Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 ⁻/⁻) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteato...
Saved in:
| Published in | Diabetologia Vol. 53; no. 11; pp. 2431 - 2441 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Berlin/Heidelberg : Springer-Verlag
01.11.2010
Springer-Verlag Springer Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0012-186X 1432-0428 1432-0428 |
| DOI | 10.1007/s00125-010-1865-y |
Cover
| Abstract | Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 ⁻/⁻) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Methods Male, 8-week-old Il6 ⁻/⁻ and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. Results Il6 ⁻/⁻ mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 ⁻/⁻ and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 ⁻/⁻ mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 ⁻/⁻ relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. |
|---|---|
| AbstractList | Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 ⁻/⁻) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Methods Male, 8-week-old Il6 ⁻/⁻ and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. Results Il6 ⁻/⁻ mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 ⁻/⁻ and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 ⁻/⁻ mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 ⁻/⁻ relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 ^sup -/-^) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Male, 8-week-old Il6 ^sup -/-^ and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. Il6 ^sup -/-^ mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 ^sup -/-^ and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 ^sup -/-^ mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 ^sup -/-^ relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.[PUBLICATION ABSTRACT] The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.AIMS/HYPOTHESISThe role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.METHODSMale, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins.RESULTSIl6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins.Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.CONCLUSIONS/INTERPRETATIONOur data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice ( Il6 −/− ) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Methods Male, 8-week-old Il6 −/− and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. Results Il6 −/− mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 −/− and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 −/− mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 −/− relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme β-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Conclusions/interpretation Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. AIMS/HYPOTHESIS: The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. METHODS: Male, 8-week-old Il6 (-/-) and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly. RESULTS: Il6 (-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 (-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 (-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 (-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme beta-hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. CONCLUSIONS/INTERPRETATION: Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. Aims/hypothesis: The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6 super(-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance. Methods: Male, 8-week-old Il6 super(-/-) and littermate control mice were fed a standard chow or HFD for 12weeks and phenotyped accordingly. Results: Il6 super(-/-) mice displayed obesity, hepatosteatosis, liver inflammation and insulin resistance when compared with control mice on a standard chow diet. When fed a HFD, the Il6 super(-/-) and control mice had marked, equivalent gains in body weight, fat mass and ectopic lipid deposition in the liver relative to chow-fed animals. Despite this normalisation, the greater liver inflammation, damage and insulin resistance observed in chow-fed Il6 super(-/-) mice relative to control persisted when both were fed the HFD. Microarray analysis from livers of mice fed a HFD revealed that genes associated with oxidative phosphorylation, the electron transport chain and tricarboxylic acid cycle were uniformly decreased in Il6 super(-/-) relative to control mice. This coincided with reduced maximal activity of the mitochondrial enzyme beta -hydroxyacyl-CoA-dehydrogenase and decreased levels of mitochondrial respiratory chain proteins. Conclusions/interpretation: Our data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism. |
| Author | Watson, N Babb, J. R Chan, M. H. S Jansson, J.-O Bruce, C. R Allen, T. L Henstridge, D. C Risis, S Jowett, J. B Matthews, V. B Watt, M. J Meikle, P. J Febbraio, M. A Zaffino, L. A Boon, J |
| Author_xml | – sequence: 1 fullname: Matthews, V. B – sequence: 2 fullname: Allen, T. L – sequence: 3 fullname: Risis, S – sequence: 4 fullname: Chan, M. H. S – sequence: 5 fullname: Henstridge, D. C – sequence: 6 fullname: Watson, N – sequence: 7 fullname: Zaffino, L. A – sequence: 8 fullname: Babb, J. R – sequence: 9 fullname: Boon, J – sequence: 10 fullname: Meikle, P. J – sequence: 11 fullname: Jowett, J. B – sequence: 12 fullname: Watt, M. J – sequence: 13 fullname: Jansson, J.-O – sequence: 14 fullname: Bruce, C. R – sequence: 15 fullname: Febbraio, M. A |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23303326$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20697689$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/126610$$DView record from Swedish Publication Index |
| BookMark | eNqNkstu1DAUhi1URKcDD8AGIiTEKnB8j5eoKlCpEguoBCvLSU4Gl8QJdgKat6-nM7RSF4WVL__3H_tcTshRGAMS8pzCWwqg3yUAymQJFEpaKVluH5EVFZyVIFh1RFY7ead8OyYnKV0BAJdCPSHHDJTRqjIr8v08zBh7XH76UKqyxc43HsNcDL7BosXf2I9T8QMnN_um8KHr3TDk_RgKF9oibdOMw42Slt6HImLyaXahwafkcef6hM8O65pcfjj7evqpvPj88fz0_UXZSKbmUnQcKeuUFBJraihlhtOa19JxLWWtagaMggJeUWgctDVvmWFCcFE7Dej4mpT7uOkPTkttp-gHF7d2dN5ulsnmq81iE1rKlKKQ-Td7forjrwXTbAefGux7F3BckjWgqQTJzT9JLbU2UGn9H6Q0qhI56pq8ukdejUsMuUAZUlxwaXZffHGAlnrA9jalv23LwOsD4FLj-i7mgvt0x3EOnDOVObrnmjimFLG7RSjY3QjZ_QhZ2J3zCNlt9uh7nsbPNx2fo_P9g0526ER-JWww3uX2kOnl3tS50bpNzGlcfmFAOdDKSBCaXwNoauIH |
