Parametric imaging of contrast ultrasound for the evaluation of neovascularization in liver tumors
Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. Methods: The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultraso...
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| Published in | Hepatology research Vol. 37; no. 6; pp. 464 - 472 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Publishing Asia
01.06.2007
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1386-6346 1872-034X |
| DOI | 10.1111/j.1872-034X.2007.00060.x |
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| Abstract | Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors.
Methods: The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin–eosin (HE) staining and CD31 staining to evaluate vascular density.
Results: Arrival time imaging (ATI) delineated the fine blood vessels (100–200 μm in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor‐free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation.
Conclusion: Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. |
|---|---|
| AbstractList | Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors.
Methods: The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin–eosin (HE) staining and CD31 staining to evaluate vascular density.
Results: Arrival time imaging (ATI) delineated the fine blood vessels (100–200 μm in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor‐free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation.
Conclusion: Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. Methods: The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin–eosin (HE) staining and CD31 staining to evaluate vascular density. Results: Arrival time imaging (ATI) delineated the fine blood vessels (100–200 μm in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor‐free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation. Conclusion: Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. Methods: The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin-eosin (HE) staining and CD31 staining to evaluate vascular density. Results: Arrival time imaging (ATI) delineated the fine blood vessels (100-200 mu m in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor-free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation. Conclusion: Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin-eosin (HE) staining and CD31 staining to evaluate vascular density. Arrival time imaging (ATI) delineated the fine blood vessels (100-200 mum in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor-free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation. Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors.AIMTo assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors.The subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin-eosin (HE) staining and CD31 staining to evaluate vascular density.METHODSThe subjects were 17 rabbits (five with normal liver and 12 with VX2 tumor implanted in the liver). The contrast agents used were SonoVue (Bracco, Milan, Italy). A diagnostic ultrasound system was used with a programmable replenishment sequence. The images obtained between the initial frame after the high mechanical index (MI) scan, which diminishes microbubbles in the scan volume, and the current frame were coded in color according to the arrival and peak times. After the experiment, the tumors were excised and sectioned. Sections were prepared for light microscopy with hematoxylin-eosin (HE) staining and CD31 staining to evaluate vascular density.Arrival time imaging (ATI) delineated the fine blood vessels (100-200 mum in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor-free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation.RESULTSArrival time imaging (ATI) delineated the fine blood vessels (100-200 mum in diameter) in all of the rabbits. Tortuous and meandering tumor vessels were visualized in the VX2 tumors. Differences of perfusion velocity between tumor tissue and tumor-free areas were shown in peak time imaging (PTI). Vascularity evaluated on the ATI and perfusion speed recognized on the ATI and PTI were related to the vascular density measured by pathological investigation.Parametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels.CONCLUSIONParametric imaging is a promising new method for the visualization of perfusion and the estimation of tumor blood vessels. |
