Ghrelin, leptin and adiponectin levels in Gaucher disease type I patients on enzyme replacement therapy
Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate. To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT). A cross-sectional st...
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| Published in | Clinical nutrition (Edinburgh, Scotland) Vol. 34; no. 4; pp. 727 - 731 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0261-5614 1532-1983 1532-1983 |
| DOI | 10.1016/j.clnu.2014.08.010 |
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| Abstract | Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate.
To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT).
A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR.
Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR.
Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. |
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| AbstractList | Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate.
To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT).
A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR.
Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR.
Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. Summary Background Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate. Objective To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT). Subjects and methods A cross-sectional study of patients with GD type I ( n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR. Results Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR. Conclusions Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate. To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT). A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR. Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR. Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate.To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT).A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR.Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR.Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate.BACKGROUNDGaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate.To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT).OBJECTIVETo evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT).A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR.SUBJECTS AND METHODSA cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR.Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR.RESULTSEight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR.Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found.CONCLUSIONSMetabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found. |
| Author | Schwartz, Ida V.D. Lopes, André L. Moulin, Cileide C. Mittelstadt, Suzana D. Doneda, Divair Teixeira, Bruno C. |
| Author_xml | – sequence: 1 givenname: Divair surname: Doneda fullname: Doneda, Divair organization: LTD Laboratory, Nutrition Program, Medical School, Universidade Federal do Rio Grande do Sul, Brazil – sequence: 2 givenname: André L. surname: Lopes fullname: Lopes, André L. organization: School of Physical Education, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil – sequence: 3 givenname: Bruno C. surname: Teixeira fullname: Teixeira, Bruno C. organization: School of Physical Education, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil – sequence: 4 givenname: Suzana D. surname: Mittelstadt fullname: Mittelstadt, Suzana D. organization: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil – sequence: 5 givenname: Cileide C. surname: Moulin fullname: Moulin, Cileide C. organization: Centre for Studies in Food and Nutrition (CESAN), HCPA/UFRGS, Brazil – sequence: 6 givenname: Ida V.D. surname: Schwartz fullname: Schwartz, Ida V.D. email: idadschwartz@gmail.com organization: Post-Graduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25239509$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_ymgmr_2019_100564 crossref_primary_10_1186_s13023_019_1211_5 crossref_primary_10_1016_j_bcmd_2016_10_012 crossref_primary_10_3390_ijms23158634 crossref_primary_10_1016_j_clnu_2014_12_017 crossref_primary_10_1152_ajpgi_00095_2016 crossref_primary_10_1016_j_clnu_2014_12_018 |
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| Keywords | HOMA-IR T2DM Gaucher disease type I SRT Ghrelin Leptin ERT Insulin GD Adiponectin BMI enzyme replacement therapy body mass index Gaucher disease type 2 diabetes mellitus substrate reduction therapy homeostatic model assessment of insulin resistance |
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| SubjectTerms | Adiponectin Adiponectin - blood Adult biomarkers Body Mass Index Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Sectional Studies Enzyme Replacement Therapy - methods Female Gastroenterology and Hepatology Gaucher Disease - blood Gaucher Disease - complications Gaucher Disease - therapy Gaucher disease type I genetic disorders Ghrelin Ghrelin - blood glucose high density lipoprotein cholesterol Humans Insulin Insulin Resistance Leptin Leptin - blood low density lipoprotein cholesterol Male metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - etiology Middle Aged Nutrition Assessment Nutritional Status overweight Overweight - blood Overweight - etiology patients therapeutics triacylglycerols Triglycerides - blood waist circumference Young Adult |
| Title | Ghrelin, leptin and adiponectin levels in Gaucher disease type I patients on enzyme replacement therapy |
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