Quantifying the shape of the maximal expiratory flow–volume curve in mild COPD
•The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves.•Compared to matched controls, COPD patients had a greater average SR.•Unlike controls, COPD patients had a SR that increased with lung volume.•The SR could be an additional metric to aid in COPD diagnosis. Maximal e...
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| Published in | Respiratory physiology & neurobiology Vol. 219; pp. 30 - 35 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.12.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1569-9048 1878-1519 1878-1519 |
| DOI | 10.1016/j.resp.2015.08.002 |
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| Abstract | •The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves.•Compared to matched controls, COPD patients had a greater average SR.•Unlike controls, COPD patients had a SR that increased with lung volume.•The SR could be an additional metric to aid in COPD diagnosis.
Maximal expiratory flow–volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (n=15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90±0.24 vs. 1.28±0.32) and Beta-angle (160±6.7 vs. 186±15.0) compared to healthy individuals (p<0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p<0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction. |
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| AbstractList | Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (n=15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90 ± 0.24 vs. 1.28 ± 0.32) and Beta-angle (160 ± 6.7 vs. 186 ± 15.0) compared to healthy individuals (p<0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p<0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction.Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (n=15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90 ± 0.24 vs. 1.28 ± 0.32) and Beta-angle (160 ± 6.7 vs. 186 ± 15.0) compared to healthy individuals (p<0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p<0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction. •The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves.•Compared to matched controls, COPD patients had a greater average SR.•Unlike controls, COPD patients had a SR that increased with lung volume.•The SR could be an additional metric to aid in COPD diagnosis. Maximal expiratory flow–volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (n=15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90±0.24 vs. 1.28±0.32) and Beta-angle (160±6.7 vs. 186±15.0) compared to healthy individuals (p<0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p<0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction. Highlights • The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves. • Compared to matched controls, COPD patients had a greater average SR. • Unlike controls, COPD patients had a SR that increased with lung volume. • The SR could be an additional metric to aid in COPD diagnosis. Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (n=15). Those with mild COPD had a significantly greater slope-ratio (SR) (1.90 ± 0.24 vs. 1.28 ± 0.32) and Beta-angle (160 ± 6.7 vs. 186 ± 15.0) compared to healthy individuals (p<0.05). The flow-ratio method showed no difference between groups. A significant positive SR-volume relationship during expiration was observed in a greater number of mild COPD subjects (94%) compared to controls (20%) (p<0.001). With its increased spatial resolution and the potential to discern etiology behind specific curvature, we suggest using the SR method when available. The change in SR throughout expiration could help identify those who fall within the lower limit of normal lung function and those who may have pathological obstruction. |
| Author | Eves, Neil D. Henderson, William R. Foster, Glen E. Dominelli, Paolo B. Dominelli, Giulio S. Sheel, A. William Haverkamp, Hans C. O’Donnell, Denis E. Guenette, Jordan A. |
