Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity

The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopami...

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Published inRespiratory physiology & neurobiology Vol. 168; no. 3; pp. 250 - 253
Main Authors Janssen, C., Beloka, S., Kayembe, P., Deboeck, G., Adamopoulos, D., Naeije, R., van de Borne, P.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 30.09.2009
Elsevier
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Online AccessGet full text
ISSN1569-9048
1878-1519
1878-1519
DOI10.1016/j.resp.2009.07.010

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Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg −1 min −1) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O 2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity.
AbstractList The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 mu g kg super(-1) min super(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the [MathML equation] output slope (24.61 +/- 1.84 vs. 23.09 +/- 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, [MathML equation] and O sub(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the [MathML equation] slope during dynamic exercise, with no change in aerobic exercise capacity.
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg −1 min −1) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O 2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity.
Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg−1 min−1 ) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity.
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.
Author Deboeck, G.
Janssen, C.
Beloka, S.
Kayembe, P.
Naeije, R.
van de Borne, P.
Adamopoulos, D.
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Cites_doi 10.1152/jappl.1974.36.4.457
10.1111/j.1749-6632.1963.tb13497.x
10.1056/NEJM197111112852002
10.1213/00000539-198204000-00004
10.1113/jphysiol.1986.sp016311
10.1113/jphysiol.1984.sp015412
10.1113/jphysiol.2007.147421
10.1113/jphysiol.1986.sp016292
10.1152/jappl.1986.61.6.2102
10.1152/jappl.1975.39.1.18
10.1152/jappl.1983.54.5.1394
10.1152/physrev.1994.74.4.829
10.1345/aph.1G685
10.1161/01.CIR.98.2.126
10.1152/ajplegacy.1971.221.6.1629
10.1111/j.1469-7793.1998.773bj.x
10.1161/01.RES.0000266974.84590.d2
10.1152/jappl.1979.47.5.954
10.1152/jappl.1986.60.3.1016
10.1152/jappl.1994.77.4.1907
10.1152/jappl.1975.39.3.354
10.1152/jappl.1986.60.6.2020
10.1249/00005768-199403000-00010
10.1016/j.cardiores.2006.03.017
10.1172/JCI106943
10.1161/01.RES.10.2.237
10.1172/JCI108983
10.1152/jappl.1973.35.2.236
10.1378/chest.106.1.131
10.1152/jappl.1993.75.3.1385
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Issue 3
Keywords Chemoreflex
Cardiopulmonary exercise testing
Autonomic nervous system
Chemoreceptor
Physical exercise
Dopamine
Catecholamine
Respiratory system
Vertebrata
Mammalia
Ventilatory response
Neurotransmitter
Chemosensitivity
Inhibition
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References Stickland, Morgan, Dempsey (bib23) 2008; 586
Beaver, Wasserman, Whipp (bib3) 1986; 60
Schneider, McEniery, Solomon, Jurimae, Wehr (bib21) 1994; 77
Winer, Brown, Michels (bib33) 1991
Gonzalez, Almaraz, Obeso, Rigual (bib10) 1994; 74
Oldendorf (bib18) 1971; 221
Heistad, Wheeler, Mark, Schmid, Abboud (bib12) 1972; 51
Wasserman, Whipp, Koyal, Cleary (bib28) 1975; 39
Jones, Robertson, Kane (bib14) 1979; 47
Horwitz, FOX, Goldberg (bib13) 1962; 10
Whipp (bib31) 1994; 26
van de Borne, Oren, Somers (bib24) 1998; 98
Boetger, Ward (bib4) 1986; 61
Whipp, Davis (bib32) 1979; 11
Lugliani, Whipp, Seard, Wasserman (bib16) 1971; 285
Welsh, Heistad, Abboud (bib30) 1978; 61
Dejours (bib6) 1963; 109
Ward, Bellville (bib25) 1982; 61
Stickland, Miller, Smith, Dempsey (bib22) 2007; 100
Dempsey, Hanson, Henderson (bib7) 1984; 355
Wasserman, Whipp, Castagna (bib27) 1974; 36
Brunton L., Lazo J., Parker K., 2005. Goodman and Gilman's the pharmacological basis of therapeutics. 11th ed. McGraw-Hill.
