Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010
ABSTRACTThe neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer’s Coordinating Center, which gathers information from...
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| Published in | Journal of neuropathology and experimental neurology Vol. 71; no. 4; pp. 266 - 273 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
American Association of Neuropathologists, Inc
01.04.2012
Lippincott Williams & Wilkins Oxford University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3069 1554-6578 1554-6578 |
| DOI | 10.1097/NEN.0b013e31824b211b |
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| Abstract | ABSTRACTThe neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer’s Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on “probable” and “possible” AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. |
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| AbstractList | The neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer's Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on "probable" and "possible" AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. The neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer's Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on "probable" and "possible" AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. [PUBLICATION ABSTRACT] ABSTRACTThe neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer’s Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on “probable” and “possible” AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. The neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer's Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on "probable" and "possible" AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies.The neuropathologic examination is considered to provide the gold standard for Alzheimer disease (AD). To determine the accuracy of currently used clinical diagnostic methods, clinical and neuropathologic data from the National Alzheimer's Coordinating Center, which gathers information from the network of National Institute on Aging (NIA)-sponsored Alzheimer Disease Centers (ADCs), were collected as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) between 2005 and 2010. A database search initially included all 1198 subjects with at least one UDS clinical assessment and who had died and been autopsied; 279 were excluded as being not demented or because critical data fields were missing. The final subject number was 919. Sensitivity and specificity were determined based on "probable" and "possible" AD levels of clinical confidence and 4 levels of neuropathologic confidence based on varying neuritic plaque densities and Braak neurofibrillary stages. Sensitivity ranged from 70.9% to 87.3%; specificity ranged from 44.3% to 70.8%. Sensitivity was generally increased with more permissive clinical criteria and specificity was increased with more restrictive criteria, whereas the opposite was true for neuropathologic criteria. When a clinical diagnosis was not confirmed by minimum levels of AD histopathology, the most frequent primary neuropathologic diagnoses were tangle-only dementia or argyrophilic grain disease, frontotemporal lobar degeneration, cerebrovascular disease, Lewy body disease and hippocampal sclerosis. When dementia was not clinically diagnosed as AD, 39% of these cases met or exceeded minimum threshold levels of AD histopathology. Neurologists of the NIA-ADCs had higher predictive accuracy when they diagnosed AD in subjects with dementia than when they diagnosed dementing diseases other than AD. The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. |
| Author | Kukull, Walter Monsell, Sarah E. Beach, Thomas G. Phillips, Leslie E. |
| AuthorAffiliation | From the Banner Sun Health Research Institute, Sun City, Arizona (TGB); and National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington (SEM, LEP, WK) |
| AuthorAffiliation_xml | – name: From the Banner Sun Health Research Institute, Sun City, Arizona (TGB); and National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington (SEM, LEP, WK) |