| Author_xml | – sequence: 1 givenname: Paolo B. surname: Dominelli fullname: Dominelli, Paolo B. email: p.dominelli@alumni.ubc.ca organization: School of Kinesiology, University of British Columbia, Vancouver, BC, Canada – sequence: 2 givenname: Glen E. surname: Foster fullname: Foster, Glen E. organization: Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada – sequence: 3 givenname: Jordan A. surname: Guenette fullname: Guenette, Jordan A. organization: Centre for Heart Lung Innovation and Department of Physical Therapy, University of British Columbia, St. Paul’s Hospital, Vancouver, BC, Canada – sequence: 4 givenname: Hans C. surname: Haverkamp fullname: Haverkamp, Hans C. organization: Johnson State College, Johnson, VT, United States – sequence: 5 givenname: Neil D. surname: Eves fullname: Eves, Neil D. organization: Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada – sequence: 6 givenname: Giulio S. surname: Dominelli fullname: Dominelli, Giulio S. organization: Division of Respirology, University of British Columbia, Vancouver, BC, Canada – sequence: 7 givenname: William R. surname: Henderson fullname: Henderson, William R. organization: School of Kinesiology, University of British Columbia, Vancouver, BC, Canada – sequence: 8 givenname: Denis E. surname: O’Donnell fullname: O’Donnell, Denis E. organization: Respiratory Investigation Unit, Department of Medicine, Queen's University & Kingston General Hospital, Kingston, Ontario, Canada – sequence: 9 givenname: A. William surname: Sheel fullname: Sheel, A. William organization: School of Kinesiology, University of British Columbia, Vancouver, BC, Canada |
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| Cites_doi | 10.1164/ajrccm.152.3.7663792 10.1152/jappl.1967.22.1.95 10.1152/jappl.1977.43.6.1054 10.1136/thx.2008.098483 10.1152/jappl.1967.23.2.221 10.1152/jappl.1968.25.6.664 10.1136/thx.42.3.173 10.1378/chest.06-1349 10.1183/09031936.00034714 10.1164/rccm.200703-456SO 10.1378/chest.129.2.369 10.1378/chest.116.2.488 10.1172/JCI60324 10.1152/jappl.1980.48.1.202 10.1378/chest.98.3.643 10.1152/jappl.1978.44.2.156 10.1136/thx.2008.095554 10.1378/chest.94.4.799 10.1183/09031936.00135110 10.1152/jappl.1974.37.1.67 10.1183/09031936.02.00023202 10.1152/jappl.1974.36.4.412 10.1016/S0272-5231(21)01070-4 10.1152/jappl.1979.46.3.565 |
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| References | Quanjer, Enright, Miller, Stocks, Ruppel, Swanney, Crapo, Pedersen, Falaschetti, Schouten, Jensen (bib0110) 2011; 37 ATS (bib0010) 2003 Guenette, Chin, Cheng, Dominelli, Raghavan, Webb, Neder, O'Donnell (bib0040) 2014; 44 Leith, Mead (bib0085) 1967; 23 Mead, Turner, Macklem, Little (bib0095) 1967; 22 Green, Mead, Turner (bib0035) 1974; 37 Hansen, Sun, Wasserman (bib0050) 2007; 131 Jansen, Peslin, Bohadana, Racineux (bib0060) 1980; 122 ATS (bib0005) 1995; 152 Tuder, Petrache (bib0130) 2012; 122 Fowler, Pluck, Hetzel (bib0030) 1987; 42 Hansen, Sun, Wasserman (bib0045) 2006; 129 Johnson, Weisman, Zeballos, Beck (bib0070) 1999; 116 Knudson, Clark, Kennedy, Knudson (bib0080) 1977; 43 Kapp, Schachter, Beck, Maunder, Witek (bib0075) 1988; 94 O'Donnell, Rose (bib0105) 1990; 98 Cerveri, Corsico, Accordini, Niniano, Ansaldo, AntÃ3, K.ünzli, Janson, Sunyer, Jarvis, Svanes, Gislason, Heinrich, Schouten, Wjst, Burney, de Marco (bib0020) 2008; 63 Johnson, Badr, Dempsey (bib0065) 1994; 15 Cotes (bib0025) 1997; 2 Hardie, Buist, Vollmer, Ellingsen, Bakke, Markve (bib0055) 2002; 20 Mead (bib0090) 1978; 44 Bruce, Jackson (bib0015) 1980; 48 Rabe, Hurd, Anzueto, Barnes, Buist, Calverley, Fukuchi, Jenkins, Rodriguez-Roisin, van Weel, Zielinski (bib0115) 2007; 176 Tien, Elliott, Mead (bib0125) 1979; 46 Niewoehner, Kleinerman (bib0100) 1974; 36 Swanney, Ruppel, Enright, Pedersen, Crapo, Miller, Jensen, Falaschetti, Schouten, Hankinson, Stocks, Quanjer (bib0120) 2008; 63 Turner, Mead, Wohl (bib0135) 1968; 25 ATS (10.1016/j.resp.2015.08.002_bib0005) 1995; 152 Leith (10.1016/j.resp.2015.08.002_bib0085) 1967; 23 Bruce (10.1016/j.resp.2015.08.002_bib0015) 1980; 48 Mead (10.1016/j.resp.2015.08.002_bib0090) 1978; 44 Swanney (10.1016/j.resp.2015.08.002_bib0120) 2008; 63 Fowler (10.1016/j.resp.2015.08.002_bib0030) 1987; 42 Johnson (10.1016/j.resp.2015.08.002_bib0065) 1994; 15 O'Donnell (10.1016/j.resp.2015.08.002_bib0105) 1990; 98 Kapp (10.1016/j.resp.2015.08.002_bib0075) 1988; 94 ATS (10.1016/j.resp.2015.08.002_bib0010) 2003 Knudson (10.1016/j.resp.2015.08.002_bib0080) 1977; 43 Tien (10.1016/j.resp.2015.08.002_bib0125) 1979; 46 Guenette (10.1016/j.resp.2015.08.002_bib0040) 2014; 44 Rabe (10.1016/j.resp.2015.08.002_bib0115) 2007; 176 Hansen (10.1016/j.resp.2015.08.002_bib0045) 2006; 129 Niewoehner (10.1016/j.resp.2015.08.002_bib0100) 1974; 36 Hansen (10.1016/j.resp.2015.08.002_bib0050) 2007; 131 Tuder (10.1016/j.resp.2015.08.002_bib0130) 2012; 122 Quanjer (10.1016/j.resp.2015.08.002_bib0110) 2011; 37 Cerveri (10.1016/j.resp.2015.08.002_bib0020) 2008; 63 Hardie (10.1016/j.resp.2015.08.002_bib0055) 2002; 20 Cotes (10.1016/j.resp.2015.08.002_bib0025) 1997; 2 Jansen (10.1016/j.resp.2015.08.002_bib0060) 1980; 122 Mead (10.1016/j.resp.2015.08.002_bib0095) 1967; 22 Green (10.1016/j.resp.2015.08.002_bib0035) 1974; 37 Johnson (10.1016/j.resp.2015.08.002_bib0070) 1999; 116 Turner (10.1016/j.resp.2015.08.002_bib0135) 1968; 25 26899171 - Respir Physiol Neurobiol. 2016 Jun 15;227:68 26687468 - Respir Physiol Neurobiol. 2016 Jun 15;227:69 |
| References_xml | – volume: 116 start-page: 488 year: 1999 end-page: 503 ident: bib0070 article-title: Emerging concepts in the evaluation of ventilatory limitation during exercise publication-title: Chest – volume: 2 start-page: 2193 year: 1997 end-page: 2203 ident: bib0025 article-title: Physiology of the aging lung publication-title: The Lung Scientific Foundations – start-page: 167 year: 2003 ident: bib0010 article-title: Statement on cardiopulmonary exercise testing publication-title: Am. J. Respir. Crit. Care Med. – volume: 131 start-page: 349 year: 2007 end-page: 355 ident: bib0050 article-title: Spirometric criteria for airway obstruction*: use percentage of fev1/fvc ratio below the fifth percentile, not <70% publication-title: Chest – volume: 42 start-page: 173 year: 1987 end-page: 182 ident: bib0030 article-title: Maximal expiratory flow–volume curves in Londoners aged 60 years and over publication-title: Thorax – volume: 94 start-page: 799 year: 1988 end-page: 806 ident: bib0075 article-title: The shape of the maximum expiratory flow volume curve publication-title: Chest – volume: 46 start-page: 565 year: 1979 end-page: 570 ident: bib0125 article-title: Variability of the configuration of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. – volume: 44 start-page: 1177 year: 2014 end-page: 1187 ident: bib0040 article-title: Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1COPD publication-title: Eur. Respir. J. – volume: 36 start-page: 412 year: 1974 end-page: 418 ident: bib0100 article-title: Morphologic basis of pulmonary resistance in the human lung and effects of aging publication-title: J. Appl. Physiol. – volume: 122 start-page: 2749 year: 2012 end-page: 2755 ident: bib0130 article-title: Pathogenesis of chronic obstructive pulmonary disease publication-title: J. Clin. Invest. – volume: 23 start-page: 221 year: 1967 end-page: 227 ident: bib0085 article-title: Mechanisms determining residual volume of the lungs in normal subjects publication-title: J. Appl. Physiol. – volume: 20 start-page: 1117 year: 2002 end-page: 1122 ident: bib0055 article-title: Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers publication-title: Eur. Respir. J. – volume: 176 start-page: 532 year: 2007 end-page: 555 ident: bib0115 article-title: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease publication-title: Am. J. Respir. Crit. Care Med. – volume: 44 start-page: 156 year: 1978 end-page: 165 ident: bib0090 article-title: Analysis of the configuration of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. – volume: 25 start-page: 664 year: 1968 end-page: 671 ident: bib0135 article-title: Elasticity of human lungs in relation to age publication-title: J. Appl. Physiol. – volume: 43 start-page: 1054 year: 1977 end-page: 1062 ident: bib0080 article-title: Effect of aging alone on mechanical properties of the normal adult human lung publication-title: J. Appl. Physiol. – volume: 37 start-page: 720 year: 2011 end-page: 722 ident: bib0110 article-title: The need to change the method for defining mild airway obstruction publication-title: Eur. Respir. J. – volume: 63 start-page: 1040 year: 2008 end-page: 1045 ident: bib0020 article-title: Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes publication-title: Thorax – volume: 122 start-page: 221 year: 1980 ident: bib0060 article-title: Usefulness of forced expiration slope ratios for detecting mild airway abnormalities publication-title: Am. Rev. Respir. Dis. – volume: 152 start-page: 1107 year: 1995 