Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
Inhibitors of the PAD4 enzyme that bind the inactive enzyme link this protein deiminase and the resultant arginine-to-citrulline modification to formation of neutrophil extracellular traps, highly decondensed chromatin structures with both host-defense and pathological roles. PAD4 has been strongly...
Saved in:
| Published in | Nature chemical biology Vol. 11; no. 3; pp. 189 - 191 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.03.2015
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1552-4450 1552-4469 1552-4469 |
| DOI | 10.1038/nchembio.1735 |
Cover
| Abstract | Inhibitors of the PAD4 enzyme that bind the inactive enzyme link this protein deiminase and the resultant arginine-to-citrulline modification to formation of neutrophil extracellular traps, highly decondensed chromatin structures with both host-defense and pathological roles.
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored. |
|---|---|
| AbstractList | PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored.PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored. Inhibitors of the PAD4 enzyme that bind the inactive enzyme link this protein deiminase and the resultant arginine-to-citrulline modification to formation of neutrophil extracellular traps, highly decondensed chromatin structures with both host-defense and pathological roles. PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored. PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored. PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD4 enzyme have, for the first time, validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation. The therapeutic potential of PAD4 inhibitors can now be explored. |
| Author | Coote, Jim E Prinjha, Rab K Bingham, Ryan P Craggs, Peter D Yao, Gang Lind, Kenneth E Davis, Rob P Maller, Claire Bicker, Kevin L Joberty, Gerard Thompson, Paul R Martinod, Kimberly Sheppard, Robert J Lewis, Huw D Rüdiger, Martin Rise, Cecil E Bax, Benjamin D Campbell, Matthew Polyakova, Oxana Drewes, Gerard Eberhard, Dirk Barker, Michael D Locke, Kelly Wilson, David M Thorpe, Jim Liddle, John Patten, Chris Chen, Yu Hua Chung, Chun-wa Wagner, Denisa D Thomas, Pamela Atkinson, Stephen J Slade, Daniel J |
| AuthorAffiliation | 2 Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts., SG1 2NY, UK 6 Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA 8 Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA 02115, USA 7 Immunology Graduate Program, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA 4 Cellzome GmbH, a GSK company. Meyerhofstrasse 1, 69117 Heidelberg, Germany 3 ELT Boston, Platform Technology and Science, GlaxoSmithKline, Waltham, MA 02451, USA 9 Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA 1 EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts., SG1 2NY, UK 5 Department of Chemistry, TSRI, Scripps Florida, 120 Scripps Way, Jupiter, FL 33458, USA |
| AuthorAffiliation_xml | – name: 4 Cellzome GmbH, a GSK company. Meyerhofstrasse 1, 69117 Heidelberg, Germany – name: 3 ELT Boston, Platform Technology and Science, GlaxoSmithKline, Waltham, MA 02451, USA – name: 5 Department of Chemistry, TSRI, Scripps Florida, 120 Scripps Way, Jupiter, FL 33458, USA – name: 2 Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts., SG1 2NY, UK – name: 6 Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115, USA – name: 1 EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts., SG1 2NY, UK – name: 8 Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA 02115, USA – name: 9 Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA – name: 7 Immunology Graduate Program, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA |
| Author_xml | – sequence: 1 givenname: Huw D surname: Lewis fullname: Lewis, Huw D email: huw.d.lewis@gsk.com organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 2 givenname: John surname: Liddle fullname: Liddle, John organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 3 givenname: Jim E surname: Coote fullname: Coote, Jim E organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 4 givenname: Stephen J surname: Atkinson fullname: Atkinson, Stephen J organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 5 givenname: Michael D surname: Barker fullname: Barker, Michael D organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 6 givenname: Benjamin D surname: Bax fullname: Bax, Benjamin D organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 7 givenname: Kevin L surname: Bicker fullname: Bicker, Kevin L organization: Department of Chemistry, Scripps Florida, The Scripps Research Institute – sequence: 8 givenname: Ryan P surname: Bingham fullname: Bingham, Ryan P organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 9 givenname: Matthew surname: Campbell fullname: Campbell, Matthew organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 10 givenname: Yu Hua surname: Chen fullname: Chen, Yu Hua organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 11 givenname: Chun-wa surname: Chung fullname: Chung, Chun-wa organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 12 givenname: Peter D surname: Craggs fullname: Craggs, Peter D organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 13 givenname: Rob P surname: Davis fullname: Davis, Rob P organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 14 givenname: Dirk surname: Eberhard fullname: Eberhard, Dirk organization: Cellzome GmbH, a GSK company – sequence: 15 givenname: Gerard surname: Joberty fullname: Joberty, Gerard organization: Cellzome GmbH, a GSK company – sequence: 16 givenname: Kenneth E surname: Lind fullname: Lind, Kenneth E organization: ELT Boston, Platform Technology and Science, GlaxoSmithKline – sequence: 17 givenname: Kelly surname: Locke fullname: Locke, Kelly organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 18 givenname: Claire surname: Maller fullname: Maller, Claire organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 19 givenname: Kimberly surname: Martinod fullname: Martinod, Kimberly organization: Program in Cellular and Molecular Medicine, Boston Children's Hospital, Division of Medical Sciences, Immunology Graduate Program, Harvard Medical School – sequence: 20 givenname: Chris surname: Patten fullname: Patten, Chris organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 21 givenname: Oxana surname: Polyakova fullname: Polyakova, Oxana organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 22 givenname: Cecil E surname: Rise fullname: Rise, Cecil E organization: ELT Boston, Platform Technology and Science, GlaxoSmithKline – sequence: 23 givenname: Martin surname: Rüdiger fullname: Rüdiger, Martin organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 24 givenname: Robert J surname: Sheppard fullname: Sheppard, Robert J organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK., Present addresses: AstraZeneca, Oncology iMed, Cambridge Science Park, Cambridge, UK (R.J.S. and D.M.W.); Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (D.J.S.); University of Massachussetts Medical School, Worcester, Massachusetts, USA (P.R.T.) – sequence: 25 givenname: Daniel J surname: Slade