Preclinical Study of Pharmacokinetic/Pharmacodynamic Analysis of Tebipenem Using Monte Carlo Simulation for Extended-Spectrum β-Lactamase-Producing Bacterial Urinary Tract Infections in Japanese Patients According to Renal Function - Ebihara, Fumiya; Maruyama, Takumi; Kasai, Hidefumi; Shiokawa, Mitsuru; Matsunaga, Nobuaki; Hamada, Yukihiro (Antibiotics (Basel), 2025)
Keywords: Adults; Analysis; Antibiotics; Antimicrobial agents; Bacterial infections; Beta lactamases; Carbapenems; Care and treatment; Clinical trials; Creatinine; Dosage; Drug dosages; E coli; Evidence-based medicine; extended-spectrum β-lactamase; Gram-positive bacteria; Health aspects; Health care expenditures; Hospitalization; Impairment; International studies; Minimum inhibitory concentration; Monte Carlo method; Monte Carlo simulation; Mortality; Patient compliance; Patients; Pediatrics; Pharmacodynamics; Pharmacokinetics; pharmacokinetics/pharmacodynamics; Regulatory approval; Renal function; Simulation methods; tebipenem; Technology application; Urinary tract; Urinary tract diseases; urinary tract infection; Urinary tract infections; Urogenital system; β Lactamase; Japan; extended-spectrum β-lactamase; renal function; tebipenem; Monte Carlo simulation; urinary tract infection; pharmacokinetics/pharmacodynamics