A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity
Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind acc...
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| Published in | Molecular cell Vol. 35; no. 2; pp. 143 - 153 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
31.07.2009
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-2765 1097-4164 1097-4164 |
| DOI | 10.1016/j.molcel.2009.05.029 |
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| Abstract | Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene expression changes. Here, we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum, validating the notion that targeting quorum sensing has potential for antimicrobial drug development. |
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| AbstractList | Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene expression changes. Here, we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum, validating the notion that targeting quorum sensing has potential for antimicrobial drug development. Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene expression changes. Here, we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum, validating the notion that targeting quorum sensing has potential for antimicrobial drug development. Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene-expression changes. Here we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum , validating the notion that targeting quorum sensing has potential for antimicrobial drug development. Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene expression changes. Here, we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum, validating the notion that targeting quorum sensing has potential for antimicrobial drug development.Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use acyl-homoserine lactone (AHL) autoinducers, which are detected by one of two receptor types. First, cytoplasmic LuxR-type receptors bind accumulated intracellular AHLs. AHL-LuxR complexes bind DNA and alter gene expression. Second, membrane-bound LuxN-type receptors bind accumulated extracellular AHLs. AHL-LuxN complexes relay information internally by phosphorylation cascades that direct gene expression changes. Here, we show that a small molecule, previously identified as an antagonist of LuxN-type receptors, is also a potent antagonist of the LuxR family, despite differences in receptor structure, localization, AHL specificity, and signaling mechanism. Derivatives were synthesized and optimized for potency, and in each case, we characterized the mode of action of antagonism. The most potent antagonist protects Caenorhabditis elegans from quorum-sensing-mediated killing by Chromobacterium violaceum, validating the notion that targeting quorum sensing has potential for antimicrobial drug development. |
| Author | Bassler, Bonnie L. Zhao, Bixiao Swem, Danielle L. Gatmaitan, Raleene O'Loughlin, Colleen T. Swem, Lee R. Ulrich, Scott M. |
| AuthorAffiliation | 2 Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA 3 Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA 1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA |
| AuthorAffiliation_xml | – name: 1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – name: 2 Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA – name: 3 Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA |
| Author_xml | – sequence: 1 givenname: Lee R. surname: Swem fullname: Swem, Lee R. organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – sequence: 2 givenname: Danielle L. surname: Swem fullname: Swem, Danielle L. organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – sequence: 3 givenname: Colleen T. surname: O'Loughlin fullname: O'Loughlin, Colleen T. organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – sequence: 4 givenname: Raleene surname: Gatmaitan fullname: Gatmaitan, Raleene organization: Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA – sequence: 5 givenname: Bixiao surname: Zhao fullname: Zhao, Bixiao organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA – sequence: 6 givenname: Scott M. surname: Ulrich fullname: Ulrich, Scott M. organization: Department of Chemistry, Ithaca College, Ithaca, NY 14850, USA – sequence: 7 givenname: Bonnie L. surname: Bassler fullname: Bassler, Bonnie L. email: bbassler@princeton.edu organization: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19647512$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1099/mic.0.27954-0 10.1073/pnas.0407661102 10.1146/annurev.micro.50.1.727 10.1128/jb.172.6.2946-2954.1990 10.1038/nature00833 10.1099/mic.0.2008/019281-0 10.1074/jbc.M604108200 10.1016/j.ijmm.2006.01.042 10.1016/j.cell.2004.06.009 10.1021/ja0530321 10.1101/gad.1502407 10.1021/ja074135h 10.1093/emboj/cdg366 10.1073/pnas.0601754103 10.1128/JB.186.20.6902-6914.2004 10.1016/S0021-9258(20)88238-6 10.1016/j.bbrc.2006.05.168 10.1146/annurev.genet.42.110807.091640 10.1111/j.1365-2958.2006.05210.x 10.1128/JB.185.23.7001-7007.2003 10.1111/j.1365-2958.1993.tb01737.x 10.1073/pnas.98.4.1507 10.1128/JB.01723-06 10.1111/j.1365-2958.2004.04529.x 10.1128/jb.176.2.269-275.1994 10.1128/jb.171.5.2406-2414.1989 10.1073/pnas.96.9.4832 10.1111/j.1365-2958.1994.tb00422.x 10.1146/annurev.bioeng.10.061807.160536 10.1016/j.bmcl.2008.07.089 10.1099/00221287-143-12-3703 10.1016/j.cell.2008.06.023 10.1128/AAC.00665-06 10.1046/j.1365-2958.2000.01684.x 10.1099/00221287-148-1-87 10.1046/j.1365-2958.2002.02987.x 10.1146/annurev.cellbio.21.012704.131001 10.1016/S1369-5274(02)00293-X |
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| References | Geske, Mattmann, Blackwell (bib12) 2008; 18 Richard (bib28) 1993; 86 Geske, Wezeman, Siegel, Blackwell (bib10) 2005; 127 Martin, Showalter, Silverman (bib21) 1989; 171 Waters, Bassler (bib37) 2005; 21 Wright, Jin, Novick (bib39) 2005; 102 Zhu, Winans (bib42) 2001; 98 Freeman, Lilley, Bassler (bib6) 2000; 35 Zhang, Pappas, Brace, Miller, Oulmassov, Molyneaux, Anderson, Bashkin, Winans, Joachimiak (bib40) 2002; 417 Minogue, Wehland-von Trebra, Bernhard, von Bodman (bib23) 2002; 44 (bib26) 2006 Fuqua, Winans, Greenberg (bib8) 1996; 50 Muh, Schuster, Heim, Singh, Olson, Greenberg (bib25) 2006; 50 Jung, Odenbach, Timmen (bib17) 2007; 189 Gale (bib9) 1981 Hentzer, Wu, Andersen, Riedel, Rasmussen, Bagge, Kumar, Schembri, Song, Kristoffersen (bib15) 2003; 22 Novick, Geisinger (bib27) 2008; 42 Fuqua, Winans, Greenberg (bib7) 1994; 176 Koch, Liljefors, Persson, Nielsen, Kjelleberg, Givskov (bib18) 2005; 151 Hentzer, Riedel, Rasmussen, Heydorn, Andersen, Parsek, Rice, Eberl, Molin, Hoiby (bib14) 2002; 148 Showalter, Martin, Silverman (bib29) 1990; 172 Swem, Swem, Wingreen, Bassler (bib31) 2008; 134 Bassler, Wright, Silverman (bib3) 1994; 13 Minogue, Carlier, Koutsoudis, von Bodman (bib24) 2005; 56 Lenz, Mok, Lilley, Kulkarni, Wingreen, Bassler (bib20) 2004; 118 Bassler, Wright, Showalter, Silverman (bib2) 1993; 9 Zhu, Winans (bib41) 1999; 96 Cao, Meighen (bib4) 1989; 264 Jayaraman, Wood (bib16) 2008; 10 Vaitkevicius, Lindmark, Ou, Song, Toma, Iwanaga, Zhu, Andersson, Hammarstrom, Tuck (bib35) 2006; 103 Geske, O'Neill, Miller, Mattmann, Blackwell (bib11) 2007; 129 Willcox, Zhu, Conibear, Hume, Givskov, Kjelleberg, Rice (bib38) 2008; 154 Sjoblom, Brader, Koch, Palva (bib30) 2006; 60 Timmen, Bassler, Jung (bib33) 2006; 281 Aballay, Ausubel (bib1) 2002; 5 Tu, Bassler (bib34) 2007; 21 Henke, Bassler (bib13) 2004; 186 McClean, Winson, Fish, Taylor, Chhabra, Camara, Daykin, Lamb, Swift, Bycroft (bib22) 1997; 143 Kong, Vuong, Otto (bib19) 2006; 296 Throup, Winson, Bainton, Bycroft, Williams, Stewart (bib32) 1995 von Bodman, Ball, Faini, Herrera, Minogue, Urbanowski, Stevens (bib36) 2003; 185 Dhakal, Lee, Kim, Choy, Ahnn, Rhee (bib5) 2006; 346 Freeman (10.1016/j.molcel.2009.05.029_bib6) 