fullname: Slade, Daniel J organization: Department of Chemistry, Scripps Florida, The Scripps Research Institute, Present addresses: AstraZeneca, Oncology iMed, Cambridge Science Park, Cambridge, UK (R.J.S. and D.M.W.); Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (D.J.S.); University of Massachussetts Medical School, Worcester, Massachusetts, USA (P.R.T.) – sequence: 26 givenname: Pamela surname: Thomas fullname: Thomas, Pamela organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 27 givenname: Jim surname: Thorpe fullname: Thorpe, Jim organization: Molecular Discovery Research, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 28 givenname: Gang surname: Yao fullname: Yao, Gang organization: ELT Boston, Platform Technology and Science, GlaxoSmithKline – sequence: 29 givenname: Gerard surname: Drewes fullname: Drewes, Gerard organization: Cellzome GmbH, a GSK company – sequence: 30 givenname: Denisa D surname: Wagner fullname: Wagner, Denisa D organization: Program in Cellular and Molecular Medicine, Boston Children's Hospital, Division of Hematology/Oncology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School – sequence: 31 givenname: Paul R surname: Thompson fullname: Thompson, Paul R organization: Department of Chemistry, Scripps Florida, The Scripps Research Institute, Present addresses: AstraZeneca, Oncology iMed, Cambridge Science Park, Cambridge, UK (R.J.S. and D.M.W.); Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (D.J.S.); University of Massachussetts Medical School, Worcester, Massachusetts, USA (P.R.T.) – sequence: 32 givenname: Rab K surname: Prinjha fullname: Prinjha, Rab K organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK – sequence: 33 givenname: David M surname: Wilson fullname: Wilson, David M organization: EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK., Present addresses: AstraZeneca, Oncology iMed, Cambridge Science Park, Cambridge, UK (R.J.S. and D.M.W.); Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (D.J.S.); University of Massachussetts Medical School, Worcester, Massachusetts, USA (P.R.T.) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25622091$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1rFTEUxYNU7Icu3UrAjZt5JpNkMtkIpVYtFBWp65BJbvpSZpJnMlPof2-er6_UoqtcyO8czr3nGB3EFAGh15SsKGH9-2jXMA0hrahk4hk6okK0DeedOniYBTlEx6XcEMK6jvYv0GErurYlih6hHxdxHYYwhxRx8vj76UeOjZ3DbZjvcCi4LN4HGyDOeE7YhZKXzYyntBTAJjq8XiYT8dfzK-xTnszW5yV67s1Y4NX9e4J-fjq_OvvSXH77fHF2etlY0ZK5MV5KwRQBTwfjwXFpDVAvuAImpAHnwPWgpPNOestkO0jfe-VNP3ChHGEn6MPOd7MMEzhbM2Yz6k0Ok8l3Opmg__6JYa2v063mTEnR02rw7t4gp18LlFlPoVgYRxOhLqhpJySjXKm2om-foDdpybGut6U60kvV8kq9eZzoIcr-3BVgO8DmVEoGr22Y_xytBgyjpkRvS9X7UvW21Kpqnqj2xv_jVzu-VC5eQ34U9p-C35oQt8M |
| CitedBy_id | crossref_primary_10_1016_j_intimp_2023_110069 crossref_primary_10_1016_j_intimp_2024_112888 crossref_primary_10_1016_j_jid_2024_07_040 crossref_primary_10_1016_j_jcf_2018_12_010 crossref_primary_10_3389_fimmu_2023_1198831 crossref_primary_10_3389_fimmu_2023_1198952 crossref_primary_10_1038_s41580_024_00715_1 crossref_primary_10_1016_j_ijmm_2024_151641 crossref_primary_10_4049_immunohorizons_2100091 crossref_primary_10_2217_fmb_15_151 crossref_primary_10_1016_j_mito_2023_07_002 crossref_primary_10_1002_rth2_12463 crossref_primary_10_1155_2023_7022337 crossref_primary_10_1007_s10495_024_01947_4 crossref_primary_10_3389_fimmu_2018_02036 crossref_primary_10_1038_s41418_018_0261_x crossref_primary_10_1007_s11426_018_9409_3 crossref_primary_10_1111_jth_15313 crossref_primary_10_1016_j_ccell_2024_12_004 crossref_primary_10_3390_ijms21239126 crossref_primary_10_26442_18151434_2022_4_201786 crossref_primary_10_3389_fimmu_2018_01182 crossref_primary_10_1021_acschembio_5b00981 crossref_primary_10_1016_j_tcb_2024_09_003 crossref_primary_10_1016_j_talanta_2024_126611 crossref_primary_10_7603_s40730_016_0021_9 crossref_primary_10_1136_rmdopen_2023_003847 crossref_primary_10_1158_0008_5472_CAN_21_4025 crossref_primary_10_1002_ajh_24970 crossref_primary_10_1007_s10238_024_01359_3 crossref_primary_10_1007_s11010_021_04315_x crossref_primary_10_1016_j_trecan_2023_01_005 crossref_primary_10_1016_j_tetlet_2022_153979 crossref_primary_10_1021_acs_jmedchem_3c01861 crossref_primary_10_1038_s41467_021_23086_z crossref_primary_10_1016_j_biomaterials_2021_120715 crossref_primary_10_1007_s12026_017_8905_3 crossref_primary_10_1111_jcmm_13717 crossref_primary_10_1021_acs_bioconjchem_1c00045 crossref_primary_10_1038_s41573_019_0054_z crossref_primary_10_1016_j_ejmech_2022_115079 crossref_primary_10_1371_journal_pone_0245594 crossref_primary_10_1021_acs_jcim_9b00779 crossref_primary_10_3390_microorganisms8111628 crossref_primary_10_1080_08916934_2021_2021193 crossref_primary_10_1016_j_trsl_2022_10_008 crossref_primary_10_1016_j_intimp_2024_112861 crossref_primary_10_1155_2022_6489923 crossref_primary_10_1038_nbt0616_577 crossref_primary_10_1186_s13058_019_1237_6 crossref_primary_10_4049_jimmunol_1701203 crossref_primary_10_1016_j_ejphar_2024_176634 crossref_primary_10_1021_acs_accounts_9b00024 crossref_primary_10_3389_fmed_2022_971121 crossref_primary_10_1038_s41598_019_53202_5 crossref_primary_10_1111_jth_13239 crossref_primary_10_3389_fcimb_2019_00227 crossref_primary_10_1007_s40203_023_00147_3 crossref_primary_10_1016_j_isci_2021_103256 crossref_primary_10_1093_cvr_cvab303 crossref_primary_10_1038_s42003_024_06074_z crossref_primary_10_1016_j_arcmed_2022_02_003 crossref_primary_10_1016_j_ejmech_2021_113840 crossref_primary_10_1172_JCI84538 crossref_primary_10_2147_IJN_S418259 crossref_primary_10_1038_s41598_023_30246_2 crossref_primary_10_1016_j_jacbts_2019_07_008 crossref_primary_10_1093_femspd_ftaa018 crossref_primary_10_1186_s12931_024_02923_x crossref_primary_10_3389_fimmu_2021_701383 crossref_primary_10_1038_nrd_2016_213 crossref_primary_10_1073_pnas_2305420120 crossref_primary_10_3390_v16101535 crossref_primary_10_3390_cancers14010194 crossref_primary_10_1016_j_taap_2021_115580 crossref_primary_10_3390_ijms232113264 crossref_primary_10_1158_0008_5472_CAN_21_4045 crossref_primary_10_3389_fvets_2021_626314 crossref_primary_10_17749_2313_7347_ob_gyn_rep_2021_204 crossref_primary_10_1038_s41598_023_45324_8 crossref_primary_10_1021_acs_bioconjchem_3c00159 crossref_primary_10_1016_j_neo_2022_100835 crossref_primary_10_3389_fonc_2022_848594 crossref_primary_10_3390_cells8090979 crossref_primary_10_1161_ATVBAHA_119_312463 crossref_primary_10_1002_slct_201904745 crossref_primary_10_1111_ajt_15703 crossref_primary_10_1016_j_bbamcr_2018_08_014 crossref_primary_10_1021_acs_jmedchem_9b01782 crossref_primary_10_3389_fneur_2024_1442613 crossref_primary_10_3390_metabo15030156 crossref_primary_10_1016_j_devcel_2018_01_019 crossref_primary_10_1126_sciimmunol_aar6676 crossref_primary_10_1111_jth_15875 crossref_primary_10_1155_2016_2182358 crossref_primary_10_1111_bjh_15869 crossref_primary_10_3389_fimmu_2021_767175 crossref_primary_10_1016_j_drudis_2016_07_013 crossref_primary_10_1038_s41598_017_12474_5 crossref_primary_10_1016_j_cbpa_2016_06_020 crossref_primary_10_1111_all_14450 crossref_primary_10_3389_fphar_2024_1465776 crossref_primary_10_1007_s11739_016_1600_x crossref_primary_10_1177_11297298251317298 