Doxycycline Prevents Preclinical Atherosclerosis, Pancreatic Islet Loss and Improves Insulin Secretion after Glycemic Stimulation: Preclinical Study in Individuals with a High-Fat Diet

Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects o...

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Published in	Biomedicines Vol. 11; no. 3; p. 717
Main Authors	Rodriguez-Hernandez, Alejandrina, Delgado-Machuca, Marina, Guardado-Mendoza, Rodolfo, Mendoza-Hernandez, Martha A., Melnikov, Valery, Delgado-Enciso, Osiris G., Tiburcio-Jimenez, Daniel, Ceja-Espiritu, Gabriel, Hernandez-Fuentes, Gustavo A., Gamboa-Dominguez, Armando, Guzman-Esquivel, Jose, Martinez-Fierro, Margarita L., Rodriguez-Sanchez, Iram P., Delgado-Enciso, Ivan
Format	Journal Article
Language	English
Published	Switzerland MDPI AG 27.02.2023 MDPI
Subjects	Adipogenesis Anti-inflammatory agents Antibodies Aorta Arteriosclerosis Atherosclerosis Bacterial infections Beta cells Carbohydrates Cardiovascular disease Chronic illnesses Cloning Coronary vessels Diabetes Diet Dosage and administration Doxycycline Drug dosages Ethanol Glucose Glucose metabolism High fat diet Inflammation Insulin Insulin secretion Laboratory animals Metabolism Pancreas Proteins Serum levels Transgenic animals treatment Mexico United States > US Germany atherosclerosis treatment doxycycline diabetes pancreas
Online Access	Get full text
ISSN	2227-9059 2227-9059
DOI	10.3390/biomedicines11030717