Griffiths, Henson, Whipp (bib11) 1986; 380
Maher, Jones, Hartley, Williams, Rose (bib17) 1975; 39
Pan, Forster, Bisgard, Kaminski, Dorsey, Busch (bib19) 1983; 54
Band, Linton (bib2) 1986; 381
Wasserman, Hansen, Sue, Stringer, Whipp (bib26) 2004
Goldberg (bib9) 1972; 24
Pan, Forster, Bisgard, Murphy, Lowry (bib20) 1986; 60
Allen (bib1) 1998; 510
Li, Xia, Zheng, Gao, Li, Liu, Patel, Wang, Schultz (bib15) 2006; 71
Wasserman, Whipp, Koyl, Beaver (bib29) 1973; 35
Zimmerman, Miller, Brown, Bhuptani, Sloane, Teirstein (bib34) 1994; 106
Forster, Dunning, Lowry, Erickson, Forster, Pan, Brice, Effros (bib8) 1993; 75
Horwitz (10.1016/j.resp.2009.07.010_bib13) 1962; 10
Oldendorf (10.1016/j.resp.2009.07.010_bib18) 1971; 221
Ward (10.1016/j.resp.2009.07.010_bib25) 1982; 61
van de Borne (10.1016/j.resp.2009.07.010_bib24) 1998; 98
Schneider (10.1016/j.resp.2009.07.010_bib21) 1994; 77
Allen (10.1016/j.resp.2009.07.010_bib1) 1998; 510
Pan (10.1016/j.resp.2009.07.010_bib20) 1986; 60
Winer (10.1016/j.resp.2009.07.010_bib33) 1991
Stickland (10.1016/j.resp.2009.07.010_bib23) 2008; 586
Whipp (10.1016/j.resp.2009.07.010_bib31) 1994; 26
Li (10.1016/j.resp.2009.07.010_bib15) 2006; 71
Lugliani (10.1016/j.resp.2009.07.010_bib16) 1971; 285
Wasserman (10.1016/j.resp.2009.07.010_bib28) 1975; 39
Beaver (10.1016/j.resp.2009.07.010_bib3) 1986; 60
Goldberg (10.1016/j.resp.2009.07.010_bib9) 1972; 24
Dempsey (10.1016/j.resp.2009.07.010_bib7) 1984; 355
Wasserman (10.1016/j.resp.2009.07.010_bib29) 1973; 35
Griffiths (10.1016/j.resp.2009.07.010_bib11) 1986; 380
Wasserman (10.1016/j.resp.2009.07.010_bib26) 2004
Wasserman (10.1016/j.resp.2009.07.010_bib27) 1974; 36
Boetger (10.1016/j.resp.2009.07.010_bib4) 1986; 61
Pan (10.1016/j.resp.2009.07.010_bib19) 1983; 54
Maher (10.1016/j.resp.2009.07.010_bib17) 1975; 39
Whipp (10.1016/j.resp.2009.07.010_bib32) 1979; 11
Stickland (10.1016/j.resp.2009.07.010_bib22) 2007; 100
Band (10.1016/j.resp.2009.07.010_bib2) 1986; 381
10.1016/j.resp.2009.07.010_bib5
Dejours (10.1016/j.resp.2009.07.010_bib6) 1963; 109
Welsh (10.1016/j.resp.2009.07.010_bib30) 1978; 61
Gonzalez (10.1016/j.resp.2009.07.010_bib10) 1994; 74
Jones (10.1016/j.resp.2009.07.010_bib14) 1979; 47
Heistad (10.1016/j.resp.2009.07.010_bib12) 1972; 51
Forster (10.1016/j.resp.2009.07.010_bib8) 1993; 75
Zimmerman (10.1016/j.resp.2009.07.010_bib34) 1994; 106
References_xml – volume: 35
  start-page: 236
  year: 1973
  end-page: 243
  ident: bib29
  article-title: Anaerobic threshold and respiratory gas exchange during exercise
  publication-title: J. Appl. Physiol.
– volume: 60
  start-page: 1016
  year: 1986
  end-page: 1024
  ident: bib20
  article-title: Independence of exercise hyperpnea and acidosis during high-intensity exercise in ponies
  publication-title: J. Appl. Physiol.
– volume: 109
  start-page: 682
  year: 1963
  end-page: 695
  ident: bib6
  article-title: Control of respiration by arterial chemoreceptors
  publication-title: Ann. N.Y. Acad. Sci.
– year: 2004
  ident: bib26
  article-title: Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications
– volume: 106
  start-page: 131
  year: 1994
  end-page: 136
  ident: bib34
  article-title: Estimated vs actual values for dead space/tidal volume ratios during incremental exercise in patients evaluated for dyspnea
  publication-title: Chest
– volume: 285
  start-page: 1105
  year: 1971
  end-page: 1111
  ident: bib16
  article-title: Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man
  publication-title: N. Engl. J. Med.