crossref_primary_10_1038_s41467_021_23881_8 crossref_primary_10_1126_scitranslmed_adh5090 crossref_primary_10_1158_0008_5472_CAN_19_3018 crossref_primary_10_3389_fcimb_2022_910908 crossref_primary_10_1002_cmdc_201800030 crossref_primary_10_1002_cncr_35559 crossref_primary_10_1136_annrheumdis_2019_215434 crossref_primary_10_1016_j_abb_2021_109015 crossref_primary_10_26508_lsa_202402788 crossref_primary_10_1016_j_prrv_2016_03_007 crossref_primary_10_1016_j_lfs_2022_121191 crossref_primary_10_1021_acs_chemrev_5b00003 crossref_primary_10_1093_ibd_izaa095 crossref_primary_10_1038_s41584_021_00738_4 crossref_primary_10_1177_1756284820974913 crossref_primary_10_1016_j_jaut_2017_01_006 crossref_primary_10_1016_j_cbpa_2021_01_010 crossref_primary_10_1016_j_phrs_2016_08_008 crossref_primary_10_1016_j_tim_2022_10_002 crossref_primary_10_3390_cancers13112832 crossref_primary_10_1186_s12959_023_00512_4 crossref_primary_10_1177_1076029620954282 crossref_primary_10_1038_s41467_022_29512_0 crossref_primary_10_1038_s41467_022_32946_1 crossref_primary_10_1016_j_chroma_2024_464643 crossref_primary_10_1016_j_jcmgh_2022_05_012 crossref_primary_10_1111_jcmm_16915 crossref_primary_10_1177_20587392211062386 crossref_primary_10_1038_s41467_024_53554_1 crossref_primary_10_1002_advs_202407346 crossref_primary_10_3389_fimmu_2023_1253667 crossref_primary_10_1021_acs_jcim_9b00729 crossref_primary_10_1007_s13277_016_5328_z crossref_primary_10_1080_14728222_2017_1294160 crossref_primary_10_1002_JLB_2RU1021_573R crossref_primary_10_1021_acsmedchemlett_8b00283 crossref_primary_10_3389_fimmu_2022_1028130 crossref_primary_10_1007_s15010_020_01528_y crossref_primary_10_3389_fcvm_2022_951670 crossref_primary_10_1172_jci_insight_124729 crossref_primary_10_1016_j_lfs_2021_119952 crossref_primary_10_1021_acs_jmedchem_7b01102 crossref_primary_10_3389_fimmu_2022_1054753 crossref_primary_10_1186_s40635_019_0251_4 crossref_primary_10_1021_acs_bioconjchem_7b00292 crossref_primary_10_1186_s12964_024_01785_6 crossref_primary_10_1016_j_heliyon_2023_e23306 crossref_primary_10_1002_rai2_12104 crossref_primary_10_3390_ijms25105261 crossref_primary_10_1126_scitranslmed_aan8292 crossref_primary_10_3389_fphar_2022_1030991 crossref_primary_10_1016_j_biopha_2024_117655 crossref_primary_10_3389_fendo_2023_1071630 crossref_primary_10_3389_fimmu_2019_02536 crossref_primary_10_1016_j_alit_2022_12_002 crossref_primary_10_2139_ssrn_4111057 crossref_primary_10_1111_cmi_13195 crossref_primary_10_1302_0301_620X_103B7_BJJ_2020_2483_R1 crossref_primary_10_3390_ijms24055034 crossref_primary_10_1055_a_2178_6491 crossref_primary_10_1016_j_cbpa_2023_102313 crossref_primary_10_3389_fimmu_2022_866747 crossref_primary_10_1016_j_heliyon_2023_e23559 crossref_primary_10_3390_ijms232415827 crossref_primary_10_1016_j_jdermsci_2016_07_001 crossref_primary_10_1016_j_jacbts_2023_11_003 crossref_primary_10_1007_s00018_019_03237_8 crossref_primary_10_1021_acs_orglett_0c01219 crossref_primary_10_1183_13993003_03157_2020 crossref_primary_10_1002_eji_201747053 crossref_primary_10_1038_s41419_020_2582_1 crossref_primary_10_1016_j_bbagen_2020_129561 crossref_primary_10_1097_BOR_0000000000000577 crossref_primary_10_1371_journal_pone_0154765 crossref_primary_10_1080_07391102_2018_1444511 crossref_primary_10_1182_blood_2017_01_764910 crossref_primary_10_3389_fmicb_2021_634043 crossref_primary_10_3389_fonc_2022_939089 crossref_primary_10_1016_j_matt_2024_09_016 crossref_primary_10_3390_life12020317 crossref_primary_10_1016_j_jep_2025_119337 crossref_primary_10_1111_jcmm_13797 crossref_primary_10_1038_s41419_020_2497_x crossref_primary_10_20517_cdr_2024_24 crossref_primary_10_3389_fimmu_2019_00012 crossref_primary_10_3389_fimmu_2021_716250 crossref_primary_10_1016_j_imbio_2019_11_002 crossref_primary_10_1080_2162402X_2015_1098803 crossref_primary_10_7554_eLife_24437 crossref_primary_10_1007_s12975_024_01318_w crossref_primary_10_1016_j_ijbiomac_2024_133163 crossref_primary_10_4049_jimmunol_1700639 crossref_primary_10_1098_rstb_2022_0240 crossref_primary_10_1098_rstb_2022_0243 crossref_primary_10_1038_s41419_022_05155_3 crossref_primary_10_1016_j_thromres_2016_01_009 crossref_primary_10_1098_rstb_2022_0247 crossref_primary_10_2478_aite_2024_0021 crossref_primary_10_3389_fvets_2018_00291 crossref_primary_10_1098_rstb_2022_0248 crossref_primary_10_1098_rstb_2022_0249 crossref_primary_10_1097_HEP_0000000000000762 crossref_primary_10_1038_s41423_023_01032_x crossref_primary_10_1183_16000617_0241_2021 crossref_primary_10_1016_j_actbio_2021_04_021 crossref_primary_10_3390_biomedicines10020217 crossref_primary_10_1021_acs_jmedchem_1c00412 crossref_primary_10_1002_smll_202404211 crossref_primary_10_1039_C6MD00373G crossref_primary_10_3389_fimmu_2019_02428 crossref_primary_10_1016_j_smim_2016_03_004 crossref_primary_10_1016_j_abb_2024_110164 crossref_primary_10_1038_s41467_021_20982_2 crossref_primary_10_1016_j_intimp_2022_109642 crossref_primary_10_1002_ddr_21608 crossref_primary_10_1016_j_ijbiomac_2023_125632 crossref_primary_10_1016_j_vetimm_2017_10_002 crossref_primary_10_3390_ijms25094641 crossref_primary_10_1038_s41467_019_09160_7 crossref_primary_10_1158_1535_7163_MCT_19_1020 crossref_primary_10_1016_j_canlet_2024_217413 crossref_primary_10_1016_j_jaci_2021_09_031 crossref_primary_10_3390_pharmaceutics16091175 crossref_primary_10_1073_pnas_1609925113 crossref_primary_10_2337_db20_0421 crossref_primary_10_3389_fimmu_2024_1452393 crossref_primary_10_1155_2022_3235524 crossref_primary_10_1016_j_exer_2021_108509 crossref_primary_10_1155_2019_8016254 crossref_primary_10_1002_JLB_4A0119_009RR crossref_primary_10_3390_ijms20092174 crossref_primary_10_1007_s00210_024_03732_1 crossref_primary_10_1038_cddis_2017_52 crossref_primary_10_3390_hemato2020018 crossref_primary_10_1016_j_ijbiomac_2024_134576 crossref_primary_10_1002_advs_202401064 crossref_primary_10_37349_en_2024_00056 crossref_primary_10_1165_rcmb_2019_0140OC crossref_primary_10_1186_s12931_023_02504_4 crossref_primary_10_3389_fcvm_2023_1155512 crossref_primary_10_1016_j_molimm_2022_09_008 crossref_primary_10_3389_fimmu_2016_00373 crossref_primary_10_1016_j_chembiol_2017_08_020 crossref_primary_10_1080_2162402X_2017_1320009 crossref_primary_10_3389_fimmu_2022_1075260 crossref_primary_10_1111_eci_12919 crossref_primary_10_3390_pharmaceutics14122551 crossref_primary_10_1016_j_bmc_2017_03_006 crossref_primary_10_1007_s00441_023_03832_z crossref_primary_10_3389_fcell_2021_789676 crossref_primary_10_3389_fimmu_2018_01323 crossref_primary_10_1073_pnas_1909546117 crossref_primary_10_1038_nm_3887 crossref_primary_10_1172_jci_insight_129687 crossref_primary_10_3390_cells9040915 crossref_primary_10_1039_C7MD00289K crossref_primary_10_3389_fimmu_2022_934444 crossref_primary_10_1080_07853890_2024_2401112 crossref_primary_10_3389_fendo_2023_1202463 crossref_primary_10_3389_fimmu_2023_1153851 crossref_primary_10_1183_13993003_02143_2021 crossref_primary_10_1007_s10787_023_01149_5 crossref_primary_10_1038_onc_2016_406 crossref_primary_10_3390_jcm11226662 crossref_primary_10_1016_j_pharmthera_2022_108328 crossref_primary_10_1016_j_thromres_2019_05_001 crossref_primary_10_3390_pharmaceutics14112414 crossref_primary_10_4110_in_2022_22_e36 crossref_primary_10_1002_ijc_33205 