Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel

ABSTRACT Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polyl...

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Published in	Journal of orthopaedic research Vol. 33; no. 4; pp. 572 - 583
Main Authors	Baek, Jihye, Chen, Xian, Sovani, Sujata, Jin, Sungho, Grogan, Shawn P., D'Lima, Darryl D.
Format	Journal Article
Language	English
Published	United States Blackwell Publishing Ltd 01.04.2015
Subjects	Adult Biocompatible Materials - chemistry Biomechanical Phenomena Cell Survival Cells, Cultured ECM hydrogel electrospinning Extracellular Matrix - chemistry Female Humans Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Male Materials Testing - methods Menisci, Tibial - cytology Menisci, Tibial - ultrastructure meniscus Tensile Strength tissue engineering Tissue Engineering - methods Tissue Scaffolds Young Adult tissue engineering ECM hydrogel electrospinning meniscus
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ISSN	0736-0266 1554-527X 1554-527X
DOI	10.1002/jor.22802

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Abstract	ABSTRACT Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus‐like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real‐time polymerase chain reaction (PCR), respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, and COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell‐based meniscus regeneration strategies. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:572–583, 2015.
AbstractList	Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are therefore likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus-like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real-time PCR, respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell-based meniscus regeneration strategies. Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus-like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real-time polymerase chain reaction (PCR), respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, and COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell-based meniscus regeneration strategies. Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus-like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real-time polymerase chain reaction (PCR), respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, and COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell-based meniscus regeneration strategies.Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus-like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real-time polymerase chain reaction (PCR), respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, and COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell-based meniscus regeneration strategies. ABSTRACT Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the meniscus are, therefore, likely to prevent or delay OA progression. We investigated the novel approach of building layers of aligned polylactic acid (PLA) electrospun (ES) scaffolds with human meniscus cells embedded in extracellular matrix (ECM) hydrogel to lead to formation of neotissues that resemble meniscus‐like tissue. PLA ES scaffolds with randomly oriented or aligned fibers were seeded with human meniscus cells derived from vascular or avascular regions. Cell viability, cell morphology, and gene expression profiles were monitored via confocal microscopy, scanning electron microscopy (SEM), and real‐time polymerase chain reaction (PCR), respectively. Seeded scaffolds were used to produce multilayered constructs and were examined via histology and immunohistochemistry. Morphology and mechanical properties of PLA scaffolds (with and without cells) were influenced by fiber direction of the scaffolds. Both PLA scaffolds supported meniscus tissue formation with increased COL1A1, SOX9, and COMP, yet no difference in gene expression was found between random and aligned PLA scaffolds. Overall, ES materials, which possess mechanical strength of meniscus and can support neotissue formation, show potential for use in cell‐based meniscus regeneration strategies. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:572–583, 2015.
Author	D'Lima, Darryl D. Jin, Sungho Grogan, Shawn P. Chen, Xian Baek, Jihye Sovani, Sujata
