The evolving epidemiology of rotavirus gastroenteritis in central Portugal with modest vaccine coverage
Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the...
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| Published in | Journal of clinical virology Vol. 56; no. 2; pp. 129 - 134 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.02.2013
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1386-6532 1873-5967 1873-5967 |
| DOI | 10.1016/j.jcv.2012.10.016 |
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| Abstract | Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010.
To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter–spring seasons.
Stool samples, collected throughout five epidemic seasons (January–June, 2006 to 2010) from children ≤36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped.
A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008–37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time.
Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. |
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| AbstractList | Abstract Background Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. Objectives To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter–spring seasons. Study design Stool samples, collected throughout five epidemic seasons (January–June, 2006 to 2010) from children ≤36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped. Results A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008–37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time. Conclusions Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010.BACKGROUNDRotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010.To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter-spring seasons.OBJECTIVESTo assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter-spring seasons.Stool samples, collected throughout five epidemic seasons (January-June, 2006 to 2010) from children ≤ 36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped.STUDY DESIGNStool samples, collected throughout five epidemic seasons (January-June, 2006 to 2010) from children ≤ 36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped.A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008-37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time.RESULTSA total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008-37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time.Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease.CONCLUSIONSOur results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter–spring seasons. Stool samples, collected throughout five epidemic seasons (January–June, 2006 to 2010) from children ≤36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped. A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008–37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time. Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter-spring seasons. Stool samples, collected throughout five epidemic seasons (January-June, 2006 to 2010) from children less than or equal to 36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped. A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008-37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time. Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and 2010. To assess trends, surveillance of children presenting with acute gastroenteritis (AG) to a large paediatric emergency service (ES) in the central region of Portugal was conducted yearly during the winter-spring seasons. Stool samples, collected throughout five epidemic seasons (January-June, 2006 to 2010) from children ≤ 36 months of age attending the ES with AG, were tested for RV by immunochromatographic rapid test and positive samples were genotyped. A total of 6145 AG cases were identified: 1956 (32%) provided a stool sample (range: 28% in 2008-37% in 2009). The proportion of AG subjects who tested positive for RV fluctuated over the five surveillance seasons (49%, 39%, 25%, 26% and 39%, respectively) as did the distribution of co-circulating RV genotypes. There were no consistent changes in seasonality or age distribution and the proportion of admitted AG subjects who tested RV-positive did not show progressive trends over time. Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. |
| Author | Gray, Jim Iturriza-Gómara, Miren Januário, Luís Nawaz, Sameena Marlow, Robin Finn, Adam Rodrigues, Fernanda |
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| CitedBy_id | crossref_primary_10_1016_j_jcv_2017_09_005 crossref_primary_10_1186_s12985_017_0721_9 crossref_primary_10_4236_wjv_2019_91002 crossref_primary_10_1007_s12325_014_0160_6 crossref_primary_10_4236_wjv_2017_74004 crossref_primary_10_1097_INF_0000000000000647 crossref_primary_10_2807_1560_7917_ES_2015_20_48_30077 |
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| Keywords | RV Rotavirus AG Immunisation ES Genotypes Acute gastroenteritis emergency service rotavirus acute gastroenteritis Immunization Acute Gastroenteritis Genotype Vaccine Epidemiology Reoviridae Virus Digestive diseases Intestinal disease Gastric disease |
| Language | English |
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| Snippet | Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42% between 2007 and... Abstract Background Rotavirus (RV) vaccines have been available on the private market in Portugal since 2006, with an estimated coverage rising from 16 to 42%... |
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| SubjectTerms | Acute gastroenteritis Age Age composition Allergy and Immunology Biological and medical sciences Child, Preschool Children Epidemics Epidemiology Feces Feces - virology Fundamental and applied biological sciences. Psychology Gastroenteritis Gastroenteritis - epidemiology Genotype Genotypes Human viral diseases Humans Immunisation Immunochromatography Infant Infant, Newborn Infectious Disease Infectious diseases Medical sciences Microbiology Miscellaneous Molecular Epidemiology Pediatrics Portugal - epidemiology RNA, Viral - genetics Rotavirus Rotavirus - classification Rotavirus - genetics Rotavirus - isolation & purification Rotavirus Infections - epidemiology Rotavirus Infections - virology Rotavirus Vaccines - administration & dosage Seasonal variations Vaccines Viral diseases Virology |
| Title | The evolving epidemiology of rotavirus gastroenteritis in central Portugal with modest vaccine coverage |
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