Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity

During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8 + T cells. The mechanisms u...

Full description

Saved in:

Bibliographic Details
Published in	Nature communications Vol. 14; no. 1; pp. 1652 - 18
Main Authors	Read, Kaitlin A., Jones, Devin M., Pokhrel, Srijana, Hales, Emily D. S., Varkey, Aditi, Tuazon, Jasmine A., Eisele, Caprice D., Abdouni, Omar, Saadey, Abbey, Leonard, Melissa R., Warren, Robert T., Powell, Michael D., Boss, Jeremy M., Hemann, Emily A., Yount, Jacob S., Xin, Gang, Ghoneim, Hazem E., Lio, Chan-Wang J., Freud, Aharon G., Collins, Patrick L., Oestreich, Kenneth J.
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 24.03.2023 Nature Publishing Group Nature Portfolio
Subjects	13/21 13/31 14/1 38 38/15 38/77 38/88 38/91 631/250/127/1213 631/250/1619/554 631/250/1619/554/1898 631/250/2502 64/60 Antibodies CD4 antigen CD8 antigen Cell differentiation Cytotoxicity Gene regulation Humanities and Social Sciences Interleukin 2 Interleukin 2 receptors Lymphocytes Lymphocytes T multidisciplinary Programming Science Science (multidisciplinary) Sensitivity enhancement Stat5 protein Transcription factors
Online Access	Get full text
ISSN	2041-1723 2041-1723
DOI	10.1038/s41467-023-37420-0

Cover

Abstract	During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8 + T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of T FH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key T FH transcription factors, and consequently reduced T FH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and T FH programming and highlight its potential as a target for manipulating CD4 + T cell responses. The regulation and direction of CD4 + T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4 + cytotoxic and T follicular helper lineages.
AbstractList	During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8 + T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of T FH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key T FH transcription factors, and consequently reduced T FH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and T FH programming and highlight its potential as a target for manipulating CD4 + T cell responses. The regulation and direction of CD4 + T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4 + cytotoxic and T follicular helper lineages. During intracellular infection, T follicular helper (TFH) and T helper 1 (TH1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8+ T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of TFH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key TFH transcription factors, and consequently reduced TFH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.During intracellular infection, T follicular helper (TFH) and T helper 1 (TH1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8+ T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of TFH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key TFH transcription factors, and consequently reduced TFH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses. During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8 + T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of T FH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key T FH transcription factors, and consequently reduced T FH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and T FH programming and highlight its potential as a target for manipulating CD4 + T cell responses. The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages. During intracellular infection, T follicular helper (TFH) and T helper 1 (TH1) cells promote humoral and cell-mediated responses, respectively. Another subset, CD4-cytotoxic T lymphocytes (CD4-CTLs), eliminate infected cells via functions typically associated with CD8+ T cells. The mechanisms underlying differentiation of these populations are incompletely understood. Here, we identify the transcription factor Aiolos as a reciprocal regulator of TFH and CD4-CTL programming. We find that Aiolos deficiency results in downregulation of key TFH transcription factors, and consequently reduced TFH differentiation and antibody production, during influenza virus infection. Conversely, CD4-CTL programming is elevated, including enhanced Eomes and cytolytic molecule expression. We further demonstrate that Aiolos deficiency allows for enhanced IL-2 sensitivity and increased STAT5 association with CD4-CTL gene targets, including Eomes, effector molecules, and IL2Ra. Thus, our collective findings identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a role for Aiolos as a regulator of the CD4+ cytotoxic and T follicular helper lineages.
ArticleNumber	1652
Author	Abdouni, Omar Read, Kaitlin A. Saadey, Abbey Oestreich, Kenneth J. Pokhrel, Srijana Hemann, Emily A. Collins, Patrick L. Tuazon, Jasmine A. Xin, Gang Jones, Devin M. Warren, Robert T. Leonard, Melissa R. Yount, Jacob S. Lio, Chan-Wang J. Varkey, Aditi Eisele, Caprice D. Ghoneim, Hazem E. Powell, Michael D. Freud, Aharon G. Boss, Jeremy M. Hales, Emily D. S.
Author_xml	– sequence: 1 givenname: Kaitlin A. surname: Read fullname: Read, Kaitlin A. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Biomedical Sciences Graduate Program – sequence: 2 givenname: Devin M. surname: Jones fullname: Jones, Devin M. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Biomedical Sciences Graduate Program – sequence: 3 givenname: Srijana surname: Pokhrel fullname: Pokhrel, Srijana organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 4 givenname: Emily D. S. surname: Hales fullname: Hales, Emily D. S. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 5 givenname: Aditi surname: Varkey fullname: Varkey, Aditi organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 6 givenname: Jasmine A. surname: Tuazon fullname: Tuazon, Jasmine A. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Biomedical Sciences Graduate Program, Medical Scientist Training Program – sequence: 7 givenname: Caprice D. surname: Eisele fullname: Eisele, Caprice D. organization: Biomedical Sciences Graduate Program, Department of Pathology, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 8 givenname: Omar surname: Abdouni fullname: Abdouni, Omar organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 9 givenname: Abbey surname: Saadey fullname: Saadey, Abbey organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Biomedical Sciences Graduate Program – sequence: 10 givenname: Melissa R. orcidid: 0000-0002-1680-3620 surname: Leonard fullname: Leonard, Melissa R. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Combined Anatomic Pathology Residency/PhD Program, The Ohio State University College of Veterinary Medicine – sequence: 11 givenname: Robert T. surname: Warren fullname: Warren, Robert T. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 12 givenname: Michael D. surname: Powell fullname: Powell, Michael D. organization: Department of Microbiology and Immunology, Emory University School of Medicine – sequence: 13 givenname: Jeremy M. surname: Boss fullname: Boss, Jeremy M. organization: Department of Microbiology and Immunology, Emory University School of Medicine – sequence: 14 givenname: Emily A. surname: Hemann fullname: Hemann, Emily A. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Infectious Diseases Institute, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 15 givenname: Jacob S. surname: Yount fullname: Yount, Jacob S. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Infectious Diseases Institute, The Ohio State University College of Medicine and Wexner Medical Center – sequence: 16 givenname: Gang surname: Xin fullname: Xin, Gang organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center – sequence: 17 givenname: Hazem E. orcidid: 0000-0002-9816-4286 surname: Ghoneim fullname: Ghoneim, Hazem E. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center – sequence: 18 givenname: Chan-Wang J. surname: Lio fullname: Lio, Chan-Wang J. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center – sequence: 19 givenname: Aharon G. orcidid: 0000-0001-6086-1521 surname: Freud fullname: Freud, Aharon G. organization: Department of Pathology, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center – sequence: 20 givenname: Patrick L. orcidid: 0000-0003-4550-4272 surname: Collins fullname: Collins, Patrick L. organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center – sequence: 21 givenname: Kenneth J. orcidid: 0000-0002-3004-072X surname: Oestreich fullname: Oestreich, Kenneth J. email: Ken.Oestreich@osumc.edu organization: Department of Microbial Infection and Immunity, The Ohio State University College of Medicine and Wexner Medical Center, Infectious Diseases Institute, The Ohio State University College of Medicine and Wexner Medical Center, Pelotonia Institute for Immuno-Oncology, The Ohio State Comprehensive Cancer Center
BookMark	eNp9UstuEzEUHaEi-qA_wMoSGyQ04FdszwpVoaWRIrEJa8vjuTM4mtjBdqJmw7fjZCqgXdQbX917zrnPy-rMBw9V9Y7gTwQz9TlxwoWsMWU1k5ziGr-qLijmpCaSsrP_7PPqOqU1Lo81RHH-pjpnohGcSHVR_b5xYQwJRdhGSAkSmn_lH9EKWRhHZA855PDgLNrGMESz2Tg_oL0zBW9d8VkzFnPYjSa74FHo0eruHuVofLLRbU_O3tgcYkLGd2ixrClK4JPLbu_y4W31ujdjguvH_6r6cXe7mt_Xy-_fFvObZW1nROW6FTPRYyMUsN7MWm6ooo3hjFJQsmubGWPWYMmlVURCg1UDpsVYAgiFS4RdVYtJtwtmrbfRbUw86GCcPjlCHLSJ2dkRdNcyQYSSqu-AQ9e2tOs5CNp3uIi3XdH6Mmltd-0GOgu-9Ds-EX0a8e6nHsJek-MGysKKwodHhRh-7SBlvXHpOHDjIeySprIhTChKVYG-fwZdh130ZVZHFKalVSwLik4oG0NKEfq_1RCsj-eip3PRJbs-nYs-zkQ9I1mXT3ssVbvxZSqbqKnk8QPEf1W9wPoDs6fWEA
CitedBy_id	crossref_primary_10_3389_fimmu_2023_1114842 crossref_primary_10_4049_jimmunol_2300270 crossref_primary_10_4049_jimmunol_2300748 crossref_primary_10_4049_jimmunol_2200861 crossref_primary_10_1016_j_celrep_2023_113182 crossref_primary_10_1172_jci_insight_180287 crossref_primary_10_61186_ijbc_16_2_84 crossref_primary_10_3390_cells13070639 crossref_primary_10_1016_j_alit_2024_07_005
Cites_doi	10.1111/imr.12936 10.1084/jem.20102144 10.4049/jimmunol.1501801 10.1111/j.1600-065X.2010.00951.x 10.1182/blood-2008-05-078154 10.1016/j.immuni.2007.02.009 10.1038/ni.3837 10.1097/RHU.0000000000001160 10.1128/JVI.00566-21 10.1016/j.immuni.2019.10.006 10.1038/nature10279 10.1371/journal.pone.0242211 10.1016/S0092-8674(00)80702-3 10.1046/j.1440-1711.1998.00709.x 10.4049/jimmunol.2000612 10.1182/blood-2014-06-582700 10.1038/s41577-021-00563-6 10.4049/jimmunol.1900581 10.1038/ni.3229 10.1073/pnas.1301138111 10.1016/j.cell.2018.11.045 10.1016/j.celrep.2015.08.049 10.1016/0896-8411(89)90013-9 10.1128/JVI.01461-13 10.1073/pnas.1110230108 10.1038/382174a0 10.1084/jem.20111174 10.1038/ni.3716 10.1038/ni.2242 10.1074/jbc.M111.324046 10.4049/jimmunol.168.11.5954 10.1084/jem.20081242 10.1126/science.1175870 10.1038/ni.3226 10.1016/j.blre.2015.03.003 10.1016/j.immuni.2009.07.002 10.1146/annurev-immunol-041015-055605 10.1038/382171a0 10.1016/j.immuni.2019.03.028 10.1126/science.1176676 10.1038/ni.2037 10.1038/srep12490 10.1016/j.immuni.2019.04.011 10.1038/srep15722 10.1038/ncomms10285 10.1038/ni794 10.1371/journal.pone.0089010 10.1128/JVI.07172-11 10.1016/j.immuni.2012.02.012 10.1111/imm.12648 10.3389/fimmu.2016.00093 10.1073/pnas.1205894109 10.1016/j.celrep.2016.10.013 10.1038/ni.2523 10.4049/jimmunol.1700106 10.1084/jem.20150519 10.1038/s41598-020-76603-3 10.1038/ni.2030 10.1038/ni.1837 10.1038/icb.2016.42 10.1016/j.immuni.2021.09.018 10.4049/jimmunol.181.12.8568 10.1016/j.immuni.2014.10.004 10.1038/ni.2059 10.1016/j.jaad.2020.11.014 10.3389/fimmu.2017.00194 10.1084/jem.20170901 10.4049/jimmunol.180.3.1643 10.1177/0963689720920825 10.1016/j.immuni.2019.12.007 10.4049/jimmunol.1601297 10.1084/jem.20121190 10.1016/j.coi.2011.08.003 10.1038/ni.2363 10.1126/sciimmunol.aaw7636 10.1084/jem.20211118
ContentType	Journal Article
Copyright	The Author(s) 2023 The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023. The Author(s).
Copyright_xml	– notice: The Author(s) 2023 – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023. The Author(s).
DBID	C6C AAYXX CITATION 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA
DOI	10.1038/s41467-023-37420-0
DatabaseName	Springer Nature OA Free Journals CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Biological science database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic CrossRef Publicly Available Content Database
Database_xml	– sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2041-1723
EndPage	18
ExternalDocumentID	oai_doaj_org_article_db3616878fde4edbb2df4e62fd0817bd PMC10039023 10_1038_s41467_023_37420_0
