Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia - Fitzhugh, Courtney D.; Hsieh, Matthew M.; Allen, Darlene; Coles, Wynona A.; Seamon, Cassie; Ring, Michael; Zhao, Xiongce; Minniti, Caterina P.; Rodgers, Griffin P.; Schechter, Alan N.; Tisdale, John F.; Taylor, James G. (PloS one, 2015)
Keywords: Adolescent; Adult; Adults; Age; Aged; Alkaline phosphatase; Anemia; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - mortality; Antisickling Agents - pharmacology; Antisickling Agents - therapeutic use; Cell survival; Creatinine; Damage tolerance; Echocardiography; Electronic medical records; Female; Fetal Hemoglobin - metabolism; Fetuses; Health hazards; Hematology; Hemoglobin; Hospitals; Humans; Hydroxyurea; Hydroxyurea - pharmacology; Hydroxyurea - therapeutic use; Laboratories; Male; Maximum Tolerated Dose; Medical electronics; Middle Aged; Mortality; Patients; Pediatrics; Proportional Hazards Models; Pulmonary hypertension; Regression analysis; Retrospective Studies; Sickle cell anemia; Sickle cell disease; Studies; Survival; Treatment Outcome; Young Adult