crossref_primary_10_1021_cb500933j crossref_primary_10_1002_path_5844 crossref_primary_10_1016_j_semcancer_2021_07_011 crossref_primary_10_1007_s44179_022_00043_9 crossref_primary_10_1038_s41598_017_15668_z crossref_primary_10_3390_scipharm92010012 crossref_primary_10_1080_1354750X_2020_1794043 crossref_primary_10_1007_s11926_020_00936_1 crossref_primary_10_1016_j_micron_2018_07_002 crossref_primary_10_1038_s41589_023_01535_8 crossref_primary_10_1038_s41598_020_68584_0 crossref_primary_10_3390_ijms22031143 crossref_primary_10_1080_14728222_2021_1918104 crossref_primary_10_1155_2023_1493684 crossref_primary_10_1016_j_tetlet_2017_12_044 crossref_primary_10_1021_acs_jproteome_1c00028 crossref_primary_10_1016_j_imbio_2022_152233 crossref_primary_10_1111_cei_12932 crossref_primary_10_3389_fimmu_2019_02481 crossref_primary_10_1002_jnr_25158 crossref_primary_10_1126_sciadv_1501257 crossref_primary_10_3389_fimmu_2016_00461 crossref_primary_10_1098_rsos_220125 crossref_primary_10_1007_s00018_022_04126_3 crossref_primary_10_3389_fimmu_2025_1487814 crossref_primary_10_1093_cvr_cvab074 crossref_primary_10_36485_1561_6274_2023_27_4_22_33 crossref_primary_10_1007_s12016_020_08804_7 crossref_primary_10_1016_j_immuni_2015_08_002 crossref_primary_10_1016_j_tibs_2021_04_004 crossref_primary_10_3389_fimmu_2021_678953 crossref_primary_10_1186_s12865_021_00397_w crossref_primary_10_1096_fj_202402514R crossref_primary_10_1021_acschembio_4c00397 crossref_primary_10_1038_s41598_022_06678_7 crossref_primary_10_1016_j_jtos_2019_03_010 crossref_primary_10_1016_j_thromres_2019_08_003 crossref_primary_10_1080_2162402X_2019_1605822 crossref_primary_10_4049_jimmunol_2001321 crossref_primary_10_1021_acs_orglett_9b02132 crossref_primary_10_1002_path_5860 crossref_primary_10_1002_dmrr_3483 crossref_primary_10_1007_s11011_023_01268_6 crossref_primary_10_2478_rir_2022_0020 crossref_primary_10_3389_fonc_2022_869706 crossref_primary_10_4049_jimmunol_1800314 crossref_primary_10_1016_j_chphi_2024_100464 crossref_primary_10_1002_rth2_12808 crossref_primary_10_1101_cshperspect_a037028 crossref_primary_10_1093_biolre_ioac173 crossref_primary_10_1111_micc_12352 crossref_primary_10_1016_j_dci_2024_105151 crossref_primary_10_1089_ten_teb_2021_0013 crossref_primary_10_1016_j_jdermsci_2015_11_006 crossref_primary_10_1515_hsz_2018_0119 crossref_primary_10_3390_ijms232112855 crossref_primary_10_1016_j_rpth_2023_100170 crossref_primary_10_3389_fmolb_2023_1150400 crossref_primary_10_3390_ijms24043598 crossref_primary_10_1002_path_5753 crossref_primary_10_3389_fimmu_2019_02148 crossref_primary_10_1038_s41467_020_20279_w crossref_primary_10_1002_JLB_3RU0620_375R crossref_primary_10_3390_ijms22147260 crossref_primary_10_1007_s10753_020_01294_x crossref_primary_10_1371_journal_pone_0226396 crossref_primary_10_1002_jcp_27874 crossref_primary_10_1080_08830185_2021_1921174 crossref_primary_10_1146_annurev_cellbio_020520_111016 crossref_primary_10_1016_j_abb_2018_03_037 crossref_primary_10_1016_j_fitote_2024_106095 crossref_primary_10_3389_fimmu_2016_00678 crossref_primary_10_1021_acs_orglett_9b04578 crossref_primary_10_1016_j_rceng_2019_11_012 crossref_primary_10_3390_ijms221910386 crossref_primary_10_1172_JCI154225 crossref_primary_10_1177_0300985819861721 crossref_primary_10_1186_s12943_025_02249_2 crossref_primary_10_3389_fimmu_2017_00081 crossref_primary_10_1021_acscombsci_8b00009 crossref_primary_10_1038_s41467_020_17066_y crossref_primary_10_1016_j_jtha_2023_09_014 crossref_primary_10_1021_acsami_5c00670 crossref_primary_10_1016_j_ajt_2024_04_018 crossref_primary_10_1186_s12931_024_02676_7 crossref_primary_10_1002_advs_202301835 crossref_primary_10_3389_fimmu_2019_01472 crossref_primary_10_1111_jth_13907 crossref_primary_10_1016_j_ebiom_2020_102925 crossref_primary_10_3389_fimmu_2019_00028 crossref_primary_10_3390_ijms242417583 crossref_primary_10_3390_pharmaceutics16030335 crossref_primary_10_1016_j_cjca_2024_09_015 crossref_primary_10_2174_2589977516666230915103730 crossref_primary_10_2337_dbi20_0026 crossref_primary_10_3389_fphar_2018_00289 crossref_primary_10_1155_2020_9254087 crossref_primary_10_3389_fmicb_2024_1441015 crossref_primary_10_3389_fonc_2023_1163802 crossref_primary_10_1186_s11658_021_00251_2 crossref_primary_10_1039_C6MD00341A crossref_primary_10_1007_s12035_021_02635_z crossref_primary_10_3389_fcimb_2022_900895 crossref_primary_10_1002_art_41407 crossref_primary_10_1080_14789450_2021_2018303 crossref_primary_10_1107_S2052252524002549 crossref_primary_10_1016_j_jtauto_2025_100280 crossref_primary_10_1111_imr_13179 crossref_primary_10_3389_fimmu_2022_1022380 crossref_primary_10_1160_TH17_02_0130 crossref_primary_10_1161_CIRCRESAHA_123_321750 crossref_primary_10_1038_nmeth_4031 crossref_primary_10_1016_j_intimp_2023_110834 crossref_primary_10_1002_pro_70033 crossref_primary_10_1158_1078_0432_CCR_23_3860 crossref_primary_10_1016_j_talanta_2024_126492 crossref_primary_10_1371_journal_pone_0163922 crossref_primary_10_1371_journal_pone_0295268 crossref_primary_10_1002_advs_202300604 crossref_primary_10_1038_s41421_023_00595_3 crossref_primary_10_3389_fimmu_2019_02462 crossref_primary_10_1016_j_jtha_2024_02_010 crossref_primary_10_1080_15592294_2017_1279371 crossref_primary_10_3389_fmicb_2021_633696 crossref_primary_10_30629_0023_2149_2021_99_11_12_608_614 crossref_primary_10_1016_j_intimp_2019_106055 crossref_primary_10_3389_fimmu_2016_00528 crossref_primary_10_1016_j_intimp_2023_110607 crossref_primary_10_1053_j_gastro_2018_12_041 crossref_primary_10_1111_imr_13284 crossref_primary_10_1182_bloodadvances_2018024026 crossref_primary_10_1002_advs_202308719 crossref_primary_10_1096_fj_202000994RR crossref_primary_10_1155_2019_2160192 crossref_primary_10_1016_S0140_6736_17_31472_1 crossref_primary_10_1242_jcs_252528 crossref_primary_10_1007_s11882_023_01082_1 crossref_primary_10_1016_j_bmcl_2022_128948 crossref_primary_10_1021_acscombsci_5b00106 crossref_primary_10_1002_mnfr_202400013 crossref_primary_10_1080_03009742_2018_1488273 crossref_primary_10_1177_2058739218805667 crossref_primary_10_1161_ATVBAHA_117_310597 crossref_primary_10_1002_mco2_70063 crossref_primary_10_1186_s12985_023_02194_w crossref_primary_10_3389_fimmu_2019_02088 crossref_primary_10_1038_s41598_018_22156_5 crossref_primary_10_1016_j_aca_2018_12_041 crossref_primary_10_1016_j_bcp_2022_115040 crossref_primary_10_1155_2018_4908328 crossref_primary_10_1016_j_bbrc_2024_149743 crossref_primary_10_1093_jleuko_qiae166 crossref_primary_10_1172_jci_insight_147564 crossref_primary_10_3390_ijms21020586 crossref_primary_10_3390_medicina55080431 crossref_primary_10_1182_blood_2019003978 crossref_primary_10_1038_srep26430 crossref_primary_10_3389_fonc_2022_975981 crossref_primary_10_1080_2162402X_2015_1134073 crossref_primary_10_4239_wjd_v12_i10_1655 crossref_primary_10_1016_j_rce_2019_11_013 crossref_primary_10_1016_j_immuni_2020_03_001 crossref_primary_10_1073_pnas_2304199121 crossref_primary_10_3389_fphar_2020_572009 crossref_primary_10_1016_j_phrs_2024_107182 crossref_primary_10_3389_fmed_2018_00019 crossref_primary_10_1002_art_40238 crossref_primary_10_3390_ijms22020559 crossref_primary_10_1016_j_trsl_2021_02_003 crossref_primary_10_1016_j_actbio_2023_05_016 