Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations
Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-spe...
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| Published in | Open biology Vol. 14; no. 9; pp. 240036 - 15 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Royal Society Publishing
01.09.2024
The Royal Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2046-2441 2046-2441 |
| DOI | 10.1098/rsob.240036 |
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| Abstract | Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-specific adaptations. Fam161 is the sole orthologue of FAM161A and FAM161B found in flies. Mutating Fam161 results in reduced male reproduction and abnormal geotaxis behaviour. Fam161 localizes to sensory neuron centrioles and their specialized TZ (the connecting cilium) in a cell type-specific manner, sometimes labelling only the centrioles, sometimes labelling the centrioles and cilium TZ and sometimes labelling the TZ with varying lengths that are longer than other TZ proteins, defining a new ciliary compartment, the extra distal TZ. These findings suggest that Fam161 is an essential centriole and TZ protein with a unique cell type-specific localization in fruit flies that can produce cell type-specific adaptations. |
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| AbstractList | Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-specific adaptations. Fam161 is the sole orthologue of FAM161A and FAM161B found in flies. Mutating Fam161 results in reduced male reproduction and abnormal geotaxis behaviour. Fam161 localizes to sensory neuron centrioles and their specialized TZ (the connecting cilium) in a cell type-specific manner, sometimes labelling only the centrioles, sometimes labelling the centrioles and cilium TZ and sometimes labelling the TZ with varying lengths that are longer than other TZ proteins, defining a new ciliary compartment, the extra distal TZ. These findings suggest that Fam161 is an essential centriole and TZ protein with a unique cell type-specific localization in fruit flies that can produce cell type-specific adaptations. Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-specific adaptations. Fam161 is the sole orthologue of FAM161A and FAM161B found in flies. Mutating Fam161 results in reduced male reproduction and abnormal geotaxis behaviour. Fam161 localizes to sensory neuron centrioles and their specialized TZ (the connecting cilium) in a cell type-specific manner, sometimes labelling only the centrioles, sometimes labelling the centrioles and cilium TZ and sometimes labelling the TZ with varying lengths that are longer than other TZ proteins, defining a new ciliary compartment, the extra distal TZ. These findings suggest that Fam161 is an essential centriole and TZ protein with a unique cell type-specific localization in fruit flies that can produce cell type-specific adaptations.Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-specific adaptations. Fam161 is the sole orthologue of FAM161A and FAM161B found in flies. Mutating Fam161 results in reduced male reproduction and abnormal geotaxis behaviour. Fam161 localizes to sensory neuron centrioles and their specialized TZ (the connecting cilium) in a cell type-specific manner, sometimes labelling only the centrioles, sometimes labelling the centrioles and cilium TZ and sometimes labelling the TZ with varying lengths that are longer than other TZ proteins, defining a new ciliary compartment, the extra distal TZ. These findings suggest that Fam161 is an essential centriole and TZ protein with a unique cell type-specific localization in fruit flies that can produce cell type-specific adaptations. |
| Author | Mukherjee, Avik Avidor-Reiss, Tomer Jaiswal, Ankit Boring, Andrew |
| Author_xml | – sequence: 1 givenname: Ankit orcidid: 0000-0002-0078-3602 surname: Jaiswal fullname: Jaiswal, Ankit organization: Department of Biological Sciences, University of Toledo , Toledo, OH 43606, USA – sequence: 2 givenname: Andrew orcidid: 0009-0005-9010-1634 surname: Boring fullname: Boring, Andrew organization: Department of Biological Sciences, University of Toledo , Toledo, OH 43606, USA, Department of Urology, College of Medicine and Life Sciences, University of Toledo , Toledo, OH 43614, USA – sequence: 3 givenname: Avik orcidid: 0009-0004-9010-5697 surname: Mukherjee fullname: Mukherjee, Avik organization: Department of Biological Sciences, University of Toledo , Toledo, OH 43606, USA – sequence: 4 givenname: Tomer orcidid: 0000-0003-0918-526X surname: Avidor-Reiss fullname: Avidor-Reiss, Tomer organization: Department of Biological Sciences, University of Toledo , Toledo, OH 43606, USA, Department of Urology, College of Medicine and Life Sciences, University of Toledo , Toledo, OH 43614, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39255847$$D View this record in MEDLINE/PubMed |
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| Snippet | Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ)... |
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| SubjectTerms | Adaptation Amino acid sequence Animals centriole Centrioles Centrioles - metabolism centrosome cilia Cilia - metabolism Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism FAM161A Geotaxis Invertebrates Labeling Localization Male Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mutation neuron Neurons Organ Specificity Photoreceptors Proteins Sperm |
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| Title | Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations |
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