| CitedBy_id | crossref_primary_10_1152_ajpendo_00166_2019 crossref_primary_10_1016_j_brainres_2019_04_013 crossref_primary_10_1073_pnas_1306799110 crossref_primary_10_1371_journal_pone_0173675 crossref_primary_10_1016_j_semcdb_2015_10_039 crossref_primary_10_1158_0008_5472_CAN_21_0321 crossref_primary_10_1371_journal_pone_0154119 crossref_primary_10_1038_s41598_019_41839_1 crossref_primary_10_1016_j_celrep_2017_03_043 crossref_primary_10_3390_ijms231911151 crossref_primary_10_1111_bph_12713 crossref_primary_10_1113_expphysiol_2012_065508 crossref_primary_10_1002_mnfr_201900770 crossref_primary_10_1097_MED_0b013e3283444b09 crossref_primary_10_1371_journal_pone_0051233 crossref_primary_10_1038_aps_2011_131 crossref_primary_10_1038_ni_2865 crossref_primary_10_1002_osp4_138 crossref_primary_10_1080_1744666X_2016_1201423 crossref_primary_10_3389_fphys_2019_01249 crossref_primary_10_1007_s00125_021_05384_9 crossref_primary_10_1007_s00335_014_9521_3 crossref_primary_10_1016_j_biochi_2020_10_014 crossref_primary_10_1371_journal_pone_0179099 crossref_primary_10_2337_db12_1095 crossref_primary_10_2337_db13_0967 crossref_primary_10_1371_journal_pgen_1005089 crossref_primary_10_1016_j_jhep_2023_01_024 crossref_primary_10_1016_j_metabol_2018_01_002 crossref_primary_10_1038_s41467_023_43787_x crossref_primary_10_1186_s12884_020_03077_6 crossref_primary_10_1172_JCI57158 crossref_primary_10_3389_fpsyt_2017_00221 crossref_primary_10_1139_apnm_2013_0316 crossref_primary_10_3889_oamjms_2015_017 crossref_primary_10_1016_j_cmet_2015_02_006 crossref_primary_10_1517_14728222_2012_660307 crossref_primary_10_3389_fendo_2020_00530 crossref_primary_10_1371_journal_pone_0041456 crossref_primary_10_1007_s12072_013_9468_6 crossref_primary_10_3390_ijms23116270 crossref_primary_10_1038_s41598_018_34186_0 crossref_primary_10_3390_ijms19092569 crossref_primary_10_3390_nu14112360 crossref_primary_10_1172_JCI125646 crossref_primary_10_1016_j_nbd_2019_104580 crossref_primary_10_1155_2014_418185 crossref_primary_10_1016_j_molmet_2020_101009 crossref_primary_10_4161_adip_20041 crossref_primary_10_31887_DCNS_2017_19_1_drubinow crossref_primary_10_1016_j_jtcme_2023_01_006 crossref_primary_10_1016_j_clinre_2016_11_002 crossref_primary_10_1016_j_jff_2018_07_010 crossref_primary_10_1016_j_mce_2013_05_013 crossref_primary_10_1111_jne_12546 crossref_primary_10_1016_j_jnutbio_2013_11_012 crossref_primary_10_1210_en_2012_1847 crossref_primary_10_1210_endrev_bnaa016 crossref_primary_10_1371_journal_pone_0014390 crossref_primary_10_1016_j_theriogenology_2021_05_022 crossref_primary_10_1016_j_cell_2020_05_054 crossref_primary_10_1038_nm_2627 crossref_primary_10_1097_CD9_0000000000000096 crossref_primary_10_1080_19396368_2022_2115326 crossref_primary_10_1194_jlr_M092510 crossref_primary_10_3390_antiox11030447 crossref_primary_10_1016_j_jnutbio_2015_04_004 crossref_primary_10_1038_s41586_019_1601_9 crossref_primary_10_1016_j_ijcard_2018_07_061 crossref_primary_10_5194_aab_64_53_2021 crossref_primary_10_1016_j_ecoenv_2022_114253 crossref_primary_10_1111_dom_12170 crossref_primary_10_1016_j_intimp_2024_111906 crossref_primary_10_1016_j_jnutbio_2012_04_012 crossref_primary_10_1093_rheumatology_kex513 crossref_primary_10_1007_s11302_018_9610_y crossref_primary_10_1016_j_bbadis_2017_08_022 crossref_primary_10_2478_phr_2024_0018 crossref_primary_10_1016_j_jnutbio_2012_04_016 crossref_primary_10_1016_j_plefa_2023_102605 crossref_primary_10_1007_s10787_018_0458_0 crossref_primary_10_1038_s41598_021_82944_4 crossref_primary_10_1007_s13311_016_0461_3 crossref_primary_10_1016_j_jneuroim_2015_05_001 crossref_primary_10_14814_phy2_12788 crossref_primary_10_1097_BOR_0000000000000255 crossref_primary_10_1016_j_bbr_2020_113101 crossref_primary_10_1371_journal_pone_0157956 crossref_primary_10_1016_j_freeradbiomed_2012_02_035 crossref_primary_10_1074_jbc_RA117_000456 crossref_primary_10_1111_j_1440_1797_2011_01547_x crossref_primary_10_1080_03007995_2022_2033049 crossref_primary_10_1096_fj_201801879RR crossref_primary_10_3390_biom12050637 crossref_primary_10_1038_nrd_2018_45 crossref_primary_10_1152_japplphysiol_00614_2017 crossref_primary_10_1016_j_cyto_2011_09_015 crossref_primary_10_2139_ssrn_4001943 crossref_primary_10_1161_CIRCRESAHA_113_301562 crossref_primary_10_1242_dmm_019166 crossref_primary_10_1007_s00418_022_02091_3 crossref_primary_10_3390_ijms25179641 crossref_primary_10_1002_osp4_396 crossref_primary_10_1007_s13539_011_0043_5 crossref_primary_10_1152_ajpendo_00547_2014 crossref_primary_10_2337_db13_0665 crossref_primary_10_1016_j_molmet_2016_06_008 crossref_primary_10_1080_21645515_2020_1761203 crossref_primary_10_1139_apnm_2016_0122 crossref_primary_10_46940_semrj_02_1007 crossref_primary_10_1007_s00394_015_1148_y crossref_primary_10_1016_j_bbrc_2024_150305 crossref_primary_10_1016_j_bbr_2018_09_022 crossref_primary_10_1016_j_molmet_2022_101488 crossref_primary_10_1016_j_metabol_2012_04_015 crossref_primary_10_1097_SHK_0000000000000849 crossref_primary_10_2337_db22_0444 crossref_primary_10_13005_bpj_2977 crossref_primary_10_3892_etm_2021_10419 crossref_primary_10_4155_cli_11_166 crossref_primary_10_1016_j_dsx_2020_06_006 crossref_primary_10_1016_j_it_2023_06_002 crossref_primary_10_1111_imcb_1002 crossref_primary_10_1152_ajpheart_00195_2015 crossref_primary_10_1038_ncomms7047 crossref_primary_10_1186_s13098_015_0012_9 crossref_primary_10_3390_cells13191603 crossref_primary_10_1530_JME_16_0009 crossref_primary_10_1016_j_bbalip_2011_04_011 crossref_primary_10_2337_db12_0029 crossref_primary_10_1371_journal_pone_0101555 crossref_primary_10_1016_j_molmet_2018_04_005 crossref_primary_10_1371_journal_pone_0072339 crossref_primary_10_2337_db10_1353 crossref_primary_10_1111_dom_12896 crossref_primary_10_1016_j_bbamcr_2021_119080 crossref_primary_10_1016_j_jhep_2022_08_022 crossref_primary_10_1126_sciadv_1700677 crossref_primary_10_1152_japplphysiol_00558_2013 crossref_primary_10_4161_epi_24656 crossref_primary_10_1152_ajpendo_00206_2019 crossref_primary_10_1002_hep_29089 crossref_primary_10_1016_j_tem_2017_11_001 crossref_primary_10_1016_j_isci_2022_105905 crossref_primary_10_1210_en_2011_0288 crossref_primary_10_1111_jne_12722 crossref_primary_10_18502_ijrm_v19i4_9057 crossref_primary_10_1155_2012_238056 crossref_primary_10_1152_ajpendo_00447_2011 crossref_primary_10_1016_j_cyto_2021_155549 crossref_primary_10_2337_db14_1910 crossref_primary_10_1002_mco2_283 crossref_primary_10_3389_fcell_2023_1147434 crossref_primary_10_1096_fj_14_264820 crossref_primary_10_1016_j_ajpath_2019_01_012 crossref_primary_10_1111_jne_12033 crossref_primary_10_1007_s00281_013_0407_3 crossref_primary_10_1007_s00213_021_05878_9 crossref_primary_10_1016_j_cophys_2019_03_009 crossref_primary_10_1249_MSS_0000000000000660 crossref_primary_10_1007_s11332_023_01102_7 crossref_primary_10_1111_bph_13423 crossref_primary_10_1007_s12539_020_00389_1 crossref_primary_10_1016_j_bbadis_2017_02_019 crossref_primary_10_1007_s00281_019_00747_2 crossref_primary_10_1016_j_tem_2010_08_007 crossref_primary_10_5812_hepatmon_24635 crossref_primary_10_1016_j_bbamcr_2011_01_034 crossref_primary_10_1038_s41575_021_00473_x crossref_primary_10_1159_000496845 crossref_primary_10_1016_j_bbrc_2016_03_159 crossref_primary_10_1016_j_preteyeres_2024_101306 crossref_primary_10_1016_j_it_2014_12_008 crossref_primary_10_3390_life12081288 crossref_primary_10_1152_japplphysiol_00946_2012 crossref_primary_10_3390_ijms18040884 crossref_primary_10_3389_fmolb_2023_1208215 crossref_primary_10_1038_icb_2014_16 crossref_primary_10_1016_j_coph_2017_08_006 crossref_primary_10_3390_antiox12051005 