– volume: 47
  start-page: 954
  year: 1979
  end-page: 960
  ident: bib14
  article-title: Difference between end-tidal and arterial
  publication-title: J. Appl. Physiol.
– volume: 586
  start-page: 1743
  year: 2008
  end-page: 1754
  ident: bib23
  article-title: Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans
  publication-title: J. Physiol.
– volume: 510
  start-page: 773
  year: 1998
  end-page: 781
  ident: bib1
  article-title: Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity
  publication-title: J. Physiol.
– volume: 61
  start-page: 2102
  year: 1986
  end-page: 2107
  ident: bib4
  article-title: Effect of dopamine on transient ventilatory response to exercise
  publication-title: J. Appl. Physiol.
– volume: 51
  start-page: 1469
  year: 1972
  end-page: 1475
  ident: bib12
  article-title: Effects of adrenergic stimulation on ventilation in man
  publication-title: J. Clin. Invest.
– volume: 74
  start-page: 829
  year: 1994
  end-page: 898
  ident: bib10
  article-title: Carotid body chemoreceptors: from natural stimuli to sensory discharges
  publication-title: Physiol. Rev.
– volume: 355
  start-page: 161
  year: 1984
  end-page: 175
  ident: bib7
  article-title: Exercise-induced arterial hypoxaemia in healthy human subjects at sea level
  publication-title: J. Physiol.
– volume: 36
  start-page: 457
  year: 1974
  end-page: 464
  ident: bib27
  article-title: Cardiodynamic hyperpnea: hyperpnea secondary to cardiac output increase
  publication-title: J. Appl. Physiol.
– volume: 54
  start-page: 1394
  year: 1983
  end-page: 1402
  ident: bib19
  article-title: Hyperventilation in ponies at the onset of and during steady-state exercise
  publication-title: J. Appl. Physiol.
– volume: 221
  start-page: 1629
  year: 1971
  end-page: 1639
  ident: bib18
  article-title: Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
  publication-title: Am. J. Physiol.
– volume: 11
  start-page: 204
  year: 1979
  end-page: 212
  ident: bib32
  article-title: Peripheral chemoreceptors and exercise hyperpnea
  publication-title: Med. Sci. Sports
– volume: 60
  start-page: 2020
  year: 1986
  end-page: 2027
  ident: bib3
  article-title: A new method for detecting anaerobic threshold by gas exchange
  publication-title: J. Appl. Physiol.
– volume: 77
  start-page: 1907
  year: 1994
  end-page: 1912
  ident: bib21
  article-title: Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment
  publication-title: J. Appl. Physiol.
– volume: 98
  start-page: 126
  year: 1998
  end-page: 131
  ident: bib24
  article-title: Dopamine depresses minute ventilation in patients with heart failure
  publication-title: Circulation
– year: 1991
  ident: bib33
  article-title: Statistical Principles in Experimental Design
– volume: 71
  start-page: 129
  year: 2006
  end-page: 138
  ident: bib15
  article-title: Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits
  publication-title: Cardiovasc. Res.
– volume: 61
  start-page: 333
  year: 1982
  end-page: 337
  ident: bib25
  article-title: Reduction of hypoxic ventilatory drive by dopamine
  publication-title: Anesth. Analg.
– reference: Brunton L., Lazo J., Parker K., 2005. Goodman and Gilman's the pharmacological basis of therapeutics. 11th ed. McGraw-Hill.
– volume: 381
  start-page: 39
  year: 1986
  end-page: 47
  ident: bib2
  article-title: The effect of potassium on carotid body chemoreceptor discharge in the anaesthetized cat
  publication-title: J. Physiol.
– volume: 100
  start-page: 1371
  year: 2007
  end-page: 1378
  ident: bib22
  article-title: Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure
  publication-title: Circ. Res.
– volume: 39
  start-page: 18
  year: 1975
  end-page: 22
  ident: bib17
  article-title: Aldosterone dynamics during graded exercise at sea level and high altitude
  publication-title: J. Appl. Physiol.
– volume: 26
  start-page: 337
  year: 1994
  end-page: 347
  ident: bib31
  article-title: Peripheral chemoreceptor control of exercise hyperpnea in humans
  publication-title: Med. Sci. Sports Exerc.
– volume: 24
  start-page: 1
  year: 1972
  end-page: 29
  ident: bib9
  article-title: Cardiovascular and renal actions of dopamine: potential clinical applications
  publication-title: Pharmacol. Rev.
