Early Childhood Caries Is Associated with Genetic Variants in Enamel Formation and Immune Response Genes

Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contr...

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Published inCaries research Vol. 49; no. 1; pp. 70 - 77
Main Authors Abbasoğlu, Zerrin, Tanboğa, İlknur, Calvano Küchler, Erika, Deeley, Kathleen, Weber, Megan, Kaspar, Cigdem, Korachi, May, Vieira, Alexandre R.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2015
Subjects
Adenine
Amelogenesis - genetics
Arachidonate 15-Lipoxygenase - genetics
Child, Preschool
Cross-Sectional Studies
Cytosine
Dental Caries - genetics
Dental Enamel Proteins - genetics
Epistasis, Genetic - genetics
Extracellular Matrix Proteins - genetics
Feeding Behavior
Female
Gene-Environment Interaction
Genes, MHC Class II - genetics
Genetic Markers - genetics
Genetic Variation - genetics
Guanine
Humans
Kallikreins - genetics
Lactoferrin - genetics
Male
Original Paper
Polymorphism, Genetic - genetics
Thymine
Risk and protective factors
Gene-environment interaction
Early childhood caries
Online AccessGet full text
ISSN0008-6568
1421-976X
1421-976X
DOI10.1159/000362825

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Abstract Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.
AbstractList Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of unequal contributions of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire and caries experience data were collected by clinical examination. Twenty-three markers in ten genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries-free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene-interactions can act as protective or risk factors for early childhood caries. These factors together contribute to the presence and severity of the disease.
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease. © 2014 S. Karger AG, Basel
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC. In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease.
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk factors and protective factors that influence the disease. The aim of this study was to assess genetic and environmental factors that may contribute to ECC. Two hundred and fifty-nine unrelated children were evaluated using a cross-sectional design. Data on oral habits were obtained through a questionnaire, and caries experience data were collected by clinical examination. Twenty-three markers in 10 genes were studied. Genotyping of the selected polymorphisms was carried out by real-time PCR. Regression analyses were performed comparing individuals with and without caries experience. Of 259 subjects, 123 were caries free. The genotype TT in ALOX15 (rs7217186) was a risk factor for ECC, whereas the genotypes GG in ENAM (rs1264848), AG and GG in KLK4 (rs198968), CT in LTF (rs4547741), and GG in TUFT1 (rs3790506) were protective for EEC.In conclusion, environmental factors and gene interactions can act as protective or risk factors for ECC. These factors together contribute to the presence and severity of the disease. copyright 2014 S. Karger AG, Basel
Author Weber, Megan
Kaspar, Cigdem
Tanboğa, İlknur
Calvano Küchler, Erika
Vieira, Alexandre R.
Deeley, Kathleen
Korachi, May
Abbasoğlu, Zerrin
AuthorAffiliation 1 Department of Pediatric Dentistry, Marmara University, Faculty of Dentistry, Istanbul, Turkey
3 Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
4 Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA
2 Department of Oral Biology, and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
6 Department of Genetics & Bio-Engineering, Yeditepe University, Istanbul, Turkey
5 Department of Biostatistics, Yeditepe University, Istanbul, Turkey
AuthorAffiliation_xml – name: 3 Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
– name: 2 Department of Oral Biology, and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
– name: 5 Department of Biostatistics, Yeditepe University, Istanbul, Turkey
– name: 1 Department of Pediatric Dentistry, Marmara University, Faculty of Dentistry, Istanbul, Turkey
– name: 4 Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA
– name: 6 Department of Genetics & Bio-Engineering, Yeditepe University, Istanbul, Turkey
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  surname: Calvano Küchler
  fullname: Calvano Küchler, Erika
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  givenname: Kathleen
  surname: Deeley
  fullname: Deeley, Kathleen
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  givenname: Megan
  surname: Weber
  fullname: Weber, Megan
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  fullname: Kaspar, Cigdem
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  givenname: Alexandre R.
  surname: Vieira
  fullname: Vieira, Alexandre R.