crossref_primary_10_1152_ajpendo_00297_2013 crossref_primary_10_1007_s00125_016_4028_y crossref_primary_10_1016_j_cmet_2021_09_004 crossref_primary_10_1016_j_jhep_2016_02_004 crossref_primary_10_1111_apha_12328 crossref_primary_10_1007_s11010_013_1896_z crossref_primary_10_1002_1873_3468_12742 crossref_primary_10_1007_s00125_012_2652_8 crossref_primary_10_1016_j_ccr_2013_11_005 crossref_primary_10_2174_0929866527666200505214555 crossref_primary_10_1161_JAHA_116_004603 crossref_primary_10_3389_fimmu_2014_00491 crossref_primary_10_1159_000499693 crossref_primary_10_1017_S0007114514002086 crossref_primary_10_1016_j_mce_2021_111531 crossref_primary_10_1242_jeb_129213 crossref_primary_10_1002_oby_21521 crossref_primary_10_1139_cjpp_2016_0071 crossref_primary_10_1016_j_celrep_2019_02_044 crossref_primary_10_1155_2017_7281986 crossref_primary_10_1016_j_bbadis_2015_01_017 crossref_primary_10_1038_s41577_018_0066_7 crossref_primary_10_1053_j_gastro_2020_02_020 crossref_primary_10_1152_ajpregu_00383_2015 crossref_primary_10_1097_MED_0b013e3283457c7d crossref_primary_10_3109_13813455_2011_562514 crossref_primary_10_1101_cshperspect_a028415 crossref_primary_10_1016_j_biochi_2021_01_015 crossref_primary_10_1097_MED_0000000000000277 crossref_primary_10_1016_j_freeradbiomed_2017_09_021 crossref_primary_10_1186_1476_511X_12_171 crossref_primary_10_1007_s13105_021_00847_4 crossref_primary_10_1016_j_tem_2014_02_004 crossref_primary_10_1021_mp400288e crossref_primary_10_1017_S2040174417000204 crossref_primary_10_1111_bph_14642 crossref_primary_10_2147_CEG_S242393 crossref_primary_10_1111_cei_13140 crossref_primary_10_1093_biolre_ioab195 crossref_primary_10_3109_07853890_2012_705015 crossref_primary_10_1007_s12192_015_0571_6 crossref_primary_10_1074_jbc_M113_461905 crossref_primary_10_3389_fendo_2022_1028808 crossref_primary_10_23736_S0391_1977_18_02914_0 crossref_primary_10_14814_phy2_12064 crossref_primary_10_1126_sciadv_adh0831 crossref_primary_10_1016_j_metabol_2011_04_004 crossref_primary_10_1002_mnfr_202000419 crossref_primary_10_1021_jf400920x crossref_primary_10_1016_j_smim_2014_01_002 crossref_primary_10_1016_j_tem_2023_08_001 crossref_primary_10_1371_journal_pone_0039100 crossref_primary_10_1016_j_smim_2014_01_001 crossref_primary_10_1016_j_plipres_2015_05_002 crossref_primary_10_1038_s41366_019_0355_7 crossref_primary_10_1016_j_cyto_2021_155684 crossref_primary_10_1038_nri2925 crossref_primary_10_1038_nri2921 crossref_primary_10_1016_j_hrthm_2023_08_026 crossref_primary_10_1038_s41467_020_20303_z crossref_primary_10_1038_s41574_019_0174_x crossref_primary_10_1038_ncomms5602 crossref_primary_10_1007_s00125_013_2869_1 crossref_primary_10_1016_j_cytogfr_2012_04_001 crossref_primary_10_3390_ijms19092474 crossref_primary_10_1016_j_autrev_2011_04_018 crossref_primary_10_1152_ajpendo_00147_2011 crossref_primary_10_1186_1475_2840_9_73 crossref_primary_10_1186_s13024_023_00596_6 crossref_primary_10_3389_fpsyt_2020_00557 crossref_primary_10_1126_scitranslmed_abg9170 |
| Cites_doi | 10.1038/nature05485 10.1038/clpt.2010.1 10.2337/db06-1733 10.1073/pnas.0506580102 10.1677/JOE-08-0113 10.1161/CIRCRESAHA.107.165472 10.1677/JOE-09-0413 10.1073/pnas.0705799105 10.1007/s00125-009-1580-8 10.1007/s00125-008-0998-8 10.1038/ng1180 10.1038/nm0102-75 10.2337/diabetes.51.12.3391 10.1152/physrev.90100.2007 10.1038/35038090 10.1016/j.cell.2009.12.052 10.1038/368339a0 10.1038/nrendo.2009.62 10.1152/ajpendo.00257.2004 10.1038/nm1383 10.1126/science.1061620 10.1073/pnas.97.21.11371 10.1210/me.2005-0490 10.1007/s00125-004-1544-y 10.2337/diabetes.53.4.1060 10.1210/en.2004-1468 10.1038/nm1166 10.1126/science.1082889 10.1002/hep.21728 10.2337/db05-1304 10.1152/ajpendo.00150.2004 10.2337/db08-1078 10.2337/db06-S002 10.1126/science.274.5291.1379 10.1126/science.1104342 10.1002/hep.23064 10.2337/db05-1404 10.1073/pnas.1032913100 10.1038/nature01137 10.1152/ajpendo.00189.2003 10.1016/j.jhep.2005.03.004 10.1056/NEJMoa031314 10.1073/pnas.0607626103 10.2337/diabetes.52.11.2784 10.2337/db08-0775 10.1172/JCI200422230 10.1053/jhep.2003.50398 10.1152/ajpendo.00038.2002 10.1096/fj.02-0670fje |
| ContentType | Journal Article |
| Copyright | Springer-Verlag 2010 2015 INIST-CNRS |
| Copyright_xml | – notice: Springer-Verlag 2010 – notice: 2015 INIST-CNRS |
| DBID | FBQ AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7T5 7X7 7XB 88E 8AO 8C1 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 7S9 L.6 ADTPV AOWAS F1U |
| DOI | 10.1007/s00125-010-1865-y |
| DatabaseName | AGRIS CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) Medical Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic SwePub SwePub Articles SWEPUB Göteborgs universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA ProQuest One Academic Middle East (New) MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1432-0428 |
| EndPage | 2441 |
| ExternalDocumentID | oai_gup_ub_gu_se_126610 2154216141 20697689 23303326 10_1007_s00125_010_1865_y US201301895047 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Australia United States--US |
| GeographicLocations_xml | – name: United States--US – name: Australia |
| GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1CY 1N0 1SB 2.D 203 28- 29F 29G 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7X7 88E 8AO 8C1 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X A8Z AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AAKSU AANXM AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABBBX ABBXA ABDZT ABECU ABFGW ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKAS ABKCH ABKTR ABLJU ABMNI ABMQK ABNWP ABOCM ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABUWZ ABWNU ABXPI ACBMV ACBRV ACBXY ACBYP ACGFS ACHSB ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACUDM ACVWB ACWMK ADBBV ADHHG ADHIR ADIMF ADINQ ADJJI ADKNI ADKPE ADMDM ADOXG ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AEQTP AESKC AESTI AETLH AEVLU AEVTX AEXYK AFAFS AFDYV AFEXP AFFNX AFJLC AFKRA AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGJBK AGKHE AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHIZS AHKAY AHMBA AHSBF AHVUH AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP EBLON EBS EIOEI EJD EMB EMOBN EN4 ESBYG ESTFP F5P FBQ FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z J5H JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LLZTM M1P M4Y MA- MVM N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P6G P9S PF0 PQQKQ PROAC PSQYO PT4 Q2X QOK QOR QOS R4E R89 R9I RHV RIG ROL RPX RRX RSV S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TR2 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK8 X7M YLTOR Z45 Z5O Z7U Z7V Z7W Z7X Z7Z Z81 Z82 Z83 Z86 Z87 Z88 Z8O Z8P Z8Q Z8T Z8U Z8V Z8W Z91 Z92 ZA5 ZGI ZMTXR ZOVNA ~EX ~KM AACDK AAEWM AAJBT AASML AAYZH ABAKF ABQSL ACAOD ACDTI ACPIV ACZOJ AEFQL AEMSY AFBBN AGQEE AGRTI AGVAE AIGIU ALIPV BSONS H13 AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PUEGO IQODW CGR CUY CVF ECM EIF NPM 7T5 7XB 8FK H94 K9. PKEHL PQEST PQUKI PRINS 7X8 7S9 L.6 ADTPV AOWAS F1U |