crossref_primary_10_3390_biomedicines9121867 crossref_primary_10_3389_fcimb_2021_639144 crossref_primary_10_1038_s41467_018_07550_x crossref_primary_10_3390_ijms25063314 crossref_primary_10_1016_j_immuni_2020_03_011 crossref_primary_10_1177_15353702231184217 crossref_primary_10_1172_jci_insight_138873 crossref_primary_10_1136_rmdopen_2023_003104 crossref_primary_10_17749_2313_7347_ob_gyn_rep_2023_432 crossref_primary_10_1016_j_ejphar_2020_173765 crossref_primary_10_1016_j_kint_2023_03_034 crossref_primary_10_1007_s11912_024_01573_y crossref_primary_10_1016_j_matbio_2020_10_005 crossref_primary_10_1038_s41581_019_0163_2 crossref_primary_10_4049_jimmunol_1800720 crossref_primary_10_1158_0008_5472_CAN_15_3051 crossref_primary_10_4103_0366_6999_235122 crossref_primary_10_1016_j_jmb_2016_06_018 crossref_primary_10_1111_cpr_12579 crossref_primary_10_1016_j_jmgm_2016_11_016 crossref_primary_10_1371_journal_ppat_1011235 crossref_primary_10_4049_jimmunol_1701382 crossref_primary_10_1097_MD_0000000000034918 crossref_primary_10_1016_j_nbd_2020_105032 crossref_primary_10_1093_cei_uxae080 crossref_primary_10_1172_JCI83873 crossref_primary_10_1016_j_antiviral_2022_105278 crossref_primary_10_1016_j_ekir_2018_11_005 crossref_primary_10_1016_j_compbiolchem_2023_107962 crossref_primary_10_3390_jcm12041399 crossref_primary_10_1021_acschembio_5b00942 crossref_primary_10_3390_cells12172199 crossref_primary_10_17749_2313_7347_ob_gyn_rep_2024_542 crossref_primary_10_3103_S0096392520040112 crossref_primary_10_3390_jcm8101568 crossref_primary_10_1038_nri_2017_105 crossref_primary_10_3389_fimmu_2023_1253964 crossref_primary_10_1111_jth_14839 crossref_primary_10_3389_fimmu_2021_649693 crossref_primary_10_1186_s13054_025_05283_0 crossref_primary_10_1002_advs_202306457 crossref_primary_10_1038_s41420_023_01402_4 crossref_primary_10_3389_fimmu_2018_03033 crossref_primary_10_1021_acs_jmedchem_5b01507 crossref_primary_10_1016_j_redox_2025_103540 crossref_primary_10_1021_acs_orglett_0c02032 crossref_primary_10_1161_HYPERTENSIONAHA_120_16252 crossref_primary_10_1007_s44272_023_00005_5 crossref_primary_10_1021_acs_jmedchem_5b01874 crossref_primary_10_1084_jem_20220011 crossref_primary_10_1172_jci_insight_92926 crossref_primary_10_3389_fimmu_2022_834247 crossref_primary_10_3389_fimmu_2022_927233 crossref_primary_10_1177_2058738420958949 crossref_primary_10_4155_ppa_2017_0001 crossref_primary_10_1038_s41467_024_55038_8 crossref_primary_10_1038_s41598_018_33385_z crossref_primary_10_1111_febs_15589 crossref_primary_10_1111_jth_13951 crossref_primary_10_1093_cei_uxae057 crossref_primary_10_1007_s12026_023_09446_5 crossref_primary_10_1124_jpet_124_002203 crossref_primary_10_1172_jci_insight_99445 crossref_primary_10_3389_fgene_2024_1373807 crossref_primary_10_1038_s41419_023_05994_8 crossref_primary_10_1096_fj_201800691R crossref_primary_10_3390_ph9030053 crossref_primary_10_1186_s12915_024_02093_8 crossref_primary_10_1084_jem_20181170 crossref_primary_10_3390_ijms20010103 crossref_primary_10_1038_s41586_024_07820_3 crossref_primary_10_4110_in_2024_24_e31 crossref_primary_10_1016_j_intimp_2025_114299 crossref_primary_10_1038_nm_4294 crossref_primary_10_1002_JLB_3VMA0918_374R crossref_primary_10_1038_s41423_024_01137_x crossref_primary_10_1021_acs_biochem_2c00158 crossref_primary_10_1152_physrev_00062_2021 crossref_primary_10_1038_s41569_021_00552_1 crossref_primary_10_1021_acs_joc_9b02504 |
| Cites_doi | 10.1126/science.1092385 10.1111/cei.12301 10.1038/nchembio.211 10.1021/bi050292m 10.1073/pnas.1301059110 10.1074/jbc.M112.375725 10.1107/S0907444911056058 10.1107/S0907444910007493 10.1038/nbt1328 10.1038/nsmb799 10.1038/nm1565 10.1038/nchembio.496 10.1038/ncb1086 10.1021/bi200309e 10.1107/S0907444909052925 10.1084/jem.20100239 10.1083/jcb.200606027 10.1073/pnas.0909927107 10.4049/jimmunol.1100450 10.1126/scitranslmed.3005370 10.1107/S0907444911001314 10.1038/onc.2010.51 10.1021/cb400841k 10.1093/oxfordjournals.jbchem.a133257 10.1093/emboj/16.12.3373 10.1021/ja0576233 10.1128/MCB.01747-07 10.1016/j.drudis.2011.06.001 10.1021/bi100363t 10.1021/cb200258q 10.1021/jm2008985 10.1021/bi061180d 10.1016/j.bbapap.2010.07.016 10.1073/pnas.1200419109 |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2015 Copyright Nature Publishing Group Mar 2015 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2015 – notice: Copyright Nature Publishing Group Mar 2015 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7TK 7TM 7U9 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. LK8 M0S M1P M2P M7N M7P P64 PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM |
| DOI | 10.1038/nchembio.1735 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Materials Science & Engineering Collection ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1552-4469 |
| EndPage | 191 |
| ExternalDocumentID | PMC4397581 3595881091 25622091 10_1038_nchembio_1735 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01 GM079357 – fundername: NHLBI NIH HHS grantid: R01 HL102101 – fundername: NHLBI NIH HHS grantid: T32 HL066987 – fundername: NIGMS NIH HHS grantid: GM079357 |
| GroupedDBID | --- 0R~ 123 29M 39C 3V. 4.4 53G 5BI 70F 7X7 88A 88E 88I 8AO 8FE 8FG 8FH 8FI 8FJ 8R4 8R5 AAEEF AARCD AAYZH AAZLF ABAWZ ABDBF ABJCF ABJNI ABLJU ABUWG ACBWK ACGFS ACGOD ACIWK ACPRK ACUHS ADBBV AENEX AEUYN AFANA AFBBN AFKRA AFRAH AFSHS AGAYW AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC BBNVY BENPR BGLVJ BHPHI BKKNO BKSAR BPHCQ BVXVI CCPQU CS3 CZ9 D1I DB5 DU5 DWQXO EBS EE. EJD EMOBN ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ KB. KC. LK5 LK8 M0L M1P M2P M7P M7R NACWA NNMJJ O9- ODYON P2P PCBAR PDBOC PQQKQ PROAC PSQYO Q2X RNT RNTTT SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP ~8M AAYXX ALPWD ATHPR CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U RC3 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c520t-af775390ef1bafed47cae1f549e357aedded8e97dfd7fc372b7f8f9fa8b459d03 |
| IEDL.DBID | 8FG |
| ISSN | 1552-4450 1552-4469 |
| IngestDate | Thu Aug 21 18:11:32 EDT 2025 Thu Sep 04 18:48:23 EDT 2025 Fri Jul 25 08:54:41 EDT 2025 Wed Feb 19 01:53:38 EST 2025 Thu Apr 24 22:53:16 EDT 2025 Tue Jul 01 01:27:44 EDT 2025 Fri Feb 21 02:39:37 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c520t-af775390ef1bafed47cae1f549e357aedded8e97dfd7fc372b7f8f9fa8b459d03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 content type line 23 Present address: Oncology iMed, AstraZeneca, Alderley Park, SK10 4TG, UK. |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC4397581 |
| PMID | 25622091 |
| PQID | 1656087924 |
| PQPubID | 29034 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4397581 proquest_miscellaneous_1657314992 proquest_journals_1656087924 pubmed_primary_25622091 crossref_citationtrail_10_1038_nchembio_1735 crossref_primary_10_1038_nchembio_1735 springer_journals_10_1038_nchembio_1735 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2015-03-01 |
| PublicationDateYYYYMMDD | 2015-03-01 |
| PublicationDate_xml | – month: 03 year: 2015 text: 2015-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States – name: Cambridge |
| PublicationTitle | Nature chemical biology |
| PublicationTitleAbbrev | Nat Chem Biol |