  email: arv11@pitt.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25531160$$D View this record in MEDLINE/PubMed
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Keywords Risk and protective factors
Gene-environment interaction
Early childhood caries
Language English
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Brancher JA, Pecharki GD, Doetzer AD, Medeitors KG, Cordeiro CA Jr, Sotomaior VS, Bauer P, Trevilatto PC: Analysis of polymorphisms in the lactotransferrin gene promoter and dental caries. Int J Dent 2011;2011:571726.2219093310.1155/2011/571726
Pavlic A, Petelin M, Battelino T: Phenotype and enamel ultrastructure characteristics in patients with ENAM gene mutations g.13185-13186insAG and 8344delG. Arch Oral Biol 2007;52:209-217.1712572810.1016/j.archoralbio.2006.10.010
Ferreira SH, Béria JU, Kramer PF, Feldens EG, Feldens CA: Dental caries in 0- to 5-year-old Brazilian children: prevalence, severity, and associated factors. Int J Paediatr Dent 2007;17:289-296.1755945710.1111/j.1365-263X.2007.00831.x
Wang X, Shaffer JR, Zeng Z, Begum F, Vieira AR, Noel J, Anjomshoaa I, Cuenco KT, Lee M-K, Beck J, Boerwinkle E, Cornelis MC, Hu FB, Crosslin DR, Laurie CC, Nelson SC, Doheny KF, Pugh EW, Polk DE, Weyant RJ, Crout R, McNeil DW, Weeks DE, Feingold E, Marazita ML: Genome-wide association scan of dental caries in the permanent dentition. J Dent Res 2012;92:432-437.2325960210.1186/1472-6831-12-57
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Ozturk A, Famili P, Vieira AR: The antimicrobial peptide DEFB1 is associated with caries. J Dent Res 2010;89:631-636.2037186610.1177/0022034510364491
Viejo-Díaz M, Andrés MT, Fierro JF: Modulation of in vitro fungicidal activity of human lactoferrin against Candida albicans by extracellular cation concentration and target cell metabolic activity. Antimicrob Agents Chemother 2004;48:1242-1248.1504752610.1128/AAC.48.4.1242-1248.2004
Briseño-Ruiz J, Shimizu T, Deeley K, Dizak PM, Ruff TD, Faraco IM Jr, Poletta FA, Brancher JA, Pecharki GD, Küchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Koruyucu M, Mereb JC, Resick JM, Brandon CA, Letra A, Silva RM, Cooper ME, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Orioli IM, Castilla EE, Marazita ML, Vieira AR: Role of TRAV locus in low caries experience. Hum Genet 2013;132:1015-1025.2365750510.1007/s00439-013-1313-4
Shaffer JR, Wang X, Feingold E, Lee M, Begum F, Weeks DE, Cuenco KT, Barmada MM, Wendell SK, Crosslin DR, Laurie CC, Doheny KF, Pugh EW, Zhang Q, Feenstra B, Geller F, Boyd HA, Zhang H, Melbye M, Murray JC, Weyant RJ, Crout R, McNeil DW, Levy SM, Slayton RL, Willing MC, Broffitt B, Vieira AR, Marazita ML: Genome-wide association scan for childhood caries implicates novel genes. J Dent Res 2011;90:1457-1462.2194052210.1177/0022034511422910
Tannure PN, Küchler EC, Romanos HF, Vieira AR, Costa MC, Granjeiro JM: Caries experience in individuals with cleft lip and palate. Pediatr Dent 2012c;34:127-131.22583885
Patir A, Seymen F, Yildirim M, Deeley K, Cooper ME, Marazita ML, Vieira AR: Enamel formation genes are associated with high caries experience in Turkish children. Caries Res 2008;42:394-400.1878106810.1159/000154785
Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J: Psychiatric genetics: search for phenotypes. Trends Neurosci 1998;21:102-105.953091510.1016/S0166-2236(97)01187-9
American Academy of Pediatric Dentistry: Policy on early childhood caries (ECC): classifications, consequences, and preventive strategies. Pediatr Dent 2008;30:40-43.19216381
Drury TF, Horowitz AM, Ismail AI, Maertens MP, Rozier RG, Selwitz RH: Diagnosing and reporting early childhood caries for research purposes. A report of a workshop sponsored by the National Institute of Dental and Craniofacial Research, the Health Resources and Services Administration, and the Health Care Financing Administration. J Public Health Dent 1999;59:192-197.1064959110.1111/j.1752-7325.1999.tb03268.x
