ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort

Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist int...

Full description

Saved in:

Bibliographic Details
Published in	Schizophrenia research Vol. 209; pp. 141 - 147
Main Authors	Sabherwal, Sophie, Föcking, Melanie, English, Jane A., Fitzsimons, Stephen, Hryniewiecka, Magdalena, Wynne, Kieran, Scaife, Caitriona, Healy, Colm, Cannon, Mary, Belton, Orina, Zammit, Stanley, Cagney, Gerard, Cotter, David R.
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.07.2019
Subjects	Adolescent ALSPAC ApoE Apolipoprotein Apolipoproteins - blood Apolipoproteins E - blood Child Chromatography, High Pressure Liquid Delusions - blood Delusions - physiopathology Disease Progression Enzyme-Linked Immunosorbent Assay Female Hallucinations - blood Hallucinations - physiopathology Humans Male Outcome Prognosis Proteomics Psychiatric/Mental Health Psychotic experience ALSPAC ApoE Psychotic experience Apolipoprotein Outcome Proteomics
Online Access	Get full text
ISSN	0920-9964 1573-2509 1573-2509
DOI	10.1016/j.schres.2019.05.002

Cover

Abstract	Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences.
AbstractList	Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences. Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences.Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences. AbstractApolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and schizophrenia. This is the first study to investigate plasma apolipoprotein expression in children with psychotic experiences that persist into adulthood. Here, using semi-targeted proteomic analysis we compared plasma apolipoprotein expression levels in age 12 subjects who reported psychotic experiences at both age 12 and age 18 (n = 37) with age-matched subjects who only experienced psychotic experiences (PEs) at age 12 (n = 38). Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in psychiatric assessment interviews at ages 12 and 18. We identified apoE, a protein with significant regulatory activity on cholesterol metabolism in the brain, to be significantly up regulated (p < 0.003) in those with persistent psychotic experiences. We confirmed this finding in these samples using ELISA. Our findings indicate elevated plasma apoE in age 12 children who experience PEs is associated with persistence psychotic experiences.
Author	Fitzsimons, Stephen Cannon, Mary Cagney, Gerard Scaife, Caitriona Sabherwal, Sophie Hryniewiecka, Magdalena Föcking, Melanie Wynne, Kieran Healy, Colm Belton, Orina Cotter, David R. Zammit, Stanley English, Jane A.
Author_xml	– sequence: 1 givenname: Sophie surname: Sabherwal fullname: Sabherwal, Sophie email: sophiesabherwal@rcsi.com organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 2 givenname: Melanie surname: Föcking fullname: Föcking, Melanie organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 3 givenname: Jane A. surname: English fullname: English, Jane A. organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 4 givenname: Stephen surname: Fitzsimons fullname: Fitzsimons, Stephen organization: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland – sequence: 5 givenname: Magdalena surname: Hryniewiecka fullname: Hryniewiecka, Magdalena organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 6 givenname: Kieran surname: Wynne fullname: Wynne, Kieran organization: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland – sequence: 7 givenname: Caitriona surname: Scaife fullname: Scaife, Caitriona organization: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland – sequence: 8 givenname: Colm orcidid: 0000-0001-7974-1861 surname: Healy fullname: Healy, Colm organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 9 givenname: Mary surname: Cannon fullname: Cannon, Mary organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland – sequence: 10 givenname: Orina surname: Belton fullname: Belton, Orina organization: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland – sequence: 11 givenname: Stanley orcidid: 0000-0002-2647-9211 surname: Zammit fullname: Zammit, Stanley organization: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK – sequence: 12 givenname: Gerard surname: Cagney fullname: Cagney, Gerard organization: School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland – sequence: 13 givenname: David R. orcidid: 0000-0003-4308-0648 surname: Cotter fullname: Cotter, David R. email: drcotter@rcsi.ie organization: Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31080155$$D View this record in MEDLINE/PubMed
BookMark	eNqVktGKEzEUhoOsuN3VNxDJpTdTTzJNO7OIUErdFQoKq-BdSJMTmzqdjEnatU_ga5vprF4IsnqVQ87_fwn_ORfkrPUtEvKcwZgBm77ajqPeBIxjDqwegxgD8EdkxMSsLLiA-oyMoOZQ1PV0ck4uYtwCABMwe0LOSwZVrsWI_Jh3fkmxwYNKzrfURapi9NqphIbeubShaYO0wxBdTNhqpN7SLh71xienKX7PLdffR2qD31H1BSnjNPmhqq7o8uDMyXjq97T56vbDfEHXLmS89hsf0lPy2Kom4rP785J8erv8uLgpVu-v3y3mq0ILNk2FrWCmcGKVsqWtmVVoasZmqlQVN2stpoqLNTAz0yAM48YyYTTnlWUwqRCgvCRi4O7bTh3vVNPILridCkfJQPbByq0cgpV9sBKEzMFm38vB1wX_bY8xyZ2LGptGtej3WctLloOuqjJLX9xL9-sdmt_8X6FnwWQQ6OBjDGj_9QtXf9i0S6eppaBc85D5zWDGHO7BYcii09iMC6iTNN79L0A3rnVaNV_xiHHr96HNg5NMRi5B3va7168eq8vMLD9nwOu_Ax5-_yfqeeq5
CitedBy_id	crossref_primary_10_1038_s41398_024_03163_9 crossref_primary_10_1038_s41398_022_02217_0 crossref_primary_10_1016_j_schres_2019_07_023 crossref_primary_10_1007_s13258_024_01545_3
