STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling - Gestermann, N; Mekinian, A; Comets, E; Loiseau, P; Puechal, X; Hachulla, E; Gottenberg, J-E; Mariette, X; Miceli-Richard, C (Genes and immunity, 2010)
Keywords: 631/208/457/649; 631/250/516; 631/45/612/822; 692/699/249/1313/498; Alleles; Antigens, Differentiation; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Cohort Studies; Confidence intervals; Cytokines; eIF-2 Kinase - metabolism; Exocrine glands; Gene Expression; Gene polymorphism; Genes; Genetic aspects; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; GTP-Binding Proteins - metabolism; Human Genetics; Humans; Immunology; Interferon; Interleukin 12; Kinases; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Lupus; Membrane Proteins - metabolism; Myxovirus Resistance Proteins; Odds Ratio; original-article; Peripheral blood mononuclear cells; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide - genetics; Risk factors; Signal Transduction - genetics; Signal Transduction - immunology; Sjogren's syndrome; Sjogren's Syndrome - genetics; Stat1 protein; Stat4 protein; STAT4 Transcription Factor - genetics; Transcription factors; France; Paris France; STAT4; promoter; Sjögren's syndrome; genetic polymorphism