MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease - Balusu, Sriram; Horré, Katrien; Thrupp, Nicola; Craessaerts, Katleen; Snellinx, An; Serneels, Lutgarde; T’Syen, Dries; Chrysidou, Iordana; Arranz, Amaia M.; Sierksma, Annerieke; Simrén, Joel; Karikari, Thomas K.; et al. (Science (American Association for the Advancement of Science), 2023)
Keywords: Alzheimer Disease; Alzheimer Disease - pathology; Alzheimer's disease; Animals; genetics; Heterografts; Humans; Kinases; Long Noncoding; metabolism; Mice; Necroptosis; Necroptosis - genetics; Neurodegenerative diseases; Neurons; Neurons - pathology; Neurosciences; Neurovetenskaper; pathology; Protein Kinases; Protein Kinases - genetics; Receptor-Interacting Protein Serine-Threonine Kinases; Receptor-Interacting Protein Serine-Threonine Kinases - genetics; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Senile plaques; Xenografts; Xenotransplantation