Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity
The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopami...
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Published in | Respiratory physiology & neurobiology Vol. 168; no. 3; pp. 250 - 253 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
30.09.2009
Elsevier |
Subjects | |
Online Access | Get full text |
ISSN | 1569-9048 1878-1519 1878-1519 |
DOI | 10.1016/j.resp.2009.07.010 |
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Abstract | The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3
μg
kg
−1
min
−1) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24
h between placebo and dopamine administrations. During the CPET, dopamine decreased the
V
˙
E
/
V
˙
C
O
2
output slope (24.61
±
1.84 vs. 23.09
±
1.81, placebo vs. Dopamine respectively,
p
=
0.025), without affecting maximum workload,
V
˙
E
and O
2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the
V
˙
E
/
V
˙
C
O
2
slope during dynamic exercise, with no change in aerobic exercise capacity. |
---|---|
AbstractList | The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 mu g kg super(-1) min super(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the [MathML equation] output slope (24.61 +/- 1.84 vs. 23.09 +/- 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, [MathML equation] and O sub(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the [MathML equation] slope during dynamic exercise, with no change in aerobic exercise capacity. The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg −1 min −1) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O 2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity. Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 μg kg−1 min−1 ) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24 h between placebo and dopamine administrations. During the CPET, dopamine decreased the V ˙ E / V ˙ C O 2 output slope (24.61 ± 1.84 vs. 23.09 ± 1.81, placebo vs. Dopamine respectively, p = 0.025), without affecting maximum workload, V ˙ E and O2 uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the V ˙ E / V ˙ C O 2 slope during dynamic exercise, with no change in aerobic exercise capacity. The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity. The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity.The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose dopamine has been reported to specifically inhibit the peripheral chemoreceptors. We therefore investigated the effects of intravenous dopamine (3 microg kg(-1)min(-1)) on cardiopulmonary exercise test (CPET) variables in 13 healthy young male subjects. The study was prospective, placebo-controlled, and randomized with more than 24h between placebo and dopamine administrations. During the CPET, dopamine decreased the .V(E)/.V(CO2) output slope (24.61+/-1.84 vs. 23.09+/-1.81, placebo vs. Dopamine respectively, p=0.025), without affecting maximum workload, .V(E) and O(2) uptake. In conclusion, our study reveals that inhibition of peripheral chemoreflex function with dopamine decreases the .V(E)/.V(CO2) slope during dynamic exercise, with no change in aerobic exercise capacity. |
Author | Deboeck, G. Janssen, C. Beloka, S. Kayembe, P. Naeije, R. van de Borne, P. Adamopoulos, D. |
Author_xml | – sequence: 1 givenname: C. surname: Janssen fullname: Janssen, C. email: chrisrv.janssen@gmail.com organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 2 givenname: S. surname: Beloka fullname: Beloka, S. organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 3 givenname: P. surname: Kayembe fullname: Kayembe, P. organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 4 givenname: G. surname: Deboeck fullname: Deboeck, G. organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 5 givenname: D. surname: Adamopoulos fullname: Adamopoulos, D. organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 6 givenname: R. surname: Naeije fullname: Naeije, R. organization: Department of Physiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium – sequence: 7 givenname: P. surname: van de Borne fullname: van de Borne, P. organization: Department of Cardiology, Erasme University Hospital, Lennik road 808, 1070 Brussels, Belgium |
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CitedBy_id | crossref_primary_10_1002_ejhf_641 crossref_primary_10_1016_j_cmpb_2012_09_007 crossref_primary_10_1113_JP271692 crossref_primary_10_1152_ajpregu_00030_2017 crossref_primary_10_3390_brainsci11070829 crossref_primary_10_28982_josam_7435 crossref_primary_10_1007_s11897_014_0188_6 |
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Keywords | Chemoreflex Cardiopulmonary exercise testing Autonomic nervous system Chemoreceptor Physical exercise Dopamine Catecholamine Respiratory system Vertebrata Mammalia Ventilatory response Neurotransmitter Chemosensitivity Inhibition |
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Snippet | The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood. Low-dose... Abstract The contribution of the peripheral chemoreflex to the ventilatory response to exercise and aerobic exercise capacity remains incompletely understood.... |
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SubjectTerms | Adult Autonomic nervous system Biological and medical sciences Cardiopulmonary exercise testing Cardiotonic Agents - pharmacology Chemoreceptor Chemoreceptor Cells - drug effects Chemoreceptor Cells - physiology Chemoreflex Dopamine - pharmacology Double-Blind Method Exercise Tolerance - drug effects Fundamental and applied biological sciences. Psychology Humans Male Medical Education Oxygen Consumption - drug effects Prospective Studies Pulmonary Ventilation - drug effects Pulmonary/Respiratory Vertebrates: respiratory system Young Adult |
Title | Decreased ventilatory response to exercise by dopamine-induced inhibition of peripheral chemosensitivity |
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