Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment
In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain reg...
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| Published in | PloS one Vol. 8; no. 2; p. e57030 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
28.02.2013
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0057030 |
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| Abstract | In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory. |
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| AbstractList | In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer’s type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory. In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory.In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT) and normal controls by modifying an existing test of spatial context memory (SCMT) designed so as to evaluate the function of brain regions affected in early m-DAT. We found that participants with a-MCI had better total scores on our modified SCMT than those with m-DAT. Furthermore, the locational memory subtest was able to discriminate between those with a-MCI and m-DAT. Additionally, compared with other screening tests, our spatial context memory test showed high sensitivity and specificity in discerning those with a-MCI from the normal population but, was relatively ineffective in discriminating a-MCI patients from those with m-DAT. We conclude that our modified test of SCMT is an effective tool for discriminating a-MCI from m-DAT and does so by detecting differences in locational memory. |
| Author | Kuo, Wan-Chin Kuo, Hung-Chou Wang, Hsuan-Min Huang, Chin-Chang Yang, Chien-Ming |
| AuthorAffiliation | 1 Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan 2 Department of Psychology, National Chengchi University, Taipei, Taiwan 3 Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan Rush University, United States of America |
| AuthorAffiliation_xml | – name: 2 Department of Psychology, National Chengchi University, Taipei, Taiwan – name: 3 Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan – name: 1 Department of Neurology, Chang Gung Memorial Hospital and University Medical College, Linkou Medical Center, Taipei, Taiwan – name: Rush University, United States of America |
| Author_xml | – sequence: 1 givenname: Hsuan-Min surname: Wang fullname: Wang, Hsuan-Min – sequence: 2 givenname: Chien-Ming surname: Yang fullname: Yang, Chien-Ming – sequence: 3 givenname: Wan-Chin surname: Kuo fullname: Kuo, Wan-Chin – sequence: 4 givenname: Chin-Chang surname: Huang fullname: Huang, Chin-Chang – sequence: 5 givenname: Hung-Chou surname: Kuo fullname: Kuo, Hung-Chou |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23468906$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jamda_2018_05_010 crossref_primary_10_3109_00207454_2014_971787 crossref_primary_10_1007_s11065_017_9360_6 crossref_primary_10_3389_fnagi_2018_00333 crossref_primary_10_1080_23279095_2024_2306128 crossref_primary_10_3389_fpsyg_2022_962025 |
| Cites_doi | 10.1136/jnnp.73.2.126 10.1001/archneur.61.1.59 10.1098/rstb.2001.0948 10.1002/hipo.20200 10.1212/WNL.34.7.939 10.1016/j.arcmed.2012.08.015 10.1212/WNL.39.9.1159 10.1523/JNEUROSCI.16-14-04491.1996 10.1038/381425a0 10.1016/j.neuroimage.2004.01.005 10.1002/hipo.20715 10.1523/JNEUROSCI.2250-06.2006 10.1037/a0021134 10.1002/ana.20163 10.1007/BF00308809 10.1073/pnas.1121588109 10.1037/a0028576 10.1177/0891988709351804 10.1016/j.conb.2006.10.012 10.1002/ana.10669 10.1001/archneur.56.3.303 10.1192/bjp.140.6.566 |
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| Copyright | 2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Wang et al 2013 Wang et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: HMW HCK CMY. Performed the experiments: HMW WCK. Analyzed the data: HMW CMY HCK. Contributed reagents/materials/analysis tools: HCK CMY CCH. Wrote the paper: HMW HCK. |
