Anticancer Therapies Based on Oxidative Damage: Lycium barbarum Inhibits the Proliferation of MCF-7 Cells by Activating Pyroptosis through Endoplasmic Reticulum Stress

Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These con...

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Published inAntioxidants Vol. 13; no. 6; p. 708
Main Authors Miranda, Maria Rosaria, Basilicata, Manuela Giovanna, Vestuto, Vincenzo, Aquino, Giovanna, Marino, Pasquale, Salviati, Emanuela, Ciaglia, Tania, Domínguez-Rodríguez, Gloria, Moltedo, Ornella, Campiglia, Pietro, Pepe, Giacomo, Manfra, Michele
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.06.2024
MDPI
Subjects
Antioxidants
Berries
Bioactive compounds
Breast cancer
breast neoplasms
Cancer therapies
cancer therapy
Carotenoids
Cell activation
Cell death
Cell proliferation
Chemotherapy
Cytotoxicity
Doxorubicin
Endoplasmic reticulum
endoplasmic reticulum stress
ER stress
Flavonoids
Fruits
goji berries
Homeostasis
humans
Hydrogen peroxide
Inflammation
Lipids
Lycium barbarum
MCF-7
Metabolomics
neoplasm cells
Nutrient deficiency
onconutraceutical
Oxidants
Oxidation
Oxidative stress
phenolic compounds
Phytochemicals
Polyphenols
Polysaccharides
pro-oxidants
Protein folding
Pyroptosis
Tumor cell lines
goji berries
ER stress
pyroptosis
onconutraceutical
pro-oxidants
MCF-7
Online AccessGet full text
ISSN2076-3921
2076-3921
DOI10.3390/antiox13060708

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Abstract Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.
AbstractList Lycium barbarum , commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.
Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.
Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of Lycium barbarum fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.
, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important source of bioactive compounds such as polysaccharides, carotenoids, phenolics, and various other non-nutritive compounds. These constituents give it a multitude of health benefits, including antioxidant, anti-inflammatory, and anticancer properties. However, the precise biochemical mechanisms responsible for its anticancer effects remain unclear, and the comprehensive composition of goji berry extracts is often insufficiently explored. This study aimed to investigate the biochemical pathways modulated in breast cancer cells by an ethanolic extract of fruit (LBE). Following metabolomic profiling using UHPLC-HRMS/MS, we assessed the antitumoral properties of LBE on different breast cancer cell lines. This investigation revealed that LBE exhibited cytotoxic effects, inducing a pro-oxidant effect that triggered pyroptosis activation through endoplasmic reticulum (ER) stress and subsequent activation of the P-IRE1α/XBP1/NLRP3 axis in MCF-7 cells. In addition, LBE did not display cytotoxicity toward healthy human cells but demonstrated antioxidant properties by neutralizing ROS generated by doxorubicin. These findings underscore the potential of LBE as a highly promising natural extract in cancer therapy.
Author Aquino, Giovanna
Miranda, Maria Rosaria
Marino, Pasquale
Domínguez-Rodríguez, Gloria
Vestuto, Vincenzo
Ciaglia, Tania
Campiglia, Pietro
Pepe, Giacomo
Basilicata, Manuela Giovanna
Salviati, Emanuela
Moltedo, Ornella
Manfra, Michele
AuthorAffiliation 5 Departamento de Química Analítica, Química Física e Ingeniería Química, Facultad de Ciencias, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain; gloria.dominguezr@uah.es
3 Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy; manuelagiovanna.basilicata@unicampania.it
4 Department of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy; pasqualemarino.pm90@gmail.com (P.M.); michele.manfra@unibas.it (M.M.)
1 Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy; mmiranda@unisa.it (M.R.M.); gaquino@unisa.it (G.A.); esalviati@unisa.it (E.S.); tciaglia@unisa.it (T.C.); pcampiglia@unisa.it (P.C.)
6 National Biodiversity Future Center (NBFC), 90133 Palermo, Italy
2 PhD Program in Drug Discovery and Development, University of Salerno, 84084 Fisciano, Italy; moltedo@unisa.it
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– name: 1 Department of Pharmacy, University of Salerno, Via G. Paolo II, 84084 Fisciano, Italy; mmiranda@unisa.it (M.R.M.); gaquino@unisa.it (G.A.); esalviati@unisa.it (E.S.); tciaglia@unisa.it (T.C.); pcampiglia@unisa.it (P.C.)
– name: 2 PhD Program in Drug Discovery and Development, University of Salerno, 84084 Fisciano, Italy; moltedo@unisa.it
– name: 5 Departamento de Química Analítica, Química Física e Ingeniería Química, Facultad de Ciencias, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain; gloria.dominguezr@uah.es
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/38929147$$D View this record in MEDLINE/PubMed
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Keywords goji berries
ER stress
pyroptosis
onconutraceutical
pro-oxidants
MCF-7
Language English
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PMID 38929147
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crossref_citationtrail_10_3390_antiox13060708
crossref_primary_10_3390_antiox13060708
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PublicationDate 20240611
PublicationDateYYYYMMDD 2024-06-11
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  year: 2024
  text: 20240611
  day: 11
PublicationDecade 2020
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PublicationTitle Antioxidants
PublicationTitleAlternate Antioxidants (Basel)
PublicationYear 2024
Publisher MDPI AG
MDPI
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Snippet Lycium barbarum, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an...
, commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an important...
Lycium barbarum , commonly recognized as goji berry or wolfberry, is highly appreciated not only for its organoleptic and nutritional properties but also as an...
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SubjectTerms Antioxidants
Berries
Bioactive compounds
Breast cancer
breast neoplasms
Cancer therapies
cancer therapy
Carotenoids
Cell activation
Cell death
Cell proliferation
Chemotherapy
Cytotoxicity
Doxorubicin
Endoplasmic reticulum
endoplasmic reticulum stress
ER stress
Flavonoids
Fruits
goji berries
Homeostasis
humans
Hydrogen peroxide
Inflammation
Lipids
Lycium barbarum
MCF-7
Metabolomics
neoplasm cells
Nutrient deficiency
onconutraceutical
Oxidants
Oxidation
Oxidative stress
phenolic compounds
Phytochemicals
Polyphenols
Polysaccharides
pro-oxidants
Protein folding
Pyroptosis
Tumor cell lines
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Title Anticancer Therapies Based on Oxidative Damage: Lycium barbarum Inhibits the Proliferation of MCF-7 Cells by Activating Pyroptosis through Endoplasmic Reticulum Stress
URI https://www.ncbi.nlm.nih.gov/pubmed/38929147
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Volume 13
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