– volume: 39
  start-page: 354
  year: 1975
  end-page: 358
  ident: bib28
  article-title: Effect of carotid body resection on ventilatory and acid-base control during exercise
  publication-title: J. Appl. Physiol.
– volume: 380
  start-page: 387
  year: 1986
  end-page: 403
  ident: bib11
  article-title: Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man
  publication-title: J. Physiol.
– volume: 75
  start-page: 1385
  year: 1993
  end-page: 1394
  ident: bib8
  article-title: Effect of asthma and ventilatory loading on arterial
  publication-title: J. Appl. Physiol.
– volume: 61
  start-page: 708
  year: 1978
  end-page: 713
  ident: bib30
  article-title: Depression of ventilation by dopamine in man. Evidence for an effect on the chemoreceptor reflex
  publication-title: J. Clin. Invest.
– volume: 10
  start-page: 237
  year: 1962
  end-page: 243
  ident: bib13
  article-title: Effects of dopamine in man
  publication-title: Circ. Res.
– volume: 36
  start-page: 457
  year: 1974
  ident: 10.1016/j.resp.2009.07.010_bib27
  article-title: Cardiodynamic hyperpnea: hyperpnea secondary to cardiac output increase
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1974.36.4.457
– volume: 109
  start-page: 682
  year: 1963
  ident: 10.1016/j.resp.2009.07.010_bib6
  article-title: Control of respiration by arterial chemoreceptors
  publication-title: Ann. N.Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1963.tb13497.x
– volume: 285
  start-page: 1105
  year: 1971
  ident: 10.1016/j.resp.2009.07.010_bib16
  article-title: Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM197111112852002
– volume: 61
  start-page: 333
  year: 1982
  ident: 10.1016/j.resp.2009.07.010_bib25
  article-title: Reduction of hypoxic ventilatory drive by dopamine
  publication-title: Anesth. Analg.
  doi: 10.1213/00000539-198204000-00004
– volume: 381
  start-page: 39
  year: 1986
  ident: 10.1016/j.resp.2009.07.010_bib2
  article-title: The effect of potassium on carotid body chemoreceptor discharge in the anaesthetized cat
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1986.sp016311
– volume: 355
  start-page: 161
  year: 1984
  ident: 10.1016/j.resp.2009.07.010_bib7
  article-title: Exercise-induced arterial hypoxaemia in healthy human subjects at sea level
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1984.sp015412
– volume: 586
  start-page: 1743
  year: 2008
  ident: 10.1016/j.resp.2009.07.010_bib23
  article-title: Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2007.147421
– volume: 380
  start-page: 387
  year: 1986
  ident: 10.1016/j.resp.2009.07.010_bib11
  article-title: Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.1986.sp016292
– volume: 61
  start-page: 2102
  year: 1986
  ident: 10.1016/j.resp.2009.07.010_bib4
  article-title: Effect of dopamine on transient ventilatory response to exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1986.61.6.2102
– volume: 39
  start-page: 18
  year: 1975
  ident: 10.1016/j.resp.2009.07.010_bib17
  article-title: Aldosterone dynamics during graded exercise at sea level and high altitude
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1975.39.1.18
– volume: 54
  start-page: 1394
  year: 1983
  ident: 10.1016/j.resp.2009.07.010_bib19
  article-title: Hyperventilation in ponies at the onset of and during steady-state exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1983.54.5.1394
– volume: 74
  start-page: 829
  year: 1994
  ident: 10.1016/j.resp.2009.07.010_bib10
  article-title: Carotid body chemoreceptors: from natural stimuli to sensory discharges
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.1994.74.4.829
– ident: 10.1016/j.resp.2009.07.010_bib5
  doi: 10.1345/aph.1G685
– volume: 98
  start-page: 126
  year: 1998
  ident: 10.1016/j.resp.2009.07.010_bib24
  article-title: Dopamine depresses minute ventilation in patients with heart failure
  publication-title: Circulation
  doi: 10.1161/01.CIR.98.2.126
– volume: 221
  start-page: 1629
  year: 1971
  ident: 10.1016/j.resp.2009.07.010_bib18
  article-title: Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajplegacy.1971.221.6.1629
– volume: 510
  start-page: 773
  issue: Pt 3
  year: 1998
  ident: 10.1016/j.resp.2009.07.010_bib1
  article-title: Angiotensin AT1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity
  publication-title: J. Physiol.