Cites_doi	10.1016/j.jad.2015.09.024 10.1161/ATVBAHA.116.307023 10.1002/pmic.201600203 10.1038/tp.2017.211 10.1194/jlr.R900015-JLR200 10.1017/S0033291711002960 10.1161/ATVBAHA.107.160192 10.1371/journal.pone.0009166 10.1074/jbc.273.41.26388 10.1017/S0033291708003760 10.2353/ajpath.2007.070166 10.1016/j.psychres.2016.01.024 10.1017/S0033291712001626 10.1192/bjp.bp.117.200907 10.1093/hmg/dds296 10.1523/JNEUROSCI.1054-16.2016 10.1176/appi.ajp.2008.07091532 10.1371/journal.pmed.1002146 10.1093/clinchem/44.5.957 10.3389/fncel.2014.00380 10.1007/s12013-015-0536-5 10.1038/nri3761 10.1186/1750-1326-8-13 10.1176/appi.ajp.2016.15070890 10.1001/jamapsychiatry.2014.1332 10.1001/archgenpsychiatry.2009.192 10.1038/sj.mp.4002108 10.15252/emmm.201708763 10.1016/S2215-0366(17)30293-6 10.1016/0021-9150(93)90038-V 10.1186/s12888-018-1767-y 10.1016/j.eurpsy.2016.01.2425 10.1176/appi.ajp.2016.15101293 10.1371/journal.pmed.0030176 10.3109/15622971003758748 10.1002/prca.201400117 10.1038/mp.2009.54 10.1016/j.psychres.2007.05.008 10.2217/clp.10.37 10.1016/j.jmii.2013.05.010 10.1038/tp.2016.170 10.1001/archpsyc.57.11.1053 10.1038/mp.2013.110 10.1016/0005-2760(89)90311-1 10.1016/S0006-3223(03)00075-1 10.1074/jbc.M115.669226 10.1016/j.jprot.2012.05.027 10.1194/jlr.M800172-JLR200 10.1016/j.jprot.2015.09.013 10.1111/j.2517-6161.1995.tb02031.x 10.1093/schbul/sbu099 10.2183/pjab.90.353 10.15252/msb.20145728 10.1073/pnas.071056198 10.1002/bmc.3084 10.1016/j.schres.2015.08.031 10.1002/wps.20144 10.1017/S0033291713002122 10.1016/j.jalz.2014.05.1749 10.1192/bjp.bp.111.101543 10.1186/1471-2210-9-10 10.1021/ac051916x 10.1371/journal.pone.0078729 10.1093/schbul/sbw152 10.1176/appi.ajp.2013.12060768 10.1038/tp.2015.91 10.1016/j.jad.2016.05.053 10.1080/14789450.2016.1252262 10.1016/j.neuron.2009.06.026 10.1016/S0893-133X(98)00031-1 10.1016/j.jalz.2017.06.2266 10.1016/S0024-3205(96)00685-6 10.1192/bjp.181.5.363 10.1093/schbul/sbx075 10.1002/wps.20131 10.1074/jbc.273.28.17483 10.1038/mp.2013.7 10.1006/exnr.2001.7631 10.1039/c2mb25158b 10.1038/tp.2015.119 10.1176/appi.ajp.2012.12060792 10.1016/j.atherosclerosis.2016.10.037
ContentType	Journal Article
Copyright	2019 Elsevier B.V. Elsevier B.V. Copyright © 2019 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2019 Elsevier B.V. – notice: Elsevier B.V. – notice: Copyright © 2019 Elsevier B.V. All rights reserved.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 ADTOC UNPAY
DOI	10.1016/j.schres.2019.05.002
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Unpaywall for CDI: Periodical Content Unpaywall
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository
DeliveryMethod	fulltext_linktorsrc
EISSN	1573-2509
EndPage	147
ExternalDocumentID	oai:http://orca-dev.cardiff.ac.uk:123027 31080155 10_1016_j_schres_2019_05_002 S092099641930163X 1_s2_0_S092099641930163X
Genre	Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: Medical Research Council grantid: MR/L010305/1 – fundername: Medical Research Council grantid: G9815508 – fundername: Medical Research Council grantid: MC_PC_19009 – fundername: Wellcome Trust grantid: 102215/2/13/2
GroupedDBID	--- --K --M -~X .1- .FO .GJ .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 4.4 457 4G. 4H- 53G 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAWTL AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABIVO ABJNI ABMAC ABMZM ABOYX ABWVN ABXDB ACDAQ ACGFS ACHQT ACIEU ACIUM ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HMK HMO HMQ HMW HVGLF HZ~ IHE J1W KOM M29 M2V M39 M3V M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SPS SSB SSH SSN SSY SSZ T5K WUQ Z5R ~G- AACTN AFCTW AFKWA AJOXV AMFUW RIG AADPK AAIAV ABLVK ABYKQ AFYLN AJBFU EFLBG LCYCR AAYXX ACLOT CITATION ~HD AGRNS CGR CUY CVF ECM EIF NPM 7X8 ADTOC UNPAY
ID	FETCH-LOGICAL-c516t-f807ae4faaf3f91faed9117a3a82dbc56a25b01d7c05d12df15dc228f1048e003
IEDL.DBID	.~1
ISSN	0920-9964 1573-2509
IngestDate	Tue Aug 19 09:28:55 EDT 2025 Wed Oct 01 14:38:01 EDT 2025 Mon Jul 21 06:02:47 EDT 2025 Thu Apr 24 23:11:45 EDT 2025 Wed Oct 01 04:37:12 EDT 2025 Fri Feb 23 02:33:30 EST 2024 Sun Feb 23 10:19:40 EST 2025 Tue Aug 26 17:09:45 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	ALSPAC ApoE Psychotic experience Apolipoprotein Outcome Proteomics
Language	English
License	Copyright © 2019 Elsevier B.V. All rights reserved. cc-by-nc-nd
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c516t-f807ae4faaf3f91faed9117a3a82dbc56a25b01d7c05d12df15dc228f1048e003
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0003-4308-0648 0000-0001-7974-1861 0000-0002-2647-9211
OpenAccessLink	https://proxy.k.utb.cz/login?url=https://orca.cardiff.ac.uk/id/eprint/123027/
PMID	31080155
PQID	2231964883
PQPubID	23479
PageCount	7
ParticipantIDs	unpaywall_primary_10_1016_j_schres_2019_05_002 proquest_miscellaneous_2231964883 pubmed_primary_31080155 crossref_primary_10_1016_j_schres_2019_05_002 crossref_citationtrail_10_1016_j_schres_2019_05_002 elsevier_sciencedirect_doi_10_1016_j_schres_2019_05_002 elsevier_clinicalkeyesjournals_1_s2_0_S092099641930163X elsevier_clinicalkey_doi_10_1016_j_schres_2019_05_002
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2019-07-01
PublicationDateYYYYMMDD	2019-07-01
PublicationDate_xml	– month: 07 year: 2019 text: 2019-07-01 day: 01
PublicationDecade	2010
PublicationPlace	Netherlands
PublicationPlace_xml	– name: Netherlands
PublicationTitle	Schizophrenia research
PublicationTitleAlternate	Schizophr Res
PublicationYear	2019
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Domenici, Wille, Tozzi, Prokopenko, Miller, Mckeown, Brittain, Rujescu, Giegling, Turck, Holsboer, Bullmore, Middleton, Merlo-Pich, Alexander, Muglia (bb0075) 2010; 5 Thomas, Dean, Pavey, Sutcliffe (bb0365) 2001; 98 Cruchaga, Kauwe, Nowotny, Bales, Pickering, Mayo, Bertelsen, Hinrichs, Alzheimer's Disease Neuroimaging, I, Fagan, Holtzman, Morris, Goate (bb0055) 2012; 21 Beasley, Honer, Ramos-Miguel, Vila-Rodriguez, Barr (bb0025) 2017 Li, Zhou, Zhang, Sun, Yang, Zhang, Ji, Tang, Wei, He, Gao, Yang, Wang, Yang, Feng, He, Wan (bb0220) 2012; 8 Shayo, McLay, Kastin, Banks (bb0340) 1997; 60 Niarchou, Zammit, Walters, Lewis, Owen, Van Den Bree (bb0275) 2013; 170 Mooijaart, Berbee, Van Heemst, Havekes, De Craen, Slagboom, Rensen, Westendorp (bb0265) 2006; 3 Clark, Baune, Schubert, Lavoie, Smesny, Rice, Schafer, Benninger, Feucht, Klier, McGorry, Amminger (bb0045) 2016; 6 Fullerton, Shirman, Strittmatter, Matthew (bb0100) 