AuthorAffiliation	2 Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, California 1 Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA
AuthorAffiliation_xml	– name: 2 Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, California – name: 1 Shiley Center for Orthopaedic Research and Education at Scripps Clinic, La Jolla, CA
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Biofabrication 5:015001. 2013; 26 1996; 17 2006; 34 2006; 12 2002; 198 1987; 224 2009; 60 2002; 13 2002; 10 2011; 32 1999; 367S 2008; 3 2001; 29 2005; 26 1999; 7 2011; 19 2013; 5 2005; 22 1998; 197 2001; 42 2013; 9 2007; 455 2007; 28 2013; 19 2009; 11 2012; 3 2001; 7 2004; 15 2004; 12 2001; 9 2013; 133 2003; 48 2009; 6 2001; 17 2007; 40 2007; 2 2012; 23 2003; 63 2009; 16 2012; 20 2010; 6 2007; 25 1998; 14 2010; 8 2007; 27 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_10_1 McCullen SD (e_1_2_7_39_1) 2007; 2 e_1_2_7_46_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 Gloria A (e_1_2_7_20_1) 2010; 8 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_36_1 e_1_2_7_37_1 e_1_2_7_38_1 15603819 - Biomaterials. 2005 Jun;26(16):3243-8 11292034 - Am J Sports Med. 2001 Mar-Apr;29(2):118-23 3311520 - Clin Orthop Relat Res. 1987 Nov;(224):52-63 12905471 - Arthritis Rheum. 2003 Aug;48(8):2178-87 19500336 - Arthritis Res Ther. 2009;11(3):R85 17179785 - Clin Orthop Relat Res. 2007 Feb;455:134-41 11337709 - Arthroscopy. 2001 May;17(5):439-44 20926132 - Biomaterials. 2011 Jan;32(2):639-51 21764438 - Biomaterials. 2011 Oct;32(30):7411-31 12210057 - J Pathol. 2002 Sep;198(1):5-13 15135144 - Osteoarthritis Cartilage. 2004 Jun;12(6):476-84 18689924 - Biomed Mater. 2008 Sep;3(3):034002 9788368 - Arthroscopy. 1998 Oct;14(7):726-37 23172542 - Biofabrication. 2013 Mar;5(1):015001 24955629 - J Funct Biomater. 2012 Jul 27;3(3):497-513 22994398 - Tissue Eng Part A. 2013 Feb;19(3-4):538-47 19853066 - Acta Biomater. 2010 Apr;6(4):1219-26 8624401 - Biomaterials. 1996 Jan;17(2):93-102 20740467 - J Appl Biomater Biomech. 2010 May-Aug;8(2):57-67 23523536 - Acta Biomater. 2013 Jul;9(7):7218-26 17457824 - J Orthop Res. 2007 Aug;25(8):1018-28 23076654 - Arch Orthop Trauma Surg. 2013 Jan;133(1):95-109 11304448 - Tissue Eng. 2001 Apr;7(2):111-29 9565324 - Anat Embryol (Berl). 1998 Apr;197(4):317-24 17056048 - J Biomech. 2007;40(8):1686-93 15332611 - J Mater Sci Mater Med. 2004 Apr;15(4):423-7 10546653 - Clin Orthop Relat Res. 1999 Oct;(367 Suppl):S281-92 11237658 - Osteoarthritis Cartilage. 2001 Feb;9(2):112-8 16213379 - Clin Podiatr Med Surg. 2005 Oct;22(4):553-60, vi 17250888 - Biomaterials. 2007 Apr;28(11):1967-77 21683797 - Osteoarthritis Cartilage. 2011 Sep;19(9):1132-41 19248081 - Arthritis Rheum. 2009 Mar;60(3):633-5 22322583 - Nanotechnology. 2012 Mar 9;23(9):095705 19751124 - Expert Rev Med Devices. 2009 Sep;6(5):515-32 22555208 - Sports Med Arthrosc. 2012 Jun;20(2):106-14 12355305 - Knee Surg Sports Traumatol Arthrosc. 2002 Sep;10(5):300-4 16157845 - Am J Sports Med. 2006 Jan;34(1):32-42 17722553 - Int J Nanomedicine. 2007;2(2):253-63 16889508 - Tissue Eng. 2006 Jul;12(7):1775-85 24057873 - Eur Cell Mater. 2013;26:150-70 19269183 - Knee. 2009 Oct;16(5):398-404
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Snippet	ABSTRACT Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace... Meniscus injury and degeneration have been linked to the development of secondary osteoarthritis (OA). Therapies that successfully repair or replace the...
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SubjectTerms	Adult Biocompatible Materials - chemistry Biomechanical Phenomena Cell Survival Cells, Cultured ECM hydrogel electrospinning Extracellular Matrix - chemistry Female Humans Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Male Materials Testing - methods Menisci, Tibial - cytology Menisci, Tibial - ultrastructure meniscus Tensile Strength tissue engineering Tissue Engineering - methods Tissue Scaffolds Young Adult
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Title	Meniscus tissue engineering using a novel combination of electrospun scaffolds and human meniscus cells embedded within an extracellular matrix hydrogel
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