| PublicationTitleAlternate | Nat Chem Biol |
| PublicationYear | 2015 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | BantscheffMNat. Biotechnol.200725103510441:CAS:528:DC%2BD2sXhtVWksLvF10.1038/nbt1328 AritaKNat. Struct. Mol. Biol.2004117777831:CAS:528:DC%2BD2cXmtVamtrs%3D10.1038/nsmb799 SlackJLJonesLEJr.BhatiaMMThompsonPRBiochemistry201150399740101:CAS:528:DC%2BC3MXkvVCls7w%3D10.1021/bi200309e LuoYBiochemistry20064511727117361:CAS:528:DC%2BD28Xpt1yqsro%3D10.1021/bi061180d DemersMProc. Natl. Acad. Sci. USA201210913076130811:CAS:528:DC%2BC38XhsVWmsrfM10.1073/pnas.1200419109 OhlssonSMClin. Exp. Immunol.20141763633721:CAS:528:DC%2BC2cXntFCmsbk%3D10.1111/cei.12301 BrinkmannVScience2004303153215351:CAS:528:DC%2BD2cXhslCgsb8%3D10.1126/science.1092385 JonesJECauseyCPKnuckleyBSlack-NoyesJLThompsonPRCurr. Opin. Drug Discov. Devel.2009126166271:CAS:528:DC%2BD1MXhsVSltL7P197366213771078 DarrahESci. Transl. Med.20135186ra6510.1126/scitranslmed.3005370 KnuckleyBBiochemistry201049485248631:CAS:528:DC%2BC3cXmtlCrsLg%3D10.1021/bi100363t AdamsPDActa Crystallogr. D Biol. Crystallogr.2010662132211:CAS:528:DC%2BC3cXhs1Sisbc%3D10.1107/S0907444909052925 WangYJ. Biol. Chem.201228725941259531:CAS:528:DC%2BC38XhtV2ns7nJ10.1074/jbc.M112.375725 SmartOSActa Crystallogr. D Biol. Crystallogr.2012683683801:CAS:528:DC%2BC38Xlt1Gns78%3D10.1107/S0907444911056058 LiPOncogene201029315331621:CAS:528:DC%2BC3cXisFOlt7Y%3D10.1038/onc.2010.51 VillanuevaEJ. Immunol.20111875385521:CAS:528:DC%2BC3MXnvValu70%3D10.4049/jimmunol.1100450 KearneyPLBiochemistry20054410570105821:CAS:528:DC%2BD2MXmtVCiu7k%3D10.1021/bi050292m HummAFritscheESteinbacherSHuberREMBO J.199716337333851:CAS:528:DyaK2sXktlCjsbY%3D10.1093/emboj/16.12.3373 EmsleyPLohkampBScottWGCowtanKActa Crystallogr. D Biol. Crystallogr.2010664865011:CAS:528:DC%2BC3cXksFKisb8%3D10.1107/S0907444910007493 JonesJEACS Chem. Biol.201271601651:CAS:528:DC%2BC3MXhtlajurzP10.1021/cb200258q CauseyCPJ. Med. Chem.201154691969351:CAS:528:DC%2BC3MXhtFygu7%2FE10.1021/jm2008985 YoungRJGreenDVLuscombeCNHillAPDrug Discov. Today2011168228301:CAS:528:DC%2BC3MXhtFCru7vF10.1016/j.drudis.2011.06.001 HakkimANat. Chem. Biol.2011775771:CAS:528:DC%2BC3cXhsFyisb%2FL10.1038/nchembio.496 LewallenDMACS Chem. Biol.201499139211:CAS:528:DC%2BC2cXht12msbY%3D10.1021/cb400841k MartinodKProc. Natl. Acad. Sci. USA2013110867486791:CAS:528:DC%2BC3sXhtFSjt7jL10.1073/pnas.1301059110 SugawaraKOyamaFJ. Biochem.1981897717741:CAS:528:DyaL3MXhtlGgtLs%3D10.1093/oxfordjournals.jbchem.a133257 MurshudovGNActa Crystallogr. D Biol. Crystallogr.2011673553671:CAS:528:DC%2BC3MXktFWqtbk%3D10.1107/S0907444911001314 BouwmeesterTNat. Cell Biol.20046971051:CAS:528:DC%2BD2cXosFSitQ%3D%3D10.1038/ncb1086 ClarkSRNat. Med.2007134634691:CAS:528:DC%2BD2sXjvVaqur0%3D10.1038/nm1565 LiPJ. Exp. Med.2010207185318621:CAS:528:DC%2BC3cXhtFensr3O10.1084/jem.20100239 ClarkMANat. Chem. Biol.200956476541:CAS:528:DC%2BD1MXpt1Ogtbo%3D10.1038/nchembio.211 LuoYKnuckleyBLeeYHStallcupMRThompsonPRJ. Am. Chem. Soc.2006128109210931:CAS:528:DC%2BD28XitV2msQ%3D%3D10.1021/ja0576233 LiPMol. Cell. Biol.200828474547581:CAS:528:DC%2BD1cXptF2ltb8%3D10.1128/MCB.01747-07 FuchsTAJ. Cell Biol.20071762312411:CAS:528:DC%2BD2sXpt1egtQ%3D%3D10.1083/jcb.200606027 LinskyTFastWBiochim. Biophys. Acta20101804194319531:CAS:528:DC%2BC3cXhtV2itb7I10.1016/j.bbapap.2010.07.016 HakkimAProc. Natl. Acad. Sci. USA2010107981398181:CAS:528:DC%2BC3cXntFGqt74%3D10.1073/pnas.0909927107 A Hakkim (BFnchembio1735_CR4) 2010; 107 K Arita (BFnchembio1735_CR16) 2004; 11 A Hakkim (BFnchembio1735_CR19) 2011; 7 P Li (BFnchembio1735_CR20) 2008; 28 JL Slack (BFnchembio1735_CR22) 2011; 50 K Sugawara (BFnchembio1735_CR26) 1981; 89 SM Ohlsson (BFnchembio1735_CR3) 2014; 176 Y Luo (BFnchembio1735_CR15) 2006; 128 RJ Young (BFnchembio1735_CR27) 2011; 16 PD Adams (BFnchembio1735_CR31) 2010; 66 A Humm (BFnchembio1735_CR18) 1997; 16 M Bantscheff (BFnchembio1735_CR33) 2007; 25 Y Luo (BFnchembio1735_CR10) 2006; 45 GN Murshudov (BFnchembio1735_CR29) 2011; 67 SR Clark (BFnchembio1735_CR7) 2007; 13 TA Fuchs (BFnchembio1735_CR35) 2007; 176 OS Smart (BFnchembio1735_CR30) 2012; 68 P Li (BFnchembio1735_CR8) 2010; 207 Y Wang (BFnchembio1735_CR13) 2012; 287 M Demers (BFnchembio1735_CR32) 2012; 109 JE Jones (BFnchembio1735_CR12) 2012; 7 V Brinkmann (BFnchembio1735_CR2) 2004; 303 E Villanueva (BFnchembio1735_CR5) 2011; 187 B Knuckley (BFnchembio1735_CR9) 2010; 49 T Linsky (BFnchembio1735_CR17) 2010; 1804 P Li (BFnchembio1735_CR21) 2010; 29 K Martinod (BFnchembio1735_CR6) 2013; 110 E Darrah (BFnchembio1735_CR24) 2013; 5 T Bouwmeester (BFnchembio1735_CR34) 2004; 6 JE Jones (BFnchembio1735_CR1) 2009; 12 P Emsley (BFnchembio1735_CR28) 2010; 66 CP Causey (BFnchembio1735_CR11) 2011; 54 DM Lewallen (BFnchembio1735_CR25) 2014; 9 MA Clark (BFnchembio1735_CR14) 2009; 5 PL Kearney (BFnchembio1735_CR23) 2005; 44 24467619 - ACS Chem Biol. 2014 Apr 18;9(4):913-21 19736621 - Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27 21460454 - Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67 17721511 - Nat Biotechnol. 2007 Sep;25(9):1035-44 20469888 - Biochemistry. 2010 Jun 15;49(23):4852-63 22826226 - Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81 21882827 - J Med Chem. 2011 Oct 13;54(19):6919-35 15001782 - Science. 2004 Mar 5;303(5663):1532-5 20654741 - Biochim Biophys Acta. 2010 Oct;1804(10):1943-53 9218780 - EMBO J. 1997 Jun 16;16(12):3373-85 21466234 - Biochemistry. 2011 May 17;50(19):3997-4010 16433522 - J Am Chem Soc. 2006 Feb 1;128(4):1092-3 20190809 - Oncogene. 2010 May 27;29(21):3153-62 17002273 - Biochemistry. 2006 Oct 3;45(39):11727-36 20383002 - Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501 17210947 - J Cell Biol. 2007 Jan 15;176(2):231-41 22605338 - J Biol Chem. 2012 Jul 27;287(31):25941-53 19648931 - Nat Chem Biol. 2009 Sep;5(9):647-54 18505818 - Mol Cell Biol. 2008 Aug;28(15):4745-58 21613614 - J Immunol. 2011 Jul 1;187(1):538-52 22505257 - Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):368-80 14743216 - Nat Cell Biol. 2004 Feb;6(2):97-105 7287639 - J Biochem. 1981 Mar;89(3):771-4 23698378 - Sci Transl Med. 2013 May 22;5(186):186ra65 20124702 - Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 17384648 - Nat Med. 2007 Apr;13(4):463-9 22004374 - ACS Chem Biol. 2012 Jan 20;7(1):160-5 21170021 - Nat Chem Biol. 2011 Feb;7(2):75-7 15247907 - Nat Struct Mol Biol. 2004 Aug;11(8):777-83 24666336 - Clin Exp Immunol. 2014 Jun;176(3):363-72 20439745 - Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8 20733033 - J Exp Med. 2010 Aug 30;207(9):1853-62 21704184 - Drug Discov Today. 2011 Sep;16(17-18):822-30 23650392 - Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9 16060666 - Biochemistry. 2005 Aug 9;44(31):10570-82 |