2001; 169 Hoofnagle, Heinecke (bb9005) 2009; 50 Welham, Scott, Williams, Najman, Bor, O'Callaghan, McGrath (bb0385) 2009; 39 Dean, Laws, Hone, Taddei, Scarr, Thomas, Harper, McClean, Masters, Lautenschlager, Gandy, Martins (bb0060) 2003; 54 Sorensen, Gamborg, Sorensen, Baker, Mortensen (bb0355) 2016; 34 Pollak, Drndarski, Stone, David, Mcguire, Abbott (bb0305) 2018; 5 Rutigliano, Valmaggia, Landi, Frascarelli, Cappucciati, Sear, Rocchetti, De Micheli, Jones, Palombini, Mcguire, Fusar-Poli (bb0325) 2016; 203 Gonzalez-Castro, Tovilla-Zarate, Hernandez-Diaz, Fresan, Juarez-Rojop, Ble-Castillo, Lopez-Narvaez, Genis, Hernandez-Alvarado (bb0105) 2015; 169 Sabherwal, English, Focking, Cagney, Cotter (bb0330) 2016; 13 Smesny, Milleit, Hipler, Milleit, Schafer, Klier, Holub, Holzer, Berger, Otto, Nenadic, Berk, McGorry, Sauer, Amminger (bb0345) 2014; 19 Elliott, Weickert, Garner (bb0080) 2010; 51 McGorry, Keshavan, Goldstone, Amminger, Allott, Berk, Lavoie, Pantelis, Yung, Wood, Hickie (bb0255) 2014; 13 Kelleher, Connor, Clarke, Devlin, Harley, Cannon (bb0160) 2012; 42 Rasmussen (bb0320) 2016; 255 Vincent-Viry, Schiele, Gueguen, Bohnet, Visvikis, Siest (bb0380) 1998; 44 Chan, Krebs, Cox, Guest, Yolken, Rahmoune, Rothermundt, Steiner, Leweke, Van Beveren, Niebuhr, Weber, Cowan, Suarez-Pinilla, Crespo-Facorro, Mam-Lam-Fook, Bourgin, Wenstrup, Kaldate, Cooper, Bahn (bb0035) 2015; 5 Chouinard, Pingali, Chouinard, Henderson, Mallya, Cypess, Cohen, Ongur (bb0040) 2016; 237 Khandaker, Pearson, Zammit, Lewis, Jones (bb0180) 2014; 71 Ramsey, Schwarz, Guest, Van Beveren, Leweke, Rothermundt, Bogerts, Steiner, Bahn (bb0315) 2013; 8 Sajic, Liu, Aebersold (bb0335) 2015; 9 Kaneko, Nakamura, Washimi, Kato, Sakurai, Arahata, Bundo, Takeda, Niida, Ito, Toba, Tanaka, Yanagisawa (bb0155) 2014; 90 Levin, Wang, Schwarz, Koethe, Leweke, Bahn (bb0210) 2010; 15 Vik-Mo, Ferno, Skrede, Steen (bb0375) 2009; 9 Haapasalo, Van Kessel, Nissila, Metso, Johansson, Miettinen, Varjosalo, Kirveskari, Kuusela, Chroni, Jauhiainen, Van Strijp, Jokiranta (bb0110) 2015; 290 Kim, Basak, Holtzman (bb0185) 2009; 63 Lee, Glass, Wand, Mcatee, Bandeen-Roche, Bolla, Schwartz (bb0205) 2008; 165 Sofat, Cooper, Kumari, Casas, Mitchell, Acharya, Thom, Hughes, Humphries, Hingorani (bb0350) 2016; 13 Huang, Liu, Rall, Taylor, Von Eckardstein, Assmann, Mahley (bb0130) 1998; 273 Jaros, Martins-De-Souza, Rahmoune, Rothermundt, Leweke, Guest, Bahn (bb0150) 2012; 76 Kopczynska, M., Zelek, W., Touchard, S., Gaughran, F., Di Forti, M., Mondelli, V., Murray, R., O'Donovan, M. C. & Morgan, B. P. 2017. Complement system biomarkers in first episode psychosis. Schizophr. Res. Heinze, Lin, Nelson, Reniers, Upthegrove, Clarke, Roche, Lowrie, Wood (bb0120) 2018; 18 Fu, Wang, He, Song, Xue, Wang (bb0095) 2014; 47 Zammit, Kounali, Cannon, David, Gunnell, Heron, Jones, Lewis, Sullivan, Wolke, Lewis (bb0395) 2013; 170 Hussain, Zanni, Kelly, Zannis (bb0140) 1989; 1001 Zuckerman, Evans, O'Neal (bb0405) 1993; 103 Dean, Digney, Sundram, Thomas, Scarr (bb0065) 2008; 158 Malhotra, Breier, Goldman, Picken, Pickar (bb0240) 1998; 19 Asellus, Nordstrom, Nordstrom, Jokinen (bb0020) 2016; 190 Lane-Donovan, Wong, Durakoglugil, Wasser, Jiang, Xian, Herz (bb0200) 2016; 36 Mahley (bb0235) 2016; 36 Hammer, Stepniak, Schneider, Papiol, Tantra, Begemann, Siren, Pardo, Sperling, Mohd Jofrry, Gurvich, Jensen, Ostmeier, Luhder, Probst, Martens, Gillis, Saher, Assogna, Spalletta, Stocker, Schulz, Nave, Ehrenreich (bb0115) 2014; 19 Cannon, Yu, Addington, Bearden, Cadenhead, Cornblatt, Heinssen, Jeffries, Mathalon, Mcglashan, Perkins, Seidman, Tsuang, Walker, Woods, Kattan (bb0030) 2016; 173 Poulton, Caspi, Moffitt, Cannon, Murray, Harrington (bb0310) 2000; 57 Yang, Wan, Li, Zhu, La, Xi, Chen, Jiang, Feng, He (bb0390) 2006; 78 Cotter, Pariante (bb0050) 2002; 181 Huang, Wang, Prabakaran, Wengenroth, Lockstone, Koethe, Gerth, Gross, Schreiber, Lilley, Wayland, Oxley, Leweke, Bahn (bb0135) 2008; 13 Ovod, Ramsey, Mawuenyega, Bollinger, Hicks, Schneider, Sullivan, Paumier, Holtzman, Morris, Benzinger, Fagan, Patterson, Bateman (bb0290) 2017; 13 Orsini, De Blasio, Zangari, Zanier, De Simoni (bb0285) 2014; 8 Liu, Buil, Collins, Gillet, Blum, Cheng, Vitek, Mouritsen, Lachance, Spector, Dermitzakis, Aebersold (bb0230) 2015; 11 Teo, Kim, Tsou, Collins, Gingras, Nesvizhskii, Choi (bb0360) 2015; 129 English, Lopez, O'Gorman, Focking, Hryniewiecka, Scaife, Sabherwal, Wynne, Dicker, Rutten, Lewis, Zammit, Cannon, Cagney, Cotter (bb0090) 2018; 44 Zhou, Wang, Yu, Shi, Li, Xu, Yu (bb0400) 2014; 28 Linscott, Van Os (bb0225) 2013; 43 Kelleher, Devlin, Wigman, Kehoe, Murtagh, Fitzpatrick, Cannon (bb0175) 2014; 44 Hye, Riddoch-Contreras, Baird, Ashton, Bazenet, Leung, Westman, Simmons, Dobson, Sattlecker, Lupton, Lunnon, Keohane, Ward, Pike, Zucht, Pepin, Zheng, Tunnicliffe, Richardson, Gauthier, Soininen, Kloszewska, Mecocci, Tsolaki, Vellas, Lovestone (bb0145) 2014; 10 English, Fan, Focking, Lopez, Hryniewiecka, Wynne, Dicker, Matigian, Cagney, Mackay-Sim, Cotter (bb0085) 2015; 5 Nabers, Perna, Lange, Mons, Schartner, Guldenhaupt, Saum, Janelidze, Holleczek, Rujescu, Hansson, Gerwert, Brenner (bb0270) 2018; 10 Pillinger, Beck, Stubbs, Howes (bb0300) 2017; 211 Ding, Guo, Hu, Jiang, Wang (bb0070) 2015; 72 Perkins, Jeffries, Addington, Bearden, Cadenhead, Cannon, Cornblatt, Mathalon, McGlashan, Seidman, Tsuang, Walker, Woods, Heinssen (bb0295) 2015; 41 Adiels, Olofsson, Taskinen, Boren (bb9000) 2008; 28 Aebersold, Bensimon, Collins, Ludwig, Sabido (bb0010) 2016; 16 Ulrich, Burchett, Restivo, Schuler, Verghese, Mahan, Landreth, Castellano, Jiang, Cirrito, Holtzman (bb0370) 2013; 8 Benjamini, Hochberg (bb8000) 1995; 57 Huang, Liu, Rall, Mahley (bb0125) 1998; 273 Martins-De-Souza, Wobrock, Zerr, Schmitt, Gawinecka, Schneider-Axmann, Falkai, Turck (bb0250) 2010; 11 Kolev, Le Friec, Kemper (bb0190) 2014; 14 