Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects - Lachmandas, Ekta; Eckold, Clare; Böhme, Julia; Koeken, Valerie A. C. M.; Marzuki, Mardiana Binte; Blok, Bastiaan; Arts, Rob J. W.; Chen, Jinmiao; Teng, Karen W. W.; Ratter, Jacqueline; Smolders, Elise J.; van den Heuvel, Corina; et al. (The Journal of infectious diseases, 2019)
Keywords: Antidiabetics; antimycobacterial mechanisms; Cell Proliferation - drug effects; Diabetes mellitus; Down-Regulation - drug effects; gene transcription; Healthy Volunteers; host-directed therapy; Host-Pathogen Interactions - drug effects; Humans; Hypoglycemic Agents - pharmacology; Immune response; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - microbiology; Major and Brief Reports; Metabolism; Metformin; Metformin - pharmacology; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Mycobacterium tuberculosis; Mycobacterium tuberculosis - pathogenicity; Myeloid cells; Myeloid Cells - drug effects; Myeloid Cells - metabolism; Oxidative phosphorylation; PATHOGENESIS AND HOST RESPONSE; Peripheral blood mononuclear cells; Phagocytosis; Phagocytosis - drug effects; Phosphorylation; Rapamycin; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; TOR protein; Transcription; Tuberculosis; Tuberculosis - metabolism; Tuberculosis - microbiology; Tumor necrosis factor-α; Up-Regulation - drug effects; γ-Interferon; gene transcription; host-directed therapy; Metformin; antimycobacterial mechanisms; tuberculosis