Bayesian decision procedures for dose-escalation based on evidence of undesirable events and therapeutic benefit - Whitehead, John; Zhou, Yinghui; Stevens, John; Blakey, Graham; Price, Jim; Leadbetter, Joanna (Statistics in medicine, 2006)
Keywords: Anticoagulants - pharmacology; Anticoagulants - therapeutic use; Bayes Theorem; Bayesian analysis; Bayesian decision procedure; Clinical Trials, Phase I as Topic - methods; continual reassessment method; Decision Making; dose-escalation; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Humans; Logistic Models; logistic regression; Maximum Tolerated Dose; Models, Statistical; phase I clinical trial; Regression analysis; Therapy; Thromboembolism - drug therapy