Vieira AR, Marazita ML, McHenry TG: Genome-wide scan finds suggestive caries loci. J Dent Res 2008;87:435-439.1843457210.1177/154405910808700506
Deeley K, Letra A, Rose EK, Brandon CA, Resick JM, Marazita ML, Vieira AR: Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. Caries Res 2008;42:8-13.1804298810.1159/000111744
Klinke T, Guggenheim B, Klimm W, Thurnheer T: Dental caries in rats associated with Candida albicans. Caries Res 2011;45:100-106.2141200110.1159/000324809
Shimizu T, Deeley K, Briseño-Ruiz J, Faraco IM Jr, Poletta FA, Brancher JA, Pecharki GD, Küchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Yildirim M, Mereb JC, Resick JM, Brandon CA, Cooper ME, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Orioli IM, Castilla EE, Marazita ML, Vireira AR: Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries. Caries Res 2013;47:273-283.2336393510.1159/000346278
Vilella AJ, Severin J, Ureta-Vidal A, Heng L, Durbin R, Birney E: EnsemblCompara GeneTrees: complete, duplication-aware phylogenetic trees in vertebrates. Genome Res 2009;19:327-335.1902953610.1101/gr.073585.107
Kelavkar UP, Badr KF: Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene. Proc Natl Acad Sci U S A 1999;96:4378-4383.1020027010.1073/pnas.96.8.4378
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Tannure PN, Küchler EC, Lips A, Costa MC, Luiz RR, Granjeiro JM, Vieira AR: Genetic variation in MMP20 contributes to higher caries experience. J Dent 2012b;40:381-386.2233032110.1016/j.jdent.2012.01.015
Shimizu T, Ho B, Deeley K, Briseño-Ruiz J, Faraco IM Jr, Schupack BI, Brancher JA, Pecharki GD, Küchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Yildirim M, Poletta FA, Mereb JC, Resick JM, Brandon CA, Orioli IM, Castilla EE, Marazita ML, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Vieira AR: Enamel formation genes influence enamel microhardness before and after cariogenic challenge. PLoS One 2012;7:e45022.2302874110.1371/journal.pone.0045022
Slayton RL, Cooper ME, Marazita ML: Tuftelin, mutans streptococci, and dental caries susceptibility. J Dent Res 2005;84:711-714.1604072710.1177/154405910508400805
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– reference: Levy SM, Warren JJ, Broffitt B, Hillis SL, Kanellis MJ: Fluoride, beverages and dental caries in the primary dentition. Caries Res 2003;37:157-165.1274053710.1159/000070438
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– reference: Tannure PN, Küchler EC, Romanos HF, Vieira AR, Costa MC, Granjeiro JM: Caries experience in individuals with cleft lip and palate. Pediatr Dent 2012c;34:127-131.22583885
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Snippet Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of an imbalance of risk...
Early childhood caries (ECC) is a chronic, infectious disease that affects the primary dentition of young children. It is the result of unequal contributions...
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SubjectTerms Adenine
Amelogenesis - genetics
Arachidonate 15-Lipoxygenase - genetics
Child, Preschool
Cross-Sectional Studies
Cytosine
Dental Caries - genetics
Dental Enamel Proteins - genetics
Epistasis, Genetic - genetics
Extracellular Matrix Proteins - genetics
Feeding Behavior
Female
Gene-Environment Interaction
Genes, MHC Class II - genetics
Genetic Markers - genetics
Genetic Variation - genetics
Guanine
Humans
Kallikreins - genetics
Lactoferrin - genetics
Male
Original Paper
Polymorphism, Genetic - genetics
Thymine
Title Early Childhood Caries Is Associated with Genetic Variants in Enamel Formation and Immune Response Genes
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https://www.proquest.com/docview/1776646166
https://pubmed.ncbi.nlm.nih.gov/PMC4376372
https://www.karger.com/Article/Pdf/362825
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