O'Gorman, Suvitaival, Ahonen, Cannon, Zammit, Lewis, Roche, Mattila, Hyotylainen, Oresic, Brennan, Cotter (bb0280) 2017; 7 Addington, Liu, Perkins, Carrion, Keefe, Woods (bb0005) 2017; 43 Markiewski, Lambris (bb0245) 2007; 171 Amminger, Schafer, Papageorgiou, Klier, Cotton, Harrigan, MacKinnon, McGorry, Berger (bb0015) 2010; 67 Li, Thompson, Kitchens (bb0215) 2008; 49 McGrath, Saha, Al-Hamzawi, Andrade, Benjet, BROMET, Browne, Caldas De Almeida, Chiu, Demyttenaere, Fayyad, Florescu, De Girolamo, Gureje, Haro, Ten Have, Hu, Kovess-Masfety, Lim, Navarro-Mateu, Sampson, Posada-Villa, Kendler, Kessler (bb0260) 2016; 173 Kelleher, Keeley, Corcoran, Lynch, Fitzpatrick, Devlin, Molloy, Roddy, Clarke, Harley, Arseneault, Wasserman, Carli, Sarchiapone, Hoven, Wasserman, Cannon (bb0165) 2012; 201 Kelleher, Cederlof, Lichtenstein (bb0170) 2014; 13 Kolev (10.1016/j.schres.2019.05.002_bb0190) 2014; 14 Haapasalo (10.1016/j.schres.2019.05.002_bb0110) 2015; 290 Dean (10.1016/j.schres.2019.05.002_bb0065) 2008; 158 Shayo (10.1016/j.schres.2019.05.002_bb0340) 1997; 60 Martins-De-Souza (10.1016/j.schres.2019.05.002_bb0250) 2010; 11 Dean (10.1016/j.schres.2019.05.002_bb0060) 2003; 54 Khandaker (10.1016/j.schres.2019.05.002_bb0180) 2014; 71 Ovod (10.1016/j.schres.2019.05.002_bb0290) 2017; 13 Levin (10.1016/j.schres.2019.05.002_bb0210) 2010; 15 Poulton (10.1016/j.schres.2019.05.002_bb0310) 2000; 57 Cotter (10.1016/j.schres.2019.05.002_bb0050) 2002; 181 Hammer (10.1016/j.schres.2019.05.002_bb0115) 2014; 19 Huang (10.1016/j.schres.2019.05.002_bb0125) 1998; 273 English (10.1016/j.schres.2019.05.002_bb0085) 2015; 5 Linscott (10.1016/j.schres.2019.05.002_bb0225) 2013; 43 Asellus (10.1016/j.schres.2019.05.002_bb0020) 2016; 190 10.1016/j.schres.2019.05.002_bb0195 Kaneko (10.1016/j.schres.2019.05.002_bb0155) 2014; 90 Vincent-Viry (10.1016/j.schres.2019.05.002_bb0380) 1998; 44 Kelleher (10.1016/j.schres.2019.05.002_bb0170) 2014; 13 Kelleher (10.1016/j.schres.2019.05.002_bb0160) 2012; 42 Hye (10.1016/j.schres.2019.05.002_bb0145) 2014; 10 Perkins (10.1016/j.schres.2019.05.002_bb0295) 2015; 41 Mahley (10.1016/j.schres.2019.05.002_bb0235) 2016; 36 McGrath (10.1016/j.schres.2019.05.002_bb0260) 2016; 173 Rasmussen (10.1016/j.schres.2019.05.002_bb0320) 2016; 255 Teo (10.1016/j.schres.2019.05.002_bb0360) 2015; 129 Amminger (10.1016/j.schres.2019.05.002_bb0015) 2010; 67 Gonzalez-Castro (10.1016/j.schres.2019.05.002_bb0105) 2015; 169 Hoofnagle (10.1016/j.schres.2019.05.002_bb9005) 2009; 50 Benjamini (10.1016/j.schres.2019.05.002_bb8000) 1995; 57 Li (10.1016/j.schres.2019.05.002_bb0215) 2008; 49 Sofat (10.1016/j.schres.2019.05.002_bb0350) 2016; 13 Ulrich (10.1016/j.schres.2019.05.002_bb0370) 2013; 8 Clark (10.1016/j.schres.2019.05.002_bb0045) 2016; 6 Pollak (10.1016/j.schres.2019.05.002_bb0305) 2018; 5 Ramsey (10.1016/j.schres.2019.05.002_bb0315) 2013; 8 Beasley (10.1016/j.schres.2019.05.002_bb0025) 2017 Adiels (10.1016/j.schres.2019.05.002_bb9000) 2008; 28 Kelleher (10.1016/j.schres.2019.05.002_bb0175) 2014; 44 Sabherwal (10.1016/j.schres.2019.05.002_bb0330) 2016; 13 Liu (10.1016/j.schres.2019.05.002_bb0230) 2015; 11 Huang (10.1016/j.schres.2019.05.002_bb0135) 2008; 13 Addington (10.1016/j.schres.2019.05.002_bb0005) 2017; 43 Li (10.1016/j.schres.2019.05.002_bb0220) 2012; 8 Orsini (10.1016/j.schres.2019.05.002_bb0285) 2014; 8 Hussain (10.1016/j.schres.2019.05.002_bb0140) 1989; 1001 Mooijaart (10.1016/j.schres.2019.05.002_bb0265) 2006; 3 Aebersold (10.1016/j.schres.2019.05.002_bb0010) 2016; 16 Markiewski (10.1016/j.schres.2019.05.002_bb0245) 2007; 171 McGorry (10.1016/j.schres.2019.05.002_bb0255) 2014; 13 Rutigliano (10.1016/j.schres.2019.05.002_bb0325) 2016; 203 Domenici (10.1016/j.schres.2019.05.002_bb0075) 2010; 5 Sorensen (10.1016/j.schres.2019.05.002_bb0355) 2016; 34 Zuckerman (10.1016/j.schres.2019.05.002_bb0405) 1993; 103 Nabers (10.1016/j.schres.2019.05.002_bb0270) 2018; 10 Cruchaga (10.1016/j.schres.2019.05.002_bb0055) 2012; 21 Sajic (10.1016/j.schres.2019.05.002_bb0335) 2015; 9 Yang (10.1016/j.schres.2019.05.002_bb0390) 2006; 78 Zammit (10.1016/j.schres.2019.05.002_bb0395) 2013; 170 Chan (10.1016/j.schres.2019.05.002_bb0035) 2015; 5 Kim (10.1016/j.schres.2019.05.002_bb0185) 2009; 63 Lane-Donovan (10.1016/j.schres.2019.05.002_bb0200) 2016; 36 Thomas (10.1016/j.schres.2019.05.002_bb0365) 2001; 98 Chouinard (10.1016/j.schres.2019.05.002_bb0040) 2016; 237 O'Gorman (10.1016/j.schres.2019.05.002_bb0280) 2017; 7 Vik-Mo (10.1016/j.schres.2019.05.002_bb0375) 2009; 9 Elliott (10.1016/j.schres.2019.05.002_bb0080) 2010; 51 Smesny (10.1016/j.schres.2019.05.002_bb0345) 2014; 19 Heinze (10.1016/j.schres.2019.05.002_bb0120) 2018; 18 Fu (10.1016/j.schres.2019.05.002_bb0095) 2014; 47 Kelleher (10.1016/j.schres.2019.05.002_bb0165) 2012; 201 Cannon (10.1016/j.schres.2019.05.002_bb0030) 2016; 173 Fullerton (10.1016/j.schres.2019.05.002_bb0100) 2001; 169 Jaros (10.1016/j.schres.2019.05.002_bb0150) 2012; 76 Lee (10.1016/j.schres.2019.05.002_bb0205) 2008; 165 English (10.1016/j.schres.2019.05.002_bb0090) 2018; 44 Welham (10.1016/j.schres.2019.05.002_bb0385) 2009; 39 Ding (10.1016/j.schres.2019.05.002_bb0070) 2015; 72 Zhou (10.1016/j.schres.2019.05.002_bb0400) 2014; 28 Niarchou (10.1016/j.schres.2019.05.002_bb0275) 2013; 170 Malhotra (10.1016/j.schres.2019.05.002_bb0240) 1998; 19 Huang (10.1016/j.schres.2019.05.002_bb0130) 1998; 273 Pillinger (10.1016/j.schres.2019.05.002_bb0300) 2017; 211