| ID | FETCH-LOGICAL-c526t-4f3e12f6545eb19112931b3b5a3755b6b20210603810ca0db3d2924434ba70ea3 |
| IEDL.DBID | U2A |
| ISSN | 0012-186X 1432-0428 |
| IngestDate | Tue Sep 09 23:27:38 EDT 2025 Sun Sep 28 02:14:00 EDT 2025 Sun Sep 28 11:33:49 EDT 2025 Sat Sep 27 19:16:34 EDT 2025 Tue Oct 07 05:41:28 EDT 2025 Thu Apr 03 07:04:28 EDT 2025 Mon Jul 21 09:15:08 EDT 2025 Wed Oct 01 02:46:30 EDT 2025 Thu Apr 24 23:03:24 EDT 2025 Fri Feb 21 02:35:22 EST 2025 Wed Dec 27 18:46:10 EST 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Type 2 diabetes Obesity Signal transduction Fatty liver Cytokines Endocrinopathy Rodentia Nutrition disorder Cytokine Metabolic diseases Hepatic disease Inflammation Interleukin 6 Target tissue resistance Vertebrata Mammalia Mouse Animal Digestive diseases Insulin resistance Nutritional status |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c526t-4f3e12f6545eb19112931b3b5a3755b6b20210603810ca0db3d2924434ba70ea3 |
| Notes | http://dx.doi.org/10.1007/s00125-010-1865-y ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 20697689 |
| PQID | 756343590 |
| PQPubID | 48469 |
| PageCount | 11 |
| ParticipantIDs | swepub_primary_oai_gup_ub_gu_se_126610 proquest_miscellaneous_907150539 proquest_miscellaneous_757790877 proquest_miscellaneous_755968405 proquest_journals_756343590 pubmed_primary_20697689 pascalfrancis_primary_23303326 crossref_primary_10_1007_s00125_010_1865_y crossref_citationtrail_10_1007_s00125_010_1865_y springer_journals_10_1007_s00125_010_1865_y fao_agris_US201301895047 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2010-11-01 |
| PublicationDateYYYYMMDD | 2010-11-01 |
| PublicationDate_xml | – month: 11 year: 2010 text: 2010-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Berlin/Heidelberg |
| PublicationPlace_xml | – name: Berlin/Heidelberg – name: Heidelberg – name: Germany |
| PublicationSubtitle | Clinical and Experimental Diabetes and Metabolism |
| PublicationTitle | Diabetologia |
| PublicationTitleAbbrev | Diabetologia |
| PublicationTitleAlternate | Diabetologia |
| PublicationYear | 2010 |
| Publisher | Berlin/Heidelberg : Springer-Verlag Springer-Verlag Springer Springer Nature B.V |
| Publisher_xml | – name: Berlin/Heidelberg : Springer-Verlag – name: Springer-Verlag – name: Springer – name: Springer Nature B.V |
| References | Chung, Nguyen, Henstridge (CR19) 2008; 105 Feve, Bastard (CR30) 2009; 5 Petersen, Befroy, Dufour (CR45) 2003; 300 Perez-Carreras, Del Hoyo, Martin (CR48) 2003; 38 Petersen, Carey, Sacchetti (CR9) 2005; 288 Yuan, Konstantopoulos, Lee (CR25) 2001; 293 Klover, Zimmers, Koniaris, Mooney (CR13) 2003; 52 Wallenius, Wallenius, Ahren (CR16) 2002; 8 Pessayre, Fromenty (CR49) 2005; 42 Carey, Steinberg, Macaulay (CR7) 2006; 55 Morino, Petersen, Shulman (CR43) 2006; 55 Solinas, Naugler, Galimi, Lee, Karin (CR24) 2006; 103 Sadagurski, Norquay, Farhang, D'Aquino, Copps, White (CR15) 2010; 53 Watt, Dzamko, Thomas (CR20) 2006; 12 Klover, Clementi, Mooney (CR39) 2005; 146 Holmes, Mesa, Neill (CR14) 2008; 198 Bruce, Hoy, Turner (CR23) 2009; 58 Patti, Butte, Crunkhorn (CR44) 2003; 100 Kim, Fillmore, Sunshine (CR28) 2004; 114 Petersen, Dufour, Befroy, Garcia, Shulman (CR46) 2004; 350 Yuen, Dwyer, Matthews (CR11) 2009; 58 Lam, Yoshii, Haber (CR27) 2002; 283 Lazar (CR3) 2005; 307 Subramanian, Tamayo, Mootha (CR22) 2005; 102 Starkie, Ostrowski, Jauffred, Febbraio, Pedersen (CR32) 2003; 17 Hotamisligil (CR1) 2006; 444 Glund, Deshmukh, Long (CR8) 2007; 56 Kim, Higashimori, Park (CR12) 2004; 53 Franckhauser, Elias, Rotter Sopasakis (CR40) 2008; 51 Fosgerau, Galle, Hansen (CR33) 2010; 204 Kim, Wei, Sowers (CR47) 2008; 102 Carey, Bruce, Sacchetti (CR2) 2004; 47 Tschop, Smiley, Heiman (CR34) 2000; 407 Di Gregorio, Hensley, Lu, Ranganathan, Kern (CR17) 2004; 287 Henkel, Neuschafer-Rube, Pathe-Neuschafer-Rube, Puschel (CR36) 2009; 50 Febbraio, Rose-John, Pedersen (CR31) 2010; 87 Mootha, Lindgren, Eriksson (CR21) 2003; 34 Pedersen, Febbraio (CR4) 2008; 88 Bruce, Dyck (CR6) 2004; 287 Senn, Klover, Nowak, Mooney (CR37) 2002; 51 Rotter Sopasakis, Larsson, Johansson, Holmang, Smith (CR10) 2004; 47 Jin, Zhang, Beer-Stolz, Zimmers, Koniaris (CR50) 2007; 46 Garcia, Wernstedt, Berndtsson (CR35) 2006; 55 Park, Lee, Yu (CR42) 2010; 140 Cressman, Greenbaum, DeAngelis (CR41) 1996; 274 Nadler, Stoehr, Schueler, Tanimoto, Yandell, Attie (CR29) 2000; 97 Kopf, Baumann, Freer (CR18) 1994; 368 Hirosumi, Tuncman, Chang (CR26) 2002; 420 Al-Khalili, Bouzakri, Glund, Lonnqvist, Koistinen, Krook (CR5) 2006; 20 Cai, Yuan, Frantz (CR38) 2005; 11 EW Petersen (1865_CR9) 2005; 288 M Kopf (1865_CR18) 1994; 368 DY Yuen (1865_CR11) 2009; 58 EJ Park (1865_CR42) 2010; 140 J Henkel (1865_CR36) 2009; 50 X Jin (1865_CR50) 2007; 46 MJ Watt (1865_CR20) 2006; 12 PJ Klover (1865_CR39) 2005; 146 M Tschop (1865_CR34) 2000; 407 KF Petersen (1865_CR45) 2003; 300 JK Kim (1865_CR28) 2004; 114 JJ Senn (1865_CR37) 2002; 51 S Franckhauser (1865_CR40) 2008; 51 AG Holmes (1865_CR14) 2008; 198 A Subramanian (1865_CR22) 2005; 102 M Sadagurski (1865_CR15) 2010; 53 GS Hotamisligil (1865_CR1) 2006; 444 BK Pedersen (1865_CR4) 2008; 88 G Solinas (1865_CR24) 2006; 103 J Hirosumi (1865_CR26) 2002; 420 M Yuan (1865_CR25) 2001; 293 L Al-Khalili (1865_CR5) 2006; 20 JA Kim (1865_CR47) 2008; 102 V Rotter Sopasakis (1865_CR10) 2004; 47 TK Lam (1865_CR27) 2002; 283 B Feve (1865_CR30) 2009; 5 HJ Kim (1865_CR12) 2004; 53 PJ Klover (1865_CR13) 2003; 52 V Wallenius (1865_CR16) 2002; 8 K Morino (1865_CR43) 2006; 55 CR Bruce (1865_CR23) 2009; 58 KF Petersen (1865_CR46) 2004; 350 M Perez-Carreras (1865_CR48) 2003; 38 MC Garcia (1865_CR35) 2006; 55 D Cai (1865_CR38) 2005; 11 D Pessayre (1865_CR49) 2005; 42 GB Gregorio Di (1865_CR17) 2004; 287 S Glund (1865_CR8) 2007; 56 VK Mootha (1865_CR21) 2003; 34 J Chung (1865_CR19) 2008; 105 K Fosgerau (1865_CR33) 2010; 204 MA Lazar (1865_CR3) 2005; 307 CR Bruce (1865_CR6) 2004; 287 AL Carey (1865_CR7) 2006; 55 ME Patti (1865_CR44) 2003; 100 AL Carey (1865_CR2) 2004; 47 MA Febbraio (1865_CR31) 2010; 87 DE Cressman (1865_CR41) 1996; 274 R Starkie (1865_CR32) 2003; 17 ST Nadler (1865_CR29) 2000; 97 15191885 - Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E182-7 16604088 - Nat Med. 2006 May;12 (5):541-8 18309108 - Circ Res. 2008 Feb 29;102(4):401-14 20141834 - Cell. 2010 Jan 22;140(2):197-208 15551046 - Diabetologia. 2004 Nov;47(11):1879-87 8127368 - Nature. 1994 Mar 24;368(6469):339-42 12447443 - Nature. 2002 Nov 21;420(6913):333-6 14960743 - N Engl J Med. 2004 Feb 12;350(7):664-71 11786910 - Nat Med. 2002 Jan;8(1):75-9 20016056 - J Endocrinol. 2010 Mar;204(3):265-73 19073774 - Diabetes. 2009 Mar;58(3):550-8 18223156 - Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44 12217885 - Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91 15047622 - Diabetes. 2004 Apr;53(4):1060-7 15885365 - J Hepatol. 2005 Jun;42(6):928-40 12750520 - Science. 