Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease - Yoo, Taekyeong; Joo, Sae Kyung; Kim, Hyo Jung; Kim, Hyun Young; Sim, Hyungtai; Lee, Jieun; Kim, Hee-Hoon; Jung, Sunhee; Lee, Youngha; Jamialahmadi, Oveis; Romeo, Stefano; Jeong, Won-Il; et al. (Journal of hepatology, 2021)
Keywords: Adult; Aged; AGXT2; Alanine; Animal models; Antifibrotic Agents - pharmacology; Antifibrotic Agents - therapeutic use; Biopsy; Cardiology and Cardiovascular Disease; Endoplasmic reticulum; eQTL; Fatty liver; Female; Fibrosis; Genetic factors; genetic variants; Genome-wide association studies; Genome-Wide Association Study - methods; Genome-Wide Association Study - statistics & numerical data; Hepatocytes; Humans; Kardiologi och kardiovaskulära sjukdomar; Liver - pathology; Liver diseases; Male; Mass Screening - methods; Mass Screening - statistics & numerical data; Middle Aged; NAFLD; NASH; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - epidemiology; Non-alcoholic Fatty Liver Disease - genetics; Palmitic acid; Patients; Quantitative trait loci; Republic of Korea - epidemiology; Single-nucleotide polymorphism; Steatosis; Transaminases - pharmacology; Transaminases - therapeutic use; Republic of Korea; genetic variants; NAFLD; eQTL; NASH; AGXT2