Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model – Application to amino acid depletion in CHO cell culture - Hagrot, Erika; Oddsdóttir, Hildur Æsa; Hosta, Joan Gonzalez; Jacobsen, Elling W.; Chotteau, Véronique (Journal of biotechnology, 2017)
Keywords: Amino acid metabolism; amino acids; Amino Acids - metabolism; Animals; biochemical pathways; bioprocessing; cell culture; Chinese hamster ovary cells; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; culture media; Elementary flux modes; equations; mammals; Metabolic Flux Analysis; Metabolic Networks and Pathways - physiology; metabolism; metabolites; Modeling; Models, Biological; Poly-pathway model; Modeling; Amino acid metabolism; Metabolic flux analysis; Elementary flux modes; Poly-pathway model; Chinese hamster ovary cells