Crucial Role of Extracellular Vesicles in Bronchial Asthma

Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for...

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Published inInternational journal of molecular sciences Vol. 20; no. 10; p. 2589
Main Authors Nagano, Tatsuya, Katsurada, Masahiro, Dokuni, Ryota, Hazama, Daisuke, Kiriu, Tatsunori, Umezawa, Kanoko, Kobayashi, Kazuyuki, Nishimura, Yoshihiro
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.05.2019
MDPI
Subjects
Allergies
Angiogenesis
Asthma
Biomarkers
Cell adhesion & migration
Chemokines
Cytokines
Extracellular vesicles
Fibroblasts
Homeostasis
Inflammation
Inflammatory diseases
Kinases
Lymphocytes
MicroRNAs
Neutrophils
Pathogenesis
Peptides
Proteins
Respiratory system
Review
Roles
Transcription factors
microparticles
extracellular vesicles
exosomes
apoptotic bodies
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms20102589

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Abstract Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.
AbstractList Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.
[...]EVs have received considerable attention as novel biomarkers and therapeutic targets. [...]by using microarray analyses of BALF, 16 miRNAs containing let-7 and miRNA-200 seem to be useful as novel biomarkers of BA [31]. Alveolar macrophages infected with mycobacteria secrete EVs which contain pathogen-derived proinflammatory molecules and secrete heat-shock proteins (HSP)70, which activates the nuclear factor-κB (NF-κB) pathway by stimulating toll-like receptors (TLRs) [44], leading to the secretion of proinflammatory cytokines [45,46]. [...]alveolar macrophages secrete EVs that contain suppressors of cytokine signaling (SOCS)-1 and SOCS-3, resulting in inhibition of Janus kinase and signal transducers and activators of transcription signaling [47]. [...]these events cause vasodilation, increased vascular permeability, bronchoconstriction, and mucus secretion from airways [56].
Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis because they contain intracellular proteins and nucleic acids. Epithelial cells from mice suffering from bronchial asthma (BA) secrete more EVs and suppress inflammation-induced EV production. Moreover, microarray analyses of bronchoalveolar lavage fluid have revealed that several microRNAs are useful novel biomarkers of BA. Mesenchymal stromal cell-derived EVs are possible candidates of novel BA therapy. In this review, we highlight the biologic roles of EVs in BA and review novel EV-targeted therapy to help understanding by clinicians and biologists.
Author Nishimura, Yoshihiro
Umezawa, Kanoko
Nagano, Tatsuya
Katsurada, Masahiro
Hazama, Daisuke
Dokuni, Ryota
Kiriu, Tatsunori
Kobayashi, Kazuyuki
AuthorAffiliation Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; mskatsu@med.kobe-u.ac.jp (M.K.); rdokuni@med.kobe-u.ac.jp (R.D.); dhazama@med.kobe-u.ac.jp (D.H.); tkiriu@med.kobe-u.ac.jp (T.K.); kanoko03@med.kobe-u.ac.jp (K.U.); kkoba@med.kobe-u.ac.jp (K.K.); nishiy@med.kobe-u.ac.jp (Y.N.)
AuthorAffiliation_xml – name: Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; mskatsu@med.kobe-u.ac.jp (M.K.); rdokuni@med.kobe-u.ac.jp (R.D.); dhazama@med.kobe-u.ac.jp (D.H.); tkiriu@med.kobe-u.ac.jp (T.K.); kanoko03@med.kobe-u.ac.jp (K.U.); kkoba@med.kobe-u.ac.jp (K.K.); nishiy@med.kobe-u.ac.jp (Y.N.)
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Keywords microparticles
extracellular vesicles
exosomes
apoptotic bodies
Language English
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PublicationYear 2019
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural...
[...]EVs have received considerable attention as novel biomarkers and therapeutic targets. [...]by using microarray analyses of BALF, 16 miRNAs containing...
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SubjectTerms Allergies
Angiogenesis
Asthma
Biomarkers
Cell adhesion & migration
Chemokines
Cytokines
Extracellular vesicles
Fibroblasts
Homeostasis
Inflammation
Inflammatory diseases
Kinases
Lymphocytes
MicroRNAs
Neutrophils
Pathogenesis
Peptides
Proteins
Respiratory system
Review
Roles
Transcription factors
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Title Crucial Role of Extracellular Vesicles in Bronchial Asthma
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