  doi: 10.1111/j.1469-7793.1998.773bj.x
– volume: 100
  start-page: 1371
  year: 2007
  ident: 10.1016/j.resp.2009.07.010_bib22
  article-title: Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000266974.84590.d2
– volume: 47
  start-page: 954
  year: 1979
  ident: 10.1016/j.resp.2009.07.010_bib14
  article-title: Difference between end-tidal and arterial PCO2 in exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1979.47.5.954
– volume: 60
  start-page: 1016
  year: 1986
  ident: 10.1016/j.resp.2009.07.010_bib20
  article-title: Independence of exercise hyperpnea and acidosis during high-intensity exercise in ponies
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1986.60.3.1016
– volume: 24
  start-page: 1
  year: 1972
  ident: 10.1016/j.resp.2009.07.010_bib9
  article-title: Cardiovascular and renal actions of dopamine: potential clinical applications
  publication-title: Pharmacol. Rev.
– volume: 77
  start-page: 1907
  year: 1994
  ident: 10.1016/j.resp.2009.07.010_bib21
  article-title: Ventilatory and hyperkalemic responses to incremental exercise after propranolol treatment
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1994.77.4.1907
– volume: 39
  start-page: 354
  year: 1975
  ident: 10.1016/j.resp.2009.07.010_bib28
  article-title: Effect of carotid body resection on ventilatory and acid-base control during exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1975.39.3.354
– volume: 60
  start-page: 2020
  year: 1986
  ident: 10.1016/j.resp.2009.07.010_bib3
  article-title: A new method for detecting anaerobic threshold by gas exchange
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1986.60.6.2020
– volume: 26
  start-page: 337
  year: 1994
  ident: 10.1016/j.resp.2009.07.010_bib31
  article-title: Peripheral chemoreceptor control of exercise hyperpnea in humans
  publication-title: Med. Sci. Sports Exerc.
  doi: 10.1249/00005768-199403000-00010
– year: 2004
  ident: 10.1016/j.resp.2009.07.010_bib26
– volume: 71
  start-page: 129
  year: 2006
  ident: 10.1016/j.resp.2009.07.010_bib15
  article-title: Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbits
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2006.03.017
– year: 1991
  ident: 10.1016/j.resp.2009.07.010_bib33
– volume: 51
  start-page: 1469
  year: 1972
  ident: 10.1016/j.resp.2009.07.010_bib12
  article-title: Effects of adrenergic stimulation on ventilation in man
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI106943
– volume: 10
  start-page: 237
  year: 1962
  ident: 10.1016/j.resp.2009.07.010_bib13
  article-title: Effects of dopamine in man
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.10.2.237
– volume: 61
  start-page: 708
  year: 1978
  ident: 10.1016/j.resp.2009.07.010_bib30
  article-title: Depression of ventilation by dopamine in man. Evidence for an effect on the chemoreceptor reflex
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI108983
– volume: 35
  start-page: 236
  year: 1973
  ident: 10.1016/j.resp.2009.07.010_bib29
  article-title: Anaerobic threshold and respiratory gas exchange during exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1973.35.2.236
– volume: 106
  start-page: 131
  year: 1994
  ident: 10.1016/j.resp.2009.07.010_bib34
  article-title: Estimated vs actual values for dead space/tidal volume ratios during incremental exercise in patients evaluated for dyspnea
  publication-title: Chest
  doi: 10.1378/chest.106.1.131
– volume: 75
  start-page: 1385
  year: 1993
  ident: 10.1016/j.resp.2009.07.010_bib8
  article-title: Effect of asthma and ventilatory loading on arterial PCO2 of humans during submaximal exercise
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1993.75.3.1385
– volume: 11
  start-page: 204
  year: 1979
  ident: 10.1016/j.resp.2009.07.010_bib32
  article-title: Peripheral chemoreceptors and exercise hyperpnea
  publication-title: Med. Sci. Sports
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Snippet The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose...
Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood....
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elsevier
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StartPage 250
SubjectTerms Adult
Autonomic nervous system
Biological and medical sciences
Cardiopulmonary exercise testing
Cardiotonic Agents - pharmacology
Chemoreceptor
Chemoreceptor Cells - drug effects
Chemoreceptor Cells - physiology
Chemoreflex
Dopamine - pharmacology
Double-Blind Method
Exercise Tolerance - drug effects
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical Education
Oxygen Consumption - drug effects
Prospective Studies
Pulmonary Ventilation - drug effects
Pulmonary/Respiratory
Vertebrates: respiratory system
Young Adult
Title Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity
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https://www.ncbi.nlm.nih.gov/pubmed/19619673
https://www.proquest.com/docview/20967505
https://www.proquest.com/docview/67632068
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