in stereotaxic coordinates year: 1998 ident: 1313_CR39 – volume: 85 start-page: 117 year: 2001 ident: 1313_CR32 publication-title: J Neurophysiol doi: 10.1152/jn.2001.85.1.117 – volume: 19 start-page: 1826 year: 2004 ident: 1313_CR50 publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2004.03278.x – volume: 14 start-page: 342 year: 2001 ident: 1313_CR49 publication-title: Eur J Neurosci doi: 10.1046/j.0953-816x.2001.01652.x – volume: 18 start-page: 10297 year: 1998 ident: 1313_CR43 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-24-10297.1998 – volume: 19 start-page: 319 year: 1996 ident: 1313_CR57 publication-title: Annu Rev Neurosci doi: 10.1146/annurev.ne.19.030196.001535 – volume: 6 start-page: 355 year: 1987 ident: 1313_CR29 publication-title: Arch Gerontol Geriat doi: 10.1016/0167-4943(87)90014-8 – volume: 47 start-page: 873 year: 2005 ident: 1313_CR38 publication-title: Neuron doi: 10.1016/j.neuron.2005.08.006 – volume: 42 start-page: 78 year: 1987 ident: 1313_CR30 publication-title: J Gerontol doi: 10.1093/geronj/42.1.78 – volume: 132 start-page: 1035 year: 2005 ident: 1313_CR23 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.02.006 – volume: 29 start-page: 565 year: 2006 ident: 1313_CR28 publication-title: Annu Rev Neurosci doi: 10.1146/annurev.neuro.29.051605.113009 – volume: 25 start-page: 227 year: 1997 ident: 1313_CR14 publication-title: Synapse doi: 10.1002/(SICI)1098-2396(199703)25:3<227::AID-SYN1>3.0.CO;2-D – volume: 10 start-page: 669 year: 1989 ident: 1313_CR44 publication-title: Neurobiol Aging doi: 10.1016/0197-4580(89)90003-1 – volume: 4 start-page: 341 year: 1992 ident: 1313_CR34 publication-title: J Subst Abuse doi: 10.1016/0899-3289(92)90041-U – volume: 118 start-page: 740 year: 2004 ident: 1313_CR19 publication-title: Behav Neurosci doi: 10.1037/0735-7044.118.4.740 – volume: 140 start-page: 831 year: 2003 ident: 1313_CR41 publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0705506 – volume: 31 start-page: 2660 year: 2006 ident: 1313_CR18 publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301014 |
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Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated... Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of... Abstract; Rationale; Objectives; Materials and methods; Results; Conclusions Food restriction (FR) enhances learned and unlearned behavioral responses to drugs... |
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| SubjectTerms | Aminoacetonitrile - analogs & derivatives Aminoacetonitrile - pharmacology Animal behavior Animal cognition Animals Benzazepines - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Dextroamphetamine - pharmacology Food Deprivation Injections, Intraperitoneal Male Medical sciences Mitogen-Activated Protein Kinase 1 - drug effects Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - drug effects Mitogen-Activated Protein Kinase 3 - metabolism Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Motor Activity - drug effects Neuropharmacology Neurosciences Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original Investigation Pharmacology. Drug treatments Pharmacology/Toxicology Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Sprague-Dawley Reward Rodents Signal Transduction - drug effects |
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| Title | Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of d-amphetamine and SKF-82958, and their augmentation by food restriction in rat |
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