MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus
Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD...
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| Published in | Clinical immunology (Orlando, Fla.) Vol. 141; no. 1; pp. 49 - 57 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
01.10.2011
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1521-6616 1521-7035 1521-7035 |
| DOI | 10.1016/j.clim.2011.05.002 |
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| Abstract | Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.
► Antibodies against MAP3733c and MAP3738c in T1DM and T2DM sera were searched. ► Both proteins are species-specific and belong to a MAP pathogenicity island. ► Sera from 43 T1DM patients, 56 T2DM patients and 48 healthy subjects were evaluated ► A significative response was observed in T1DM patients but not in T2DM ► A MAP specific humoral response in T1DM but not in T2DM patients was observed |
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| AbstractList | Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.
► Antibodies against MAP3733c and MAP3738c in T1DM and T2DM sera were searched. ► Both proteins are species-specific and belong to a MAP pathogenicity island. ► Sera from 43 T1DM patients, 56 T2DM patients and 48 healthy subjects were evaluated ► A significative response was observed in T1DM patients but not in T2DM ► A MAP specific humoral response in T1DM but not in T2DM patients was observed Abstract Mycobacterium avium subsp. paratuberculosis ( Map ) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection. Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection.Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection. Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies have linked Map to type I Diabetes mellitus (T1DM). We searched the presence of antibodies against two specific proteins of Map (MptD and MAP3738c) in sera of patients affected by T1DM and type II Diabetes mellitus (T2DM). MptD protein (MAP3733c) has been recognized as a Map virulent factor whereas MAP3738c has not yet been studied. Both proteins are encoded by genes belonging to a Map specific pathogenicity island. Forty three T1DM patients' sera, 56 T2DM patients' sera and 48 healthy subjects' sera were screened by ELISA to evaluate the immunoresponse against MptD or MAP3738c recombinant proteins. Results showed a positive response to both proteins in T1DM patients whereas no difference with controls was found for T2DM patients. Results suggest a potential relation between T1DM and the bacterial infection. |
| Author | Paccagnini, Daniela Sechi, Leonardo Antonio Cossu, Andrea Cossu, Davide Pacifico, Adolfo Rosu, Valentina |
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| Cites_doi | 10.1128/CVI.00381-07 10.1016/S1473-3099(03)00724-2 10.1371/journal.pone.0004386 10.1111/j.1572-0241.2005.41415.x 10.1159/000053368 10.3748/wjg.v12.i44.7161 10.1016/j.micpath.2009.01.010 10.1111/j.1365-2249.2010.04132.x 10.1016/j.vetmic.2008.01.014 10.1371/journal.pone.0018482 10.1371/journal.pone.0007109 10.1186/1476-0711-7-9 10.1128/IAI.72.3.1265-1274.2004 10.1073/pnas.0505662102 10.1053/j.gastro.2006.04.021 10.1016/j.mehy.2006.04.029 10.1016/j.tube.2003.08.012 10.1016/j.mehy.2008.07.036 10.1016/S0378-1135(00)00247-9 10.1073/pnas.93.23.12828 10.1128/IAI.73.7.4214-4221.2005 10.1016/S1097-2765(00)80250-6 |
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| Keywords | Seroactivity Mycobacterium avium subsp. paratuberculosis Type I Diabetes mellitus (T1DM) Autoimmune diseases Recombinant proteins Endocrinopathy Immunopathology Paratuberculosis Mycobacterium avium Autoimmune disease Mycobacterial infection Infection Immunology Mycobacteriales Type 1 diabetes Bacteriosis Mycobacteriaceae Bacteria Actinomycetes Recombinant protein Mycobacterium avium subsp |
