Osteoarthritis year 2011 in review: genetics

In the last decades, many researchers aimed to identify causal genetic variants by means of candidate gene analyses, genome wide linkage and association studies to elucidate underlying mechanisms of osteoarthritis (OA). Although several consistent genetic variants were identified the successes are l...

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Bibliographic Details
Published inOsteoarthritis and cartilage Vol. 20; no. 3; pp. 218 - 222
Main Author Meulenbelt, I.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2012
Subjects
Genetic Association Studies
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
Humans
Osteoarthritis - genetics
Phenotype
Rheumatology
Genetics
OA
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ISSN1063-4584
1522-9653
1522-9653
DOI10.1016/j.joca.2012.01.007

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Summary:In the last decades, many researchers aimed to identify causal genetic variants by means of candidate gene analyses, genome wide linkage and association studies to elucidate underlying mechanisms of osteoarthritis (OA). Although several consistent genetic variants were identified the successes are limited. This review has a focus on studies published until mid 2011 and on data presented at the Osteoarthritis Research Society International 2011 (OARSI) in San Diego and that aim to elucidate the primary molecular and cellular events commencing OA onset in humans by applying genetic study designs.
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ISSN:1063-4584
1522-9653
1522-9653
DOI:10.1016/j.joca.2012.01.007