Manifold population modeling as a neuro-imaging biomarker: Application to ADNI and ADNI-GO - Guerrero, R.; Wolz, R.; Rao, A.W.; Rueckert, D. (NeuroImage (Orlando, Fla.), 2014)
Keywords: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease - diagnosis; Alzheimer Disease - epidemiology; Alzheimer's disease; Alzheimer's disease (AD); Artificial Intelligence; Biological and medical sciences; Biomarkers; Brain - pathology; Causality; Classification; Clinical trials; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - epidemiology; Comorbidity; Computer Simulation; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Kernel density estimation; Laplacian eigenmaps; Magnetic Resonance Imaging - methods; Male; Manifold learning; Medical imaging; Medical sciences; Middle Aged; Mild cognitive impairment (MCI); Models, Statistical; Neuroimaging - methods; Neurology; Older people; Organic mental disorders. Neuropsychology; Patients; Pattern Recognition, Automated - methods; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reproducibility of Results; Sensitivity and Specificity; Sparse regression; Studies; Laplacian eigenmaps; Mild cognitive impairment (MCI); Classification; Alzheimer's disease (AD); Sparse regression; Manifold learning; Kernel density estimation; Nervous system diseases; Alzheimer disease; Biological marker; Density; Cerebral disorder; Learning; Acquisition process; Imaging; Central nervous system disease; Degenerative disease; mild cognitive impairment