2000; 35 Waters (10.1016/j.molcel.2009.05.029_bib37) 2005; 21 McClean (10.1016/j.molcel.2009.05.029_bib22) 1997; 143 Novick (10.1016/j.molcel.2009.05.029_bib27) 2008; 42 (10.1016/j.molcel.2009.05.029_bib26) 2006 Zhang (10.1016/j.molcel.2009.05.029_bib40) 2002; 417 Sjoblom (10.1016/j.molcel.2009.05.029_bib30) 2006; 60 Zhu (10.1016/j.molcel.2009.05.029_bib41) 1999; 96 Lenz (10.1016/j.molcel.2009.05.029_bib20) 2004; 118 Jung (10.1016/j.molcel.2009.05.029_bib17) 2007; 189 Throup (10.1016/j.molcel.2009.05.029_bib32) 1995 Aballay (10.1016/j.molcel.2009.05.029_bib1) 2002; 5 Kong (10.1016/j.molcel.2009.05.029_bib19) 2006; 296 Henke (10.1016/j.molcel.2009.05.029_bib13) 2004; 186 Hentzer (10.1016/j.molcel.2009.05.029_bib14) 2002; 148 Minogue (10.1016/j.molcel.2009.05.029_bib24) 2005; 56 Jayaraman (10.1016/j.molcel.2009.05.029_bib16) 2008; 10 Martin (10.1016/j.molcel.2009.05.029_bib21) 1989; 171 Geske (10.1016/j.molcel.2009.05.029_bib12) 2008; 18 Swem (10.1016/j.molcel.2009.05.029_bib31) 2008; 134 Dhakal (10.1016/j.molcel.2009.05.029_bib5) 2006; 346 Willcox (10.1016/j.molcel.2009.05.029_bib38) 2008; 154 Gale (10.1016/j.molcel.2009.05.029_bib9) 1981 Hentzer (10.1016/j.molcel.2009.05.029_bib15) 2003; 22 Wright (10.1016/j.molcel.2009.05.029_bib39) 2005; 102 Koch (10.1016/j.molcel.2009.05.029_bib18) 2005; 151 Minogue (10.1016/j.molcel.2009.05.029_bib23) 2002; 44 Cao (10.1016/j.molcel.2009.05.029_bib4) 1989; 264 Timmen (10.1016/j.molcel.2009.05.029_bib33) 2006; 281 Vaitkevicius (10.1016/j.molcel.2009.05.029_bib35) 2006; 103 Richard (10.1016/j.molcel.2009.05.029_bib28) 1993; 86 Muh (10.1016/j.molcel.2009.05.029_bib25) 2006; 50 Fuqua (10.1016/j.molcel.2009.05.029_bib7) 1994; 176 von Bodman (10.1016/j.molcel.2009.05.029_bib36) 2003; 185 Bassler (10.1016/j.molcel.2009.05.029_bib3) 1994; 13 Zhu (10.1016/j.molcel.2009.05.029_bib42) 2001; 98 Geske (10.1016/j.molcel.2009.05.029_bib10) 2005; 127 Fuqua (10.1016/j.molcel.2009.05.029_bib8) 1996; 50 Geske (10.1016/j.molcel.2009.05.029_bib11) 2007; 129 Showalter (10.1016/j.molcel.2009.05.029_bib29) 1990; 172 Tu (10.1016/j.molcel.2009.05.029_bib34) 2007; 21 Bassler (10.1016/j.molcel.2009.05.029_bib2) 1993; 9 |
| References_xml | – volume: 42 start-page: 541 year: 2008 end-page: 564 ident: bib27 article-title: Quorum sensing in staphylococci publication-title: Annu. Rev. Genet. – volume: 127 start-page: 12762 year: 2005 end-page: 12763 ident: bib10 article-title: Small molecule inhibitors of bacterial quorum sensing and biofilm formation publication-title: J. Am. Chem. Soc. – volume: 21 start-page: 221 year: 2007 end-page: 233 ident: bib34 article-title: Multiple small RNAs act additively to integrate sensory information and control quorum sensing in publication-title: Genes Dev. – volume: 44 start-page: 1625 year: 2002 end-page: 1635 ident: bib23 article-title: The autoregulatory role of EsaR, a quorum-sensing regulator in publication-title: Mol. Microbiol. – volume: 118 start-page: 69 year: 2004 end-page: 82 ident: bib20 article-title: The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in publication-title: Cell – volume: 134 start-page: 461 year: 2008 end-page: 473 ident: bib31 article-title: Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in publication-title: Cell – start-page: 89 year: 1995 end-page: 92 ident: bib32 article-title: Signalling in bacteria beyond bioluminescence publication-title: Bioluminescence and Chemiluminescence: Fundamentals and Applied Aspects – year: 1981 ident: bib9 article-title: The Molecular Basis of Antibiotic Action – volume: 13 start-page: 273 year: 1994 end-page: 286 ident: bib3 article-title: Multiple signalling systems controlling expression of luminescence in publication-title: Mol. Microbiol. – volume: 86 start-page: 169 year: 1993 end-page: 173 ident: bib28 article-title: [Chromobacterium violaceum, opportunist pathogenic bacteria in tropical and subtropical