Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naïve Subjects at a New Facility for Sporozoite Challenge - Talley, Angela K.; Healy, Sara A.; Finney, Olivia C.; Murphy, Sean C.; Kublin, James; Salas, Carola J.; Lundebjerg, Susan; Gilbert, Peter; Van Voorhis, Wesley C.; Whisler, John; Wang, Ruobing; Ockenhouse, Chris F.; et al. (PloS one, 2014)
Keywords: Adult; Animals; Anopheles - parasitology; Anopheles - physiology; Antibodies; Antigens; Aquatic insects; Biology and Life Sciences; Biomedical research; Bites and Stings - parasitology; Blood; Chloroquine; Circumsporozoite protein; Clinical trials; Controlled conditions; Culicidae; Diagnosis; Diagnostic systems; Drug development; Drug dosages; Enrollments; Female; Human Experimentation; Humans; Immunology; Infections; Infectious diseases; Insect bites; Laboratories; Liver; Lymphocytes T; Malaria; Malaria, Falciparum - complications; Malaria, Falciparum - diagnosis; Malaria, Falciparum - etiology; Malaria, Falciparum - immunology; Male; Medical research; Medicine and Health Sciences; Merozoite surface protein 1; Microscopy; Mosquitoes; Parasitemia; Parasites; Peripheral blood; Plasmodium falciparum; Plasmodium falciparum - pathogenicity; Plasmodium falciparum - physiology; Polymerase chain reaction; Product development; Reagents; RNA-directed DNA polymerase; Safety; Signs and symptoms; Smear; Sporozoites; Studies; Vaccines; Vector-borne diseases