Emotion anticipation and processing in depression: Behavioral, neural, and physiological reactivity

Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with he...

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Published inEUROPEAN PSYCHIATRY Vol. 68; no. 1; p. e68
Main Authors Wlad, Magdalena, Struckmann, Wiebke, Persson, Jonas, Rosén, Jörgen, Fällmar, David, Bodén, Robert, Gingnell, Malin
Format Journal Article Publication
LanguageEnglish
Published England Cambridge University Press 11.06.2025
Subjects
Adult
Anhedonia - physiology
anterior cingulate cortex
Anticipation, Psychological - physiology
Arousal - physiology
Brain - physiopathology
Brain Mapping
Brain research
Case-Control Studies
Data analysis
depression
electrodermal activity
Emotions
Emotions - physiology
Female
functional magnetic resonance imaging
Galvanic Skin Response - physiology
Gyrus Cinguli - physiopathology
Humans
Hyperactivity
insula
Magnetic Resonance Imaging
Male
Mental depression
Mental disorders
Mental health
Middle Aged
Physiology
salience network
Scanners
Substance abuse treatment
Young Adult
Sweden
electrodermal activity
depression
insula
salience network
anterior cingulate cortex
functional magnetic resonance imaging
Online AccessGet full text
ISSN0924-9338
1778-3585
1778-3585
DOI10.1192/j.eurpsy.2025.10043

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Abstract Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls. The study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups. Patients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls. Ongoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
AbstractList Background: Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls. Methods: The study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups. Results: Patients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls. Conclusions: Ongoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls. The study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups. Patients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls. Ongoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
BackgroundDepression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls.MethodsThe study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups.ResultsPatients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls.ConclusionsOngoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
Abstract Background Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls. Methods The study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups. Results Patients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls. Conclusions Ongoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls.BACKGROUNDDepression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and electrodermal reactivities in patients with depression compared with healthy controls.The study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups.METHODSThe study included 42 patients (27 females) and 44 healthy controls (21 females). Subjects underwent functional magnetic resonance imaging with simultaneous measurement of electrodermal activity. During scanning, red or green color cues were presented, followed by pictures of negative or positive valence, respectively. Behavioral valence and arousal ratings of the picture stimuli were conducted after scanning. Anhedonia was assessed through a semi-structured interview in both subject groups.Patients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls.RESULTSPatients perceived positive pictures as less positive than controls did. Positive anticipation (i.e., green color cues) elicited stronger activations in the anterior cingulate cortex and the right insula in patients than in healthy controls, indicating salience network disturbances. An exploratory analysis of all regions in the Automated Anatomical Labeling Atlas 2 found significant differences in activity to positive anticipation between groups in several brain regions involved in cognition and emotion processing. Positive and negative anticipation elicited stronger electrodermal responses in healthy controls. However, electrodermal reactivity to negative pictures was higher in patients than in controls.Ongoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.CONCLUSIONSOngoing depression affects emotion anticipation and processing at the behavioral, neural, and physiological levels. These findings contribute to increased understanding of the disorder.
ArticleNumber e68
Author Wlad, Magdalena
Bodén, Robert
Rosén, Jörgen
Fällmar, David
Gingnell, Malin
Persson, Jonas
Struckmann, Wiebke
AuthorAffiliation 4 Department of Surgical Sciences, Neuroradiology, https://ror.org/048a87296 Uppsala University , Uppsala , Sweden
1 Department of Medical Sciences, Psychiatry, https://ror.org/048a87296 Uppsala University , Uppsala , Sweden
2 Department of Psychiatry and Behavioral Sciences, https://ror.org/00f54p054 Stanford University , Stanford , CA , USA
3 Department of Clinical Neuroscience, https://ror.org/056d84691 Karolinska Institute , Solna , Sweden
5 Department of Psychology, https://ror.org/048a87296 Uppsala University , Uppsala , Sweden
AuthorAffiliation_xml – name: 1 Department of Medical Sciences, Psychiatry, https://ror.org/048a87296 Uppsala University , Uppsala , Sweden
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– name: 5 Department of Psychology, https://ror.org/048a87296 Uppsala University , Uppsala , Sweden
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Keywords electrodermal activity
depression
insula
salience network
anterior cingulate cortex
functional magnetic resonance imaging
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Snippet Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion...
BackgroundDepression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied...
Background: Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we...
Abstract Background Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here,...
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SubjectTerms Adult
Anhedonia - physiology
anterior cingulate cortex
Anticipation, Psychological - physiology
Arousal - physiology
Brain - physiopathology
Brain Mapping
Brain research
Case-Control Studies
Data analysis
depression
electrodermal activity
Emotions
Emotions - physiology
Female
functional magnetic resonance imaging
Galvanic Skin Response - physiology
Gyrus Cinguli - physiopathology
Humans
Hyperactivity
insula
Magnetic Resonance Imaging
Male
Mental depression
Mental disorders
Mental health
Middle Aged
Physiology
salience network
Scanners
Substance abuse treatment
Young Adult
Title Emotion anticipation and processing in depression: Behavioral, neural, and physiological reactivity
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