regions] publication-title: Bul. Soc. Pathol. Exot. – volume: 151 start-page: 3589 year: 2005 end-page: 3602 ident: bib18 article-title: The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors publication-title: Microbiology – volume: 281 start-page: 24398 year: 2006 end-page: 24404 ident: bib33 article-title: AI-1 influences the kinase activity but not the phosphatase activity of LuxN of publication-title: J. Biol. Chem. – volume: 22 start-page: 3803 year: 2003 end-page: 3815 ident: bib15 article-title: Attenuation of publication-title: EMBO J. – volume: 186 start-page: 6902 year: 2004 end-page: 6914 ident: bib13 article-title: Three parallel quorum-sensing systems regulate gene expression in publication-title: J. Bacteriol. – volume: 172 start-page: 2946 year: 1990 end-page: 2954 ident: bib29 article-title: Cloning and nucleotide sequence of publication-title: J. Bacteriol. – volume: 176 start-page: 269 year: 1994 end-page: 275 ident: bib7 article-title: Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators publication-title: J. Bacteriol. – volume: 50 start-page: 727 year: 1996 end-page: 751 ident: bib8 article-title: Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators publication-title: Annu. Rev. Microbiol. – volume: 5 start-page: 97 year: 2002 end-page: 101 ident: bib1 article-title: as a host for the study of host-pathogen interactions publication-title: Curr. Opin. Microbiol. – year: 2006 ident: bib26 article-title: Treating Infectious Diseases in a Microbial World – volume: 189 start-page: 2945 year: 2007 end-page: 2948 ident: bib17 article-title: The quorum-sensing hybrid histidine kinase LuxN of publication-title: J. Bacteriol. – volume: 10 start-page: 145 year: 2008 end-page: 167 ident: bib16 article-title: Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease publication-title: Annu. Rev. Biomed. Eng. – volume: 56 start-page: 189 year: 2005 end-page: 203 ident: bib24 article-title: The cell density-dependent expression of stewartan exopolysaccharide in publication-title: Mol. Microbiol. – volume: 346 start-page: 751 year: 2006 end-page: 757 ident: bib5 article-title: as a simple model host for publication-title: Biochem. Biophys. Res. Commun. – volume: 264 start-page: 21670 year: 1989 end-page: 21676 ident: bib4 article-title: Purification and structural identification of an autoinducer for the luminescence system of publication-title: J. Biol. Chem. – volume: 154 start-page: 2184 year: 2008 end-page: 2194 ident: bib38 article-title: Role of quorum sensing by publication-title: Microbiology – volume: 60 start-page: 1474 year: 2006 end-page: 1489 ident: bib30 article-title: Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen publication-title: Mol. Microbiol. – volume: 96 start-page: 4832 year: 1999 end-page: 4837 ident: bib41 article-title: Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells publication-title: Proc. Natl. Acad. Sci. USA – volume: 171 start-page: 2406 year: 1989 end-page: 2414 ident: bib21 article-title: Identification of a locus controlling expression of luminescence genes in publication-title: J. Bacteriol. – volume: 21 start-page: 319 year: 2005 end-page: 346 ident: bib37 article-title: QUORUM SENSING: Cell-to-Cell Communication in Bacteria publication-title: Annu. Rev. Cell Dev. Biol. – volume: 98 start-page: 1507 year: 2001 end-page: 1512 ident: bib42 article-title: The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization publication-title: Proc. Natl. Acad. Sci. USA – volume: 143 start-page: 3703 year: 1997 end-page: 3711 ident: bib22 article-title: Quorum sensing and publication-title: Microbiology – volume: 417 start-page: 971 year: 2002 end-page: 974 ident: bib40 article-title: Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA publication-title: Nature – volume: 296 start-page: 133 year: 2006 end-page: 139 ident: bib19 article-title: quorum sensing in biofilm formation and infection