References_xml	– volume: 63 start-page: 287 year: 2009 end-page: 303 ident: bb0185 article-title: The role of apolipoprotein E in Alzheimer's disease publication-title: Neuron – volume: 211 start-page: 339 year: 2017 end-page: 349 ident: bb0300 article-title: Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis publication-title: Br. J. Psychiatry – volume: 5 start-page: 79 year: 2018 end-page: 92 ident: bb0305 article-title: The blood-brain barrier in psychosis publication-title: Lancet Psychiatry – volume: 255 start-page: 145 year: 2016 end-page: 155 ident: bb0320 article-title: Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: a review publication-title: Atherosclerosis – volume: 5 start-page: e601 year: 2015 ident: bb0035 article-title: Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset publication-title: Transl. Psychiatry – volume: 169 start-page: 355 year: 2015 end-page: 368 ident: bb0105 article-title: No association between ApoE and schizophrenia: evidence of systematic review and updated meta-analysis publication-title: Schizophr. Res. – volume: 181 start-page: 363 year: 2002 end-page: 365 ident: bb0050 article-title: Stress and the progression of the developmental hypothesis of schizophrenia publication-title: Br. J. Psychiatry – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bb8000 article-title: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing publication-title: J R Stat Soc Ser B Methodol – volume: 13 start-page: 841 year: 2017 end-page: 849 ident: bb0290 article-title: Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis publication-title: Alzheimers Dement. – volume: 41 start-page: 419 year: 2015 end-page: 428 ident: bb0295 article-title: Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project publication-title: Schizophr. Bull. – volume: 7 year: 2017 ident: bb0280 article-title: Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort publication-title: Transl. Psychiatry – volume: 15 start-page: 1088 year: 2010 end-page: 1100 ident: bb0210 article-title: Global proteomic profiling reveals altered proteomic signature in schizophrenia serum publication-title: Mol. Psychiatry – volume: 190 start-page: 137 year: 2016 end-page: 142 ident: bb0020 article-title: Plasma apolipoprotein E and severity of suicidal behaviour publication-title: J. Affect. Disord. – volume: 237 start-page: 304 year: 2016 end-page: 310 ident: bb0040 article-title: Factors associated with overweight and obesity in schizophrenia, schizoaffective and bipolar disorders publication-title: Psychiatry Res. – volume: 173 start-page: 997 year: 2016 end-page: 1006 ident: bb0260 article-title: The bidirectional associations between psychotic experiences and DSM-IV mental disorders publication-title: Am. J. Psychiatry – volume: 43 start-page: 57 year: 2017 end-page: 63 ident: bb0005 article-title: The role of cognition and social functioning as predictors in the transition to psychosis for youth with attenuated psychotic symptoms publication-title: Schizophr. Bull. – volume: 1001 start-page: 90 year: 1989 end-page: 101 ident: bb0140 article-title: Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins publication-title: Biochim. Biophys. Acta – reference: Kopczynska, M., Zelek, W., Touchard, S., Gaughran, F., Di Forti, M., Mondelli, V., Murray, R., O'Donovan, M. C. & Morgan, B. P. 2017. Complement system biomarkers in first episode psychosis. Schizophr. Res. – volume: 49 start-page: 1782 year: 2008 end-page: 1793 ident: bb0215 article-title: Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors publication-title: J. Lipid Res. – volume: 44 start-page: 297 year: 2018 end-page: 306 ident: bb0090 article-title: Blood-based protein changes in childhood are associated with increased risk for later psychotic disorder: evidence from a nested case-control study of the ALSPAC longitudinal birth cohort publication-title: Schizophr. Bull. – volume: 47 start-page: 122 year: 2014 end-page: 129 ident: bb0095 article-title: Elevated serum ApoE levels are associated with bacterial infections in pediatric patients publication-title: J Microbiol Immunol Infect – volume: 76 start-page: 43 year: 2012 end-page: 55 ident: bb0150 article-title: Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls publication-title: J. Proteome – volume: 8 year: 2013 ident: bb0370 article-title: In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis publication-title: Mol. Neurodegener. – volume: 8 year: 2013 ident: bb0315 article-title: Distinct molecular phenotypes in male and female schizophrenia patients publication-title: PLoS One – volume: 28 start-page: 654 year: 2014 end-page: 659 ident: bb0400 article-title: Mass spectrum analysis of serum biomarker proteins from patients with schizophrenia publication-title: Biomed. Chromatogr. – volume: 44 start-page: 957 year: 1998 end-page: 965 ident: bb0380 article-title: Biological variations and genetic reference values for apolipoprotein E serum concentrations: results from the STANISLAS cohort study publication-title: Clin. Chem. – volume: 39 start-page: 625 year: 2009 end-page: 634 ident: bb0385 article-title: Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study publication-title: Psychol. Med. – volume: 5 year: 2010 ident: bb0075 article-title: Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections publication-title: PLoS One – volume: 170 start-page: 550 year: 2013 end-page: 557 ident: bb0275 article-title: Defective processing speed and nonclinical psychotic experiences in children: longitudinal analyses in a large birth cohort publication-title: Am. J. Psychiatry – volume: 14 start-page: 811 year: 2014 end-page: 820 ident: bb0190 article-title: Complement–tapping into new sites and effector systems publication-title: Nat Rev Immunol – volume: 3 year: 2006 ident: bb0265 article-title: ApoE plasma levels and risk of cardiovascular mortality in old age publication-title: PLoS Med. – volume: 50 start-page: 1967 year: 2009 end-page: 1975 ident: bb9005 article-title: Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins publication-title: J Lipid Res – volume: 43 start-page: 1133 year: 2013 end-page: 1149 ident: bb0225 article-title: An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders publication-title: Psychol. Med. – volume: 57 start-page: 1053 year: 2000 end-page: 1058 ident: bb0310 