end-page: 1136 ident: bib0005 article-title: Standardization of spirometry, 1994 update publication-title: Am. Thorac. Soc. Am. J. Respir. Crit. Care Med. – volume: 98 start-page: 643 year: 1990 end-page: 646 ident: bib0105 article-title: The flow-ratio index. an approach for measuring the influence of age and cigarette smoking on maximum expiratory flow–volume curve configuration publication-title: Chest – volume: 63 start-page: 1046 year: 2008 end-page: 1051 ident: bib0120 article-title: Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction publication-title: Thorax – volume: 37 start-page: 67 year: 1974 end-page: 74 ident: bib0035 article-title: Variability of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. – volume: 22 start-page: 95 year: 1967 end-page: 108 ident: bib0095 article-title: Significance of the relationship between lung recoil and maximum expiratory flow publication-title: J. Appl. Physiol. – volume: 48 start-page: 202 year: 1980 end-page: 206 ident: bib0015 article-title: Smoothing of MEFV curves by digital filtering of flow as a function of volume publication-title: J. Appl. Physiol. – volume: 15 start-page: 229 year: 1994 ident: bib0065 article-title: Impact of the aging pulmonary system on the response to exercise publication-title: Clin. Chest Med. – volume: 129 start-page: 369 year: 2006 end-page: 377 ident: bib0045 article-title: Discriminating measures and normal values for expiratory obstruction publication-title: Chest – volume: 152 start-page: 1107 year: 1995 ident: 10.1016/j.resp.2015.08.002_bib0005 article-title: Standardization of spirometry, 1994 update publication-title: Am. Thorac. Soc. Am. J. Respir. Crit. Care Med. doi: 10.1164/ajrccm.152.3.7663792 – volume: 22 start-page: 95 year: 1967 ident: 10.1016/j.resp.2015.08.002_bib0095 article-title: Significance of the relationship between lung recoil and maximum expiratory flow publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1967.22.1.95 – volume: 43 start-page: 1054 year: 1977 ident: 10.1016/j.resp.2015.08.002_bib0080 article-title: Effect of aging alone on mechanical properties of the normal adult human lung publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1977.43.6.1054 – volume: 63 start-page: 1046 year: 2008 ident: 10.1016/j.resp.2015.08.002_bib0120 article-title: Using the lower limit of normal for the FEV1/FVC ratio reduces the misclassification of airway obstruction publication-title: Thorax doi: 10.1136/thx.2008.098483 – volume: 23 start-page: 221 year: 1967 ident: 10.1016/j.resp.2015.08.002_bib0085 article-title: Mechanisms determining residual volume of the lungs in normal subjects publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1967.23.2.221 – volume: 25 start-page: 664 year: 1968 ident: 10.1016/j.resp.2015.08.002_bib0135 article-title: Elasticity of human lungs in relation to age publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1968.25.6.664 – volume: 42 start-page: 173 year: 1987 ident: 10.1016/j.resp.2015.08.002_bib0030 article-title: Maximal expiratory flow–volume curves in Londoners aged 60 years and over publication-title: Thorax doi: 10.1136/thx.42.3.173 – volume: 131 start-page: 349 year: 2007 ident: 10.1016/j.resp.2015.08.002_bib0050 article-title: Spirometric criteria for airway obstruction*: use percentage of fev1/fvc ratio below the fifth percentile, not <70% publication-title: Chest doi: 10.1378/chest.06-1349 – volume: 122 start-page: 221 year: 1980 ident: 10.1016/j.resp.2015.08.002_bib0060 article-title: Usefulness of forced expiration slope ratios for detecting mild airway abnormalities publication-title: Am. Rev. Respir. Dis. – volume: 2 start-page: 2193 year: 1997 ident: 10.1016/j.resp.2015.08.002_bib0025 article-title: Physiology of the aging lung – volume: 44 start-page: 1177 year: 2014 ident: 10.1016/j.resp.2015.08.002_bib0040 article-title: Mechanisms of exercise intolerance in global initiative for chronic obstructive lung disease grade 1COPD publication-title: Eur. Respir. J. doi: 10.1183/09031936.00034714 – volume: 176 start-page: 532 year: 2007 ident: 10.1016/j.resp.2015.08.002_bib0115 article-title: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.200703-456SO – volume: 129 start-page: 369 year: 2006 ident: 10.1016/j.resp.2015.08.002_bib0045 article-title: Discriminating