Epigenetic Modifications and Therapy in Chronic Obstructive Pulmonary Disease (COPD): An Update Review
Chronic obstructive pulmonary disease (COPD) that is one of the most prevalent chronic adult diseases and the third leading cause of fatality until 2020. Elastase/anti-elastase hypothesis, chronic inflammation, apoptosis, oxidant-antioxidant balance and infective repair cause pathogenesis of COPD ar...
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| Published in | Chronic obstructive pulmonary disease Vol. 17; no. 3; pp. 333 - 342 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Taylor & Francis
03.05.2020
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1541-2555 1541-2563 1541-2563 |
| DOI | 10.1080/15412555.2020.1780576 |
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| Abstract | Chronic obstructive pulmonary disease (COPD) that is one of the most prevalent chronic adult diseases and the third leading cause of fatality until 2020. Elastase/anti-elastase hypothesis, chronic inflammation, apoptosis, oxidant-antioxidant balance and infective repair cause pathogenesis of COPD are among the factors at play. Epigenetic changes are post-translational modifications in histone proteins and DNA such as methylation and acetylation as well as dysregulation of miRNAs expression. In this update review, we have examined recent studies on the upregulation or downregulation of methylation in different genes associated with COPD. Dysregulation of HDAC activity which is caused by some factors and miRNAs plays a key role in the suppression and reduction of COPD development. Also, some therapeutic approaches are proposed against COPD by targeting HDAC2 and miRNAs, which have therapeutic effects. |
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| AbstractList | Chronic obstructive pulmonary disease (COPD) that is one of the most prevalent chronic adult diseases and the third leading cause of fatality until 2020. Elastase/anti-elastase hypothesis, chronic inflammation, apoptosis, oxidant-antioxidant balance and infective repair cause pathogenesis of COPD are among the factors at play. Epigenetic changes are post-translational modifications in histone proteins and DNA such as methylation and acetylation as well as dysregulation of miRNAs expression. In this update review, we have examined recent studies on the upregulation or downregulation of methylation in different genes associated with COPD. Dysregulation of HDAC activity which is caused by some factors and miRNAs plays a key role in the suppression and reduction of COPD development. Also, some therapeutic approaches are proposed against COPD by targeting HDAC2 and miRNAs, which have therapeutic effects.Chronic obstructive pulmonary disease (COPD) that is one of the most prevalent chronic adult diseases and the third leading cause of fatality until 2020. Elastase/anti-elastase hypothesis, chronic inflammation, apoptosis, oxidant-antioxidant balance and infective repair cause pathogenesis of COPD are among the factors at play. Epigenetic changes are post-translational modifications in histone proteins and DNA such as methylation and acetylation as well as dysregulation of miRNAs expression. In this update review, we have examined recent studies on the upregulation or downregulation of methylation in different genes associated with COPD. Dysregulation of HDAC activity which is caused by some factors and miRNAs plays a key role in the suppression and reduction of COPD development. Also, some therapeutic approaches are proposed against COPD by targeting HDAC2 and miRNAs, which have therapeutic effects. Chronic obstructive pulmonary disease (COPD) that is one of the most prevalent chronic adult diseases and the third leading cause of fatality until 2020. Elastase/anti-elastase hypothesis, chronic inflammation, apoptosis, oxidant-antioxidant balance and infective repair cause pathogenesis of COPD are among the factors at play. Epigenetic changes are post-translational modifications in histone proteins and DNA such as methylation and acetylation as well as dysregulation of miRNAs expression. In this update review, we have examined recent studies on the upregulation or downregulation of methylation in different genes associated with COPD. Dysregulation of HDAC activity which is caused by some factors and miRNAs plays a key role in the suppression and reduction of COPD development. Also, some therapeutic approaches are proposed against COPD by targeting HDAC2 and miRNAs, which have therapeutic effects. |
| Author | Valizadeh, Hamed Bidares, Ramtin Alipourfard, Iraj Zhang, Lingzhi Aghebati-Maleki, Leili Ahmadi, Majid |
| Author_xml | – sequence: 1 givenname: Lingzhi surname: Zhang fullname: Zhang, Lingzhi email: datar7@126.com, Ahmadi.m@tbzmed.ac.ir organization: Department of Emergency Medicine, Shengjing Hospital of China Medical University – sequence: 2 givenname: Hamed surname: Valizadeh fullname: Valizadeh, Hamed organization: Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences – sequence: 3 givenname: Iraj surname: Alipourfard fullname: Alipourfard, Iraj organization: Faculty of Sciences, School of Pharmacy, University of Rome Tor Vergata – sequence: 4 givenname: Ramtin surname: Bidares fullname: Bidares, Ramtin organization: Department of Experimental Medicine, Sapienza University – sequence: 5 givenname: Leili orcidid: 0000-0002-0044-5961 surname: Aghebati-Maleki fullname: Aghebati-Maleki, Leili organization: Immunology Research Center, Tabriz University of Medical Sciences – sequence: 6 givenname: Majid orcidid: 0000-0003-4787-5261 surname: Ahmadi fullname: Ahmadi, Majid email: datar7@126.com, Ahmadi.m@tbzmed.ac.ir organization: Student Research Committee, Tabriz University of Medical Sciences |
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