2003 May 16;300(5622):1140-2 14578297 - Diabetes. 2003 Nov;52(11):2784-9 14512887 - Hepatology. 2003 Oct;38(4):999-1007 15662001 - Science. 2005 Jan 21;307(5708):373-5 11027337 - Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11371-6 19575453 - Hepatology. 2009 Sep;50(3):781-90 17003332 - Diabetes. 2006 Oct;55(10 ):2688-97 16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 17167474 - Nature. 2006 Dec 14;444(7121):860-7 17130651 - Diabetes. 2006 Dec;55 Suppl 2:S9-S15 15685173 - Nat Med. 2005 Feb;11(2):183-90 18523033 - J Endocrinol. 2008 Aug;198(2):367-74 18437347 - Diabetologia. 2008 Jul;51(7):1306-16 12626436 - FASEB J. 2003 May;17(8):884-6 15845623 - Endocrinology. 2005 Aug;146(8):3417-27 17050683 - Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16454-9 17668886 - Hepatology. 2007 Sep;46(3):802-12 12832613 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71 16644674 - Diabetes. 2006 May;55(5):1205-13 15372106 - J Clin Invest. 2004 Sep;114(6):823-7 12453891 - Diabetes. 2002 Dec;51(12):3391-9 20305672 - Clin Pharmacol Ther. 2010 Apr;87(4):396-8 15168015 - Diabetologia. 2004 Jun;47(6):1029-37 17363741 - Diabetes. 2007 Jun;56(6):1630-7 19188427 - Diabetes. 2009 May;58(5):1086-95 19902173 - Diabetologia. 2010 Mar;53(3):525-35 18923185 - Physiol Rev. 2008 Oct;88(4):1379-406 12808457 - Nat Genet. 2003 Jul;34(3):267-73 11533494 - Science. 2001 Aug 31;293(5535):1673-7 15383370 - Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E155-62 8910279 - Science. 1996 Nov 22;274(5291):1379-83 19399017 - Nat Rev Endocrinol. 2009 Jun;5(6):305-11 11057670 - Nature. 2000 Oct 19;407(6806):908-13 15149950 - Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E616-21 16945991 - Mol Endocrinol. 2006 Dec;20(12 ):3364-75 |
| References_xml | – volume: 444 start-page: 860 year: 2006 end-page: 867 ident: CR1 article-title: Inflammation and metabolic disorders publication-title: Nature doi: 10.1038/nature05485 – volume: 87 start-page: 396 year: 2010 end-page: 398 ident: CR31 article-title: Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases? publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2010.1 – volume: 56 start-page: 1630 year: 2007 end-page: 1637 ident: CR8 article-title: Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle publication-title: Diabetes doi: 10.2337/db06-1733 – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: CR22 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506580102 – volume: 47 start-page: 1029 year: 2004 end-page: 1037 ident: CR2 article-title: Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness publication-title: Diabetologia – volume: 198 start-page: 367 year: 2008 end-page: 374 ident: CR14 article-title: Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats publication-title: J Endocrinol doi: 10.1677/JOE-08-0113 – volume: 283 start-page: E682 year: 2002 end-page: E691 ident: CR27 article-title: Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta publication-title: Am J Physiol Endocrinol Metab – volume: 102 start-page: 401 year: 2008 end-page: 414 ident: CR47 article-title: Role of mitochondrial dysfunction in insulin resistance publication-title: Circ Res doi: 10.1161/CIRCRESAHA.107.165472 – volume: 204 start-page: 265 year: 2010 end-page: 273 ident: CR33 article-title: Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes publication-title: J Endocrinol doi: 10.1677/JOE-09-0413 – volume: 105 start-page: 1739 year: 2008 end-page: 1744 ident: CR19 article-title: HSP72 protects against obesity-induced insulin resistance publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0705799105 – volume: 53 start-page: 525 year: 2010 end-page: 535 ident: CR15 article-title: Human IL6 enhances leptin action in mice publication-title: Diabetologia doi: 10.1007/s00125-009-1580-8 – volume: 114 start-page: 823 year: 2004 end-page: 827 ident: CR28 article-title: PKC-theta knockout mice are protected from fat-induced insulin resistance publication-title: J Clin Invest – volume: 51 start-page: 1306 year: 2008 end-page: 1316 ident: CR40 article-title: Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice publication-title: Diabetologia doi: 10.1007/s00125-008-0998-8 – volume: 34 start-page: 267 year: 2003 end-page: 273 ident: CR21 article-title: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat Genet doi: 10.1038/ng1180 – volume: 8 start-page: 75 year: 2002 end-page: 79 ident: CR16 article-title: Interleukin-6-deficient mice develop mature-onset obesity publication-title: Nat Med doi: 10.1038/nm0102-75 – volume: 51 start-page: 3391 year: 2002 end-page: 3399 ident: CR37 article-title: Interleukin-6 induces cellular insulin resistance in hepatocytes publication-title: Diabetes doi: 10.2337/diabetes.51.12.3391 – volume: 88 start-page: 1379 year: 2008 end-page: 1406 ident: CR4 article-title: Muscle as an endocrine organ: focus on muscle-derived interleukin-6 publication-title: Physiol Rev doi: 10.1152/physrev.90100.2007 – volume: 17 start-page: 884 year: 2003 end-page: 886 ident: CR32 article-title: Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans publication-title: FASEB J – volume: 407 start-page: 908 year: 2000 end-page: 913 ident: CR34 article-title: Ghrelin induces adiposity in rodents publication-title: Nature doi: 10.1038/35038090 – volume: 140 start-page: 197 year: 2010 end-page: 208 ident: CR42 article-title: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression publication-title: Cell doi: 10.1016/j.cell.2009.12.052 – volume: 368 start-page: 339 year: 1994 end-page: 342 ident: CR18 article-title: Impaired immune and acute-phase responses in interleukin-6-deficient mice publication-title: Nature doi: 10.1038/368339a0 – volume: 5 start-page: 305 year: 2009 end-page: 311 ident: CR30 article-title: The role of interleukins in insulin resistance and type 2 diabetes mellitus publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.62 – volume: 288 start-page: E155 year: 2005 end-page: E162 ident: CR9 article-title: Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00257.2004 – volume: 12 start-page: 541 year: 2006 end-page: 548 ident: CR20 article-title: CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK publication-title: Nat Med doi: 10.1038/nm1383 – volume: 38 start-page: 999 year: 2003 end-page: 1007 ident: CR48 article-title: Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis publication-title: Hepatology – volume: 293 start-page: 1673 year: 2001 end-page: 1677 ident: CR25 article-title: Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta publication-title: Science doi: 10.1126/science.1061620 – volume: 97 start-page: 11371 year: 2000 end-page: 11376 ident: CR29 article-title: The expression of adipogenic genes is decreased in obesity and diabetes mellitus publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.21.11371 – volume: 20 start-page: 3364 year: 2006 end-page: 3375 ident: CR5 