HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis - Zhang, Da-Wei; Zhao, You-Xu; Wei, Ding; Li, Ya-Lin; Zhang, Yang; Wu, Jiao; Xu, Jing; Chen, Changsheng; Tang, Hao; Zhang, Wei; Gong, Li; Han, Ying; et al. (Journal of hepatology, 2012)
Keywords: Animals; Antibody; Apoptosis; Basigin - physiology; Biological and medical sciences; Carbon Tetrachloride - metabolism; Carbon Tetrachloride - toxicity; Cell Line; EMMPRIN; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatic Stellate Cells - physiology; Humans; Liver cirrhosis; Liver Cirrhosis - etiology; Liver Cirrhosis - therapy; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical sciences; Mice; Mice, Inbred BALB C; Myofibroblasts; Other diseases. Semiology; TGF-β1; Transforming Growth Factor beta1 - physiology; ALAT; IHC; Antibody; HCC; snc-RNA; EMT; ECM; MMP; α-SMA; FITC; ECOD; HTNV; CYP450; CCl4; TGF-β1; EMMPRIN; HSCs; Myofibroblasts; HBV; Liver cirrhosis; TIMP; 7-ethoxycoumarin O-deethylase; α-smooth muscle actin; hepatitis B virus; alanine aminotransferase; extracellular matrix metalloproteinase inducer; Hantan virus; silencer-negative control siRNA; transforming growth factor-β1; immunohistochemistry; fluorescein isothiocyanate; hepatocellular carcinoma; epithelial–mesenchymal transition; hepatic stellate cells; carbon tetrachloride; cytochrome P450; CCl 4; tissue inhibitor of metalloproteinase; matrix metalloproteinase; extracellular matrix; Spider cell; Hepatic fibrosis; Targeted therapy; Liver; Myofibroblast; Hepatic disease; Activation; Cirrhosis; Treatment; Gastroenterology; Digestive diseases