article-title: Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study publication-title: Arch. Gen. Psychiatry – volume: 78 start-page: 3571 year: 2006 end-page: 3576 ident: bb0390 article-title: Altered levels of acute phase proteins in the plasma of patients with schizophrenia publication-title: Anal. Chem. – volume: 34 start-page: 64 year: 2016 end-page: 69 ident: bb0355 article-title: Childhood body mass index and risk of schizophrenia in relation to childhood age, sex and age of first contact with schizophrenia publication-title: Eur Psychiatry – volume: 103 start-page: 43 year: 1993 end-page: 54 ident: bb0405 article-title: Exogenous glucocorticoids increase macrophage secretion of apo E by cholesterol-independent pathways publication-title: Atherosclerosis – volume: 290 start-page: 28977 year: 2015 end-page: 28987 ident: bb0110 article-title: Complement factor H binds to human serum apolipoprotein E and mediates complement regulation on high density lipoprotein particles publication-title: J. Biol. Chem. – volume: 13 start-page: 1118 year: 2008 end-page: 1128 ident: bb0135 article-title: Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues publication-title: Mol. Psychiatry – volume: 36 start-page: 10141 year: 2016 end-page: 10150 ident: bb0200 article-title: Genetic restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice publication-title: J. Neurosci. – volume: 171 start-page: 715 year: 2007 end-page: 727 ident: bb0245 article-title: The role of complement in inflammatory diseases from behind the scenes into the spotlight publication-title: Am. J. Pathol. – volume: 13 start-page: 211 year: 2014 end-page: 223 ident: bb0255 article-title: Biomarkers and clinical staging in psychiatry publication-title: World Psychiatry – volume: 9 start-page: 10 year: 2009 ident: bb0375 article-title: Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells publication-title: BMC Pharmacol. – volume: 5 start-page: e663 year: 2015 ident: bb0085 article-title: Reduced protein synthesis in schizophrenia patient-derived olfactory cells publication-title: Transl. Psychiatry – volume: 203 start-page: 101 year: 2016 end-page: 110 ident: bb0325 article-title: Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis publication-title: J. Affect. Disord. – volume: 169 start-page: 13 year: 2001 end-page: 22 ident: bb0100 article-title: Impairment of the blood-nerve and blood-brain barriers in apolipoprotein E knockout mice publication-title: Exp. Neurol. – volume: 21 start-page: 4558 year: 2012 end-page: 4571 ident: bb0055 article-title: Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease publication-title: Hum. Mol. Genet. – volume: 51 start-page: 555 year: 2010 end-page: 573 ident: bb0080 article-title: Apolipoproteins in the brain: implications for neurological and psychiatric disorders publication-title: Clin Lipidol – volume: 13 start-page: 184 year: 2014 end-page: 188 ident: bb0170 article-title: Psychotic experiences as a predictor of the natural course of suicidal ideation: a Swedish cohort study publication-title: World Psychiatry – volume: 98 start-page: 4066 year: 2001 end-page: 4071 ident: bb0365 article-title: Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 129 start-page: 108 year: 2015 end-page: 120 ident: bb0360 article-title: mapDIA: preprocessing and statistical analysis of quantitative proteomics data from data independent acquisition mass spectrometry publication-title: J. Proteome – volume: 60 start-page: Pl115 year: 1997 end-page: Pl118 ident: bb0340 article-title: The putative blood-brain barrier transporter for the beta-amyloid binding protein apolipoprotein J is saturated at physiological concentrations publication-title: Life Sci. – volume: 19 start-page: 317 year: 2014 end-page: 324 ident: bb0345 article-title: Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis publication-title: Mol. Psychiatry – volume: 273 start-page: 26388 year: 1998 end-page: 26393 ident: bb0130 article-title: Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia publication-title: J. Biol. Chem. – volume: 36 start-page: 1305 year: 2016 end-page: 1315 ident: bb0235 article-title: Central nervous system lipoproteins ApoE and regulation of cholesterol metabolism publication-title: Arteriosclerosis Thrombosis and Vascular Biology – volume: 19 start-page: 445 year: 1998 end-page: 448 ident: bb0240 article-title: The apolipoprotein E epsilon 4 allele is associated with blunting of ketamine-induced psychosis in schizophrenia - a preliminary report publication-title: Neuropsychopharmacology – volume: 9 start-page: 307 year: 2015 end-page: 321 ident: bb0335 article-title: Using data-independent, high-resolution mass spectrometry in protein biomarker research: perspectives and clinical applications publication-title: Proteomics Clin Appl – volume: 10 year: 2018 ident: bb0270 article-title: Amyloid blood biomarker detects Alzheimer's disease publication-title: EMBO Mol Med – volume: 6 start-page: e897 year: 2016 ident: bb0045 article-title: Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers publication-title: Transl. Psychiatry – volume: 71 start-page: 1121 year: 2014 end-page: 1128 ident: bb0180 article-title: Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study publication-title: JAMA Psychiatry – volume: 16 start-page: 2065 year: 2016 end-page: 2067 ident: bb0010 article-title: Applications and developments in targeted proteomics: from SRM to DIA/SWATH publication-title: Proteomics – volume: 13 start-page: 1141 year: 2016 end-page: 1155 ident: bb0330 article-title: Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays publication-title: Expert Rev Proteomics – year: 2017 ident: bb0025 article-title: Prefrontal fatty acid composition in schizophrenia and bipolar disorder: association with reelin expression publication-title: Schizophr. Res. – volume: 201 start-page: 26 year: 2012 end-page: 32 ident: bb0165 