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Abstract	Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm2, in addition to losing large islets. The index of β cell function (∆Insulin0–30/∆Glucose0–30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups.
AbstractList	Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm2, in addition to losing large islets. The index of β cell function (∆Insulin0–30/∆Glucose0–30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups. Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm2, in addition to losing large islets. The index of β cell function (∆Insulin0-30/∆Glucose0-30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups.Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm2, in addition to losing large islets. The index of β cell function (∆Insulin0-30/∆Glucose0-30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups. Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm , in addition to losing large islets. The index of β cell function (∆Insulin0-30/∆Glucose0-30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups. Doxycycline (Doxy) is an antibiotic, which has exhibited anti-inflammatory activity and glucose metabolism improvement. The present study was proposed to evaluate its effects on glucose metabolism and other associated processes, such as lipemia and adipogenesis, as well as, to evaluate its effects on the liver, pancreas, and aorta in subjects fed with an occidental high-fat diet (HFD). The trial followed three groups of BALB/c mice for 6 months: (1) Standard diet (SD); (2) HFD-placebo (saline solution); and (3) HFD-Doxy (10 mg/kg/day). Intrahepatic fat accumulation (steatohepatosis) and the epididymal fat pad, as well as the hepatic inflammatory infiltrate and ALT serum levels were higher in both groups with the HFD (with/without doxycycline) in comparison with the SD group. The thickness of the aorta (preclinic atherosclerosis) was significantly elevated in the HFD group with respect to the HFD + Doxy and SD group, these two being similar groups to each other. The HFD-Doxy group had pancreatic morphological parameters very similar to those of the SD group; on the contrary, the HFD group reduced the number of pancreatic islets and the number of β cells per mm[sup.2], in addition to losing large islets. The index of β cell function (∆Insulin0–30/∆Glucose0–30 ratio) was significantly higher in the HFD + Doxy group, compared to the rest of the groups.
Audience	Academic
Author	Ceja-Espiritu, Gabriel Rodriguez-Sanchez, Iram P. Melnikov, Valery Tiburcio-Jimenez, Daniel Delgado-Enciso, Osiris G. Gamboa-Dominguez, Armando Martinez-Fierro, Margarita L. Mendoza-Hernandez, Martha A. Guardado-Mendoza, Rodolfo Delgado-Enciso, Ivan Guzman-Esquivel, Jose Rodriguez-Hernandez, Alejandrina Hernandez-Fuentes, Gustavo A. Delgado-Machuca, Marina
AuthorAffiliation	6 Molecular Medicine Laboratory, Unidad de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico 1 School of Medicine, Universidad de Colima, Colima 28040, Mexico 3 Department of Medicine and Nutrition, Universidad de Guanajuato, Campus León, León 37320, Mexico 5 Belisario Domínguez Sección XVI, Pathology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico 4 Clinical Epidemiology Research Unit, Mexican Institute of Social Security, Instituto Mexicano del Seguro Social, Villa de Álvarez 28984, Mexico 2 Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico 7 Molecular and Structural Physiology Laboratory, School of Biological Sciences, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Mexico
AuthorAffiliation_xml	– name: 1 School of Medicine, Universidad de Colima, Colima 28040, Mexico – name: 7 Molecular and Structural Physiology Laboratory, School of Biological Sciences, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Mexico – name: 3 Department of Medicine and Nutrition, Universidad de Guanajuato, Campus León, León 37320, Mexico – name: 4 Clinical Epidemiology Research Unit, Mexican Institute of Social Security, Instituto Mexicano del Seguro Social, Villa de Álvarez 28984, Mexico – name: 5 Belisario Domínguez Sección XVI, Pathology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico – name: 6 Molecular Medicine Laboratory, Unidad de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98160, Mexico – name: 2 Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico
Author_xml	– sequence: 1 givenname: Alejandrina surname: Rodriguez-Hernandez fullname: Rodriguez-Hernandez, Alejandrina – sequence: 2 givenname: Marina orcidid: 0000-0003-0835-5562 surname: Delgado-Machuca fullname: Delgado-Machuca, Marina – sequence: 3 givenname: Rodolfo surname: Guardado-Mendoza fullname: Guardado-Mendoza, Rodolfo – sequence: 4 givenname: Martha A. orcidid: 0000-0002-7646-0842 surname: Mendoza-Hernandez fullname: Mendoza-Hernandez, Martha A. – sequence: 5 givenname: Valery surname: Melnikov fullname: Melnikov, Valery – sequence: 6 givenname: Osiris G. surname: Delgado-Enciso fullname: Delgado-Enciso, Osiris G. – sequence: 7 givenname: Daniel surname: Tiburcio-Jimenez fullname: Tiburcio-Jimenez, Daniel – sequence: 8 givenname: Gabriel surname: Ceja-Espiritu fullname: Ceja-Espiritu, Gabriel – sequence: 9 givenname: Gustavo A. surname: Hernandez-Fuentes fullname: Hernandez-Fuentes, Gustavo A. – sequence: 10 givenname: Armando surname: Gamboa-Dominguez fullname: Gamboa-Dominguez, Armando – sequence: 11 givenname: Jose surname: Guzman-Esquivel fullname: Guzman-Esquivel, Jose – sequence: 12 givenname: Margarita L. orcidid: 0000-0003-1478-9068 surname: Martinez-Fierro fullname: Martinez-Fierro, Margarita L. – sequence: 13 givenname: Iram P. orcidid: 0000-0002-5988-4168 surname: Rodriguez-Sanchez fullname: Rodriguez-Sanchez, Iram P. – sequence: 14 givenname: Ivan orcidid: 0000-0001-9848-862X surname: Delgado-Enciso fullname: Delgado-Enciso, Ivan
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SubjectTerms	Adipogenesis Anti-inflammatory agents Antibodies Aorta Arteriosclerosis Atherosclerosis Bacterial infections Beta cells Carbohydrates Cardiovascular disease Chronic illnesses Cloning Coronary vessels Diabetes Diet Dosage and administration Doxycycline Drug dosages Ethanol Glucose Glucose metabolism High fat diet Inflammation Insulin Insulin secretion Laboratory animals Metabolism Pancreas Proteins Serum levels Transgenic animals treatment
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Title	Doxycycline Prevents Preclinical Atherosclerosis, Pancreatic Islet Loss and Improves Insulin Secretion after Glycemic Stimulation: Preclinical Study in Individuals with a High-Fat Diet
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