| Author_xml | – sequence: 1 givenname: Thomas surname: Beach middlename: G. fullname: Beach, Thomas G. organization: From the Banner Sun Health Research Institute, Sun City, Arizona (TGB); and National Alzheimer’s Coordinating Center, University of Washington, Seattle, Washington (SEM, LEP, WK) – sequence: 2 givenname: Sarah surname: Monsell middlename: E. fullname: Monsell, Sarah E. – sequence: 3 givenname: Leslie surname: Phillips middlename: E. fullname: Phillips, Leslie E. – sequence: 4 givenname: Walter surname: Kukull fullname: Kukull, Walter |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25773178$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22437338$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.jalz.2011.03.003 10.1007/s00401-011-0910-3 10.1001/archneur.1994.00540210060013 10.1016/S0140-6736(00)03589-3 10.1001/archneur.56.12.1489 10.1016/S0140-6736(96)01251-2 10.1097/WAD.0b013e318142774e 10.1016/S0197-4580(97)00057-2 10.1159/000106639 10.1097/NEN.0b013e3181d8db07 10.1007/s00401-002-0529-5 10.1001/archneurol.2011.53 10.1136/jnnp.64.1.18 10.1016/j.jalz.2011.10.007 10.1111/j.1532-5415.1999.tb02571.x 10.3233/JAD-2009-1042 10.1176/ajp.152.10.1476 10.1212/WNL.58.12.1791 10.1212/WNL.38.3.359 10.1097/00005072-199911000-00004 10.1097/01.wad.0000165507.67993.47 10.1016/S1474-4422(11)70156-9 10.1212/WNL.45.3.461 10.1212/WNL.59.7.1022 10.1007/s004010050412 10.1007/s00415-010-5815-x 10.1056/NEJM199802193380804 10.1017/S1041610298005389 10.1212/WNL.34.7.939 10.3233/JAD-2009-1182 10.1001/archneur.1985.04060100083029 10.1002/ana.410240110 10.1212/WNL.57.2.226 10.1097/00002093-199601040-00002 10.1007/BF00308809 10.1093/jnen/63.10.1028 10.3233/JAD-2011-111340 10.1016/S1474-4422(09)70299-6 10.1159/000017222 10.1159/000017050 10.3233/JAD-2009-1105 10.1212/WNL.55.12.1854 10.1001/archneur.1996.00550010045015 10.1159/000017038 10.1007/BF02982566 10.1111/j.1750-3639.2008.00244.x 10.1212/WNL.41.4.479 10.1186/1750-1172-1-30 10.1097/00005072-199405000-00012 10.3233/JAD-1999-14-506 10.1212/WNL.58.6.989 |
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| References | 2016030323402251000_71.4.266.18 2016030323402251000_71.4.266.19 2016030323402251000_71.4.266.9 Knopman (2016030323402251000_71.4.266.3) 2001; 56 2016030323402251000_71.4.266.20 2016030323402251000_71.4.266.25 2016030323402251000_71.4.266.26 2016030323402251000_71.4.266.27 Haneuse (2016030323402251000_71.4.266.2) 2009; 17 2016030323402251000_71.4.266.28 2016030323402251000_71.4.266.21 2016030323402251000_71.4.266.22 Larner (2016030323402251000_71.4.266.45) 2009; 17 2016030323402251000_71.4.266.23 2016030323402251000_71.4.266.24 Brayne (2016030323402251000_71.4.266.43) 2009; 18 Villareal (2016030323402251000_71.4.266.14) 1999; 1 Beach (2016030323402251000_71.4.266.50) 2012; 28 2016030323402251000_71.4.266.4 2016030323402251000_71.4.266.51 2016030323402251000_71.4.266.1 2016030323402251000_71.4.266.52 2016030323402251000_71.4.266.7 2016030323402251000_71.4.266.8 2016030323402251000_71.4.266.5 2016030323402251000_71.4.266.15 2016030323402251000_71.4.266.16 2016030323402251000_71.4.266.17 2016030323402251000_71.4.266.10 2016030323402251000_71.4.266.11 2016030323402251000_71.4.266.12 2016030323402251000_71.4.266.13 2016030323402251000_71.4.266.40 2016030323402251000_71.4.266.41 Thal (2016030323402251000_71.4.266.49) 2002; 58 2016030323402251000_71.4.266.42 2016030323402251000_71.4.266.48 2016030323402251000_71.4.266.44 2016030323402251000_71.4.266.46 2016030323402251000_71.4.266.29 Wszolek (2016030323402251000_71.4.266.47) 2009; 1 2016030323402251000_71.4.266.30 2016030323402251000_71.4.266.31 2016030323402251000_71.4.266.36 2016030323402251000_71.4.266.37 2016030323402251000_71.4.266.38 2016030323402251000_71.4.266.39 2016030323402251000_71.4.266.32 McKeel (2016030323402251000_71.4.266.6) 2004; 63 2016030323402251000_71.4.266.33 2016030323402251000_71.4.266.34 2016030323402251000_71.4.266.35 |
| References_xml | – ident: 2016030323402251000_71.4.266.52 doi: 10.1016/j.jalz.2011.03.003 – ident: 2016030323402251000_71.4.266.40 doi: 10.1007/s00401-011-0910-3 – ident: 2016030323402251000_71.4.266.10 doi: 10.1001/archneur.1994.00540210060013 – ident: 2016030323402251000_71.4.266.42 doi: 10.1016/S0140-6736(00)03589-3 – ident: 2016030323402251000_71.4.266.23 doi: 10.1001/archneur.56.12.1489 – ident: 2016030323402251000_71.4.266.13 doi: 10.1016/S0140-6736(96)01251-2 – ident: 2016030323402251000_71.4.266.31 doi: 10.1097/WAD.0b013e318142774e – ident: 2016030323402251000_71.4.266.30 doi: 10.1016/S0197-4580(97)00057-2 – ident: 2016030323402251000_71.4.266.34 doi: 10.1159/000106639 – ident: 2016030323402251000_71.4.266.32 doi: 10.1097/NEN.0b013e3181d8db07 – ident: 2016030323402251000_71.4.266.37 doi: 10.1007/s00401-002-0529-5 – ident: 2016030323402251000_71.4.266.44 doi: 10.1001/archneurol.2011.53 – ident: 2016030323402251000_71.4.266.11 doi: 10.1136/jnnp.64.1.18 – ident: 2016030323402251000_71.4.266.39 doi: 10.1016/j.jalz.2011.10.007 – ident: 2016030323402251000_71.4.266.20 doi: 10.1111/j.1532-5415.1999.tb02571.x – volume: 17 start-page: 259 year: 2009 ident: 