A Novel Calcium Phosphate–Based Nanocomposite for Augmentation of Cortical Bone Trajectory Screw Fixation
Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN). Material and Methods: CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided...
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| Published in | International journal of nanomedicine Vol. 17; pp. 3059 - 3071 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Macclesfield
Dove Medical Press Limited
01.01.2022
Taylor & Francis Ltd Dove Dove Medical Press |
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| Online Access | Get full text |
| ISSN | 1178-2013 1176-9114 1178-2013 |
| DOI | 10.2147/IJN.S365149 |
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| Abstract | Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN). Material and Methods: CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN. Results: After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 [+ or -] 358.21 N vs PMMA, 1778.45 [+ or -] 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 [+ or -] 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 [+ or -] 0.78 N*m vs control, 0.97 [+ or -] 0.58 N*m) and lower than that in the PMMA group (1.93 [+ or -] 0.81 N*m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model. Conclusion: The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability. Keywords: cement augmentation, CBT screws, osteoporotic spine, PMMA, CPN |
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| AbstractList | To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN).PurposeTo evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN).CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN.Material and MethodsCBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN.After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 ± 358.21 N vs PMMA, 1778.45 ± 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 ± 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 ± 0.78 N∙m vs control, 0.97 ± 0.58 N∙m) and lower than that in the PMMA group (1.93 ± 0.81 N∙m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model.ResultsAfter cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 ± 358.21 N vs PMMA, 1778.45 ± 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 ± 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 ± 0.78 N∙m vs control, 0.97 ± 0.58 N∙m) and lower than that in the PMMA group (1.93 ± 0.81 N∙m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model.The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability.ConclusionThe biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability. Yuetian Wang,1,* Chun Liu,2,* Huiling Liu,3 Haoyong Fu,1 Chunde Li,1 Lei Yang,3,4 Haolin Sun1 1Department of Orthopedics, Peking University First Hospital, Beijing, People’s Republic of China; 2Medical Research Centre, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Jiangsu, People’s Republic of China; 3Institute of Orthopedics, Department of Orthopedics, Soochow University, Suzhou, People’s Republic of China; 4Center for Health Sciences and Engineering (CHSE), School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Yang; Haolin Sun, Tel +86 13681146156, Email ylei@hebut.edu.cn; sunhaolin@vip.163.comPurpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate–based nanocomposite (CPN).Material and Methods: CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN.Results: After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 ± 358.21 N vs PMMA, 1778.45 ± 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 ± 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 ± 0.78 N∙m vs control, 0.97 ± 0.58 N∙m) and lower than that in the PMMA group (1.93 ± 0.81 N∙m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model.Conclusion: The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability.Keywords: cement augmentation, CBT screws, osteoporotic spine, PMMA, CPN Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate–based nanocomposite (CPN). Material and Methods: CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN. Results: After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 ± 358.21 N vs PMMA, 1778.45 ± 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 ± 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 ± 0.78 N∙m vs control, 0.97 ± 0.58 N∙m) and lower than that in the PMMA group (1.93 ± 0.81 N∙m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model. Conclusion: The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability. Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN). Material and Methods: CBT screws were placed into cadaveric lumbar vertebrae. Depending on the material used for augmentation, they were divided into the following three groups: CPN, polymethylmethacrylate (PMMA), and control. Radiological imaging was used to evaluate the cement dispersion. Biomechanical tests were conducted to measure the stability of CBT screws. A rat cranial defect model was used to evaluate biodegradation and osseointegration of the CPN. Results: After cement augmentation, the CPN tended to disperse into the distal part of the screws, whereas PMMA remained limited to the proximal part of the screws (P < 0.05). As for cement morphology, the CPN tended to form a concentrated mass, whereas PMMA arranged itself as a scattered cement cloud, but the difference was not significant (P > 0.05). The axial pullout test showed that the average maximal pullout force (Fmax) of CPN-augmented CBT screws was similar to that of the PMMA group (CPN, 1639.56 [+ or -] 358.21 N vs PMMA, 1778.45 [+ or -] 399.83 N; P = 0.745) and was significantly greater than that of the control group (1019.01 [+ or -] 371.98 N; P < 0.05). The average torque value in the CPN group was higher than that in the control group (CPN, 1.51 [+ or -] 0.78 N*m vs control, 0.97 [+ or -] 0.58 N*m) and lower than that in the PMMA group (1.93 [+ or -] 0.81 N*m), but there were no statistically significant differences (P > 0.05). The CPN could be biodegraded and gradually replaced by newly formed bone tissue after 12 weeks in a rat cranial defect model. Conclusion: The biocompatible CPN could be a valuable augmentation material to enhance CBT screw stability. Keywords: cement augmentation, CBT screws, osteoporotic spine, PMMA, CPN |
| Audience | Academic |
| Author | Liu, Huiling Yang, Lei Liu, Chun Sun, Haolin Wang, Yuetian Fu, Haoyong Li, Chunde |
| Author_xml | – sequence: 1 givenname: Yuetian surname: Wang fullname: Wang, Yuetian – sequence: 2 givenname: Chun surname: Liu fullname: Liu, Chun – sequence: 3 givenname: Huiling surname: Liu fullname: Liu, Huiling – sequence: 4 givenname: Haoyong surname: Fu fullname: Fu, Haoyong – sequence: 5 givenname: Chunde surname: Li fullname: Li, Chunde – sequence: 6 givenname: Lei orcidid: 0000-0002-3681-2874 surname: Yang fullname: Yang, Lei – sequence: 7 givenname: Haolin orcidid: 0000-0002-4938-9198 surname: Sun fullname: Sun, Haolin |
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| Snippet | Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN).... Purpose: To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate–based nanocomposite (CPN).... To evaluate the effect of cement augmentation of cortical bone trajectory (CBT) screws using a novel calcium phosphate-based nanocomposite (CPN).PurposeTo... Yuetian Wang,1,* Chun Liu,2,* Huiling Liu,3 Haoyong Fu,1 Chunde Li,1 Lei Yang,3,4 Haolin Sun1 1Department of Orthopedics, Peking University First Hospital,... |
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| SubjectTerms | Biocompatibility Biodegradation Biomechanics Calcium phosphate Calcium phosphates cbt screws Cement cement augmentation Clinical medicine cpn Evaluation Human subjects Mechanical properties Nanocomposites Nanomaterials Original Research Osteoporosis osteoporotic spine pmma Polymethylmethacrylate Rheology Surgeons Vertebrae Viscosity |
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| Title | A Novel Calcium Phosphate–Based Nanocomposite for Augmentation of Cortical Bone Trajectory Screw Fixation |
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