Is continuous infusion of imipenem always the best choice? - Suchánková, Hana; Lipš, Michal; Urbánek, Karel; Neely, Michael N.; Strojil, Jan (International journal of antimicrobial agents, 2017)
Keywords: Acinetobacter; Aged; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; bacteria; Critical Illness; Critically ill; Cross Infection - drug therapy; data collection; Escherichia coli; Extended infusion; Female; Gram-Negative Bacteria - drug effects; Humans; imipenem; Imipenem - administration & dosage; Imipenem - pharmacokinetics; Infectious Disease; Infusions, Intravenous - methods; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Middle Aged; Monte Carlo method; Monte Carlo simulation; pathogens; patients; Pharmacodynamics; Pharmacokinetics; Plasma - chemistry; Pneumonia; Pneumonia, Bacterial - drug therapy; prediction; Pseudomonas aeruginosa; risk factors; Staphylococcus aureus; Staphylococcus aureus - drug effects; Time Factors; Pneumonia; Pharmacodynamics; Pharmacokinetics; Critically ill; Extended infusion; Monte Carlo simulation