2016030323402251000_71.4.266.45 article-title: Genotype-phenotype relationships of presenilin-1 mutations in Alzheimer's disease: An update publication-title: J Alzheimer Dis doi: 10.3233/JAD-2009-1042 – ident: 2016030323402251000_71.4.266.18 doi: 10.1176/ajp.152.10.1476 – volume: 58 start-page: 17910800 year: 2002 ident: 2016030323402251000_71.4.266.49 article-title: Phases of A beta-deposition in the human brain and its relevance for the development of AD publication-title: Neurology doi: 10.1212/WNL.58.12.1791 – ident: 2016030323402251000_71.4.266.28 doi: 10.1212/WNL.38.3.359 – ident: 2016030323402251000_71.4.266.38 doi: 10.1097/00005072-199911000-00004 – volume: 56 start-page: 1143 year: 2001 ident: 2016030323402251000_71.4.266.3 article-title: Practice parameter: Diagnosis of dementia (an evidence-based review) publication-title: Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology – ident: 2016030323402251000_71.4.266.48 doi: 10.1097/01.wad.0000165507.67993.47 – ident: 2016030323402251000_71.4.266.51 doi: 10.1016/S1474-4422(11)70156-9 – ident: 2016030323402251000_71.4.266.9 doi: 10.1212/WNL.45.3.461 – ident: 2016030323402251000_71.4.266.16 doi: 10.1212/WNL.59.7.1022 – ident: 2016030323402251000_71.4.266.12 doi: 10.1007/s004010050412 – ident: 2016030323402251000_71.4.266.46 doi: 10.1007/s00415-010-5815-x – ident: 2016030323402251000_71.4.266.4 doi: 10.1056/NEJM199802193380804 – ident: 2016030323402251000_71.4.266.21 doi: 10.1017/S1041610298005389 – ident: 2016030323402251000_71.4.266.26 doi: 10.1212/WNL.34.7.939 – volume: 18 start-page: 645058 year: 2009 ident: 2016030323402251000_71.4.266.43 article-title: Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study publication-title: J Alzheimer Dis doi: 10.3233/JAD-2009-1182 – ident: 2016030323402251000_71.4.266.27 doi: 10.1001/archneur.1985.04060100083029 – ident: 2016030323402251000_71.4.266.24 doi: 10.1002/ana.410240110 – ident: 2016030323402251000_71.4.266.8 doi: 10.1212/WNL.57.2.226 – ident: 2016030323402251000_71.4.266.7 doi: 10.1097/00002093-199601040-00002 – ident: 2016030323402251000_71.4.266.33 doi: 10.1007/BF00308809 – volume: 63 start-page: 1028 year: 2004 ident: 2016030323402251000_71.4.266.6 article-title: Neuropathologic criteria for diagnosing Alzheimer disease in persons with pure dementia of Alzheimer type publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/63.10.1028 – volume: 28 start-page: 869 year: 2012 ident: 2016030323402251000_71.4.266.50 article-title: Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: Implications for amyloid imaging publication-title: J Alzheimer Dis doi: 10.3233/JAD-2011-111340 – ident: 2016030323402251000_71.4.266.1 doi: 10.1016/S1474-4422(09)70299-6 – ident: 2016030323402251000_71.4.266.25 doi: 10.1159/000017222 – ident: 2016030323402251000_71.4.266.22 doi: 10.1159/000017050 – volume: 17 start-page: 875 year: 2009 ident: 2016030323402251000_71.4.266.2 article-title: Neuropathology-based risk scoring for dementia diagnosis in the elderly publication-title: J Alzheimer Dis doi: 10.3233/JAD-2009-1105 – ident: 2016030323402251000_71.4.266.17 doi: 10.1212/WNL.55.12.1854 – ident: 2016030323402251000_71.4.266.19 doi: 10.1001/archneur.1996.00550010045015 – ident: 2016030323402251000_71.4.266.36 doi: 10.1159/000017038 – ident: 2016030323402251000_71.4.266.5 doi: 10.1007/BF02982566 – ident: 2016030323402251000_71.4.266.41 doi: 10.1111/j.1750-3639.2008.00244.x – ident: 2016030323402251000_71.4.266.29 doi: 10.1212/WNL.41.4.479 – volume: 1 start-page: 30 year: 2009 ident: 2016030323402251000_71.4.266.47 article-title: Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) publication-title: Orphanet J Rare Dis doi: 10.1186/1750-1172-1-30 – ident: 2016030323402251000_71.4.266.35 doi: 10.1097/00005072-199405000-00012 – volume: 1 start-page: 249 year: 1999 ident: 2016030323402251000_71.4.266.14 article-title: The diagnosis of Alzheimer's disease publication-title: J Alzheimer Dis doi: 10.3233/JAD-1999-14-506 – ident: 2016030323402251000_71.4.266.15 doi: 10.1212/WNL.58.6.989 |
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| SubjectTerms | Accuracy Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Biomarkers Brain diseases Databases, Factual - standards Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Estimates Female Humans Male Medical diagnosis Medical sciences Middle Aged National Institute on Aging (U.S.) - standards National Institute on Aging (U.S.) - trends Neurology Statistical methods Studies United States - epidemiology |
| Title | Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 |
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