Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease

Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma concentrations of NP products within the normal range reflect cardio-metabolic health is unknown. Plasma NTproANP, NTproBNP and NTproCNP and...

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Published inScientific reports Vol. 9; no. 1; pp. 12108 - 10
Main Authors Prickett, Timothy C. R., Spittlehouse, Janet K., Miller, Allison L., Liau, Yusmiati, Kennedy, Martin A., Cameron, Vicky A., Pearson, John F., Boden, Joseph M., Troughton, Richard W., Espiner, Eric A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 20.08.2019
Nature Publishing Group
Subjects
13/1
13/56
692/4019/592
692/499
692/53/2423
82/80
Atrial Natriuretic Factor - blood
Cardiovascular disease
Cardiovascular diseases
Cardiovascular System - metabolism
Cardiovascular System - pathology
Coronary artery disease
Female
Genetic diversity
Genetic factors
Genetic variance
Heart diseases
Heart Diseases - blood
Heart Diseases - epidemiology
Heart Diseases - pathology
Humanities and Social Sciences
Humans
Male
Metabolism
Middle Aged
multidisciplinary
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, C-Type - blood
Natriuretic Peptides - blood
Peptide Fragments - blood
Peptides
Risk Factors
Science
Science (multidisciplinary)
Sex Characteristics
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-019-48553-y

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Abstract Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma concentrations of NP products within the normal range reflect cardio-metabolic health is unknown. Plasma NTproANP, NTproBNP and NTproCNP and their bioactive counterparts were measured in a random sample of 348 community dwellers aged 49–51 yr without heart disease and associations sought with established vascular risk factors, echocardiographic indices and a genetic variant previously linked with BNP. Stratified by sex, each of ten vascular risk factors were positively associated with NTproCNP whereas associations with NTproBNP and NTproANP were all negative. In both sexes, higher plasma NTproCNP was associated with higher arterial elastance, lower LV stroke volume and lower LV end diastolic volume. Exactly opposite associations were found with plasma NTproBNP or NTproANP. Sex specific differences were identified: positive association of NTproBNP with LV end systolic volume and the negative association with LV elastance were found only in males. The genetic variant rs198358 was independently associated with NTproBNP but not with NTproANP. In conclusion, higher NTproCNP is likely to be an adaptive response to impaired LV relaxation whereas genetic factors likely contribute to higher NTproBNP and improved cardio-metabolic health at midlife.
AbstractList Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma concentrations of NP products within the normal range reflect cardio-metabolic health is unknown. Plasma NTproANP, NTproBNP and NTproCNP and their bioactive counterparts were measured in a random sample of 348 community dwellers aged 49-51 yr without heart disease and associations sought with established vascular risk factors, echocardiographic indices and a genetic variant previously linked with BNP. Stratified by sex, each of ten vascular risk factors were positively associated with NTproCNP whereas associations with NTproBNP and NTproANP were all negative. In both sexes, higher plasma NTproCNP was associated with higher arterial elastance, lower LV stroke volume and lower LV end diastolic volume. Exactly opposite associations were found with plasma NTproBNP or NTproANP. Sex specific differences were identified: positive association of NTproBNP with LV end systolic volume and the negative association with LV elastance were found only in males. The genetic variant rs198358 was independently associated with NTproBNP but not with NTproANP. In conclusion, higher NTproCNP is likely to be an adaptive response to impaired LV relaxation whereas genetic factors likely contribute to higher NTproBNP and improved cardio-metabolic health at midlife.Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma concentrations of NP products within the normal range reflect cardio-metabolic health is unknown. Plasma NTproANP, NTproBNP and NTproCNP and their bioactive counterparts were measured in a random sample of 348 community dwellers aged 49-51 yr without heart disease and associations sought with established vascular risk factors, echocardiographic indices and a genetic variant previously linked with BNP. Stratified by sex, each of ten vascular risk factors were positively associated with NTproCNP whereas associations with NTproBNP and NTproANP were all negative. In both sexes, higher plasma NTproCNP was associated with higher arterial elastance, lower LV stroke volume and lower LV end diastolic volume. Exactly opposite associations were found with plasma NTproBNP or NTproANP. Sex specific differences were identified: positive association of NTproBNP with LV end systolic volume and the negative association with LV elastance were found only in males. The genetic variant rs198358 was independently associated with NTproBNP but not with NTproANP. In conclusion, higher NTproCNP is likely to be an adaptive response to impaired LV relaxation whereas genetic factors likely contribute to higher NTproBNP and improved cardio-metabolic health at midlife.
Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma concentrations of NP products within the normal range reflect cardio-metabolic health is unknown. Plasma NTproANP, NTproBNP and NTproCNP and their bioactive counterparts were measured in a random sample of 348 community dwellers aged 49–51 yr without heart disease and associations sought with established vascular risk factors, echocardiographic indices and a genetic variant previously linked with BNP. Stratified by sex, each of ten vascular risk factors were positively associated with NTproCNP whereas associations with NTproBNP and NTproANP were all negative. In both sexes, higher plasma NTproCNP was associated with higher arterial elastance, lower LV stroke volume and lower LV end diastolic volume. Exactly opposite associations were found with plasma NTproBNP or NTproANP. Sex specific differences were identified: positive association of NTproBNP with LV end systolic volume and the negative association with LV elastance were found only in males. The genetic variant rs198358 was independently associated with NTproBNP but not with NTproANP. In conclusion, higher NTproCNP is likely to be an adaptive response to impaired LV relaxation whereas genetic factors likely contribute to higher NTproBNP and improved cardio-metabolic health at midlife.
ArticleNumber 12108
Author Liau, Yusmiati
Boden, Joseph M.
Espiner, Eric A.
Prickett, Timothy C. R.
Spittlehouse, Janet K.
Pearson, John F.
Miller, Allison L.
Troughton, Richard W.
Cameron, Vicky A.
Kennedy, Martin A.
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Snippet Natriuretic Peptides (NP) are important in maintaining normal cardiac and metabolic status and have been used to predict cardiovascular events. Whether plasma...
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pubmedcentral
proquest
pubmed
crossref
springer
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Index Database
Enrichment Source
Publisher
StartPage 12108
SubjectTerms 13/1
13/56
692/4019/592
692/499
692/53/2423
82/80
Atrial Natriuretic Factor - blood
Cardiovascular disease
Cardiovascular diseases
Cardiovascular System - metabolism
Cardiovascular System - pathology
Coronary artery disease
Female
Genetic diversity
Genetic factors
Genetic variance
Heart diseases
Heart Diseases - blood
Heart Diseases - epidemiology
Heart Diseases - pathology
Humanities and Social Sciences
Humans
Male
Metabolism
Middle Aged
multidisciplinary
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, C-Type - blood
Natriuretic Peptides - blood
Peptide Fragments - blood
Peptides
Risk Factors
Science
Science (multidisciplinary)
Sex Characteristics
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Title Contrasting signals of cardiovascular health among natriuretic peptides in subjects without heart disease
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