Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies

Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-...

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Published inPloS one Vol. 13; no. 1; p. e0190214
Main Authors Kratz, Harald, Taupitz, Matthias, Ariza de Schellenberger, Angela, Kosch, Olaf, Eberbeck, Dietmar, Wagner, Susanne, Trahms, Lutz, Hamm, Bernd, Schnorr, Jörg
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.01.2018
Public Library of Science (PLoS)
Subjects
Atmospheric oxygen
Biocompatibility
Biology and Life Sciences
Biomedical materials
Cancer
Cell cycle
Contrast agents
Decomposition
Dextran
Earth Sciences
Engineering and Technology
Green rust
Higher harmonics
Humans
Hyperthermia
In vivo methods and tests
Iron
Iron chlorides
Lymph nodes
Magnetic properties
Magnetic resonance
Magnetic Resonance Imaging
Magnetics
Magnetite
Medical imaging
Medical research
Medical wastes
Medicine and Health Sciences
Mesenchymal stem cells
Methods
Microscopy, Electron, Transmission
Nanoparticles
NMR
Nuclear magnetic resonance
Oxygen
Physical Sciences
Precipitation
Rainfall
Research and Analysis Methods
Signal strength
Spectroscopy
Stem cells
Synthesis
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0190214

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Abstract Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medical imaging modality, and magnetic resonance imaging (MRI). The magnetic nanoparticles are biocompatible and thus potential candidates for future biomedical applications such as cardiovascular imaging, sentinel lymph node mapping in cancer patients, and stem cell tracking. The new MCP that we introduce here have three times higher magnetic particle spectroscopy performance at lower and middle harmonics and five times higher MPS signal strength at higher harmonics compared with Resovist®. In addition, the new MCP have also an improved in vivo MPI performance compared to Resovist®, and we here report the first in vivo MPI investigation of this new generation of magnetic nanoparticles.
AbstractList Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medical imaging modality, and magnetic resonance imaging (MRI). The magnetic nanoparticles are biocompatible and thus potential candidates for future biomedical applications such as cardiovascular imaging, sentinel lymph node mapping in cancer patients, and stem cell tracking. The new MCP that we introduce here have three times higher magnetic particle spectroscopy performance at lower and middle harmonics and five times higher MPS signal strength at higher harmonics compared with Resovist®. In addition, the new MCP have also an improved in vivo MPI performance compared to Resovist®, and we here report the first in vivo MPI investigation of this new generation of magnetic nanoparticles.
Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medical imaging modality, and magnetic resonance imaging (MRI). The magnetic nanoparticles are biocompatible and thus potential candidates for future biomedical applications such as cardiovascular imaging, sentinel lymph node mapping in cancer patients, and stem cell tracking. The new MCP that we introduce here have three times higher magnetic particle spectroscopy performance at lower and middle harmonics and five times higher MPS signal strength at higher harmonics compared with Resovist®. In addition, the new MCP have also an improved in vivo MPI performance compared to Resovist®, and we here report the first in vivo MPI investigation of this new generation of magnetic nanoparticles.Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medical imaging modality, and magnetic resonance imaging (MRI). The magnetic nanoparticles are biocompatible and thus potential candidates for future biomedical applications such as cardiovascular imaging, sentinel lymph node mapping in cancer patients, and stem cell tracking. The new MCP that we introduce here have three times higher magnetic particle spectroscopy performance at lower and middle harmonics and five times higher MPS signal strength at higher harmonics compared with Resovist®. In addition, the new MCP have also an improved in vivo MPI performance compared to Resovist®, and we here report the first in vivo MPI investigation of this new generation of magnetic nanoparticles.
Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric oxygen. This step yields green rust, which is oxidized to obtain magnetic nanoparticles, which probably consist of a magnetite/maghemite mixed-phase. Final growth and annealing at 90°C in the presence of a large excess of carboxymethyl dextran gives MCP very promising magnetic properties for magnetic particle imaging (MPI), an emerging medical imaging modality, and magnetic resonance imaging (MRI). The magnetic nanoparticles are biocompatible and thus potential candidates for future biomedical applications such as cardiovascular imaging, sentinel lymph node mapping in cancer patients, and stem cell tracking. The new MCP that we introduce here have three times higher magnetic particle spectroscopy performance at lower and middle harmonics and five times higher MPS signal strength at higher harmonics compared with Resovist®. In addition, the new MCP have also an improved in vivo MPI performance compared to Resovist ® , and we here report the first in vivo MPI investigation of this new generation of magnetic nanoparticles.
Author Hamm, Bernd
Trahms, Lutz
Schnorr, Jörg
Taupitz, Matthias
Ariza de Schellenberger, Angela
Eberbeck, Dietmar
Kratz, Harald
Kosch, Olaf
Wagner, Susanne
AuthorAffiliation 1 Charité –Universitätsmedizin Berlin, Institute of Radiology, Berlin, Germany
2 Physikalisch-Technische Bundesanstalt, Berlin, Germany
The University of Liverpool, UNITED KINGDOM
AuthorAffiliation_xml – name: The University of Liverpool, UNITED KINGDOM
– name: 1 Charité –Universitätsmedizin Berlin, Institute of Radiology, Berlin, Germany
– name: 2 Physikalisch-Technische Bundesanstalt, Berlin, Germany
Author_xml – sequence: 1
  givenname: Harald
  orcidid: 0000-0003-0126-0288
  surname: Kratz
  fullname: Kratz, Harald
– sequence: 2
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  surname: Taupitz
  fullname: Taupitz, Matthias
– sequence: 3
  givenname: Angela
  surname: Ariza de Schellenberger
  fullname: Ariza de Schellenberger, Angela
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  fullname: Kosch, Olaf
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  fullname: Schnorr, Jörg
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29300729$$D View this record in MEDLINE/PubMed
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Copyright 2018 Kratz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2018 Kratz et al 2018 Kratz et al
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Snippet Synthesis of novel magnetic multicore particles (MCP) in the nano range, involves alkaline precipitation of iron(II) chloride in the presence of atmospheric...
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SubjectTerms Atmospheric oxygen
Biocompatibility
Biology and Life Sciences
Biomedical materials
Cancer
Cell cycle
Contrast agents
Decomposition
Dextran
Earth Sciences
Engineering and Technology
Green rust
Higher harmonics
Humans
Hyperthermia
In vivo methods and tests
Iron
Iron chlorides
Lymph nodes
Magnetic properties
Magnetic resonance
Magnetic Resonance Imaging
Magnetics
Magnetite
Medical imaging
Medical research
Medical wastes
Medicine and Health Sciences
Mesenchymal stem cells
Methods
Microscopy, Electron, Transmission
Nanoparticles
NMR
Nuclear magnetic resonance
Oxygen
Physical Sciences
Precipitation
Rainfall
Research and Analysis Methods
Signal strength
Spectroscopy
Stem cells
Synthesis
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Title Novel magnetic multicore nanoparticles designed for MPI and other biomedical applications: From synthesis to first in vivo studies
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http://dx.doi.org/10.1371/journal.pone.0190214
Volume 13
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