GrantInformation_xml	– fundername: U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID) grantid: AI134972; AI127800; AI161857; AI113021; AI156411 funderid: https://doi.org/10.13039/100000060 – fundername: U.S. Department of Health & Human Services \| NIH \| National Cancer Institute (NCI) – fundername: U.S. Department of Health & Human Services \| NIH \| National Institute of Allergy and Infectious Diseases (NIAID) – fundername: U.S. Department of Health & Human Services \| NIH \| National Cancer Institute (NCI) grantid: CA241290; CA199447; CA208353 funderid: https://doi.org/10.13039/100000054 – fundername: ; – fundername: ; grantid: AI134972; AI127800; AI161857; AI113021; AI156411 – fundername: ; grantid: CA241290; CA199447; CA208353
GroupedDBID	--- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX CITATION PHGZM PHGZT 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS PUEGO RC3 SOI 7X8 5PM
ID	FETCH-LOGICAL-c518t-b656f0a68e3fa5b4a2829a4322e87db9533ca0747c817e9089eab007ee680ca03
IEDL.DBID	M48
ISSN	2041-1723
IngestDate	Wed Aug 27 01:12:13 EDT 2025 Thu Aug 21 18:38:30 EDT 2025 Fri Sep 05 10:17:28 EDT 2025 Sat Aug 23 14:32:32 EDT 2025 Tue Jul 01 00:58:45 EDT 2025 Thu Apr 24 23:10:18 EDT 2025 Fri Feb 21 02:40:04 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c518t-b656f0a68e3fa5b4a2829a4322e87db9533ca0747c817e9089eab007ee680ca03
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-3004-072X 0000-0002-1680-3620 0000-0002-9816-4286 0000-0003-4550-4272 0000-0001-6086-1521
OpenAccessLink	http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-023-37420-0
PMID	36964178
PQID	2790208907
PQPubID	546298
PageCount	18
ParticipantIDs	doaj_primary_oai_doaj_org_article_db3616878fde4edbb2df4e62fd0817bd pubmedcentral_primary_oai_pubmedcentral_nih_gov_10039023 proquest_miscellaneous_2791368228 proquest_journals_2790208907 crossref_primary_10_1038_s41467_023_37420_0 crossref_citationtrail_10_1038_s41467_023_37420_0 springer_journals_10_1038_s41467_023_37420_0
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2023-03-24
PublicationDateYYYYMMDD	2023-03-24
PublicationDate_xml	– month: 03 year: 2023 text: 2023-03-24 day: 24
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London
PublicationTitle	Nature communications
PublicationTitleAbbrev	Nat Commun
PublicationYear	2023
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	Crotty (CR2) 2014; 41 Workman, Jacobs, Vogel, Condon, Brown (CR47) 2014; 9 Read (CR38) 2017; 199 Weber (CR41) 2011; 476 Olson (CR67) 2016; 94 Takeuchi, Saito (CR4) 2017; 8 Choi (CR14) 2015; 16 Aitmehdi (CR69) 2021; 84 CR37 Liao, Lin, Wang, Li, Leonard (CR58) 2011; 12 Leonard, Lin, O’Shea (CR55) 2019; 50 Crotty (CR5) 2019; 50 Kaplan, Sun, Hoey, Grusby (CR24) 1996; 382 Barnden, Allison, Heath, Carbone (CR72) 1998; 76 Zhu, Paul (CR7) 2010; 238 Scoville (CR73) 2015; 5 Liao, Lin, Leonard (CR34) 2011; 23 Szabo (CR27) 2000; 100 Jones, Read, Oestreich (CR33) 2020; 205 Strutt, McKinstry, Kuang, Bradley, Swain (CR46) 2012; 109 Botta (CR65) 2017; 18 Kortum, Zhu, Shi, Jedlowski, Stewart (CR68) 2015; 29 Klein-Schneegans, Kuntz, Fonteneau, Loor (CR74) 1989; 2 Johnston, Choi, Diamond, Yang, Crotty (CR32) 2012; 209 Oestreich, Huang, Weinmann (CR63) 2011; 208 Johnston (CR8) 2009; 325 Xu (CR18) 2019; 51 Quintana (CR39) 2012; 13 Collins (CR76) 2019; 176 Brown, Lampe, Workman (CR3) 2016; 7 Fu (CR66) 2018; 215 Germar (CR42) 2011; 108 Oestreich, Mohn, Weinmann (CR13) 2012; 13 Haigh (CR52) 2008; 180 Brien, Uhrlaub, Nikolich-Zugich (CR53) 2008; 181 Vinuesa, Linterman, Yu, MacLennan (CR19) 2016; 34 Nurieva (CR9) 2009; 325 Marshall (CR48) 2017; 198 Zhu, Paul (CR1) 2008; 112 Cruz-Guilloty (CR30) 2009; 206 Appay (CR51) 2002; 168 Wang (CR71) 2020; 29 Ballesteros-Tato (CR59) 2012; 36 Lazarevic, Glimcher (CR6) 2011; 12 Molnar, Georgopoulos (CR60) 1994; 14 Xu (CR17) 2015; 16 Goedhart, Luijsterburg (CR75) 2020; 10 Cooley, Read, Oestreich (CR57) 2015; 5 Yu (CR11) 2009; 31 Hua (CR29) 2013; 87 Read, Jones, Freud, Oestreich (CR43) 2021; 300 Sledzinska (CR36) 2020; 52 Afkarian (CR26) 2002; 3 Mucida (CR56) 2013; 14 McDonald (CR77) 2016; 7 Read, Powell, Oestreich (CR10) 2016; 149 Olson, Verdan, Hufford, Dent, Kaplan (CR62) 2016; 196 Crotty, Johnston, Schoenberger (CR12) 2010; 11 Zhao, Shan, Xue (CR20) 2022; 22 Brown, Lee, Garcia-Hernandez Mde, Swain (CR28) 2012; 86 Katerndahl (CR45) 2017; 18 Nurieva (CR35) 2012; 287 Curran (CR31) 2013; 210 Heizmann (CR44) 2020; 15 Liao (CR61) 2014; 111 Wu (CR16) 2015; 12 Shao (CR22) 2019; 203 CR64 Donnarumma (CR21) 2016; 17 Ise (CR15) 2011; 12 Thierfelder (CR25) 1996; 382 Knudson (CR49) 2021; 95 Wan (CR23) 2021; 54 Weinstein (CR40) 2014; 124 Laurence (CR54) 2007; 26 Yuki (CR70) 2021; 27 Takeuchi (CR50) 2016; 213 T Donnarumma (37420_CR21) 2016; 17 KM Kortum (37420_CR68) 2015; 29 P Shao (37420_CR22) 2019; 203 MH Kaplan (37420_CR24) 1996; 382 WE Thierfelder (37420_CR25) 1996; 382 A Takeuchi (37420_CR4) 2017; 8 J Goedhart (37420_CR75) 2020; 10 V Lazarevic (37420_CR6) 2011; 12 J Zhu (37420_CR7) 2010; 238 EFN Yuki (37420_CR70) 2021; 27 A Takeuchi (37420_CR50) 2016; 213 WJ Leonard (37420_CR55) 2019; 50 KJ Oestreich (37420_CR63) 2011; 208 KA Read (37420_CR38) 2017; 199 D Botta (37420_CR65) 2017; 18 RJ Johnston (37420_CR8) 2009; 325 W Ise (37420_CR15) 2011; 12 S Wan (37420_CR23) 2021; 54 D Mucida (37420_CR56) 2013; 14 MR Olson (37420_CR62) 2016; 196 R Aitmehdi (37420_CR69) 2021; 84 M Afkarian (37420_CR26) 2002; 3 Z Wang (37420_CR71) 2020; 29 S Crotty (37420_CR2) 2014; 41 CG Vinuesa (37420_CR19) 2016; 34 RI Nurieva (37420_CR35) 2012; 287 KA Read (37420_CR10) 2016; 149 YS Choi (37420_CR14) 2015; 16 W Liao (37420_CR58) 2011; 12 K Germar (37420_CR42) 2011; 108 ID Cooley (37420_CR57) 2015; 5 TA Haigh (37420_CR52) 2008; 180 D Yu (37420_CR11) 2009; 31 BN Weber (37420_CR41) 2011; 476 37420_CR64 L Hua (37420_CR29) 2013; 87 PL Collins (37420_CR76) 2019; 176 W Liao (37420_CR34) 2011; 23 S Crotty (37420_CR5) 2019; 50 V Appay (37420_CR51) 2002; 168 X Zhao (37420_CR20) 2022; 22 MR Olson (37420_CR67) 2016; 94 MA Curran (37420_CR31) 2013; 210 F Cruz-Guilloty (37420_CR30) 2009; 206 CJ Knudson (37420_CR49) 2021; 95 MJ Barnden (37420_CR72) 1998; 76 JS Weinstein (37420_CR40) 2014; 124 TM Strutt (37420_CR46) 2012; 109 L Xu (37420_CR17) 2015; 16 W Xu (37420_CR18) 2019; 51 DM Brown (37420_CR3) 2016; 7 AM Workman (37420_CR47) 2014; 9 A Sledzinska (37420_CR36) 2020; 52 SD Scoville (37420_CR73) 2015; 5 AS Klein-Schneegans (37420_CR74) 1989; 2 SJ Szabo (37420_CR27) 2000; 100 KA Read (37420_CR43) 2021; 300 DM Jones (37420_CR33) 2020; 205 RJ Johnston (37420_CR32) 2012; 209 W Liao (37420_CR61) 2014; 111 W Fu (37420_CR66) 2018; 215 DM Brown (37420_CR28) 2012; 86 NB Marshall (37420_CR48) 2017; 198 T Wu (37420_CR16) 2015; 12 J Zhu (37420_CR1) 2008; 112 PW McDonald (37420_CR77) 2016; 7 37420_CR37 KJ Oestreich (37420_CR13) 2012; 13 S Crotty (37420_CR12) 2010; 11 RI Nurieva (37420_CR9) 2009; 325 A Laurence (37420_CR54) 2007; 26 A Molnar (37420_CR60) 1994; 14 B Heizmann (37420_CR44) 2020; 15 JD Brien (37420_CR53) 2008; 181 A Ballesteros-Tato (37420_CR59) 2012; 36 CDS Katerndahl (37420_CR45) 2017; 18 FJ Quintana (37420_CR39) 2012; 13
