Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E

• Published in: Clinical and molecular allergy CMA Vol. 16; no. 1; pp. 23 - 9
• Main Authors: Rasheed, Zafar, Zedan, Khaled, Saif, Ghada Bin, Salama, Ragaa H., Salem, Tarek, Ahmed, Ahmed A., El-Moniem, Alaa Abd, Elkholy, Maha, Al Robaee, Ahmad A., Alzolibani, Abdullateef A.
• Format: Journal Article
• Language: English
• Published: London BioMed Central 12.11.2018; BioMed Central Ltd; Springer Nature B.V; BMC
• Subjects: Allergic rhinitis; Allergology; Asthma; Atopic dermatitis; Atopic disorders; Bronchial asthma; Dermatitis; Disease; Eczema; Filaggrin; Food allergies; Histamine; Immunoglobulins; Immunology; Medicine; Medicine & Public Health; Molecular Medicine; Mutation; Pathogenesis; Pediatric patients; Pediatrics; Proteins; Studies; Young adults; Atopic disorders; Eosinophil MBP; Bronchial asthma; Atopic dermatitis; Allergic rhinitis; IgE; Filaggrin; Pediatric patients
• ISSN: 1476-7961; 1476-7961
• DOI: 10.1186/s12948-018-0102-y

Background Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggrin protein, eosinophil major basic protein (MBP) and immunoglobulin E (IgE) to elicit allergic response or to contribute to atopic disorders remains largely unexplored in pediatric patients. This study was undertaken to investigate the status and contribution of filaggrin protein, eosinophil MBP and total IgE in pediatric patients with AD, AR and BA. Methods Sera from 395 pediatric patients of AD, AR or BA with varying levels of disease activity according to the disease activity index and 410 age-matched non-atopic healthy controls were evaluated for serum levels of atopic markers, including filaggrin, eosinophil MBP and IgE. Results Serum analysis showed that filaggrin levels were remarkably high in pediatric patients with AD, followed by BA and AR, whereas its levels were low in non-atopic pediatric controls. Eosinophil MBP levels in sera of atopic patients were significantly high as compared with their respective controls, but its levels were highest in AR patients, followed by AD and BA. Total IgE in sera of AD patients was markedly high, followed by AR and BA patients, whereas its levels were low in non-atopic pediatric controls. Interestingly, not only was an increased number of subjects positive for filaggrin protein, eosinophil MBP or total IgE, but also their levels were statistically significantly higher among those atopic patients whose disease activity scores were higher as compared with atopic patients with lower disease activity scores. Conclusions These findings strongly support a role of filaggrin protein, eosinophil MBP and IgE in the onset of allergic reactions in pediatric patients with AD, AR and BA. The data suggest that filaggrin, eosinophil MBP or IgE might be useful in evaluating the progression of AD, AR or BA and in elucidating the mechanisms involved in the pathogenesis of these pediatric disorders.