article-title: Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle publication-title: Mol Endocrinol doi: 10.1210/me.2005-0490 – volume: 47 start-page: 1879 year: 2004 end-page: 1887 ident: CR10 article-title: Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats publication-title: Diabetologia doi: 10.1007/s00125-004-1544-y – volume: 53 start-page: 1060 year: 2004 end-page: 1067 ident: CR12 article-title: Differential effects of interleukin-6 and 10 on skeletal muscle and liver insulin action in vivo publication-title: Diabetes doi: 10.2337/diabetes.53.4.1060 – volume: 146 start-page: 3417 year: 2005 end-page: 3427 ident: CR39 article-title: Interleukin-6 depletion selectively improves hepatic insulin action in obesity publication-title: Endocrinology doi: 10.1210/en.2004-1468 – volume: 11 start-page: 183 year: 2005 end-page: 190 ident: CR38 article-title: Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB publication-title: Nat Med doi: 10.1038/nm1166 – volume: 300 start-page: 1140 year: 2003 end-page: 1142 ident: CR45 article-title: Mitochondrial dysfunction in the elderly: possible role in insulin resistance publication-title: Science doi: 10.1126/science.1082889 – volume: 46 start-page: 802 year: 2007 end-page: 812 ident: CR50 article-title: Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection publication-title: Hepatology doi: 10.1002/hep.21728 – volume: 55 start-page: 1205 year: 2006 end-page: 1213 ident: CR35 article-title: Mature-onset obesity in interleukin-1 receptor I knockout mice publication-title: Diabetes doi: 10.2337/db05-1304 – volume: 287 start-page: E616 year: 2004 end-page: E621 ident: CR6 article-title: Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00150.2004 – volume: 58 start-page: 550 year: 2009 end-page: 558 ident: CR23 article-title: Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance publication-title: Diabetes doi: 10.2337/db08-1078 – volume: 55 start-page: S9 issue: Suppl 2 year: 2006 end-page: S15 ident: CR43 article-title: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction publication-title: Diabetes doi: 10.2337/db06-S002 – volume: 274 start-page: 1379 year: 1996 end-page: 1383 ident: CR41 article-title: Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice publication-title: Science doi: 10.1126/science.274.5291.1379 – volume: 307 start-page: 373 year: 2005 end-page: 375 ident: CR3 article-title: How obesity causes diabetes: not a tall tale publication-title: Science doi: 10.1126/science.1104342 – volume: 50 start-page: 781 year: 2009 end-page: 790 ident: CR36 article-title: Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes publication-title: Hepatology doi: 10.1002/hep.23064 – volume: 55 start-page: 2688 year: 2006 end-page: 2697 ident: CR7 article-title: Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase publication-title: Diabetes doi: 10.2337/db05-1404 – volume: 100 start-page: 8466 year: 2003 end-page: 8471 ident: CR44 article-title: Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1032913100 – volume: 420 start-page: 333 year: 2002 end-page: 336 ident: CR26 article-title: A central role for JNK in obesity and insulin resistance publication-title: Nature doi: 10.1038/nature01137 – volume: 287 start-page: E182 year: 2004 end-page: E187 ident: CR17 article-title: Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00189.2003 – volume: 42 start-page: 928 year: 2005 end-page: 940 ident: CR49 article-title: NASH: a mitochondrial disease publication-title: J Hepatol doi: 10.1016/j.jhep.2005.03.004 – volume: 350 start-page: 664 year: 2004 end-page: 671 ident: CR46 article-title: Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes publication-title: N Engl J Med doi: 10.1056/NEJMoa031314 – volume: 103 start-page: 16454 year: 2006 end-page: 16459 ident: CR24 article-title: Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0607626103 – volume: 52 start-page: 2784 year: 2003 end-page: 2789 ident: CR13 article-title: Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice publication-title: Diabetes doi: 10.2337/diabetes.52.11.2784 – volume: 58 start-page: 1086 year: 2009 end-page: 1095 ident: CR11 article-title: Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor-alpha expression publication-title: Diabetes doi: 10.2337/db08-0775 – volume: 288 start-page: E155 year: 2005 ident: 1865_CR9 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00257.2004 – volume: 42 start-page: 928 year: 2005 ident: 1865_CR49 publication-title: J Hepatol doi: 10.1016/j.jhep.2005.03.004 – volume: 300 start-page: 1140 year: 2003 ident: 1865_CR45 publication-title: Science doi: 10.1126/science.1082889 – volume: 87 start-page: 396 year: 2010 ident: 1865_CR31 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2010.1 – volume: 55 start-page: 1205 year: 2006 ident: 1865_CR35 publication-title: Diabetes doi: 10.2337/db05-1304 – volume: 350 start-page: 664 year: 2004 ident: 1865_CR46 publication-title: N Engl J Med doi: 10.1056/NEJMoa031314 – volume: 204 start-page: 265 year: 2010 ident: 1865_CR33 publication-title: J Endocrinol doi: 10.1677/JOE-09-0413 – volume: 8 start-page: 75 year: 2002 ident: 1865_CR16 publication-title: Nat Med doi: 10.1038/nm0102-75 – volume: 11 start-page: 183 year: 2005 ident: 1865_CR38 publication-title: Nat Med doi: 10.1038/nm1166 – volume: 5 start-page: 305 year: 2009 ident: 1865_CR30 publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2009.62 – volume: 114 start-page: 823 year: 2004 ident: 1865_CR28 publication-title: J Clin Invest doi: 10.1172/JCI200422230 – volume: 58 start-page: 1086 year: 2009 ident: 1865_CR11 publication-title: Diabetes doi: 10.2337/db08-0775 – volume: 38 start-page: 999 year: 2003 ident: 1865_CR48 publication-title: Hepatology doi: 10.1053/jhep.2003.50398 – volume: 102 start-page: 401 year: 2008 ident: 1865_CR47 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.107.165472 – volume: 56 start-page: 1630 year: 2007 ident: 1865_CR8 publication-title: Diabetes doi: 10.2337/db06-1733 – volume: 52 start-page: 2784 year: 2003 ident: 1865_CR13 publication-title: Diabetes doi: 10.2337/diabetes.52.11.2784 – volume: 140 start-page: 197 year: 2010 ident: 1865_CR42 publication-title: Cell doi: 10.1016/j.cell.2009.12.052 – volume: 100 start-page: 8466 year: 2003 ident: 1865_CR44 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1032913100 – volume: 287 start-page: E182 year: 2004 ident: 1865_CR17 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00189.2003 – volume: 12 start-page: 541 year: 2006 ident: 1865_CR20 publication-title: Nat Med doi: 10.1038/nm1383 – volume: 420 start-page: 333 year: 2002 ident: 1865_CR26 publication-title: Nature doi: 10.1038/nature01137 – volume: 307 start-page: 373 year: 2005 ident: 1865_CR3 publication-title: Science doi: 10.1126/science.1104342 – volume: 103 start-page: 16454 year: 2006 ident: 1865_CR24 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0607626103 – volume: 407 start-page: 908 year: 2000 