| Author | Sugimoto, Katsutoshi Metoki, Ryo Kamiyama, Naohisa Iijima, Hiroko Moriyasu, Fuminori |
| Author_xml | – sequence: 1 givenname: Katsutoshi surname: Sugimoto fullname: Sugimoto, Katsutoshi email: sugimoto@tokyo-med.ac.jp organization: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo – sequence: 2 givenname: Fuminori surname: Moriyasu fullname: Moriyasu, Fuminori organization: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo – sequence: 3 givenname: Naohisa surname: Kamiyama fullname: Kamiyama, Naohisa organization: The Ultrasound Systems Development Department, Toshiba Medical Systems Corporation, Tochigi and – sequence: 4 givenname: Ryo surname: Metoki fullname: Metoki, Ryo organization: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo – sequence: 5 givenname: Hiroko surname: Iijima fullname: Iijima, Hiroko organization: Department of Diagnostic Ultrasound, Medical Imaging Center, Hyogo College of Medicine, Hyogo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17539818$$D View this record in MEDLINE/PubMed |
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| References | Donney E, Geng L, Wojcicki WE, Fleische AC. Hallahan DE. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology 2001; 219: 166-70. Forsberg F, Liu JB, Merton DAet al. Gray-scale liver enhancement in VX2 tumor-bearing rabbits using BR14, a new ultrasonographic contrast agent. Invest Radiol 1997; 32: 410-17. Watanabe R, Matsumura M, Chen CJ, Kaneda Y, Ishihara M, Fujimaki M. Gray-scale liver enhancement with Sonazoid (NC100100), a novel ultrasound contrast agent; detection of hepatic tumors in a rabbit model. Biol Pharm Bull 2003; 26: 1272-7. Denis F, Bougnoux P, De Poncheville Let al. In vivo quantitation of tumor vascularisation assessed by Doppler sonography in rat mammary tumors. Ultrasound Med Biol 2002; 28: 431-7. Forsberg F, Dicker AP, Thakur MLet al. Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary result. Ultrasound Med Biol 2002; 28: 445-51. Ricci P, Laghi A, Cantisani Vet al. Contrast-enhanced sonography with SonoVue: enhancement patterns of benign focal liver lesions and correlation with dynamic gadopenate dimeglumine-enhanced MRI. Am J Roentgenol 2005; 184: 821-7. Kono Y, Moriyasu F, Nada Tet al. Gray scale second harmonic imaging of the liver: a preliminary animal study. Ultrasound Med Biol 1997; 23: 719-26. Fujita T, Ito K, Honjo Ket al. Detection of hepatocellular carcinoma: comparison of T2-weighted breath-hold fast spin-echo sequences and high-resolution dynamic MR imaging with a phased-array body coil. J Magn Reson Imaging 1999; 9: 274-9. Ding H, Wang WP, Huang BJet al. Imaging of focal liver lesions: low-mechanical-index real-time ultrasonography with SonoVue. J Ultrasound Med 2005; 24: 285-97. Ueda K, Kitagawa K, Kadoya Met al. Detection of hypervascular hepatocellular carcinoma by using spiral volume tric CT: comparison of US and MR imaging. Abdom Imaging 1995; 20: 547-53. Schlosser T, Pohl C, Veltmann Cet al. Feasibility of the flash-replenishment concept in renal tissue: which parameters affect the assessment of the contrast replenishment? Ultrasound Med Biol 2001; 27: 937-44. Maruyama H, Matsutani S, Saisho H, Mine Y, Yuki H, Miyata K. Extra-low acoustic power harmonic images of the liver with perflutren: novel imaging for real-time observation of liver perfusion. J Ultrasound Med 2003; 22: 931-8. Wei K, Jayaweera AR, Firoozan Set al. Quantification of myocardial blood flow using ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998; 97: 473-83. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8. Krix M, Plathow C, Kiessling Fet al. Quantification of perfusion of liver tissue and metastases using a multivessel model for replenishment kinetics of ultrasound contrast agents. Ultrasound Med Biol 2004; 30: 1355-63. Iordanescu I, Becker C, Zetter B, Dunning P, Taylor GA. Tumor vascularity: evaluation in a murine model with contrast-enhanced color Doppler US effect of angiogenesis inhibitors. Radiology 2002; 222: 460-7. Burns PN, Wilson SR, Simpson DH. Pulse inversion imaging of liver blood flow: improved method for characterizing focal masses with microbubble contrast. Invest Radiol 2000; 35: 58-71. Crawford AR, Lin X-Z, Crawford JM. The normal adult human liver biopsy: a quantitative reference standard. Hepatology 1998; 28: 323. Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma. J Clin Oncol 1995; 13: 765-82. Bosari S, Lee AK, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML. Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 1992; 23: 755-61. 1995; 20 2002; 28 2004; 30 1998; 28 2005; 184 1997; 32 2000; 35 1995; 13 2002; 222 1997; 23 2003; 26 2001; 27 1992; 23 1991; 324 1998; 97 2001; 219 2005; 24 2003; 22 1999; 9 e_1_2_5_14_2 e_1_2_5_13_2 e_1_2_5_9_2 e_1_2_5_16_2 e_1_2_5_8_2 e_1_2_5_15_2 e_1_2_5_7_2 e_1_2_5_10_2 e_1_2_5_6_2 e_1_2_5_5_2 e_1_2_5_12_2 e_1_2_5_20_2 e_1_2_5_4_2 e_1_2_5_11_2 e_1_2_5_21_2 e_1_2_5_3_2 e_1_2_5_2_2 e_1_2_5_18_2 e_1_2_5_17_2 e_1_2_5_19_2 |
| References_xml | – reference: Krix M, Plathow C, Kiessling Fet al. Quantification of perfusion of liver tissue and metastases using a multivessel model for replenishment kinetics of ultrasound contrast agents. Ultrasound Med Biol 2004; 30: 1355-63. – reference: Forsberg F, Dicker AP, Thakur MLet al. Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary result. Ultrasound Med Biol 2002; 28: 445-51. – reference: Iordanescu I, Becker C, Zetter B, Dunning P, Taylor GA. Tumor vascularity: evaluation in a murine model with contrast-enhanced color Doppler US effect of angiogenesis inhibitors. Radiology 2002; 222: 460-7. – reference: Kono Y, Moriyasu F, Nada Tet al. Gray scale second harmonic imaging of the liver: a preliminary animal study. Ultrasound Med Biol 1997; 23: 719-26. – reference: Schlosser T, Pohl C, Veltmann Cet al. Feasibility of the flash-replenishment concept in renal tissue: which parameters affect the assessment of the contrast replenishment? Ultrasound Med Biol 2001; 27: 937-44. – reference: Ding H, Wang WP, Huang BJet al. Imaging of focal liver lesions: low-mechanical-index real-time ultrasonography with SonoVue. J Ultrasound Med 2005; 24: 285-97. – reference: Bosari S, Lee AK, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML. Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 1992; 23: 755-61. – reference: Maruyama H, Matsutani S, Saisho H, Mine Y, Yuki H, Miyata K. Extra-low acoustic power harmonic images of the liver with perflutren: novel imaging for real-time observation of liver perfusion. J Ultrasound Med 2003; 22: 931-8. – reference: Crawford AR, Lin X-Z, Crawford JM. The normal adult human liver biopsy: a quantitative reference standard. Hepatology 1998; 28: 323. – reference: Donney E, Geng L, Wojcicki WE, Fleische AC. Hallahan DE. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology 2001; 219: 166-70. – reference: Watanabe R, Matsumura M, Chen CJ, Kaneda Y, Ishihara M, Fujimaki M. Gray-scale liver enhancement with Sonazoid (NC100100), a novel ultrasound contrast agent; detection of hepatic tumors in a rabbit model. Biol Pharm Bull 2003; 26: 1272-7. – reference: Ricci P, Laghi A, Cantisani Vet al. Contrast-enhanced sonography with SonoVue: enhancement patterns of benign focal liver lesions and correlation with dynamic gadopenate dimeglumine-enhanced MRI. Am J Roentgenol 2005; 184: 821-7. – reference: Gasparini G, Harris AL. Clinical importance of the determination of tumor angiogenesis in breast carcinoma. J Clin Oncol 1995; 13: 765-82. – reference: Wei K, Jayaweera AR, Firoozan Set al. Quantification of myocardial blood flow using ultrasound-induced destruction of microbubbles administered as a constant venous infusion. 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Methods: The subjects were 17 rabbits (five with... Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. Methods: The subjects were 17 rabbits (five with... To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. The subjects were 17 rabbits (five with normal liver and... Aim: To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors. Methods: The subjects were 17 rabbits (five with... To assess the efficacy of parametric imaging for the diagnosis of neovascularization in liver tumors.AIMTo assess the efficacy of parametric imaging for the... |
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| Title | Parametric imaging of contrast ultrasound for the evaluation of neovascularization in liver tumors |
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