IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP - Li, Yue; Chang, Li-Hong; Huang, Wei-Qiang; Bao, Hong-Wei; Li, Xia; Chen, Xiao-Hong; Wu, Hao-Tian; Yao, Zhou-Zhou; Huang, Zi-Zhen; Weinberg, Samuel E.; Fang, De-Yu; Zhang, Ya-Na; et al. (Journal of allergy and clinical immunology, 2022)
Keywords: Epithelial cells; IL-17A; NLRP3 inflammasome; pyroptosis; steroid resistance; NP; C-Caspase-1; Epithelial cells; CRS; IHC; JNK; VAS; CRSwNP; NLRP3 inflammasome; CRSsNP; pyroptosis; ASC; NF-κB; NLRP3; IF; steroid resistance; GSDMD; IL-17A; GRβ; DEG; GRα; qRT-PCR; siRNA; GR; MAPK; IκBα; p; CT; MEK; hNEC; ERK