publication-title: Int. J. Med. Microbiol. – volume: 50 start-page: 3674 year: 2006 end-page: 3679 ident: bib25 article-title: Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen publication-title: Antimicrob. Agents Chemother. – volume: 129 start-page: 13613 year: 2007 end-page: 13625 ident: bib11 article-title: Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action publication-title: J. Am. Chem. Soc. – volume: 102 start-page: 1691 year: 2005 end-page: 1696 ident: bib39 article-title: Transient interference with staphylococcal quorum sensing blocks abscess formation publication-title: Proc. Natl. Acad. Sci. USA – volume: 185 start-page: 7001 year: 2003 end-page: 7007 ident: bib36 article-title: The quorum sensing negative regulators EsaR and ExpR(Ecc), homologues within the LuxR family, retain the ability to function as activators of transcription publication-title: J. Bacteriol. – volume: 9 start-page: 773 year: 1993 end-page: 786 ident: bib2 article-title: Intercellular signalling in publication-title: Mol. Microbiol. – volume: 148 start-page: 87 year: 2002 end-page: 102 ident: bib14 article-title: Inhibition of quorum sensing in publication-title: Microbiology – volume: 103 start-page: 9280 year: 2006 end-page: 9285 ident: bib35 article-title: A publication-title: Proc. Natl. Acad. Sci. USA – volume: 35 start-page: 139 year: 2000 end-page: 149 ident: bib6 article-title: A genetic analysis of the functions of LuxN: a two-component hybrid sensor kinase that regulates quorum sensing in publication-title: Mol. Microbiol. – volume: 18 start-page: 5978 year: 2008 end-page: 5981 ident: bib12 article-title: Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators publication-title: Bioorg. Med. Chem. Lett. – volume: 151 start-page: 3589 year: 2005 ident: 10.1016/j.molcel.2009.05.029_bib18 article-title: The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors publication-title: Microbiology doi: 10.1099/mic.0.27954-0 – volume: 102 start-page: 1691 year: 2005 ident: 10.1016/j.molcel.2009.05.029_bib39 article-title: Transient interference with staphylococcal quorum sensing blocks abscess formation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0407661102 – volume: 50 start-page: 727 year: 1996 ident: 10.1016/j.molcel.2009.05.029_bib8 article-title: Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators publication-title: Annu. Rev. Microbiol. doi: 10.1146/annurev.micro.50.1.727 – volume: 172 start-page: 2946 year: 1990 ident: 10.1016/j.molcel.2009.05.029_bib29 article-title: Cloning and nucleotide sequence of luxR, a regulatory gene controlling bioluminescence in Vibrio harveyi publication-title: J. Bacteriol. doi: 10.1128/jb.172.6.2946-2954.1990 – volume: 417 start-page: 971 year: 2002 ident: 10.1016/j.molcel.2009.05.029_bib40 article-title: Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA publication-title: Nature doi: 10.1038/nature00833 – volume: 154 start-page: 2184 year: 2008 ident: 10.1016/j.molcel.2009.05.029_bib38 article-title: Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis publication-title: Microbiology doi: 10.1099/mic.0.2008/019281-0 – year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib26 – volume: 281 start-page: 24398 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib33 article-title: AI-1 influences the kinase activity but not the phosphatase activity of LuxN of Vibrio harveyi publication-title: J. Biol. Chem. doi: 10.1074/jbc.M604108200 – volume: 296 start-page: 133 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib19 article-title: Staphylococcus quorum sensing in biofilm formation and infection publication-title: Int. J. Med. Microbiol. doi: 10.1016/j.ijmm.2006.01.042 – volume: 118 start-page: 69 year: 2004 ident: 10.1016/j.molcel.2009.05.029_bib20 article-title: The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae publication-title: Cell doi: 10.1016/j.cell.2004.06.009 – volume: 127 start-page: 12762 year: 2005 ident: 10.1016/j.molcel.2009.05.029_bib10 article-title: Small molecule inhibitors of bacterial quorum sensing and biofilm formation publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0530321 – volume: 21 start-page: 221 year: 2007 ident: 10.1016/j.molcel.2009.05.029_bib34 article-title: Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi publication-title: Genes Dev. doi: 10.1101/gad.1502407 – volume: 129 start-page: 13613 year: 2007 ident: 10.1016/j.molcel.2009.05.029_bib11 article-title: Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action publication-title: J. Am. Chem. Soc. doi: 10.1021/ja074135h – volume: 22 start-page: 3803 year: 2003 ident: 10.1016/j.molcel.2009.05.029_bib15 article-title: Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors publication-title: EMBO J. doi: 10.1093/emboj/cdg366 – volume: 103 start-page: 9280 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib35 article-title: A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0601754103 – volume: 186 start-page: 6902 year: 2004 ident: 10.1016/j.molcel.2009.05.029_bib13 article-title: Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi publication-title: J. Bacteriol. doi: 10.1128/JB.186.20.6902-6914.2004 – volume: 86 start-page: 169 year: 1993 ident: 10.1016/j.molcel.2009.05.029_bib28 article-title: [Chromobacterium violaceum, opportunist pathogenic bacteria in tropical and subtropical regions] publication-title: Bul. Soc. Pathol. Exot. – volume: 264 start-page: 21670 year: 1989 ident: 10.1016/j.molcel.2009.05.029_bib4 article-title: Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(20)88238-6 – volume: 346 start-page: 751 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib5 article-title: Caenorhabditis elegans as a simple model host for Vibrio vulnificus infection publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2006.05.168 – volume: 42 start-page: 541 year: 2008 ident: 10.1016/j.molcel.2009.05.029_bib27 article-title: Quorum sensing in staphylococci publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.genet.42.110807.091640 – volume: 60 start-page: 1474 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib30 article-title: Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.2006.05210.x – volume: 185 start-page: 7001 year: 2003 ident: 10.1016/j.molcel.2009.05.029_bib36 article-title: The quorum sensing negative regulators EsaR and ExpR(Ecc), homologues within the LuxR family, retain the ability to function as activators of transcription publication-title: J. Bacteriol. doi: 10.1128/JB.185.23.7001-7007.2003 – volume: 9 start-page: 773 year: 1993 ident: 10.1016/j.molcel.2009.05.029_bib2 article-title: Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.1993.tb01737.x – volume: 98 start-page: 1507 year: 2001 ident: 10.1016/j.molcel.2009.05.029_bib42 article-title: The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.98.4.1507 – volume: 189 start-page: 2945 year: 2007 ident: 10.1016/j.molcel.2009.05.029_bib17 article-title: The quorum-sensing hybrid histidine kinase LuxN of Vibrio harveyi contains a periplasmically located N terminus publication-title: J. Bacteriol. doi: 10.1128/JB.01723-06 – volume: 56 start-page: 189 year: 2005 ident: 10.1016/j.molcel.2009.05.029_bib24 article-title: The cell density-dependent expression of stewartan exopolysaccharide in Pantoea stewartii ssp. stewartii is a function of EsaR-mediated repression of the rcsA gene publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.2004.04529.x – volume: 176 start-page: 269 year: 1994 ident: 10.1016/j.molcel.2009.05.029_bib7 article-title: Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators publication-title: J. Bacteriol. doi: 10.1128/jb.176.2.269-275.1994 – volume: 171 start-page: 2406 year: 1989 ident: 10.1016/j.molcel.2009.05.029_bib21 article-title: Identification of a locus controlling expression of luminescence genes in Vibrio harveyi publication-title: J. Bacteriol. doi: 10.1128/jb.171.5.2406-2414.1989 – volume: 96 start-page: 4832 year: 1999 ident: 10.1016/j.molcel.2009.05.029_bib41 article-title: Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.9.4832 – volume: 13 start-page: 273 year: 1994 ident: 10.1016/j.molcel.2009.05.029_bib3 article-title: Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway publication-title: Mol. Microbiol. doi: 10.1111/j.1365-2958.1994.tb00422.x – volume: 10 start-page: 145 year: 2008 ident: 10.1016/j.molcel.2009.05.029_bib16 article-title: Bacterial quorum sensing: signals, circuits, and implications for biofilms and disease publication-title: Annu. Rev. Biomed. Eng. doi: 10.1146/annurev.bioeng.10.061807.160536 – volume: 18 start-page: 5978 year: 2008 ident: 10.1016/j.molcel.2009.05.029_bib12 article-title: Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2008.07.089 – volume: 143 start-page: 3703 year: 1997 ident: 10.1016/j.molcel.2009.05.029_bib22 article-title: Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones publication-title: Microbiology doi: 10.1099/00221287-143-12-3703 – volume: 134 start-page: 461 year: 2008 ident: 10.1016/j.molcel.2009.05.029_bib31 article-title: Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi publication-title: Cell doi: 10.1016/j.cell.2008.06.023 – volume: 50 start-page: 3674 year: 2006 ident: 10.1016/j.molcel.2009.05.029_bib25 article-title: Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.00665-06 – start-page: 89 year: 1995 ident: 10.1016/j.molcel.2009.05.029_bib32 article-title: Signalling in bacteria beyond bioluminescence – year: 1981 ident: 10.1016/j.molcel.2009.05.029_bib9 – volume: 35 start-page: 139 year: 2000 ident: 10.1016/j.molcel.2009.05.029_bib6 article-title: A genetic analysis of the functions of LuxN: a two-component hybrid sensor kinase that regulates quorum sensing in Vibrio harveyi publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.2000.01684.x – volume: 148 start-page: 87 year: 2002 ident: 10.1016/j.molcel.2009.05.029_bib14 article-title: Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound publication-title: Microbiology doi: 10.1099/00221287-148-1-87 – volume: 44 start-page: 1625 year: 2002 ident: 10.1016/j.molcel.2009.05.029_bib23 article-title: The autoregulatory role of EsaR, a quorum-sensing regulator in Pantoea stewartii ssp. stewartii: evidence for a repressor function publication-title: Mol. Microbiol. doi: 10.1046/j.1365-2958.2002.02987.x – volume: 21 start-page: 319 year: 2005 ident: 10.1016/j.molcel.2009.05.029_bib37 article-title: QUORUM SENSING: Cell-to-Cell Communication in Bacteria publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.21.012704.131001 – volume: 5 start-page: 97 year: 2002 ident: 10.1016/j.molcel.2009.05.029_bib1 article-title: Caenorhabditis elegans as a host for the study of host-pathogen interactions publication-title: Curr. Opin. Microbiol. doi: 10.1016/S1369-5274(02)00293-X |
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| Snippet | Quorum sensing is a process of bacterial communication involving production and detection of secreted molecules called autoinducers. Gram-negative bacteria use... |
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| SubjectTerms | Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Caenorhabditis elegans - microbiology Chromobacterium - drug effects Chromobacterium - pathogenicity Chromobacterium - physiology Escherichia coli - genetics HUMDISEASE Inhibitory Concentration 50 Microbial Sensitivity Tests MICROBIO Quorum Sensing - drug effects Receptors, Cell Surface - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Repressor Proteins - antagonists & inhibitors SIGNALING Trans-Activators - antagonists & inhibitors |
| Title | A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity |
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