article-title: Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies publication-title: Br. J. Psychiatry – volume: 10 start-page: 799 year: 2014 end-page: 807 ident: bb0145 article-title: Plasma proteins predict conversion to dementia from prodromal disease publication-title: Alzheimers Dement. – volume: 11 start-page: 786 year: 2015 ident: bb0230 article-title: Quantitative variability of 342 plasma proteins in a human twin population publication-title: Mol. Syst. Biol. – volume: 42 start-page: 1857 year: 2012 end-page: 1863 ident: bb0160 article-title: Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies publication-title: Psychol. Med. – volume: 273 start-page: 17483 year: 1998 end-page: 17490 ident: bb0125 article-title: Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins publication-title: J. Biol. Chem. – volume: 173 start-page: 980 year: 2016 end-page: 988 ident: bb0030 article-title: An individualized risk calculator for research in prodromal psychosis publication-title: Am. J. Psychiatry – volume: 19 start-page: 1143 year: 2014 end-page: 1149 ident: bb0115 article-title: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity publication-title: Mol. Psychiatry – volume: 18 start-page: 214 year: 2018 ident: bb0120 article-title: The impact of psychotic experiences in the early stages of mental health problems in young people publication-title: BMC Psychiatry – volume: 11 start-page: 719 year: 2010 end-page: 728 ident: bb0250 article-title: Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controls publication-title: World J. Biol. Psychiatry – volume: 72 start-page: 799 year: 2015 end-page: 805 ident: bb0070 article-title: Protein biomarkers in serum of patients with schizophrenia publication-title: Cell Biochem. Biophys. – volume: 8 start-page: 2664 year: 2012 end-page: 2671 ident: bb0220 article-title: Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia publication-title: Mol. BioSyst. – volume: 54 start-page: 616 year: 2003 end-page: 622 ident: bb0060 article-title: Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia publication-title: Biol. Psychiatry – volume: 158 start-page: 75 year: 2008 end-page: 78 ident: bb0065 article-title: Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder publication-title: Psychiatry Res. – volume: 13 year: 2016 ident: bb0350 article-title: Circulating apolipoprotein E concentration and cardiovascular disease risk: meta-analysis of results from three studies publication-title: PLoS Med. – volume: 165 start-page: 1456 year: 2008 end-page: 1464 ident: bb0205 article-title: Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults publication-title: Am. J. Psychiatry – volume: 28 start-page: 1225 year: 2008 end-page: 1236 ident: bb9000 article-title: Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome publication-title: Arterioscler Thromb Vasc Biol – volume: 67 start-page: 146 year: 2010 end-page: 154 ident: bb0015 article-title: Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial publication-title: Arch. Gen. Psychiatry – volume: 44 start-page: 1615 year: 2014 end-page: 1624 ident: bb0175 article-title: Psychotic experiences in a mental health clinic sample: implications for suicidality, multimorbidity and functioning publication-title: Psychol. Med. – volume: 8 start-page: 380 year: 2014 ident: bb0285 article-title: Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis publication-title: Front. Cell. Neurosci. – volume: 170 start-page: 742 year: 2013 end-page: 750 ident: bb0395 article-title: Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study publication-title: Am. J. Psychiatry – volume: 90 start-page: 353 year: 2014 end-page: 364 ident: bb0155 article-title: Novel plasma biomarker surrogating cerebral amyloid deposition publication-title: Proc Jpn Acad Ser B Phys Biol Sci – volume: 190 start-page: 137 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0020 article-title: Plasma apolipoprotein E and severity of suicidal behaviour publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2015.09.024 – volume: 36 start-page: 1305 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0235 article-title: Central nervous system lipoproteins ApoE and regulation of cholesterol metabolism publication-title: Arteriosclerosis Thrombosis and Vascular Biology doi: 10.1161/ATVBAHA.116.307023 – volume: 16 start-page: 2065 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0010 article-title: Applications and developments in targeted proteomics: from SRM to DIA/SWATH publication-title: Proteomics doi: 10.1002/pmic.201600203 – volume: 7 year: 2017 ident: 10.1016/j.schres.2019.05.002_bb0280 article-title: Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort publication-title: Transl. Psychiatry doi: 10.1038/tp.2017.211 – volume: 50 start-page: 1967 year: 2009 ident: 10.1016/j.schres.2019.05.002_bb9005 article-title: Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins publication-title: J Lipid Res doi: 10.1194/jlr.R900015-JLR200 – volume: 42 start-page: 1857 year: 2012 ident: 10.1016/j.schres.2019.05.002_bb0160 article-title: Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies publication-title: Psychol. Med. doi: 10.1017/S0033291711002960 – volume: 28 start-page: 1225 year: 2008 ident: 10.1016/j.schres.2019.05.002_bb9000 article-title: Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.107.160192 – volume: 5 year: 2010 ident: 10.1016/j.schres.2019.05.002_bb0075 article-title: Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections publication-title: PLoS One doi: 10.1371/journal.pone.0009166 – volume: 273 start-page: 26388 year: 1998 ident: 10.1016/j.schres.2019.05.002_bb0130 article-title: Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.41.26388 – volume: 39 start-page: 625 year: 2009 ident: 10.1016/j.schres.2019.05.002_bb0385 article-title: Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study