Estimation of serum C-reactive protein activity in periodontal health and disease and response to treatment: a clinico-biochemical study

• Published in: PeerJ (San Francisco, CA) Vol. 11; p. e16495
• Main Authors: Saquib Abullais, Shahabe, Wykole, Yogesh, Abdul Khader, Mohasin, Mohamed Shamsudeen, Shaik, Alanazi, Sultan, Ullah Khateeb, Shafait, Saleem Bhat, Mohammad Yunis, Shamsuddin, Shaheen
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 04.12.2023; PeerJ, Inc; PeerJ Inc
• Subjects: Bacterial infections; Biochemical study; Bone resorption; C-reactive protein; Cardiovascular diseases; Clinical study; Communicable diseases; Development and progression; Edema; Gingival index; Gum disease; Hormone replacement therapy; Infectious diseases; Inflammation; Periodontal diseases; Periodontal health; Periodontitis; Periodontium; Plaque index; Proteins; Response to treatment; serum C-reactive protein; Teeth; Response to treatment; Biochemical study; serum C-reactive protein; Periodontal health; Clinical study
• ISSN: 2167-8359; 2167-8359
• DOI: 10.7717/peerj.16495

Periodontitis is a chronic infectious disease affecting periodontium having multifactorial etiology, can cause significant systemic challengein addition to localized inflammation, tissue damage, and bone resorption. A serological marker of systemic inflammation known as C-reactive protein has been linked to an increased risk for a number of pathological conditions, including cardiovascular diseases. To estimate levels of serum C-reactive protein in healthy individuals and subjects with periodontal diseases and to compare serum C-reactive protein levels in subjects having periodontal disease pre-operatively & post-operatively. The study was conducted on 60 subjects age ranging from 35 to 60 years. 30 individuals with healthy periodontium were in group 1 (control group) and the remaining 30 were diagnosed as adult periodontitis were in group 2 (experimental group). Periodontal examination done using gingival index, plaque index, periodontal pocket depth, and Russel's index. CRP levels were examined between group 1 and group 2 and in group 2 between baseline visit before treatment and 2 months after treatment. The findings of this study show a significant connection between periodontal disease and the inflammatory marker CRP in the body, as well as a tendency for a significant decrease in serumCRP levels following periodontitis therapy. At baseline, there was a positive correlation among C-reactive protein, probing pocket depth, and Russell's index. As CRP is a key mediator for cardiovascular disease, an increase in C- reactive protein levels in periodontal diseases suggests a significant connection between periodontitis and cardiovascular diseases. Early periodontal treatment might decrease the severity of cardiovascular disease that already exists. This suggests that periodontal examination should be part of routine practicealong with cardiovascular examination.