References_xml	– volume: 300 start-page: 82 year: 2021 end-page: 99 ident: CR43 article-title: Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function publication-title: Immunol. Rev. doi: 10.1111/imr.12936 – volume: 208 start-page: 1001 year: 2011 end-page: 1013 ident: CR63 article-title: The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns publication-title: J. Exp. Med. doi: 10.1084/jem.20102144 – volume: 196 start-page: 3297 year: 2016 end-page: 3304 ident: CR62 article-title: STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1501801 – volume: 238 start-page: 247 year: 2010 end-page: 262 ident: CR7 article-title: Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2010.00951.x – volume: 112 start-page: 1557 year: 2008 end-page: 1569 ident: CR1 article-title: CD4 T cells: fates, functions, and faults publication-title: Blood doi: 10.1182/blood-2008-05-078154 – volume: 26 start-page: 371 year: 2007 end-page: 381 ident: CR54 article-title: Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation publication-title: Immunity doi: 10.1016/j.immuni.2007.02.009 – volume: 18 start-page: 1249 year: 2017 end-page: 1260 ident: CR65 article-title: Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection publication-title: Nat. Immunol. doi: 10.1038/ni.3837 – volume: 27 start-page: 248 year: 2021 end-page: 259 ident: CR70 article-title: Thalidomide and lenalidomide for refractory systemic/cutaneous lupus erythematosus treatment: a narrative review of literature for clinical practice publication-title: J. Clin. Rheumatol. doi: 10.1097/RHU.0000000000001160 – volume: 95 start-page: e0056621 year: 2021 ident: CR49 article-title: Mechanisms of antiviral cytotoxic CD4 T cell differentiation publication-title: J. Virol. doi: 10.1128/JVI.00566-21 – volume: 14 start-page: 8292 year: 1994 end-page: 8303 ident: CR60 article-title: The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins publication-title: Mol Cell Biol – volume: 51 start-page: 826 year: 2019 end-page: 839.e825 ident: CR18 article-title: The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility publication-title: Immunity doi: 10.1016/j.immuni.2019.10.006 – volume: 476 start-page: 63 year: 2011 end-page: 68 ident: CR41 article-title: A critical role for TCF-1 in T-lineage specification and differentiation publication-title: Nature doi: 10.1038/nature10279 – volume: 15 start-page: e0242211 year: 2020 ident: CR44 article-title: Ikaros antagonizes DNA binding by STAT5 in pre-B cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0242211 – volume: 100 start-page: 655 year: 2000 end-page: 669 ident: CR27 article-title: A novel transcription factor, T-bet, directs Th1 lineage commitment publication-title: Cell doi: 10.1016/S0092-8674(00)80702-3 – volume: 76 start-page: 34 year: 1998 end-page: 40 ident: CR72 article-title: Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements publication-title: Immunol. Cell Biol. doi: 10.1046/j.1440-1711.1998.00709.x – volume: 205 start-page: 1721 year: 2020 end-page: 1730 ident: CR33 article-title: Dynamic roles for IL-2-STAT5 signaling in effector and regulatory CD4(+) T cell populations publication-title: J. Immunol. doi: 10.4049/jimmunol.2000612 – volume: 124 start-page: 3719 year: 2014 end-page: 3729 ident: CR40 article-title: Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes publication-title: Blood doi: 10.1182/blood-2014-06-582700 – volume: 22 start-page: 147 year: 2022 end-page: 157 ident: CR20 article-title: TCF1 in T cell immunity: a broadened frontier publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-021-00563-6 – volume: 203 start-page: 801 year: 2019 end-page: 806 ident: CR22 article-title: Cutting edge: Tcf1 instructs T follicular helper cell differentiation by repressing Blimp1 in response to acute viral infection publication-title: J, Immunol, doi: 10.4049/jimmunol.1900581 – volume: 16 start-page: 991 year: 2015 end-page: 999 ident: CR17 article-title: The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection publication-title: Nat. Immunol. doi: 10.1038/ni.3229 – volume: 111 start-page: 3508 year: 2014 end-page: 3513 ident: CR61 article-title: Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1301138111 – volume: 176 start-page: 348 year: 2019 end-page: 360.e312 ident: CR76 article-title: Gene regulatory programs conferring phenotypic identities to human NK cells publication-title: Cell doi: 10.1016/j.cell.2018.11.045 – volume: 12 start-page: 2099 year: 2015 end-page: 2110 ident: CR16 article-title: TCF1 is required for the T follicular helper cell response to viral infection publication-title: Cell Rep doi: 10.1016/j.celrep.2015.08.049 – volume: 2 start-page: 869 year: 1989 end-page: 875 ident: CR74 article-title: Serum concentrations of IgM, IgG1, IgG2b, IgG3 and IgA in C57BL/6 mice and their congenics at the lpr (lymphoproliferation) locus publication-title: J. Autoimmun. doi: 10.1016/0896-8411(89)90013-9 – volume: 87 start-page: 11884 year: 2013 end-page: 11893 ident: CR29 article-title: Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection publication-title: J. Virol. doi: 10.1128/JVI.01461-13 – volume: 108 start-page: 20060 year: 2011 end-page: 20065 ident: CR42 article-title: T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1110230108 – volume: 382 start-page: 174 year: 1996 end-page: 177 ident: CR24 article-title: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice publication-title: Nature doi: 10.1038/382174a0 – volume: 209 start-page: 243 year: 2012 end-page: 250 ident: CR32 article-title: STAT5 is a potent negative regulator of TFH cell differentiation publication-title: J. Exp. Med. doi: 10.1084/jem.20111174 – volume: 18 start-page: 694 year: 2017 end-page: 704 ident: CR45 article-title: Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival publication-title: Nat. Immunol. doi: 10.1038/ni.3716 – volume: 13 start-page: 405 year: 2012 end-page: 411 ident: CR13 article-title: Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile publication-title: Nat. Immunol. doi: 10.1038/ni.2242 – volume: 287 start-page: 11234 year: 2012 end-page: 11239 ident: CR35 article-title: STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.324046 – volume: 168 start-page: 5954 year: 2002 end-page: 5958 ident: CR51 article-title: Characterization of CD4(+) CTLs ex vivo publication-title: J. Immunol. doi: 10.4049/jimmunol.168.11.5954 – volume: 206 start-page: 51 year: 2009 end-page: 59 ident: CR30 article-title: Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs publication-title: J. Exp. Med. doi: 10.1084/jem.20081242 – volume: 325 start-page: 1006 year: 2009 end-page: 1010 ident: CR8 article-title: Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation publication-title: Science doi: 10.1126/science.1175870 – volume: 16 start-page: 980 year: 2015 end-page: 990 ident: CR14 article-title: LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 publication-title: Nat. Immunol. doi: 10.1038/ni.3226 – ident: CR64 – volume: 29 start-page: 329 year: 2015 end-page: 334 ident: CR68 article-title: Cereblon binding molecules in multiple myeloma publication-title: Blood Rev. doi: 10.1016/j.blre.2015.03.003 – volume: 31 start-page: 457 year: 2009 end-page: 468 ident: CR11 article-title: The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment publication-title: Immunity doi: 10.1016/j.immuni.2009.07.002 – volume: 34 start-page: 335 year: 2016 end-page: 368 ident: CR19 article-title: Follicular helper T cells publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-041015-055605 – volume: 382 start-page: 171 year: 1996 end-page: 174 ident: CR25 article-title: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells publication-title: Nature doi: 10.1038/382171a0 – volume: 50 start-page: 832 year: 2019 end-page: 850 ident: CR55 article-title: The gammac family of cytokines: basic biology to therapeutic ramifications publication-title: Immunity doi: 10.1016/j.immuni.2019.03.028 – volume: 325 start-page: 1001 year: 2009 end-page: 1005 ident: CR9 article-title: Bcl6 mediates the development of T follicular helper cells publication-title: Science doi: 10.1126/science.1176676 – volume: 12 start-page: 536 year: 2011 end-page: 543 ident: CR15 article-title: The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells publication-title: Nat. Immunol. doi: 10.1038/ni.2037 – volume: 5 year: 2015 ident: CR73 article-title: Rapid column-free enrichment of mononuclear cells from solid tissues publication-title: Sci Rep doi: 10.1038/srep12490 – volume: 50 start-page: 1132 year: 2019 end-page: 1148 ident: CR5 article-title: T follicular helper cell biology: a decade of discovery and diseases publication-title: Immunity doi: 10.1016/j.immuni.2019.04.011 – volume: 5 year: 2015 ident: CR57 article-title: Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells publication-title: Sci. Rep. doi: 10.1038/srep15722 – volume: 7 year: 2016 ident: CR77 article-title: IL-7 signalling represses Bcl-6 and the TFH gene program publication-title: Nat. Commun. doi: 10.1038/ncomms10285 – ident: CR37 – volume: 3 start-page: 549 year: 2002 end-page: 557 ident: CR26 article-title: T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells publication-title: Nat, Immunol, doi: 10.1038/ni794 – volume: 9 start-page: e89010 year: 2014 ident: CR47 article-title: Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0089010 – volume: 86 start-page: 6792 year: 2012 end-page: 6803 ident: CR28 article-title: Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection publication-title: J, Virol, doi: 10.1128/JVI.07172-11 – volume: 36 start-page: 847 year: 2012 end-page: 856 ident: CR59 article-title: Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation publication-title: Immunity doi: 10.1016/j.immuni.2012.02.012 – volume: 149 start-page: 253 year: 2016 end-page: 261 ident: CR10 article-title: T follicular helper cell programming by cytokine-mediated events publication-title: Immunology doi: 10.1111/imm.12648 – volume: 7 start-page: 93 year: 2016 ident: CR3 article-title: The differentiation and protective function of cytolytic CD4 T Cells in Influenza Infection publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00093 – volume: 109 start-page: E2551 year: 2012 end-page: E2560 ident: CR46 article-title: Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1205894109 – volume: 17 start-page: 1571 year: 2016 end-page: 1583 ident: CR21 article-title: Opposing development of cytotoxic and follicular helper CD4 T cells controlled by the TCF-1-Bcl6 Nexus publication-title: Cell Rep, doi: 10.1016/j.celrep.2016.10.013 – volume: 14 start-page: 281 year: 2013 end-page: 289 ident: CR56 article-title: Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes publication-title: Nat. Immunol. doi: 10.1038/ni.2523 – volume: 199 start-page: 2377 year: 2017 end-page: 2387 ident: CR38 article-title: Integrated STAT3 and Ikaros zinc finger transcription factor activities regulate Bcl-6 expression in CD4(+) Th cells publication-title: J. Immunol. doi: 10.4049/jimmunol.1700106 – volume: 213 start-page: 123 year: 2016 end-page: 138 ident: CR50 article-title: CRTAM determines the CD4+ cytotoxic T lymphocyte lineage publication-title: J. Exp. Med. doi: 10.1084/jem.20150519 – volume: 10 year: 2020 ident: CR75 article-title: VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots publication-title: Sci. Rep. doi: 10.1038/s41598-020-76603-3 – volume: 12 start-page: 551 year: 2011 end-page: 559 ident: CR58 article-title: Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages publication-title: Nat. Immunol. doi: 10.1038/ni.2030 – volume: 11 start-page: 114 year: 2010 end-page: 120 ident: CR12 article-title: Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation publication-title: Nat Immunol doi: 10.1038/ni.1837 – volume: 94 start-page: 729 year: 2016 end-page: 740 ident: CR67 article-title: Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2016.42 – volume: 54 start-page: 2740 year: 2021 end-page: 2755.e2746 ident: CR23 article-title: Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation publication-title: Immunity doi: 10.1016/j.immuni.2021.09.018 – volume: 181 start-page: 8568 year: 2008 end-page: 8575 ident: CR53 article-title: West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection publication-title: J Immunol doi: 10.4049/jimmunol.181.12.8568 – volume: 41 start-page: 529 year: 2014 end-page: 542 ident: CR2 article-title: T follicular helper cell differentiation, function, and roles in disease publication-title: Immunity doi: 10.1016/j.immuni.2014.10.004 – volume: 12 start-page: 597 year: 2011 end-page: 606 ident: CR6 article-title: T-bet in disease publication-title: Nat. Immunol. doi: 10.1038/ni.2059 – volume: 84 start-page: 1171 year: 2021 end-page: 1174 ident: CR69 article-title: Long-term efficacy and safety outcomes of lenalidomide for cutaneous lupus erythematosus: a multicenter retrospective observational study of 40 patients publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2020.11.014 – volume: 8 start-page: 194 year: 2017 ident: CR4 article-title: CD4 CTL, a cytotoxic subset of CD4(+) T cells, their differentiation and function publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00194 – volume: 215 start-page: 815 year: 2018 end-page: 825 ident: CR66 article-title: Deficiency in T follicular regulatory cells promotes autoimmunity publication-title: J.Exp. Med. doi: 10.1084/jem.20170901 – volume: 180 start-page: 1643 year: 2008 end-page: 1654 ident: CR52 article-title: EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines publication-title: J. Immunol. doi: 10.4049/jimmunol.180.3.1643 – volume: 29 start-page: 963689720920825 year: 2020 ident: CR71 article-title: Lenalidomide enhances CAR-T cell activity against solid tumor cells publication-title: Cell Transplant doi: 10.1177/0963689720920825 – volume: 52 start-page: 151 year: 2020 end-page: 166 e156 ident: CR36 article-title: Regulatory T cells restrain interleukin-2- and Blimp-1-dependent acquisition of cytotoxic function by CD4(+) T cells publication-title: Immunity doi: 10.1016/j.immuni.2019.12.007 – volume: 198 start-page: 1142 year: 2017 end-page: 1155 ident: CR48 article-title: NKG2C/E marks the unique cytotoxic CD4 T cell subset, ThCTL, generated by influenza infection publication-title: J. Immunol. doi: 10.4049/jimmunol.1601297 – volume: 210 start-page: 743 year: 2013 end-page: 755 ident: CR31 article-title: Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin publication-title: J. Exp. Med. doi: 10.1084/jem.20121190 – volume: 23 start-page: 598 year: 2011 end-page: 604 ident: CR34 article-title: IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2011.08.003 – volume: 13 start-page: 770 year: 2012 end-page: 777 ident: CR39 article-title: Aiolos promotes TH17 differentiation by directly silencing Il2 expression publication-title: Nat. Immunol. doi: 10.1038/ni.2363 – volume: 100 start-page: 655 year: 2000 ident: 37420_CR27 publication-title: Cell doi: 10.1016/S0092-8674(00)80702-3 – volume: 7 start-page: 93 year: 2016 ident: 37420_CR3 publication-title: Front. Immunol. doi: 10.3389/fimmu.2016.00093 – volume: 29 start-page: 963689720920825 year: 2020 ident: 37420_CR71 publication-title: Cell Transplant doi: 10.1177/0963689720920825 – volume: 196 start-page: 3297 year: 2016 ident: 37420_CR62 publication-title: J. Immunol. doi: 10.4049/jimmunol.1501801 – volume: 8 start-page: 194 year: 2017 ident: 37420_CR4 publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00194 – volume: 86 start-page: 6792 year: 2012 ident: 37420_CR28 publication-title: J, Virol, doi: 10.1128/JVI.07172-11 – volume: 180 start-page: 1643 year: 2008 ident: 37420_CR52 publication-title: J. Immunol. doi: 10.4049/jimmunol.180.3.1643 – volume: 11 start-page: 114 year: 2010 ident: 37420_CR12 publication-title: Nat Immunol doi: 10.1038/ni.1837 – volume: 95 start-page: e0056621 year: 2021 ident: 37420_CR49 publication-title: J. Virol. doi: 10.1128/JVI.00566-21 – volume: 124 start-page: 3719 year: 2014 ident: 37420_CR40 publication-title: Blood doi: 10.1182/blood-2014-06-582700 – volume: 16 start-page: 991 year: 2015 ident: 37420_CR17 publication-title: Nat. Immunol. doi: 10.1038/ni.3229 – volume: 7 year: 2016 ident: 37420_CR77 publication-title: Nat. Commun. doi: 10.1038/ncomms10285 – volume: 382 start-page: 174 year: 1996 ident: 37420_CR24 publication-title: Nature doi: 10.1038/382174a0 – volume: 18 start-page: 694 year: 2017 ident: 37420_CR45 publication-title: Nat. Immunol. doi: 10.1038/ni.3716 – volume: 94 start-page: 729 year: 2016 ident: 37420_CR67 publication-title: Immunol. Cell Biol. doi: 10.1038/icb.2016.42 – volume: 12 start-page: 2099 year: 2015 ident: 37420_CR16 publication-title: Cell Rep doi: 10.1016/j.celrep.2015.08.049 – volume: 168 start-page: 5954 year: 2002 ident: 37420_CR51 publication-title: J. Immunol. doi: 10.4049/jimmunol.168.11.5954 – volume: 325 start-page: 1006 year: 2009 ident: 37420_CR8 publication-title: Science doi: 10.1126/science.1175870 – volume: 5 year: 2015 ident: 37420_CR57 publication-title: Sci. Rep. doi: 10.1038/srep15722 – volume: 54 start-page: 2740 year: 2021 ident: 37420_CR23 publication-title: Immunity doi: 10.1016/j.immuni.2021.09.018 – volume: 476 start-page: 63 year: 2011 ident: 37420_CR41 publication-title: Nature doi: 10.1038/nature10279 – volume: 14 start-page: 8292 year: 1994 ident: 37420_CR60 publication-title: Mol Cell Biol – volume: 29 start-page: 329 year: 2015 ident: 37420_CR68 publication-title: Blood Rev. doi: 10.1016/j.blre.2015.03.003 – volume: 210 start-page: 743 year: 2013 ident: 37420_CR31 publication-title: J. Exp. Med. doi: 10.1084/jem.20121190 – volume: 17 start-page: 1571 year: 2016 ident: 37420_CR21 publication-title: Cell Rep, doi: 10.1016/j.celrep.2016.10.013 – volume: 52 start-page: 151 year: 2020 ident: 37420_CR36 publication-title: Immunity doi: 10.1016/j.immuni.2019.12.007 – volume: 203 start-page: 801 year: 2019 ident: 37420_CR22 publication-title: J, Immunol, doi: 