measures and normal values for expiratory obstruction publication-title: Chest doi: 10.1378/chest.129.2.369 – volume: 116 start-page: 488 year: 1999 ident: 10.1016/j.resp.2015.08.002_bib0070 article-title: Emerging concepts in the evaluation of ventilatory limitation during exercise publication-title: Chest doi: 10.1378/chest.116.2.488 – volume: 122 start-page: 2749 year: 2012 ident: 10.1016/j.resp.2015.08.002_bib0130 article-title: Pathogenesis of chronic obstructive pulmonary disease publication-title: J. Clin. Invest. doi: 10.1172/JCI60324 – volume: 48 start-page: 202 year: 1980 ident: 10.1016/j.resp.2015.08.002_bib0015 article-title: Smoothing of MEFV curves by digital filtering of flow as a function of volume publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1980.48.1.202 – volume: 98 start-page: 643 year: 1990 ident: 10.1016/j.resp.2015.08.002_bib0105 article-title: The flow-ratio index. an approach for measuring the influence of age and cigarette smoking on maximum expiratory flow–volume curve configuration publication-title: Chest doi: 10.1378/chest.98.3.643 – volume: 44 start-page: 156 year: 1978 ident: 10.1016/j.resp.2015.08.002_bib0090 article-title: Analysis of the configuration of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1978.44.2.156 – volume: 63 start-page: 1040 year: 2008 ident: 10.1016/j.resp.2015.08.002_bib0020 article-title: Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and functional outcomes publication-title: Thorax doi: 10.1136/thx.2008.095554 – volume: 94 start-page: 799 year: 1988 ident: 10.1016/j.resp.2015.08.002_bib0075 article-title: The shape of the maximum expiratory flow volume curve publication-title: Chest doi: 10.1378/chest.94.4.799 – start-page: 167 year: 2003 ident: 10.1016/j.resp.2015.08.002_bib0010 article-title: Statement on cardiopulmonary exercise testing publication-title: Am. J. Respir. Crit. Care Med. – volume: 37 start-page: 720 year: 2011 ident: 10.1016/j.resp.2015.08.002_bib0110 article-title: The need to change the method for defining mild airway obstruction publication-title: Eur. Respir. J. doi: 10.1183/09031936.00135110 – volume: 37 start-page: 67 year: 1974 ident: 10.1016/j.resp.2015.08.002_bib0035 article-title: Variability of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1974.37.1.67 – volume: 20 start-page: 1117 year: 2002 ident: 10.1016/j.resp.2015.08.002_bib0055 article-title: Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers publication-title: Eur. Respir. J. doi: 10.1183/09031936.02.00023202 – volume: 36 start-page: 412 year: 1974 ident: 10.1016/j.resp.2015.08.002_bib0100 article-title: Morphologic basis of pulmonary resistance in the human lung and effects of aging publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1974.36.4.412 – volume: 15 start-page: 229 year: 1994 ident: 10.1016/j.resp.2015.08.002_bib0065 article-title: Impact of the aging pulmonary system on the response to exercise publication-title: Clin. Chest Med. doi: 10.1016/S0272-5231(21)01070-4 – volume: 46 start-page: 565 year: 1979 ident: 10.1016/j.resp.2015.08.002_bib0125 article-title: Variability of the configuration of maximum expiratory flow–volume curves publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1979.46.3.565 – reference: 26899171 - Respir Physiol Neurobiol. 2016 Jun 15;227:68 – reference: 26687468 - Respir Physiol Neurobiol. 2016 Jun 15;227:69 |
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| Snippet | •The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves.•Compared to matched controls, COPD patients had a greater average... Highlights • The slope-ratio (SR) quantifies the shape of maximal expiratory flow–volume curves. • Compared to matched controls, COPD patients had a greater... Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease,... |
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| SubjectTerms | Aged Effort independent Female Humans Lung heterogeneity Lung Volume Measurements Male Maximal Expiratory Flow-Volume Curves Medical Education Middle Aged Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary function Pulmonary/Respiratory Retrospective Studies Slope-ratio Spirometry |
| Title | Quantifying the shape of the maximal expiratory flow–volume curve in mild COPD |
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