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| References | Chiodini, Thayer, Coutu (bb0015) 1996 Dow (bb0035) 2008; 71 Getts, Miller (bb0040) 2010; 160 Glickman, Cox, Jacobs (bb0085) 2000; 5 Dow (bb0005) 2006; 67 Sechi, Rosu, Pacifico, Fadda, Ahmed, Zanetti (bb0045) 2008; 15 Bannantine, Stabel (bb0110) 2000; 76 Crowe, Masone, Ribbe (bb0055) 1996; 58 Rosu, Ahmed, Paccagnini, Pacifico, Zanetti, Sechi (bb0115) 2008; 7 Polymeros, Bogdanos, Day, Arioli, Vergani, Forbes (bb0090) 2006; 131 Rosu, Ahmed, Paccagnini, Gerlach, Fadda, Hasnain, Zanetti, Sechi (bb0095) 2009; 4 Sechi, Gazouli, Sieswerda, Molicotti, Ahmed, Ikonomopoulos, Scanu, Paccagnini, Zanetti (bb0025) 2006; 12 Cossu, Cocco, Paccagnini, Masala, Ahmed, Frau, Marrosu, Sechi (bb0120) 2011 Passarino, Underhill, Cavalli-Sforza, Semino, Pes, Carru, Ferrucci, Bonafe, Franceschi, Deiana, Baggio, De Benedictis (bb0020) 2001; 52 Heinzmann, Wilkens, Dohmann, Gerlach (bb0070) 2008; 130 Greenstein (bb0010) 2003; 3 Sechi, Scanu, Molicotti, Cannas, Mura, Dettori, Fadda, Zanetti (bb0100) 2005; 100 Li, Bannantine, Zhang, Amonsin, May, Alt, Banerji, Kanjilal, Kapur (bb0050) 2005; 102 Miltner, Daroogheh, Mehta, Cirillo, Cirillo, Bermudez (bb0080) 2005; 73 Paccagnini, Sieswerda, Rosu, Masala, Pacifico, Gazouli, Ikonomopoulos, Ahmed, Zanetti, Sechi (bb0030) 2009; 4 Ratledge (bb0060) 2004; 84 Stratmann, Strommenger, Goethe, Dohmann, Gerlach, Stevenson, Li, Zhang, Kapur, Bull (bb0065) 2004; 72 Wu, Schmoller, Bannantine, Eckstein, Inamine, Livesey, Albrecht, Talaat (bb0105) 2009; 46 Yuan, Barry (bb0075) 1996; 93 Bannantine (10.1016/j.clim.2011.05.002_bb0110) 2000; 76 Getts (10.1016/j.clim.2011.05.002_bb0040) 2010; 160 Greenstein (10.1016/j.clim.2011.05.002_bb0010) 2003; 3 Cossu (10.1016/j.clim.2011.05.002_bb0120) 2011 Crowe (10.1016/j.clim.2011.05.002_bb0055) 1996; 58 Rosu (10.1016/j.clim.2011.05.002_bb0115) 2008; 7 Dow (10.1016/j.clim.2011.05.002_bb0035) 2008; 71 Sechi (10.1016/j.clim.2011.05.002_bb0045) 2008; 15 Wu (10.1016/j.clim.2011.05.002_bb0105) 2009; 46 Chiodini (10.1016/j.clim.2011.05.002_bb0015) 1996 Sechi (10.1016/j.clim.2011.05.002_bb0025) 2006; 12 Miltner (10.1016/j.clim.2011.05.002_bb0080) 2005; 73 Glickman (10.1016/j.clim.2011.05.002_bb0085) 2000; 5 Dow (10.1016/j.clim.2011.05.002_bb0005) 2006; 67 Li (10.1016/j.clim.2011.05.002_bb0050) 2005; 102 Ratledge (10.1016/j.clim.2011.05.002_bb0060) 2004; 84 Polymeros (10.1016/j.clim.2011.05.002_bb0090) 2006; 131 Paccagnini (10.1016/j.clim.2011.05.002_bb0030) 2009; 4 Heinzmann (10.1016/j.clim.2011.05.002_bb0070) 2008; 130 Yuan (10.1016/j.clim.2011.05.002_bb0075) 1996; 93 Rosu (10.1016/j.clim.2011.05.002_bb0095) 2009; 4 Sechi (10.1016/j.clim.2011.05.002_bb0100) 2005; 100 Passarino (10.1016/j.clim.2011.05.002_bb0020) 2001; 52 Stratmann (10.1016/j.clim.2011.05.002_bb0065) 2004; 72 |
| References_xml | – volume: 130 start-page: 330 year: 2008 end-page: 337 ident: bb0070 article-title: subsp. publication-title: Vet. Microbiol. – year: 2011 ident: bb0120 article-title: Association of publication-title: PLoS One – volume: 102 start-page: 12344 year: 2005 end-page: 12349 ident: bb0050 article-title: The complete genome sequence of Mycobacterium avium subspecies paratuberculosis publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 46 start-page: 222 year: 2009 end-page: 230 ident: bb0105 article-title: A novel cell wall lipopeptide is important for biofilm formation and pathogenicity of publication-title: Microb. Pathog. – start-page: 324 year: 1996 end-page: 328 ident: bb0015 article-title: Presence of Mycobacterium paratuberculosis antibodies in animal healthcare workers publication-title: Proceedings of the Fifth International Colloquium on Paratuberculosis – volume: 84 start-page: 110 year: 2004 end-page: 130 ident: bb0060 article-title: Iron, mycobacteria and tuberculosis publication-title: Tuberculosis – volume: 73 start-page: 4214 year: 2005 end-page: 4221 ident: bb0080 article-title: Identification of publication-title: Infect. Immun. – volume: 15 start-page: 320 year: 2008 end-page: 326 ident: bb0045 article-title: Humoral immune responses of type 1 diabetes patients to publication-title: Clin. Vaccine Immunol. – volume: 4 start-page: e4386 year: 2009 ident: bb0095 article-title: Specific immunoassays confirm association of publication-title: PLoS One – volume: 52 start-page: 136 year: 2001 end-page: 139 ident: bb0020 article-title: Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population publication-title: Hum. Hered. – volume: 71 start-page: 858 year: 2008 end-page: 861 ident: bb0035 article-title: Cows, Crohn's and more: is publication-title: Med. Hypotheses – volume: 72 start-page: 1265 year: 2004 end-page: 1274 ident: bb0065 article-title: A 38-kilobase pathogenicity island specific for publication-title: Infect. Immun. – volume: 3 start-page: 507 year: 2003 end-page: 514 ident: bb0010 article-title: Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease publication-title: Lancet Infect. Dis. – volume: 160 start-page: 15 year: 2010 end-page: 21 ident: bb0040 article-title: 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections publication-title: Clin. Exp. Immunol. – volume: 4 start-page: e7109 year: 2009 ident: bb0030 article-title: Linking chronic infection and autoimmune diseases: publication-title: PLoS One – volume: 100 start-page: 1529 year: 2005 end-page: 1536 ident: bb0100 article-title: Detection and isolation of publication-title: Am. J. Gastroenterol. – volume: 131 start-page: 85 year: 2006 end-page: 96 ident: bb0090 article-title: Does cross-reactivity between publication-title: Gastroenterology – volume: 76 start-page: 343 year: 2000 end-page: 358 ident: bb0110 article-title: HspX is present within publication-title: Vet. Microbiol. – volume: 67 start-page: 782 year: 2006 end-page: 785 ident: bb0005 article-title: Paratuberculosis and type I diabetes: is this the trigger? publication-title: Med. Hypotheses – volume: 5 start-page: 717 year: 2000 end-page: 727 ident: bb0085 article-title: A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of publication-title: Mol. Cell – volume: 58 start-page: 491 year: 1996 end-page: 510 ident: bb0055 article-title: One-step purification of recombinant proteins with the 6xHis tag and Ni-NTA resin publication-title: Methods Mol. Biol. – volume: 12 start-page: 7161 year: 2006 end-page: 7164 ident: bb0025 article-title: Relationship between Crohn's disease, infection with publication-title: World J. Gastroenterol. – volume: 93 start-page: 12828 year: 1996 end-page: 12833 ident: bb0075 article-title: A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 7 start-page: 9 year: 2008 ident: bb0115 article-title: subspecies publication-title: Ann. Clin. Microbiol. Antimicrob. – volume: 15 start-page: 320 year: 2008 ident: 10.1016/j.clim.2011.05.002_bb0045 article-title: Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis publication-title: Clin. Vaccine Immunol. doi: 10.1128/CVI.00381-07 – volume: 3 start-page: 507 year: 2003 ident: 10.1016/j.clim.2011.05.002_bb0010 article-title: Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(03)00724-2 – start-page: 324 year: 1996 ident: 10.1016/j.clim.2011.05.002_bb0015 article-title: Presence of Mycobacterium paratuberculosis antibodies in animal healthcare workers – volume: 58 start-page: 491 year: 1996 ident: 10.1016/j.clim.2011.05.002_bb0055 article-title: One-step purification of recombinant proteins with the 6xHis tag and Ni-NTA resin publication-title: Methods Mol. Biol. – volume: 4 start-page: e4386 year: 2009 ident: 10.1016/j.clim.2011.05.002_bb0095 article-title: Specific immunoassays confirm association of Mycobacterium avium subsp. paratuberculosis with type-1 but not type-2 diabetes mellitus publication-title: PLoS One doi: 10.1371/journal.pone.0004386 – volume: 100 start-page: 1529 year: 2005 ident: 10.1016/j.clim.2011.05.002_bb0100 article-title: Detection and isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn′s disease in Sardinia publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2005.41415.x – volume: 52 start-page: 136 year: 2001 ident: 10.1016/j.clim.2011.05.002_bb0020 article-title: Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population publication-title: Hum. Hered. doi: 10.1159/000053368 – volume: 12 start-page: 7161 year: 2006 ident: 10.1016/j.clim.2011.05.002_bb0025 article-title: Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v12.i44.7161 – volume: 46 start-page: 222 year: 2009 ident: 10.1016/j.clim.2011.05.002_bb0105 article-title: A novel cell wall lipopeptide is important for biofilm formation and pathogenicity of Mycobacterium avium subspecies paratuberculosis publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2009.01.010 – volume: 160 start-page: 15 year: 2010 ident: 10.1016/j.clim.2011.05.002_bb0040 article-title: 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections publication-title: Clin. Exp. Immunol. doi: 10.1111/j.1365-2249.2010.04132.x – volume: 130 start-page: 330 year: 2008 ident: 10.1016/j.clim.2011.05.002_bb0070 article-title: Mycobacterium avium subsp. paratuberculosis-specific mpt operon expressed in M. bovis BCG as vaccine candidate publication-title: Vet. Microbiol. doi: 10.1016/j.vetmic.2008.01.014 – year: 2011 ident: 10.1016/j.clim.2011.05.002_bb0120 article-title: Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients publication-title: PLoS One doi: 10.1371/journal.pone.0018482 – volume: 4 start-page: e7109 year: 2009 ident: 10.1016/j.clim.2011.05.002_bb0030 article-title: Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus publication-title: PLoS One doi: 10.1371/journal.pone.0007109 – volume: 7 start-page: 9 year: 2008 ident: 10.1016/j.clim.2011.05.002_bb0115 article-title: Mycobacterium avium subspecies paratuberculosis is not associated with type-2 diabetes mellitus publication-title: Ann. Clin. Microbiol. Antimicrob. doi: 10.1186/1476-0711-7-9 – volume: 72 start-page: 1265 year: 2004 ident: 10.1016/j.clim.2011.05.002_bb0065 article-title: A 38-kilobase pathogenicity island specific for Mycobacterium avium subsp. paratuberculosis encodes cell surface proteins expressed in the host publication-title: Infect. Immun. doi: 10.1128/IAI.72.3.1265-1274.2004 – volume: 102 start-page: 12344 year: 2005 ident: 10.1016/j.clim.2011.05.002_bb0050 article-title: The complete genome sequence of Mycobacterium avium subspecies paratuberculosis publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0505662102 – volume: 131 start-page: 85 year: 2006 ident: 10.1016/j.clim.2011.05.002_bb0090 article-title: Does cross-reactivity between Mycobacterium avium paratuberculosis and human intestinal antigens characterize Crohn's disease? publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.04.021 – volume: 67 start-page: 782 year: 2006 ident: 10.1016/j.clim.2011.05.002_bb0005 article-title: Paratuberculosis and type I diabetes: is this the trigger? publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2006.04.029 – volume: 84 start-page: 110 year: 2004 ident: 10.1016/j.clim.2011.05.002_bb0060 article-title: Iron, mycobacteria and tuberculosis publication-title: Tuberculosis doi: 10.1016/j.tube.2003.08.012 – volume: 71 start-page: 858 year: 2008 ident: 10.1016/j.clim.2011.05.002_bb0035 article-title: Cows, Crohn's and more: is Mycobacterium paratuberculosis a superantigen? publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2008.07.036 – volume: 76 start-page: 343 year: 2000 ident: 10.1016/j.clim.2011.05.002_bb0110 article-title: HspX is present within Mycobacterium paratuberculosis-infected macrophages and is recognized by sera from some infected cattle publication-title: Vet. Microbiol. doi: 10.1016/S0378-1135(00)00247-9 – volume: 93 start-page: 12828 year: 1996 ident: 10.1016/j.clim.2011.05.002_bb0075 article-title: A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.93.23.12828 – volume: 73 start-page: 4214 year: 2005 ident: 10.1016/j.clim.2011.05.002_bb0080 article-title: Identification of Mycobacterium avium genes that affect invasion of the intestinal epithelium publication-title: Infect. Immun. doi: 10.1128/IAI.73.7.4214-4221.2005 – volume: 5 start-page: 717 year: 2000 ident: 10.1016/j.clim.2011.05.002_bb0085 article-title: A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80250-6 |
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| Snippet | Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent studies... Abstract Mycobacterium avium subsp. paratuberculosis ( Map ) is the causative agent of Johne's disease, a chronic inflammation of ruminants' intestine. Recent... |
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| SubjectTerms | Adult Aged Allergy and Immunology Antibodies, Bacterial - blood Antigens, Bacterial - genetics Autoimmune diseases Bacterial Proteins - genetics Bacterial Proteins - immunology Base Sequence Biological and medical sciences Case-Control Studies Diabetes Complications - immunology Diabetes Complications - microbiology Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - microbiology Diabetes. Impaired glucose tolerance DNA, Bacterial - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Bacterial Humans Male Medical sciences Middle Aged Mycobacterium avium Mycobacterium avium subsp. paratuberculosis Mycobacterium avium subsp. paratuberculosis - genetics Mycobacterium avium subsp. paratuberculosis - immunology Paratuberculosis - complications Paratuberculosis - immunology Paratuberculosis - microbiology Recombinant proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Ruminantia Seroactivity Type I Diabetes mellitus (T1DM) Young Adult |
| Title | MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus |
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