10.4049/jimmunol.1900581 – volume: 198 start-page: 1142 year: 2017 ident: 37420_CR48 publication-title: J. Immunol. doi: 10.4049/jimmunol.1601297 – volume: 12 start-page: 551 year: 2011 ident: 37420_CR58 publication-title: Nat. Immunol. doi: 10.1038/ni.2030 – volume: 300 start-page: 82 year: 2021 ident: 37420_CR43 publication-title: Immunol. Rev. doi: 10.1111/imr.12936 – volume: 382 start-page: 171 year: 1996 ident: 37420_CR25 publication-title: Nature doi: 10.1038/382171a0 – volume: 213 start-page: 123 year: 2016 ident: 37420_CR50 publication-title: J. Exp. Med. doi: 10.1084/jem.20150519 – volume: 9 start-page: e89010 year: 2014 ident: 37420_CR47 publication-title: PLoS ONE doi: 10.1371/journal.pone.0089010 – volume: 205 start-page: 1721 year: 2020 ident: 37420_CR33 publication-title: J. Immunol. doi: 10.4049/jimmunol.2000612 – volume: 14 start-page: 281 year: 2013 ident: 37420_CR56 publication-title: Nat. Immunol. doi: 10.1038/ni.2523 – volume: 238 start-page: 247 year: 2010 ident: 37420_CR7 publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2010.00951.x – volume: 112 start-page: 1557 year: 2008 ident: 37420_CR1 publication-title: Blood doi: 10.1182/blood-2008-05-078154 – volume: 5 year: 2015 ident: 37420_CR73 publication-title: Sci Rep doi: 10.1038/srep12490 – volume: 208 start-page: 1001 year: 2011 ident: 37420_CR63 publication-title: J. Exp. Med. doi: 10.1084/jem.20102144 – volume: 10 year: 2020 ident: 37420_CR75 publication-title: Sci. Rep. doi: 10.1038/s41598-020-76603-3 – volume: 16 start-page: 980 year: 2015 ident: 37420_CR14 publication-title: Nat. Immunol. doi: 10.1038/ni.3226 – volume: 18 start-page: 1249 year: 2017 ident: 37420_CR65 publication-title: Nat. Immunol. doi: 10.1038/ni.3837 – volume: 31 start-page: 457 year: 2009 ident: 37420_CR11 publication-title: Immunity doi: 10.1016/j.immuni.2009.07.002 – volume: 12 start-page: 536 year: 2011 ident: 37420_CR15 publication-title: Nat. Immunol. doi: 10.1038/ni.2037 – volume: 108 start-page: 20060 year: 2011 ident: 37420_CR42 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1110230108 – volume: 41 start-page: 529 year: 2014 ident: 37420_CR2 publication-title: Immunity doi: 10.1016/j.immuni.2014.10.004 – ident: 37420_CR37 doi: 10.1126/sciimmunol.aaw7636 – volume: 13 start-page: 770 year: 2012 ident: 37420_CR39 publication-title: Nat. Immunol. doi: 10.1038/ni.2363 – volume: 23 start-page: 598 year: 2011 ident: 37420_CR34 publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2011.08.003 – volume: 181 start-page: 8568 year: 2008 ident: 37420_CR53 publication-title: J Immunol doi: 10.4049/jimmunol.181.12.8568 – volume: 209 start-page: 243 year: 2012 ident: 37420_CR32 publication-title: J. Exp. Med. doi: 10.1084/jem.20111174 – ident: 37420_CR64 doi: 10.1084/jem.20211118 – volume: 13 start-page: 405 year: 2012 ident: 37420_CR13 publication-title: Nat. Immunol. doi: 10.1038/ni.2242 – volume: 176 start-page: 348 year: 2019 ident: 37420_CR76 publication-title: Cell doi: 10.1016/j.cell.2018.11.045 – volume: 215 start-page: 815 year: 2018 ident: 37420_CR66 publication-title: J.Exp. Med. doi: 10.1084/jem.20170901 – volume: 27 start-page: 248 year: 2021 ident: 37420_CR70 publication-title: J. Clin. Rheumatol. doi: 10.1097/RHU.0000000000001160 – volume: 287 start-page: 11234 year: 2012 ident: 37420_CR35 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.324046 – volume: 12 start-page: 597 year: 2011 ident: 37420_CR6 publication-title: Nat. Immunol. doi: 10.1038/ni.2059 – volume: 76 start-page: 34 year: 1998 ident: 37420_CR72 publication-title: Immunol. Cell Biol. doi: 10.1046/j.1440-1711.1998.00709.x – volume: 199 start-page: 2377 year: 2017 ident: 37420_CR38 publication-title: J. Immunol. doi: 10.4049/jimmunol.1700106 – volume: 111 start-page: 3508 year: 2014 ident: 37420_CR61 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1301138111 – volume: 2 start-page: 869 year: 1989 ident: 37420_CR74 publication-title: J. Autoimmun. doi: 10.1016/0896-8411(89)90013-9 – volume: 206 start-page: 51 year: 2009 ident: 37420_CR30 publication-title: J. Exp. Med. doi: 10.1084/jem.20081242 – volume: 87 start-page: 11884 year: 2013 ident: 37420_CR29 publication-title: J. Virol. doi: 10.1128/JVI.01461-13 – volume: 84 start-page: 1171 year: 2021 ident: 37420_CR69 publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2020.11.014 – volume: 34 start-page: 335 year: 2016 ident: 37420_CR19 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-041015-055605 – volume: 50 start-page: 1132 year: 2019 ident: 37420_CR5 publication-title: Immunity doi: 10.1016/j.immuni.2019.04.011 – volume: 149 start-page: 253 year: 2016 ident: 37420_CR10 publication-title: Immunology doi: 10.1111/imm.12648 – volume: 22 start-page: 147 year: 2022 ident: 37420_CR20 publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-021-00563-6 – volume: 36 start-page: 847 year: 2012 ident: 37420_CR59 publication-title: Immunity doi: 10.1016/j.immuni.2012.02.012 – volume: 3 start-page: 549 year: 2002 ident: 37420_CR26 publication-title: Nat, Immunol, doi: 10.1038/ni794 – volume: 51 start-page: 826 year: 2019 ident: 37420_CR18 publication-title: Immunity doi: 10.1016/j.immuni.2019.10.006 – volume: 26 start-page: 371 year: 2007 ident: 37420_CR54 publication-title: Immunity doi: 10.1016/j.immuni.2007.02.009 – volume: 15 start-page: e0242211 year: 2020 ident: 37420_CR44 publication-title: PLoS ONE doi: 10.1371/journal.pone.0242211 – volume: 50 start-page: 832 year: 2019 ident: 37420_CR55 publication-title: Immunity doi: 10.1016/j.immuni.2019.03.028 – volume: 325 start-page: 1001 year: 2009 ident: 37420_CR9 publication-title: Science doi: 10.1126/science.1176676 – volume: 109 start-page: E2551 year: 2012 ident: 37420_CR46 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1205894109
SSID	ssj0000391844
Score	2.4958582
Snippet	During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively. Another... During intracellular infection, T follicular helper (TFH) and T helper 1 (TH1) cells promote humoral and cell-mediated responses, respectively. Another subset,... The regulation and direction of CD4+ T cells into phenotypic and functional lineages is coordinated by a complex set of mechanisms. Here the authors show a...
