α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population - Gall, Walter E.; Beebe, Kirk; Lawton, Kay A.; Adam, Klaus-Peter; Mitchell, Matthew W.; Nakhle, Pamela J.; Ryals, John A.; Milburn, Michael V.; Nannipieri, Monica; Camastra, Stefania; Natali, Andrea; Ferrannini, Ele (PloS one, 2010)
Keywords: Adult; Amino acids; Biochemistry; Bioindicators; Biomarkers; Biomarkers - metabolism; Biosynthesis; Biotechnology; Blood glucose; Blood Glucose - metabolism; Body mass; Cardiovascular disease; Cardiovascular diseases; Chromatography; Correlation analysis; Demography; Diabetes; Diabetes and Endocrinology; Diabetes and Endocrinology/Obesity; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus - blood; Diabetes Mellitus - metabolism; Diagnostic systems; Dilution; Disease control; Fatty acids; Female; Glucose; Glucose Intolerance - metabolism; Glucose tolerance; Health risks; Humans; Hydroxybutyrates - metabolism; Identification methods; Insulin; Insulin Resistance; Intermediates; Internal medicine; Intolerance; Lipid peroxidation; Male; Mass spectrometry; Mass spectroscopy; Medicine; Metabolism; Metabolites; Metabolome; Middle Aged; Models, Biological; Organic acids; Oxidation; Oxidative stress; Pathogenesis; Population (statistical); Public Health and Epidemiology/Preventive Medicine; Receptor, Insulin - metabolism; Resistance factors; Risk factors; Rodents; Scientific imaging; Sensitivity; Sensitivity analysis; Statistical analysis; North Carolina; United States--US; Italy