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| References | BC Dickerson (ref21) 2004; 56 ref11 T Fujii (ref7) 2004; 21 RC Petersen (ref1) 1999; 56 JC Morris (ref14) 1989; 39 J Lindeboom (ref10) 2002; 73 L Davachi (ref16) 2006; 16 T Gómez-Isla (ref19) 1996; 16 S Corkin (ref4) 1998; 53 PJ Nestor (ref24) 2003; 54 L Ehreke (ref9) 2011; 23 J O’Keefe (ref25) 1996; 381 WL Chuang (ref15) 2010; 23 M Grundman (ref22) 2004; 61 LM Frank (ref26) 2006; 16 G McKhann (ref12) 1984; 34 J Peña-Casanova (ref6) 2012; 43 KA Celone (ref20) 2006; 26 CM Bird (ref23) 2010; 20 H Braak (ref18) 1991; 82 N Burgess (ref5) 2001; 356 MJ Summers (ref8) 2012; 26 Z Nedelsk (ref3) 2012; 109 CP Hughes (ref13) 1982; 140 NL Saunders (ref2) 2011; 252 WL Chuang (ref17) 2006; 15 19852032 - Hippocampus. 2010 Oct;20(10):1154-69 23072720 - Arch Med Res. 2012 Nov;43(8):686-93 7104545 - Br J Psychiatry. 1982 Jun;140:566-72 6610841 - Neurology. 1984 Jul;34(7):939-44 22308496 - Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2590-4 11571039 - Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1493-503 10190820 - Arch Neurol. 1999 Mar;56(3):303-8 17021177 - J Neurosci. 2006 Oct 4;26(40):10222-31 16921502 - Hippocampus. 2006;16(9):775-84 2771064 - Neurology. 1989 Sep;39(9):1159-65 8632799 - Nature. 1996 May 30;381(6581):425-8 17097284 - Curr Opin Neurobiol. 2006 Dec;16(6):693-700 22612573 - Neuropsychology. 2012 Jul;26(4):498-508 1759558 - Acta Neuropathol. 1991;82(4):239-59 15236399 - Ann Neurol. 2004 Jul;56(1):27-35 9745629 - Geriatrics. 1998 Sep;53 Suppl 1:S13-5 8699259 - J Neurosci. 1996 Jul 15;16(14):4491-500 21381828 - Neuropsychology. 2011 Mar;25(2):237-48 21813037 - Int Psychogeriatr. 2011 Dec;23(10):1592-601 12122168 - J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):126-33 15050583 - Neuroimage. 2004 Apr;21(4):1596-603 12953266 - Ann Neurol. 2003 Sep;54(3):343-51 16871896 - Acta Neurol Taiwan. 2006 Jun;15(2):98-104 14732621 - Arch Neurol. 2004 Jan;61(1):59-66 20145290 - J Geriatr Psychiatry Neurol. 2010 Mar;23(1):42-8 |
| References_xml | – volume: 73 start-page: 126 year: 2002 ident: ref10 article-title: Visual association test early dementia of the Alzheimer’s type publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.73.2.126 – volume: 61 start-page: 59 year: 2004 ident: ref22 article-title: Mild cognitive impairment can be distinguished from Alzheimer’s disease and normal aging for clinical trials publication-title: Arch Neurol doi: 10.1001/archneur.61.1.59 – volume: 356 start-page: 1493 year: 2001 ident: ref5 article-title: Memory for events and their spatial context: models and experiments publication-title: Philos Trans R Soc Lond B Biol Sci doi: 10.1098/rstb.2001.0948 – volume: 16 start-page: 775 year: 2006 ident: ref26 article-title: Hippocampal and cortical place cell plasticity: implications for episodic memory publication-title: Hippocampus doi: 10.1002/hipo.20200 – volume: 34 start-page: 939 year: 1984 ident: ref12 article-title: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 43 start-page: 686 year: 2012 ident: ref6 article-title: Neuropsychology of Alzheimer’s Disease publication-title: Arch Med Res doi: 10.1016/j.arcmed.2012.08.015 – volume: 23 start-page: 1502 year: 2011 ident: ref9 article-title: Clock drawing test – screening utility for mild cognitive impairment according to different scoring systems: results of the Leipzig longitudinal study of the aged (LEILA 75+) Int Psychogeriatr – volume: 39 start-page: 1159 year: 1989 ident: ref14 article-title: The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease publication-title: Neurology doi: 10.1212/WNL.39.9.1159 – volume: 15 start-page: 98 year: 2006 ident: ref17 article-title: Visual association memory test in differentiating early stage of Alzheimer’s disease from vascular dementia publication-title: Acta Neurol Taiwan – volume: 16 start-page: 4491 year: 1996 ident: ref19 article-title: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease publication-title: J Neurosci doi: 10.1523/JNEUROSCI.16-14-04491.1996 – volume: 381 start-page: 425 year: 1996 ident: ref25 article-title: Geometric determinants of the place fields of hippocampus neuron publication-title: Nature doi: 10.1038/381425a0 – volume: 21 start-page: 1596 year: 2004 ident: ref7 article-title: Neural correlates of context memory with real-world events publication-title: NeuroImage doi: 10.1016/j.neuroimage.2004.01.005 – volume: 20 start-page: 1154 year: 2010 ident: ref23 article-title: Topographic short-term memory differentiates Alzheimer’s disease from frontotemporal lobar degeneration publication-title: Hippocampus doi: 10.1002/hipo.20715 – volume: 26 start-page: 10222 year: 2006 ident: ref20 article-title: Alterations in memory networks in mild cognitive impairment and Alzheimer’s disease: An independent component analysis publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2250-06.2006 – volume: 252 start-page: 237 year: 2011 ident: ref2 article-title: Longitudinal deficits to attention, executive, and working memory in subtypes of mild cognitive impairment publication-title: Neuropsychology doi: 10.1037/a0021134 – volume: 56 start-page: 27 year: 2004 