Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice - Jabara, Haifa H.; Lee, John J.; Janssen, Erin; Ullas, Sumana; Liadaki, Kyriaki; Garibyan, Lilit; Benson, Halli; Sannikova, Tatyana; Bram, Richard; Hammarstrom, Lennart; Cruz, Anthony C.; Siegel, Richard; et al. (Journal of allergy and clinical immunology, 2017)
Keywords: Allergy and Immunology; Animals; Antigens; Apoptosis; Blood & organ donations; B cells; Cloning; common variable immunodeficiency; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gene Knock-In Techniques; Haploinsufficiency; HEK293 Cells; Heterozygote; Homeostasis; Human subjects; Humans; Immune response; Immune system; Immunoglobulins; Ligands; Lymphocyte Activation - immunology; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Mutation; natural antibodies; pneumococcal susceptibility; Pneumonia, Pneumococcal - genetics; Pneumonia, Pneumococcal - immunology; Polymerase Chain Reaction; Stem cells; Streptococcus infections; Tetanus; Transmembrane activator and calcium modulator ligand interactor; Transmembrane Activator and CAML Interactor Protein - genetics; Transmembrane Activator and CAML Interactor Protein - immunology; BAFF; TNFR; Transmembrane activator and calcium modulator ligand interactor; common variable immunodeficiency; natural antibodies; TD; pneumococcal susceptibility; CVID; NF-κB; TNP-KLH; CRD; TACI; TI; B cells; NP-OVA; WT; APRIL; Cysteine-rich domain; A proliferation-inducing ligand; 4-Hydroxy-3-nitrophenyl acetyl–ovalbumin; Nuclear factor κB; T independent; Trinitrophenyl–keyhole limpet hemocyanin; T dependent; Wild-type; TNF receptor; B cell–activating factor