ident: 1865_CR34 publication-title: Nature doi: 10.1038/35038090 – volume: 51 start-page: 3391 year: 2002 ident: 1865_CR37 publication-title: Diabetes doi: 10.2337/diabetes.51.12.3391 – volume: 47 start-page: 1879 year: 2004 ident: 1865_CR10 publication-title: Diabetologia doi: 10.1007/s00125-004-1544-y – volume: 51 start-page: 1306 year: 2008 ident: 1865_CR40 publication-title: Diabetologia doi: 10.1007/s00125-008-0998-8 – volume: 55 start-page: 2688 year: 2006 ident: 1865_CR7 publication-title: Diabetes doi: 10.2337/db05-1404 – volume: 105 start-page: 1739 year: 2008 ident: 1865_CR19 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0705799105 – volume: 34 start-page: 267 year: 2003 ident: 1865_CR21 publication-title: Nat Genet doi: 10.1038/ng1180 – volume: 287 start-page: E616 year: 2004 ident: 1865_CR6 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00150.2004 – volume: 46 start-page: 802 year: 2007 ident: 1865_CR50 publication-title: Hepatology doi: 10.1002/hep.21728 – volume: 283 start-page: E682 year: 2002 ident: 1865_CR27 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00038.2002 – volume: 444 start-page: 860 year: 2006 ident: 1865_CR1 publication-title: Nature doi: 10.1038/nature05485 – volume: 274 start-page: 1379 year: 1996 ident: 1865_CR41 publication-title: Science doi: 10.1126/science.274.5291.1379 – volume: 58 start-page: 550 year: 2009 ident: 1865_CR23 publication-title: Diabetes doi: 10.2337/db08-1078 – volume: 53 start-page: 525 year: 2010 ident: 1865_CR15 publication-title: Diabetologia doi: 10.1007/s00125-009-1580-8 – volume: 55 start-page: S9 issue: Suppl 2 year: 2006 ident: 1865_CR43 publication-title: Diabetes doi: 10.2337/db06-S002 – volume: 20 start-page: 3364 year: 2006 ident: 1865_CR5 publication-title: Mol Endocrinol doi: 10.1210/me.2005-0490 – volume: 198 start-page: 367 year: 2008 ident: 1865_CR14 publication-title: J Endocrinol doi: 10.1677/JOE-08-0113 – volume: 293 start-page: 1673 year: 2001 ident: 1865_CR25 publication-title: Science doi: 10.1126/science.1061620 – volume: 368 start-page: 339 year: 1994 ident: 1865_CR18 publication-title: Nature doi: 10.1038/368339a0 – volume: 97 start-page: 11371 year: 2000 ident: 1865_CR29 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.97.21.11371 – volume: 146 start-page: 3417 year: 2005 ident: 1865_CR39 publication-title: Endocrinology doi: 10.1210/en.2004-1468 – volume: 47 start-page: 1029 year: 2004 ident: 1865_CR2 publication-title: Diabetologia – volume: 53 start-page: 1060 year: 2004 ident: 1865_CR12 publication-title: Diabetes doi: 10.2337/diabetes.53.4.1060 – volume: 17 start-page: 884 year: 2003 ident: 1865_CR32 publication-title: FASEB J doi: 10.1096/fj.02-0670fje – volume: 50 start-page: 781 year: 2009 ident: 1865_CR36 publication-title: Hepatology doi: 10.1002/hep.23064 – volume: 88 start-page: 1379 year: 2008 ident: 1865_CR4 publication-title: Physiol Rev doi: 10.1152/physrev.90100.2007 – volume: 102 start-page: 15545 year: 2005 ident: 1865_CR22 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506580102 – reference: 17003332 - Diabetes. 2006 Oct;55(10 ):2688-97 – reference: 20305672 - Clin Pharmacol Ther. 2010 Apr;87(4):396-8 – reference: 15168015 - Diabetologia. 2004 Jun;47(6):1029-37 – reference: 18309108 - Circ Res. 2008 Feb 29;102(4):401-14 – reference: 15383370 - Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E155-62 – reference: 8910279 - Science. 1996 Nov 22;274(5291):1379-83 – reference: 15662001 - Science. 2005 Jan 21;307(5708):373-5 – reference: 19399017 - Nat Rev Endocrinol. 2009 Jun;5(6):305-11 – reference: 18923185 - Physiol Rev. 2008 Oct;88(4):1379-406 – reference: 16604088 - Nat Med. 2006 May;12 (5):541-8 – reference: 17363741 - Diabetes. 2007 Jun;56(6):1630-7 – reference: 18523033 - J Endocrinol. 2008 Aug;198(2):367-74 – reference: 15372106 - J Clin Invest. 2004 Sep;114(6):823-7 – reference: 15845623 - Endocrinology. 2005 Aug;146(8):3417-27 – reference: 16945991 - Mol Endocrinol. 2006 Dec;20(12 ):3364-75 – reference: 12217885 - Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E682-91 – reference: 14578297 - Diabetes. 2003 Nov;52(11):2784-9 – reference: 15149950 - Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E616-21 – reference: 17167474 - Nature. 2006 Dec 14;444(7121):860-7 – reference: 11533494 - Science. 2001 Aug 31;293(5535):1673-7 – reference: 12832613 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71 – reference: 12750520 - Science. 2003 May 16;300(5622):1140-2 – reference: 17668886 - Hepatology. 2007 Sep;46(3):802-12 – reference: 19073774 - Diabetes. 2009 Mar;58(3):550-8 – reference: 15551046 - Diabetologia. 2004 Nov;47(11):1879-87 – reference: 14960743 - N Engl J Med. 2004 Feb 12;350(7):664-71 – reference: 20141834 - Cell. 2010 Jan 22;140(2):197-208 – reference: 16644674 - Diabetes. 2006 May;55(5):1205-13 – reference: 18223156 - Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44 – reference: 15191885 - Am J Physiol Endocrinol Metab. 2004 Jul;287(1):E182-7 – reference: 19188427 - Diabetes. 2009 May;58(5):1086-95 – reference: 15685173 - Nat Med. 2005 Feb;11(2):183-90 – reference: 12808457 - Nat Genet. 2003 Jul;34(3):267-73 – reference: 14512887 - Hepatology. 2003 Oct;38(4):999-1007 – reference: 11057670 - Nature. 2000 Oct 19;407(6806):908-13 – reference: 12453891 - Diabetes. 2002 Dec;51(12):3391-9 – reference: 17130651 - Diabetes. 2006 Dec;55 Suppl 2:S9-S15 – reference: 12447443 - Nature. 2002 Nov 21;420(6913):333-6 – reference: 17050683 - Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16454-9 – reference: 19575453 - Hepatology. 2009 Sep;50(3):781-90 – reference: 11027337 - Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11371-6 – reference: 11786910 - Nat Med. 2002 Jan;8(1):75-9 – reference: 19902173 - Diabetologia. 2010 Mar;53(3):525-35 – reference: 15885365 - J Hepatol. 2005 Jun;42(6):928-40 – reference: 8127368 - Nature. 1994 Mar 24;368(6469):339-42 – reference: 18437347 - Diabetologia. 2008 Jul;51(7):1306-16 – reference: 15047622 - Diabetes. 2004 Apr;53(4):1060-7 – reference: 20016056 - J Endocrinol. 2010 Mar;204(3):265-73 – reference: 16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 – reference: 12626436 - FASEB J. 2003 May;17(8):884-6 |
| SSID | ssj0003546 |
| Score | 2.4860709 |
| Snippet | Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to... Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to... The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether... Aims/hypothesis: The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to... AIMS/HYPOTHESIS: The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to... |
| SourceID | swepub proquest pubmed pascalfrancis crossref springer fao |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2431 |