SourceID	doaj pubmedcentral proquest crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Enrichment Source Index Database Publisher
StartPage	1652
SubjectTerms	13/21 13/31 14/1 38 38/15 38/77 38/88 38/91 631/250/127/1213 631/250/1619/554 631/250/1619/554/1898 631/250/2502 64/60 Antibodies CD4 antigen CD8 antigen Cell differentiation Cytotoxicity Gene regulation Humanities and Social Sciences Interleukin 2 Interleukin 2 receptors Lymphocytes Lymphocytes T multidisciplinary Programming Science Science (multidisciplinary) Sensitivity enhancement Stat5 protein Transcription factors
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQpUpcEE8RKMhI3EpUJ3Ec51jarhYEnLZSb5afYiVIqk2K6IXfzoyd3TaVgAu3KHYS2_O2J98Q8haxb31Zm9yHOuTcepdrUwlw5Nq6dt6CP4f_O3_-Ipbn_ONFfXGr1BfmhCV44LRwRw6eLIRsZHCee2dM6QL3ogwOjFljHGpf1rJbwVTUwVULoQuf_pJhlTwaeNQJYKJApjjETGxmiSJg_8zLvJsjeeegNNqfxUPyYHIc6XEa8CNyz3ePyX4qJXn9hPw6xquBblJmqx_oySk_pCuKO_PUXo_92P9cWzrlY32Hb9Afa00R3AKNGLx6k8rSA6FoH-hqsaQjGrKtWqFTaR6qO0c_fMpLOmDye6o-8ZScL85WJ8t8qq2Q27qQY27AjwtMC-mroGvDNZ6oag7i7WXjDCadWo3g-hZW2ePhoNcgoY33QjJoqZ6Rva7v_HNCRdMGY60NOgR4D4cIpTUWd-xEAPVVZqTYrrOyE_A41r_4puIBeCVVoo0C2qhIG8Uycrh75jLBbvy193sk364nQmbHG8BIamIk9S9GysjBlvhqkuNBlU2LVUxb1mTkza4ZJBCJpzvfX8U-RSXA0ZIZkTOmmQ1o3tKtv0Ys7wJZFaaSkXdb_rr5-p9n_OJ_zPgluV-iPLAqL_kB2Rs3V_4VuFijeR2l6Td0ACV5 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba9RAFD7ULYIv4hWjVUbwrYZmk0ky-yDS1i6r6CKyhb4Nc60LmtRNKvbF3-45yWRLCvYtZCbXc52ZM98H8Iawb12a69j53MfcOBsrnRWYyM3y3DqD-Rztd_6yLBan_NNZfrYDy2EvDJVVDj6xc9S2NjRHfpCWM-KTxLHc-4tfMbFG0erqQKGhArWCfddBjN2BXXTJeTKB3aOT5ddv21kXwkMXnIfdM0kmDhre-QoMXWhrHMdSyShCdUD-o-zzZu3kjQXULi7NH8D9kFCyw14DHsKOqx7B3Z5i8uox_D2ko4Zt-opX17DjD3yfrRjN2DNz1dZt_WdtWKjT-onPYL_XihHoBQU3vPWmp6tHAbLas9V8wVoKcIO7YYGyh6nKso-f45Q1VBTfs1I8gdP5yep4EQfOhdjgf2tjjfmdT1QhXOZVrrmilVbF0eydKK2mYlSjCHTfiGnpaNHQKbTc0rlCJNiSPYVJVVfuGbCinHltjPHKe7wPx5HLTBuaySs8urU0gunwn6UJgOTEi_FDdgvjmZC9bCTKRnaykUkE-9trLno4jlt7H5H4tj0JSrs7UW_OZbBMaVE1p4UohbeOO6t1aj13ReotZkulthHsDcKXwb4bea2NEbzeNqNlkvBU5erLrs80KzABExGIkdKMXmjcUq2_dxjfU1JV_JQI3g76df30_3_x89tf9gXcS0nTkyxO-R5M2s2le4lJVatfBUv5B5qdIeI priority: 102 providerName: ProQuest – databaseName: Springer Nature OA Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELaqIiQuCAqIQIuMxK1E5OHYzrFdWC0IOG2l3iw_YSWaoE1atRd-OzNOsigVVOIWxWPHzsx4xvb4G0LeIPatLyqT-lCFlFnvUm1KDo5cXVXOW_Dn8L7zl698dcY-nVfne6SY7sLEoP0IaRmn6Sk67F3HokqDhQGVYLDkgWX6PSnKCqV6wRe7fRVEPJeMjfdjslL-perMBkWo_pl_eTs68tYRabQ8y0fk4egy0pOhk4_Jnm8OyP0hieTNE_LrBJ86uh1iWn1HF-_ZMV1T3JOn9qZv-_Z6Y-kYiXUB36BXG00R1gLNFzS9HRLSA4toG-h6uaI9mrBpQqFjUh6qG0c_fk4L2mHY-5B34ik5W35YL1bpmFUhtVUu-9SABxcyzaUvg64M03iWqhkotpfCGQw3tRph9a3MhcdjQa9BN4X3XGZQUj4j-03b-OeEclEHY60NOgRoh8HapDYW9-p4gImrSEg-_WdlR8hxzHzxQ8Wj71KqgTcKeKMib1SWkONdnZ8D4Mad1KfIvh0lgmXHF-32mxqFRzkQvpxLIYPzzDtjCheY50Vw4A8J4xJyODFfjRrcqULUmL-0zkRCXu-KQfeQebrx7WWkyUsOLpZMiJwJzaxD85Jm8z2ieOcoqjCUhLyd5OvP1_894hf_R_6SPChQ8rMyLdgh2e-3l_4I3KjevIp68xsj2hkL priority: 102 providerName: Springer Nature
Title	Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
URI	https://link.springer.com/article/10.1038/s41467-023-37420-0 https://www.proquest.com/docview/2790208907 https://www.proquest.com/docview/2791368228 https://pubmed.ncbi.nlm.nih.gov/PMC10039023 https://doaj.org/article/db3616878fde4edbb2df4e62fd0817bd
Volume	14
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NTaC9ID5FxqiMxNsINImTOA8IdWWlVDAhaKW-RbZjQ6WRjDZD6wt_O3dOUug0eOAljWInbnJ3vjvf-X4Az6j2rQlj5RsbW59rU_hSRQkaclkcF0ajPUf7nT-cJuMZn8zj-Q50cEftB1xd69oRntRsefbi8vv6NQr8q2bLuHi54k7cUfuguHB0h9CF33PxIkrla819NzNHGTo0vN07c_2t-3CLIO54QMBrf6gqV9F_ywy9mkR5JZLqFNToDtxuLUs2aFjhLuyY8h7cbLAm1_fh54DOVmzZpL6aFRu-4Udsymjpnul1XdXV5UKzNmHrG47Bfiwko-oXpOXw0csGtx4pySrLpqMxq0nTdfMOa7F7mCwL9u69H7IVZcc38BQPYDY6mQ7Hfgu-4Os4ELWv0NCzfZkIE1kZKy4p5Co5yr8RaaEoK1VLqr6vRZAaih4aiSKcGpOIPrZED2G3rErzCFiSZlZpra20Fp_D0YXJlKYlvcTi_BZ6EHTfOddtZXICyDjLXYQ8EnlDphzJlDsy5X0Pjjb3nDd1Of7Z-5jIt-lJNbXdhWr5JW9FNC-QR4NEpMIWhptCqbCw3CShLdBsSlXhwWFH_Lzj0zxMM4I5zfqpB083zSiiRDxZmurC9QmiBC0x4YHYYpqtP7TdUi6-umLfAXEtvooHzzv--j3639_44P9Hegz7IQlEP_JDfgi79fLCPEHLq1Y9uJHOUzyK0dse7A0Gk88T_D0-Of34Ca8Ok2HPrWn0nNj9AnLjMrc
linkProvider	Scholars Portal
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVAguiKdqKLBIcCpWHXttbw4V6itKaRohlEq9LfsskcAusQvkwk_jtzFjr1OlEr31FmXX68fMzszuzH4fIW8R-9bGqQqtS13ItDWhVEkGgdwgTY3VEM_heeeTSTY6ZR_P0rM18rc7C4NllZ1NbAy1KTXukW_H-QD5JGEt9-HiR4isUZhd7Sg0pKdWMDsNxJg_2HFsF79gCVftHB2AvN_F8fBwuj8KPctAqKFnHSqIaFwkM24TJ1PFJOYWJQNFtzw3CssvtUSYec37ucU0mZWgq7m1GY-gJYFx75B1hhsoPbK-dzj59Hm5y4P465wxf1onSvh2xRrbBK4S5jaDtVu04hEb4oCVaPd6rea1hG3jB4cPyQMfwNLdVuMekTVbPCZ3W0rLxRPyZxd_VXTeVtjaiu4fsC06pZghoHpRl3X5e6aprwv7DvegP2eSIsgGOlMYem7PPacYLR2dDke0RofamTfqKYKoLAw9GocxrbAIv2XBeEpOb-XrPyO9oizsBqFZPnBKa-2kczAOg5XSQGncOcwcmNE4IP3uOwvtAdCRh-ObaBLxCRetbATIRjSyEVFAtpbXXLTwHzf23kPxLXsidHfzRzk_F94SCANToZ_xnDtjmTVKxcYxm8XOQHSWKxOQzU74wtuTSlxpf0DeLJvBEqDwZGHLy6ZPP8kg4OMB4StKs_JAqy3F7GuDKd5HVYVXCcj7Tr-u7v7_N35-88O-JvdG05OxGB9Njl-Q-zFqfZSEMdskvXp-aV9CQFerV37WUPLltifqPy_6XjU
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYgL4qkGChgJTiXaxHES7wGh0mW1S0vFYSvtzfhZVoKkbFJgL_wwfh0zeWy1leittyh2HCfztGc8HyGvsPatY6kOnU99yI2zodJJBo7cME2tM-DP4XnnT8fZ5IR_nKfzLfK3PwuDaZW9TmwUtS0N7pEPWD5EPElYyw18lxbxeTR-d_YjRAQpjLT2cBotixy61S9YvlVvpyOg9WvGxh9mB5OwQxgITRqLOtTgzfhIZcIlXqWaK4wrKg5M7kRuNaZeGoUl5o2Ic4chMqeAT3PnMhFBSwLj3iA384RzhI3I5_l6fwcrrwvOu3M6USIGFW-0EhhJkGoOq7ZowxY2kAEbfu7lLM1LodrGAo7vkbud60r3W167T7Zc8YDcasEsVw_Jn328quiyza11FT0Y8T06oxgboGZVl3X5e2FolxH2Hd5Bfy4UxfIaaEZh6KU77dDEaOnpbDyhNZrSXrHRDhyIqsLS6VHIaIXp9y3-xSNyci3__jHZLsrC7RCa5UOvjTFeeQ_jcFgjDbXBPcPMgwJlAYn7_yxNV_ocETi-ySYEnwjZ0kYCbWRDGxkFZG_9zFlb-OPK3u-RfOueWLS7uVEuT2WnA6QFIYgzkQtvHXdWa2Y9dxnzFvyyXNuA7PbEl50mqeQF3wfk5boZdAASTxWuPG_6xEkGrp4IiNhgmo0JbbYUi69NNfEYWRU-JSBvev66ePv_v_jJ1ZN9QW6DeMqj6fHhU3KHIdNHScj4Ltmul-fuGXhytX7eiAwlX65bRv8Bn7Fb0Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aiolos+represses+CD4%2B+T+cell+cytotoxic+programming+via+reciprocal+regulation+of+TFH+transcription+factors+and+IL-2+sensitivity&rft.jtitle=Nature+communications&rft.au=Read%2C+Kaitlin+A.&rft.au=Jones%2C+Devin+M.&rft.au=Pokhrel%2C+Srijana&rft.au=Hales%2C+Emily+D.+S.&rft.date=2023-03-24&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=14&rft_id=info:doi/10.1038%2Fs41467-023-37420-0&rft_id=info%3Apmid%2F36964178&rft.externalDocID=PMC10039023
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon