Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers

Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online...

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Published inPhysiological reports Vol. 7; no. 20; pp. e14264 - n/a
Main Authors Bashir, Shahid, Al‐Hussain, Fawaz, Hamza, Ali, Asim Niaz, Talha, Albaradie, Raidah, Habib, Syed S.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.10.2019
John Wiley and Sons Inc
Wiley
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Online AccessGet full text
ISSN2051-817X
2051-817X
DOI10.14814/phy2.14264

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Abstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population. Little is known about the online effects of tDCS on cognition in healthy humans. Data showed that cognitive performance would only increase during online real stimulation as compared to sham stimulation. The safety and tolerability aspects of online 2mA tDCS to local population?
AbstractList Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population.
Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population.
Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double-blind, sham-controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well-tolerated and safe that further supports the safety of tDCS in local healthy population.Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double-blind, sham-controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well-tolerated and safe that further supports the safety of tDCS in local healthy population.
Abstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population.
Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have been reported in healthy subject and there is paucity of data on the cognitive effects of online tDCS. Therefore, we aimed to assess the online effect of tDCS over the left dorsolateral prefrontal cortex (DLPFC) on cognitive function and obtain safety data in healthy adults. We recruited 36 healthy (20 male) participants for this double‐blind, sham‐controlled parallel design. We used Stop Signal Task (SST) Go Trial and Pattern Recognition Memory (PRM) tests to evaluate cognitive function during 2 mA (20 min) anodal or sham tDCS stimulation over the left DLPFC. In active conditions, left dorsolateral prefrontal cortex was selected for electrode placement with reference over right supraorbital cortex. All related tasks were done during the online tDCS section in both groups (active/sham). There were statistically significant differences in cognitive function according to the PRM test (P = 0.003), SST (P = 0.021), and SST correct response time on Go Trials (P = 0.02) during active stimulation compared to the sham group. Our results reveal that cognitive performance is affected by a single dose of active online tDCS over DLPFC area compared to sham stimulation. In our study, tDCS is well‐tolerated and safe that further supports the safety of tDCS in local healthy population. Little is known about the online effects of tDCS on cognition in healthy humans. Data showed that cognitive performance would only increase during online real stimulation as compared to sham stimulation. The safety and tolerability aspects of online 2mA tDCS to local population?
Author Hamza, Ali
Asim Niaz, Talha
Albaradie, Raidah
Bashir, Shahid
Habib, Syed S.
Al‐Hussain, Fawaz
AuthorAffiliation 3 Department of Electrical Engineering National University of Computer and Emerging Sciences Lahore Pakistan
1 Neuroscience Center King Fahad Specialist Hospital Dammam Dammam Saudi Arabia
2 Department of Neurology College of Medicine King Saud University Riyadh Saudi Arabia
4 Department of Physiology College of Medicine King Saud University Riyadh Saudi Arabia
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– name: 4 Department of Physiology College of Medicine King Saud University Riyadh Saudi Arabia
– name: 3 Department of Electrical Engineering National University of Computer and Emerging Sciences Lahore Pakistan
– name: 2 Department of Neurology College of Medicine King Saud University Riyadh Saudi Arabia
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31660693$$D View this record in MEDLINE/PubMed
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Issue 20
Keywords stop signal task
Memory
safety
transcranial direct current stimulation
Language English
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Notes Funding information
The authors appreciate the “Research centre of the college of Medicine and Deanship of Scientific Research at King Saud University” for supporting this research.
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Snippet Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results have...
Abstract Although cognitive function has been reported to change following the anodal transcranial direct current stimulation (tDCS) but still variable results...
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StartPage e14264
SubjectTerms Age
Brain research
Cellular and Molecular Neuroscience
Central Nervous System
Cognition & reasoning
Cognitive ability
Cognitive and Behavioural Neuroscience
Consent
Electrical stimulation of the brain
Electrodes
ESB
Internet
Memory
Original Research
Pattern recognition
Physiology
Prefrontal cortex
safety
Software
Statistical analysis
stop signal task
Studies
transcranial direct current stimulation
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Title Cognitive function assessment during 2 mA transcranial direct current stimulation in DLPFC in healthy volunteers
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