| SubjectTerms | Adipocytes Adipocytes - metabolism Adipocytes - pathology Adiposity Adiposity - genetics Animals Biological and medical sciences Body Composition Body Composition - genetics Body fat Calorimetry, Indirect Cell Size Cytokines deficiency Dehydrogenases Diabetes Diabetes. Impaired glucose tolerance Diet Diglycerides Diglycerides - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty liver Fatty Liver - genetics Fatty Liver - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen genetics Glucose Human Physiology immunology Inflammation Inflammation - genetics Insulin Resistance Insulin Resistance - genetics Interleukin-6 Interleukin-6 - deficiency Interleukin-6 - genetics Internal Medicine Kinases Lipids Liver Liver - immunology Liver - metabolism Liver - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical and Health Sciences Medical research Medical sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mice, Knockout Musculoskeletal system noninsulin-dependent diabetes mellitus Obesity Obesity - genetics Obesity - metabolism Other diseases. Semiology pathology Physiology Proteins Signal transduction Triglycerides Triglycerides - metabolism Type 2 diabetes |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELbarYS4IN4NhcoHxAFk4cSxnRwQAtSqQtoKASstJ8uvbBFVdmF3D_33zDiPUgR73LUTJZ7xzOfMzDeEPA8Reby8ZZVrIiutCMxqX7NCaxu09Y2VWCg8PVdns_LjXM73yHSohcG0ysEmJkMdlh6_kb_WUglw7TV_u_rJsGkUBleHDhq276wQ3iSGsX1yUCAx1oQcvD85__R5NM2ir9wBq8zySs2HMCdPrKLg61lKVqiUZFc3HNV-Y5eYNmnXsHJN1_LiX5j0j3jqX9yjyV-d3iV3eqBJ33WacY_sxfY-uTXtQ-kPyLf0LfAybn98b5liISKVBHggiv3paV9LRS8iZlx7CnoIqtOVOVLbBtoxQKeRlMxO4diOUBR06CGZnZ58_XDG-j4LzMtCbVjZiJgXjQIwBZa7RgQmciectEJL6ZQr8GCoMKbIveXBiVDAsa0UpbOaRysekUm7bOMhoR6jiq6wdZM3JVxZVU0QkQfprOOe-4zwYVGN70nIsRfGpRnpk5McDMffIAdzlZGX4yWrjoFj1-RDkJSxC7CQZvalwLhsXtWSlzojxzfEN96sEODGAcVm5GiQp-k38tqMapcROo7CDsSwim3jcotTZI2UOXLXFKR1rLT-_5QasB6gUVFn5HGnS9cPyBWAxgpGXg3Kdf2AO5biRad_432QSXyxXRn4a7E162hyRGf8yc73PiK3U8JEKr98SiabX9v4DHDYxh33u-s3bkQuNA priority: 102 providerName: ProQuest |
| Title | Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance |
| URI | https://link.springer.com/article/10.1007/s00125-010-1865-y https://www.ncbi.nlm.nih.gov/pubmed/20697689 https://www.proquest.com/docview/756343590 https://www.proquest.com/docview/755968405 https://www.proquest.com/docview/757790877 https://www.proquest.com/docview/907150539 https://gup.ub.gu.se/publication/126610 |
| Volume | 53 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Food Science Source customDbUrl: eissn: 1432-0428 dateEnd: 20241101 omitProxy: false ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: A8Z dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=fsr providerName: EBSCOhost – providerCode: PRVLSH databaseName: SpringerLink Journals customDbUrl: mediaType: online eissn: 1432-0428 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: AFBBN dateStart: 19970101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1432-0428 dateEnd: 20241101 omitProxy: true ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: 7X7 dateStart: 19990101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1432-0428 dateEnd: 20241101 omitProxy: true ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: BENPR dateStart: 19990101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1432-0428 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: 8C1 dateStart: 19990101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK - Czech Republic Consortium customDbUrl: eissn: 1432-0428 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: AGYKE dateStart: 19970101 isFulltext: true titleUrlDefault: http://link.springer.com providerName: Springer Nature – providerCode: PRVAVX databaseName: SpringerLink Journals (ICM) customDbUrl: eissn: 1432-0428 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0003546 issn: 0012-186X databaseCode: U2A dateStart: 19970101 isFulltext: true titleUrlDefault: http://www.springerlink.com/journals/ providerName: Springer Nature |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED_RTUK8IL4XBpUfEA8gS04cx8ljmTom0CYEVOqeLNtxOsSUTrR52H_PXb7G0KjES6rUFyvynX0_5-5-BnhTBuLx8pbnrgo8tbLkVvuCJ1rbUltfWUWFwqdn2cki_bRUy76OezNkuw8hyXalHovdyDNTohnFIjPFryewr4jNC414kczG5Vf21TkoTYLLIZR5Vxe3nNGksmtKjbQbHJ2qO9biLtz5R8z0L37R1icdP4KHPZhks077j-FeqJ_A_dM-XP4UztvvfZeh-fmj5hkvA9FFoJdhdAY96-ul2EWgrGrP0NbQPLpSRmbrknUsz21Lm7DOcGtOcBPt5Bksjuffj054f5YC9yrJtjytZIiTKkPAhKtzQShLxk46ZaVWymUuoc1fRnFD4a0onSwT3JqlMnVWi2Dlc9ir13U4AOYpcugSW1RxleKTeV6VMohSOeuEFz4CMQyq8T3ROJ13cWlGiuRWD0bQPerBXEfwbnzkqmPZ2CV8gJoydoWroFl8Syj2GueFEqmOYHpLfWNniURXjUg1gsNBn6afrBujVSYRNRYiAja24iyj0Imtw7ohEVUQLY7aJULUjbnW_xYpEM8h4pRFBC86W7p5QZEhMMyx5f1gXDcvuGMo3nb2N_ZDbOGr5srgX6vGbIKJCYGJl__V7SE8aJMk2pLLV7C3_dWE14i9tm4KE73UeM2P4inszz6ef57j74f52Zev03Ye_gZ3lCns |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF71IQEXxLumUHwADqAVa6_Xj0OFeLRKaRMhaKRwWvblULU4oUmE8uP4b8ysH6UIcuvR8Xrl7MzOfOuZ-YaQp9Yhj5dRNNelo4nilqrMFDTOMmUzZUolsFC4P0h7w-TDSIzWyK-2FgbTKlub6A21nRj8Rv4qEykH116w19MfFJtGYXC17aChms4KdtczjDV1HYdu-RNOcLPdg_cg7mdxvL93_K5HmyYD1Ig4ndOk5C6KyxSQBJitAuEHjzTXQvFMCJ3qGE9FKQbUmFHMam5jOLMkPNEqY05xmHedbMJ1AWe_zbd7g4-fOlfAm0oh8AI0ytNRG1ZlnsUUsAX1yRF5KujykmNcL9UE0zTVDCRV1i02_oWB_4jf_sV16v3j_i1yswG24ZtaE2-TNVfdIdf6Tej-Lvnivz2eucXpSUVTah1SV4DHC7-DqQqb2q3wm8MMbxOC3oOq1mWVoapsWDNO-zs-eT48dzOEvqCz98jwSpb8PtmoJpXbIqHBKKaOVVFGZQJP5nlpuWNWaKWZYSYgrF1UaRrSc-y9cSY7umYvB8nwGuQglwF50T0yrRk_Vg3eAklJNQaLLIefY4wDR3khWJIFZOeS-LrJYg6wAVBzQLZbecrGcMxkp-YBCbu7sOMxjKMqN1ngEFEgRY9YNQRpJPMs-_-QArAloF9eBORBrUsXL8hSAKk53HnZKtfFC65Yiue1_nXzIHP5eDGV8NN4IWdORogG2cOV__sJud477h_Jo4PB4Ta54ZM1fOnnI7IxP1-4x4AB53qn2Wkh-XrVm_s3MQhoqg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbaIlVcEO-GQvEBOICsOnEcJweEEGXVUlohwUrLydiOs0Vts0t3V2h_Gv-OGedRimBvPSZ2rMQzHn_OzHxDyLPSI4-XMyy3lWepESUzyhUsUcqUyrjKSEwUPjrO9ofph5EcrZFfXS4MhlV2NjEY6nLi8B_5rpKZgK294LtVGxXxaW_wZvqDYQEpdLR21TQaDTn0y59wepu9PtgDUT9PksH7L-_2WVtggDmZZHOWVsLHSZUBigCTVSD0ELEVVhqhpLSZTfBElKEzjTvDSyvKBM4rqUitUdwbAeOukxtKiAKjCdWoP-tx0eYIgf1ncZ6NOocqD_ylgCpYCIvIM8mWV7bE9cpMMEDTzEBGVVNc41_o9w_P7V8sp2FnHNwmt1pIS982OniHrPn6Ltk8ap3298jX8NfxzC9Ov9csY6VH0grY6-g5GCnaZm3RE4-x3Y6CxoOSNgmV1NQlbbimQ0sIm6cXfoagF7T1Phley4Q_IBv1pPZbhDr0X9rEFFVcpfBknlel8LyU1ljuuIsI7yZVu5buHKtunOmeqDnIQXO8BjnoZURe9o9MG66PVZ23QFLajMEW6-HnBD3AcV5InqqI7FwRXz9YIgAwAF6OyHYnT92ajJnuFTwitG-FtY4OHFP7yQK7yALJeeSqLkggmSv1_y4FoErAvaKIyMNGly5fkGcAT3NoedUp1-ULrpiKF43-9eMgZ_l4MdVwa7zQM69jxIH80crvfko2YUnrjwfHh9vkZojSCDmfj8nG_GLhnwD4m9udsMwo-Xbd6_o3MMJmRA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-6-deficient+mice+develop+hepatic+inflammation+and+systemic+insulin+resistance&rft.jtitle=Diabetologia&rft.au=Matthews%2C+V.+B&rft.au=Allen%2C+T.+L&rft.au=Risis%2C+S&rft.au=Chan%2C+M.+H.+S&rft.date=2010-11-01&rft.pub=Berlin%2FHeidelberg+%3A+Springer-Verlag&rft.issn=0012-186X&rft.eissn=1432-0428&rft.volume=53&rft.issue=11&rft.spage=2431&rft.epage=2441&rft_id=info:doi/10.1007%2Fs00125-010-1865-y&rft.externalDocID=US201301895047 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-186X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-186X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-186X&client=summon |