Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy - Ferrarini, Marina; Steimberg, Nathalie; Ponzoni, Maurilio; Belloni, Daniela; Berenzi, Angiola; Girlanda, Stefania; Caligaris-Cappio, Federico; Mazzoleni, Giovanna; Ferrero, Elisabetta (PloS one, 2013)
Keywords: Adult; Aged; Angiogenesis; Angiopoietin; Angiopoietin-2 - metabolism; Animals; beta 2-Microglobulin - metabolism; Biology; Bioreactors; Blood vessels; Bone and Bones - pathology; Bone marrow; Bone Marrow Cells - cytology; Boronic Acids - pharmacology; Boronic Acids - therapeutic use; Bortezomib; Cancer therapies; Cell Communication; Cell culture; Cell Culture Techniques; Cell interactions; Cytotoxicity; Drug development; Drugs; Engineering; Explants; Female; Genetic Markers; Human tissues; Humans; Immunohistochemistry; Joint surgery; Laboratories; Lamellae; Leukemia; Liver; Male; Medicine; Middle Aged; Multiple myeloma; Multiple Myeloma - metabolism; Neovascularization, Pathologic; Oncology; Pathology; Patients; Proteasome Inhibitors - pharmacology; Proteasomes; Pyrazines - pharmacology; Pyrazines - therapeutic use; Rats; Rats, Sprague-Dawley; Stem cell transplantation; Therapy; Three dimensional models; Tibia - pathology; Tissue culture; Tissue engineering; Tissues; Tumor Cells, Cultured - cytology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Italy