Dynamics of Nasal Irritation from Pulsed Homologous Alcohols
Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1...
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| Published in | Chemical senses Vol. 35; no. 9; pp. 823 - 829 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Oxford University Press
01.11.2010
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0379-864X 1464-3553 1464-3553 |
| DOI | 10.1093/chemse/bjq086 |
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| Abstract | Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n-butanol, or n-hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well. |
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| AbstractList | Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n-butanol, or n-hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well. Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n-butanol, or n-hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well.Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n-butanol, or n-hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well. Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of volatile organic compounds interspersed with 3-s pulses of clean air. Each trial, subjects received 9 pulses of a chemical vapor over about 1 min. Subjects rated nasal irritation from each pulse using magnitude estimation. Within a trial, compound and concentration were fixed. Compound (ethanol, n -butanol, or n -hexanol) and concentration (4 levels for each compound) varied across trials. For all stimuli, rated irritation decreased over time (adaptation). Plots of log-rated intensity versus elapsed time were approximately linear (intensity decreased by a fixed ratio per unit time). Interestingly, the slopes of intensity versus time functions differed very little: Regardless of concentration and compound, rated irritation decreased by about 32% over the 9 pulses. The basic mechanism of short-term adaptation may be the same for the 3 alcohols studied. Regardless, these data suggest that very simple models might be able to describe some aspects of perceptual dynamics quite well. |
| Author | Zhao, Kai Wise, Paul M. Wysocki, Charles J. |
| AuthorAffiliation | Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA |
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| Cites_doi | 10.1080/10917691.1994.12288923 10.1007/s002210050270 10.1093/chemse/26.4.351 10.1093/chemse/bjj023 10.1016/S0074-7742(08)60694-7 10.1016/j.neulet.2009.11.008 10.1093/toxsci/47.1.93 10.1093/chemse/bjh079 10.1111/j.1749-6632.2009.03912.x 10.1006/taap.1998.8492 10.1080/08958370390229852 10.1093/chemse/bjg065 10.1007/s004200050168 10.1016/0168-5597(94)90020-5 10.1093/toxsci/kfi229 10.1093/chemse/27.7.593 10.1007/BF02741375 10.1093/chemse/23.1.71 10.1093/chemse/27.6.551 10.1080/08958370600602322 10.1016/0031-9384(78)90070-7 10.1093/toxsci/kfg242 10.1080/08958370118185 10.1080/00039899909602241 10.1080/08958370802555880 10.1111/j.1600-0668.1997.t01-1-00002.x 10.1007/BF02289823 10.1016/0304-3940(96)12767-1 10.1016/0304-3959(92)90187-G 10.1016/j.physbeh.2006.03.035 10.1093/toxsci/kfm144 |
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| Snippet | Relatively, few studies have focused on how nasal irritation changes over time. To simulate the rhythm of natural respiration, subjects received 3-s pulses of... |
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| SubjectTerms | 1-Butanol - pharmacology Adult Alcohols - pharmacology Analysis of Variance Biological and medical sciences chemesthesis exposure Female Fundamental and applied biological sciences. Psychology Hexanols - pharmacology Humans inhalation toxicology Irritants - pharmacology Male Nasal Mucosa - drug effects Olfaction. Taste Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Sensory Thresholds - drug effects VOC Young Adult |
| Title | Dynamics of Nasal Irritation from Pulsed Homologous Alcohols |
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