| References_xml | – reference: LewallenDMACS Chem. Biol.201499139211:CAS:528:DC%2BC2cXht12msbY%3D10.1021/cb400841k – reference: EmsleyPLohkampBScottWGCowtanKActa Crystallogr. D Biol. Crystallogr.2010664865011:CAS:528:DC%2BC3cXksFKisb8%3D10.1107/S0907444910007493 – reference: DemersMProc. Natl. Acad. Sci. USA201210913076130811:CAS:528:DC%2BC38XhsVWmsrfM10.1073/pnas.1200419109 – reference: YoungRJGreenDVLuscombeCNHillAPDrug Discov. Today2011168228301:CAS:528:DC%2BC3MXhtFCru7vF10.1016/j.drudis.2011.06.001 – reference: AdamsPDActa Crystallogr. D Biol. Crystallogr.2010662132211:CAS:528:DC%2BC3cXhs1Sisbc%3D10.1107/S0907444909052925 – reference: BrinkmannVScience2004303153215351:CAS:528:DC%2BD2cXhslCgsb8%3D10.1126/science.1092385 – reference: FuchsTAJ. Cell Biol.20071762312411:CAS:528:DC%2BD2sXpt1egtQ%3D%3D10.1083/jcb.200606027 – reference: KearneyPLBiochemistry20054410570105821:CAS:528:DC%2BD2MXmtVCiu7k%3D10.1021/bi050292m – reference: DarrahESci. Transl. Med.20135186ra6510.1126/scitranslmed.3005370 – reference: LuoYBiochemistry20064511727117361:CAS:528:DC%2BD28Xpt1yqsro%3D10.1021/bi061180d – reference: WangYJ. Biol. Chem.201228725941259531:CAS:528:DC%2BC38XhtV2ns7nJ10.1074/jbc.M112.375725 – reference: LinskyTFastWBiochim. Biophys. Acta20101804194319531:CAS:528:DC%2BC3cXhtV2itb7I10.1016/j.bbapap.2010.07.016 – reference: JonesJEACS Chem. Biol.201271601651:CAS:528:DC%2BC3MXhtlajurzP10.1021/cb200258q – reference: ClarkMANat. Chem. Biol.200956476541:CAS:528:DC%2BD1MXpt1Ogtbo%3D10.1038/nchembio.211 – reference: AritaKNat. Struct. Mol. Biol.2004117777831:CAS:528:DC%2BD2cXmtVamtrs%3D10.1038/nsmb799 – reference: ClarkSRNat. Med.2007134634691:CAS:528:DC%2BD2sXjvVaqur0%3D10.1038/nm1565 – reference: LiPJ. Exp. Med.2010207185318621:CAS:528:DC%2BC3cXhtFensr3O10.1084/jem.20100239 – reference: MartinodKProc. Natl. Acad. Sci. USA2013110867486791:CAS:528:DC%2BC3sXhtFSjt7jL10.1073/pnas.1301059110 – reference: LiPOncogene201029315331621:CAS:528:DC%2BC3cXisFOlt7Y%3D10.1038/onc.2010.51 – reference: CauseyCPJ. Med. Chem.201154691969351:CAS:528:DC%2BC3MXhtFygu7%2FE10.1021/jm2008985 – reference: SugawaraKOyamaFJ. Biochem.1981897717741:CAS:528:DyaL3MXhtlGgtLs%3D10.1093/oxfordjournals.jbchem.a133257 – reference: LiPMol. Cell. Biol.200828474547581:CAS:528:DC%2BD1cXptF2ltb8%3D10.1128/MCB.01747-07 – reference: MurshudovGNActa Crystallogr. D Biol. Crystallogr.2011673553671:CAS:528:DC%2BC3MXktFWqtbk%3D10.1107/S0907444911001314 – reference: JonesJECauseyCPKnuckleyBSlack-NoyesJLThompsonPRCurr. Opin. Drug Discov. Devel.2009126166271:CAS:528:DC%2BD1MXhsVSltL7P197366213771078 – reference: HakkimAProc. Natl. Acad. Sci. USA2010107981398181:CAS:528:DC%2BC3cXntFGqt74%3D10.1073/pnas.0909927107 – reference: SmartOSActa Crystallogr. D Biol. Crystallogr.2012683683801:CAS:528:DC%2BC38Xlt1Gns78%3D10.1107/S0907444911056058 – reference: LuoYKnuckleyBLeeYHStallcupMRThompsonPRJ. Am. Chem. Soc.2006128109210931:CAS:528:DC%2BD28XitV2msQ%3D%3D10.1021/ja0576233 – reference: SlackJLJonesLEJr.BhatiaMMThompsonPRBiochemistry201150399740101:CAS:528:DC%2BC3MXkvVCls7w%3D10.1021/bi200309e – reference: VillanuevaEJ. Immunol.20111875385521:CAS:528:DC%2BC3MXnvValu70%3D10.4049/jimmunol.1100450 – reference: OhlssonSMClin. Exp. Immunol.20141763633721:CAS:528:DC%2BC2cXntFCmsbk%3D10.1111/cei.12301 – reference: HummAFritscheESteinbacherSHuberREMBO J.199716337333851:CAS:528:DyaK2sXktlCjsbY%3D10.1093/emboj/16.12.3373 – reference: HakkimANat. Chem. Biol.2011775771:CAS:528:DC%2BC3cXhsFyisb%2FL10.1038/nchembio.496 – reference: KnuckleyBBiochemistry201049485248631:CAS:528:DC%2BC3cXmtlCrsLg%3D10.1021/bi100363t – reference: BantscheffMNat. Biotechnol.200725103510441:CAS:528:DC%2BD2sXhtVWksLvF10.1038/nbt1328 – reference: BouwmeesterTNat. Cell Biol.20046971051:CAS:528:DC%2BD2cXosFSitQ%3D%3D10.1038/ncb1086 – volume: 303 start-page: 1532 year: 2004 ident: BFnchembio1735_CR2 publication-title: Science doi: 10.1126/science.1092385 – volume: 176 start-page: 363 year: 2014 ident: BFnchembio1735_CR3 publication-title: Clin. Exp. Immunol. doi: 10.1111/cei.12301 – volume: 5 start-page: 647 year: 2009 ident: BFnchembio1735_CR14 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.211 – volume: 44 start-page: 10570 year: 2005 ident: BFnchembio1735_CR23 publication-title: Biochemistry doi: 10.1021/bi050292m – volume: 110 start-page: 8674 year: 2013 ident: BFnchembio1735_CR6 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1301059110 – volume: 287 start-page: 25941 year: 2012 ident: BFnchembio1735_CR13 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.375725 – volume: 68 start-page: 368 year: 2012 ident: BFnchembio1735_CR30 publication-title: Acta Crystallogr. D Biol. Crystallogr. doi: 10.1107/S0907444911056058 – volume: 66 start-page: 486 year: 2010 ident: BFnchembio1735_CR28 publication-title: Acta Crystallogr. D Biol. Crystallogr. doi: 10.1107/S0907444910007493 – volume: 25 start-page: 1035 year: 2007 ident: BFnchembio1735_CR33 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1328 – volume: 11 start-page: 777 year: 2004 ident: BFnchembio1735_CR16 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb799 – volume: 13 start-page: 463 year: 2007 ident: BFnchembio1735_CR7 publication-title: Nat. Med. doi: 10.1038/nm1565 – volume: 7 start-page: 75 year: 2011 ident: BFnchembio1735_CR19 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.496 – volume: 6 start-page: 97 year: 2004 ident: BFnchembio1735_CR34 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1086 – volume: 50 start-page: 3997 year: 2011 ident: BFnchembio1735_CR22 publication-title: Biochemistry doi: 10.1021/bi200309e – volume: 66 start-page: 213 year: 2010 ident: BFnchembio1735_CR31 publication-title: Acta Crystallogr. D Biol. Crystallogr. doi: 10.1107/S0907444909052925 – volume: 207 start-page: 1853 year: 2010 ident: BFnchembio1735_CR8 publication-title: J. Exp. Med. doi: 10.1084/jem.20100239 – volume: 176 start-page: 231 year: 2007 ident: BFnchembio1735_CR35 publication-title: J. Cell Biol. doi: 10.1083/jcb.200606027 – volume: 107 start-page: 9813 year: 2010 ident: BFnchembio1735_CR4 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0909927107 – volume: 187 start-page: 538 year: 2011 ident: BFnchembio1735_CR5 publication-title: J. Immunol. doi: 10.4049/jimmunol.1100450 – volume: 5 start-page: 186ra65 year: 2013 ident: BFnchembio1735_CR24 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3005370 – volume: 67 start-page: 355 year: 2011 ident: BFnchembio1735_CR29 publication-title: Acta Crystallogr. D Biol. Crystallogr. doi: 10.1107/S0907444911001314 – volume: 29 start-page: 3153 year: 2010 ident: BFnchembio1735_CR21 publication-title: Oncogene doi: 10.1038/onc.2010.51 – volume: 9 start-page: 913 year: 2014 ident: BFnchembio1735_CR25 publication-title: ACS Chem. Biol. doi: 10.1021/cb400841k – volume: 89 start-page: 771 year: 1981 ident: BFnchembio1735_CR26 publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a133257 – volume: 16 start-page: 3373 year: 1997 ident: BFnchembio1735_CR18 publication-title: EMBO J. doi: 10.1093/emboj/16.12.3373 – volume: 128 start-page: 1092 year: 2006 ident: BFnchembio1735_CR15 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0576233 – volume: 28 start-page: 4745 year: 2008 ident: BFnchembio1735_CR20 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01747-07 – volume: 16 start-page: 822 year: 2011 ident: BFnchembio1735_CR27 publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2011.06.001 – volume: 49 start-page: 4852 year: 2010 ident: BFnchembio1735_CR9 publication-title: Biochemistry doi: 10.1021/bi100363t – volume: 7 start-page: 160 year: 2012 ident: BFnchembio1735_CR12 publication-title: ACS Chem. Biol. doi: 10.1021/cb200258q – volume: 12 start-page: 616 year: 2009 ident: BFnchembio1735_CR1 publication-title: Curr. Opin. Drug Discov. Devel. – volume: 54 start-page: 6919 year: 2011 ident: BFnchembio1735_CR11 publication-title: J. Med. Chem. doi: 10.1021/jm2008985 – volume: 45 start-page: 11727 year: 2006 ident: BFnchembio1735_CR10 publication-title: Biochemistry doi: 10.1021/bi061180d – volume: 1804 start-page: 1943 year: 2010 ident: BFnchembio1735_CR17 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbapap.2010.07.016 – volume: 109 start-page: 13076 year: 2012 ident: BFnchembio1735_CR32 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1200419109 – reference: 14743216 - Nat Cell Biol. 2004 Feb;6(2):97-105 – reference: 16060666 - Biochemistry. 2005 Aug 9;44(31):10570-82 – reference: 16433522 - J Am Chem Soc. 2006 Feb 1;128(4):1092-3 – reference: 20190809 - Oncogene. 2010 May 27;29(21):3153-62 – reference: 24467619 - ACS Chem Biol. 2014 Apr 18;9(4):913-21 – reference: 20439745 - Proc Natl Acad Sci U S A. 2010 May 25;107(21):9813-8 – reference: 20733033 - J Exp Med. 2010 Aug 30;207(9):1853-62 – reference: 7287639 - J Biochem. 1981 Mar;89(3):771-4 – reference: 17721511 - Nat Biotechnol. 2007 Sep;25(9):1035-44 – reference: 24666336 - Clin Exp Immunol. 2014 Jun;176(3):363-72 – reference: 18505818 - Mol Cell Biol. 2008 Aug;28(15):4745-58 – reference: 17384648 - Nat Med. 2007 Apr;13(4):463-9 – reference: 20654741 - Biochim Biophys Acta. 2010 Oct;1804(10):1943-53 – reference: 23698378 - Sci Transl Med. 2013 May 22;5(186):186ra65 – reference: 21466234 - Biochemistry. 2011 May 17;50(19):3997-4010 – reference: 20124702 - Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21 – reference: 21460454 - Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67 – reference: 21882827 - J Med Chem. 2011 Oct 13;54(19):6919-35 – reference: 21170021 - Nat Chem Biol. 2011 Feb;7(2):75-7 – reference: 21613614 - J Immunol. 2011 Jul 1;187(1):538-52 – reference: 22505257 - Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):368-80 – reference: 22605338 - J Biol Chem. 2012 Jul 27;287(31):25941-53 – reference: 20383002 - Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501 – reference: 21704184 - Drug Discov Today. 2011 Sep;16(17-18):822-30 – reference: 17210947 - J Cell Biol. 2007 Jan 15;176(2):231-41 – reference: 17002273 - Biochemistry. 2006 Oct 3;45(39):11727-36 – reference: 19736621 - Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27 – reference: 9218780 - EMBO J. 1997 Jun 16;16(12):3373-85 – reference: 15001782 - Science. 2004 Mar 5;303(5663):1532-5 – reference: 22826226 - Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81 – reference: 20469888 - Biochemistry. 2010 Jun 15;49(23):4852-63 – reference: 22004374 - ACS Chem Biol. 2012 Jan 20;7(1):160-5 – reference: 15247907 - Nat Struct Mol Biol. 2004 Aug;11(8):777-83 – reference: 23650392 - Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9 – reference: 19648931 - Nat Chem Biol. 2009 Sep;5(9):647-54 |
| SSID | ssj0036618 |
| Score | 2.6319642 |
| Snippet | Inhibitors of the PAD4 enzyme that bind the inactive enzyme link this protein deiminase and the resultant arginine-to-citrulline modification to formation of... PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in... PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 189 |
| SubjectTerms | 101/58 13 14 631/250 631/535 631/92/613 82/51 82/80 Animals Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Binding, Competitive Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Calcium - metabolism Cell Biology Chemistry Chemistry/Food Science Citrulline - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Genetics HEK293 Cells Histones - metabolism Humans Hydrolases - antagonists & inhibitors In Vitro Techniques Mice Models, Molecular Neutrophils - drug effects Protein-Arginine Deiminases Small Molecule Libraries Substrate Specificity |
| Title | Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation |
| URI | https://link.springer.com/article/10.1038/nchembio.1735 https://www.ncbi.nlm.nih.gov/pubmed/25622091 https://www.proquest.com/docview/1656087924 https://www.proquest.com/docview/1657314992 https://pubmed.ncbi.nlm.nih.gov/PMC4397581 |
| Volume | 11 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFH9i2wEuCDY-MkZlJDQuhCVOXCcn1G4tA4lqmjapt8iObS0Sc8qSHvbf8-wmYWPAKQe_yLGfY78v_34A7402StGShiIZ6zCNVRTKcSlDxyaiHERc6dH5vy_Gp5fptyVbdgG3piur7PdEv1GrunQx8iOPEpNxdBc-r36GjjXKZVc7Co0t2IkpnrXupvj8S78TJ3j2-KtwjNEwTVnUYWxGSXZkcUquZVV_irlnertzJj0wNB_WS_6RNPVn0fwZPO2MSDLZaP05PNJ2F_YmFh3o61tySHxZp4-X78Lj457SbQ_Ov9qrSvoiLVIbcjY5SYm72OD4I0jVkGbtASWwf9LWRFXNzXrVEhcc0ERYRTyhH1nMLshw5_EFXM5nF8enYUeqEJaMRm0oDEcPJY-0iaUwWqW8FDo26CbqhHGhcbtTmc65MoqbMuFUcpOZ3IhMpixH9b2EbVtb_RqI1lmWGoHC-Cyllky4qCJXckxTQ_MAPvbTWpQd4rgjvvhR-Mx3khW9FgqnhQAOB_HVBmrjX4IHvY6K7o9rit_rI4B3QzPOr0uACKtxqpwMT9AlzGkArzYqHXpC049SNJ4C4PeUPQg4HO77Lba68njczqZjGb75oV8Wdz7rbwPY__8A3sATNMvYptLtALbbm7V-i6ZPK0ewxZd85Ff5CHYm05PpHJ_T2eLs_Bd8lQwN |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcigXBC2P0AJGgnIhNGsn6-SA0KrtskvbFUJbqbdgx7YaiSbbJivUP8VvZOw8aClw6ykHT-LYM7Zn7PH3Abw22ihFM-oLNtR-OFCBL4eZ9C2biLIQcZlD5z-aDSfH4eeT6GQFfnZ3YWxaZTcnuolalZndI99xKDExx3Dh4-Lct6xR9nS1o9BozOJAX_7AkK36MN1D_b6hdLw_3534LauAn0U0qH1hOLroSaDNQAqjVcgzoQcG4yTNIi40jncV64Qro7jJGKeSm9gkRsQyjBL8f_zuHbgbMsZsCmE8_tTN_AzXOnf1LoqoH4ZR0GJ6BizeKVAFZzIv3w-4Y5a7sgbecGxv5mf-cUjr1r7xA7jfOq1k1FjZQ1jRxTpsjAoM2M8uyTZxaaRuf34d1nY7CrkN-DotTnPpksJIaciX0V5I7EUKy1dB8opUSwdggfWTuiQqry6Wi5rYzQhNRKGIIxAks_056e9YPoLjW-nux7BalIV-CkTrOA6NQGF8ZlLLSNhdTK7kkIaGJh6867o1zVqEc0u08T11J-0sTjstpFYLHmz34osG2uNfgludjtJ2hFfpb3v04FVfjP1rD1xEobGrrAxnGIIm1IMnjUr7mtDVpBSdNQ_4NWX3Ahb3-3pJkZ86_G_rQ0Yxvvm2M4srv_W3Bjz7fwNewtpkfnSYHk5nB5twD13CqMmy24LV-mKpn6PbVcsXztYJfLvtwfULgCJIbA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgEXBC2PQAEjQbkQNus46-SAqlW3qy6FVYVaaW_Bjm01Ek2WJivUv8avY-w82lLg1lMOnsSxZ2zP2OPvA3hjtFGKZtQX4Uj7bKgCX44y6Vs2EWUh4jKHzv9lPto_Zp8W0WINfnV3YWxaZTcnuolalZndIx84lJiYY7gwMG1axOFkurP84VsGKXvS2tFpNCZyoM9_YvhWfZxNUNdvKZ3uHe3u-y3DgJ9FNKh9YTi660mgzVAKoxXjmdBDgzGTDiMuNI59FeuEK6O4yUJOJTexSYyIJYsSbAt-9xbc5iFjljaCL_pgL8R1z13DiyLqMxYFLb5nEMaDAtVxKvPyw5A7lrlL6-E1J_d6ruYfB7ZuHZw-gPutA0vGjcU9hDVdbMDmuMDg_fScbBOXUur26jfg7m5HJ7cJX2fFSS5dghgpDTkcTxixlyosdwXJK1KtHJgF1k_qkqi8Olsta2I3JjQRhSKOTJDM945If9_yERzfSHc_hvWiLPRTIFrHMTMChfGZSS0jYXc0uZIjygxNPHjfdWuatWjnlnTje-pO3cM47bSQWi14sN2LLxuYj38JbnU6StvRXqUXtunB674Y-9cevohCY1dZGR5iOJpQD540Ku1rQreTUnTcPOBXlN0LWAzwqyVFfuKwwK0_GcX45rvOLC791t8a8Oz_DXgFd3BYpZ9n84PncA-9w6hJuNuC9fpspV-gB1bLl87UCXy76bH1Gz7nTJ8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inhibition+of+PAD4+activity+is+sufficient+to+disrupt+mouse+and+human+NET+formation&rft.jtitle=Nature+chemical+biology&rft.au=Lewis%2C+Huw+D.&rft.au=Liddle%2C+John&rft.au=Coote%2C+Jim+E.&rft.au=Atkinson%2C+Stephen+J.&rft.date=2015-03-01&rft.issn=1552-4450&rft.eissn=1552-4469&rft.volume=11&rft.issue=3&rft.spage=189&rft.epage=191&rft_id=info:doi/10.1038%2Fnchembio.1735&rft_id=info%3Apmid%2F25622091&rft.externalDocID=PMC4397581 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1552-4450&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1552-4450&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1552-4450&client=summon |