ident: ref21 article-title: Medial temporal lobe function and structure in mild cognitive impairment publication-title: Ann Neurol doi: 10.1002/ana.20163 – ident: ref11 – volume: 82 start-page: 239 year: 1991 ident: ref18 article-title: Neuropathological staging of Alzheimer- related changes publication-title: Acta Neuropathol doi: 10.1007/BF00308809 – volume: 109 start-page: 2590 year: 2012 ident: ref3 article-title: Spatial navigation impairment is proportional to right hippocampal volume publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1121588109 – volume: 26 start-page: 498 year: 2012 ident: ref8 article-title: Neuropsychological measures predict decline to Alzheimer’s dementia from mild cognitive impairment publication-title: Neuropsychology doi: 10.1037/a0028576 – volume: 23 start-page: 42 year: 2010 ident: ref15 article-title: Association of apolipoproteins E4 and C1 with onset age and memory: A study of sporadic Alzheimer’s disease in Taiwan publication-title: J Geriatr Psychiatry Neurol doi: 10.1177/0891988709351804 – volume: 16 start-page: 693 year: 2006 ident: ref16 article-title: Item, context, and relational episodic encoding in humans publication-title: Curr Opin Neurobiol doi: 10.1016/j.conb.2006.10.012 – volume: 53 start-page: S13 year: 1998 ident: ref4 article-title: Functional MRI for studying episodic memory in aging and Alzheimer’s disease publication-title: Geriatrics – volume: 54 start-page: 343 year: 2003 ident: ref24 article-title: Limbic hypometabolism in Alzheimer’s disease and mild cognitive impairment publication-title: Ann Neurol doi: 10.1002/ana.10669 – volume: 56 start-page: 303 year: 1999 ident: ref1 article-title: Mild cognitive impairment: Clinical characterrizeation and outcome publication-title: Arch Neurol doi: 10.1001/archneur.56.3.303 – volume: 140 start-page: 566 year: 1982 ident: ref13 article-title: A new clinical scale for the staging of dementia publication-title: Br J Psychiatry doi: 10.1192/bjp.140.6.566 – reference: 8632799 - Nature. 1996 May 30;381(6581):425-8 – reference: 21813037 - Int Psychogeriatr. 2011 Dec;23(10):1592-601 – reference: 1759558 - Acta Neuropathol. 1991;82(4):239-59 – reference: 20145290 - J Geriatr Psychiatry Neurol. 2010 Mar;23(1):42-8 – reference: 17097284 - Curr Opin Neurobiol. 2006 Dec;16(6):693-700 – reference: 8699259 - J Neurosci. 1996 Jul 15;16(14):4491-500 – reference: 12122168 - J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):126-33 – reference: 9745629 - Geriatrics. 1998 Sep;53 Suppl 1:S13-5 – reference: 2771064 - Neurology. 1989 Sep;39(9):1159-65 – reference: 14732621 - Arch Neurol. 2004 Jan;61(1):59-66 – reference: 17021177 - J Neurosci. 2006 Oct 4;26(40):10222-31 – reference: 15236399 - Ann Neurol. 2004 Jul;56(1):27-35 – reference: 11571039 - Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1493-503 – reference: 12953266 - Ann Neurol. 2003 Sep;54(3):343-51 – reference: 19852032 - Hippocampus. 2010 Oct;20(10):1154-69 – reference: 6610841 - Neurology. 1984 Jul;34(7):939-44 – reference: 16921502 - Hippocampus. 2006;16(9):775-84 – reference: 21381828 - Neuropsychology. 2011 Mar;25(2):237-48 – reference: 22308496 - Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2590-4 – reference: 7104545 - Br J Psychiatry. 1982 Jun;140:566-72 – reference: 10190820 - Arch Neurol. 1999 Mar;56(3):303-8 – reference: 15050583 - Neuroimage. 2004 Apr;21(4):1596-603 – reference: 22612573 - Neuropsychology. 2012 Jul;26(4):498-508 – reference: 23072720 - Arch Med Res. 2012 Nov;43(8):686-93 – reference: 16871896 - Acta Neurol Taiwan. 2006 Jun;15(2):98-104 |
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| Snippet | In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer's type (m-DAT)... In this study we sought to differentiate participants with amnestic mild cognitive impairment (a-MCI) from those with mild dementia of Alzheimer’s type (m-DAT)... |
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| SubjectTerms | Age Aged Alzheimer Disease - complications Biology Brain Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Consortia Dementia Dementia disorders Disease Education Female Hospitals Humans Impairment Male Medicine Memory Mental disorders Middle Aged Neurology Neuropathology Neuropsychological Tests NMR Nuclear magnetic resonance Pathology Patients Psychiatry ROC Curve Spatial memory |
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| Title | Use of a Modified Spatial-Context Memory Test to Detect Amnestic Mild Cognitive Impairment |
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