publication-title: Psychol. Med. doi: 10.1017/S0033291708003760 – volume: 171 start-page: 715 year: 2007 ident: 10.1016/j.schres.2019.05.002_bb0245 article-title: The role of complement in inflammatory diseases from behind the scenes into the spotlight publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2007.070166 – volume: 237 start-page: 304 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0040 article-title: Factors associated with overweight and obesity in schizophrenia, schizoaffective and bipolar disorders publication-title: Psychiatry Res. doi: 10.1016/j.psychres.2016.01.024 – volume: 43 start-page: 1133 year: 2013 ident: 10.1016/j.schres.2019.05.002_bb0225 article-title: An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders publication-title: Psychol. Med. doi: 10.1017/S0033291712001626 – volume: 211 start-page: 339 year: 2017 ident: 10.1016/j.schres.2019.05.002_bb0300 article-title: Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis publication-title: Br. J. Psychiatry doi: 10.1192/bjp.bp.117.200907 – volume: 21 start-page: 4558 year: 2012 ident: 10.1016/j.schres.2019.05.002_bb0055 article-title: Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds296 – volume: 36 start-page: 10141 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0200 article-title: Genetic restoration of plasma ApoE improves cognition and partially restores synaptic defects in ApoE-deficient mice publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1054-16.2016 – volume: 165 start-page: 1456 year: 2008 ident: 10.1016/j.schres.2019.05.002_bb0205 article-title: Apolipoprotein e genotype, cortisol, and cognitive function in community-dwelling older adults publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2008.07091532 – volume: 13 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0350 article-title: Circulating apolipoprotein E concentration and cardiovascular disease risk: meta-analysis of results from three studies publication-title: PLoS Med. doi: 10.1371/journal.pmed.1002146 – volume: 44 start-page: 957 year: 1998 ident: 10.1016/j.schres.2019.05.002_bb0380 article-title: Biological variations and genetic reference values for apolipoprotein E serum concentrations: results from the STANISLAS cohort study publication-title: Clin. Chem. doi: 10.1093/clinchem/44.5.957 – volume: 8 start-page: 380 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0285 article-title: Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2014.00380 – volume: 72 start-page: 799 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0070 article-title: Protein biomarkers in serum of patients with schizophrenia publication-title: Cell Biochem. Biophys. doi: 10.1007/s12013-015-0536-5 – volume: 14 start-page: 811 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0190 article-title: Complement–tapping into new sites and effector systems publication-title: Nat Rev Immunol doi: 10.1038/nri3761 – volume: 8 year: 2013 ident: 10.1016/j.schres.2019.05.002_bb0370 article-title: In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-8-13 – volume: 173 start-page: 980 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0030 article-title: An individualized risk calculator for research in prodromal psychosis publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2016.15070890 – volume: 71 start-page: 1121 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0180 article-title: Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2014.1332 – volume: 67 start-page: 146 year: 2010 ident: 10.1016/j.schres.2019.05.002_bb0015 article-title: Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial publication-title: Arch. Gen. Psychiatry doi: 10.1001/archgenpsychiatry.2009.192 – volume: 13 start-page: 1118 year: 2008 ident: 10.1016/j.schres.2019.05.002_bb0135 article-title: Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4002108 – volume: 10 year: 2018 ident: 10.1016/j.schres.2019.05.002_bb0270 article-title: Amyloid blood biomarker detects Alzheimer's disease publication-title: EMBO Mol Med doi: 10.15252/emmm.201708763 – volume: 5 start-page: 79 year: 2018 ident: 10.1016/j.schres.2019.05.002_bb0305 article-title: The blood-brain barrier in psychosis publication-title: Lancet Psychiatry doi: 10.1016/S2215-0366(17)30293-6 – volume: 103 start-page: 43 year: 1993 ident: 10.1016/j.schres.2019.05.002_bb0405 article-title: Exogenous glucocorticoids increase macrophage secretion of apo E by cholesterol-independent pathways publication-title: Atherosclerosis doi: 10.1016/0021-9150(93)90038-V – volume: 18 start-page: 214 year: 2018 ident: 10.1016/j.schres.2019.05.002_bb0120 article-title: The impact of psychotic experiences in the early stages of mental health problems in young people publication-title: BMC Psychiatry doi: 10.1186/s12888-018-1767-y – volume: 34 start-page: 64 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0355 article-title: Childhood body mass index and risk of schizophrenia in relation to childhood age, sex and age of first contact with schizophrenia publication-title: Eur Psychiatry doi: 10.1016/j.eurpsy.2016.01.2425 – volume: 173 start-page: 997 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0260 article-title: The bidirectional associations between psychotic experiences and DSM-IV mental disorders publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2016.15101293 – volume: 3 year: 2006 ident: 10.1016/j.schres.2019.05.002_bb0265 article-title: ApoE plasma levels and risk of cardiovascular mortality in old age publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030176 – volume: 11 start-page: 719 year: 2010 ident: 10.1016/j.schres.2019.05.002_bb0250 article-title: Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controls publication-title: World J. Biol. Psychiatry doi: 10.3109/15622971003758748 – volume: 9 start-page: 307 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0335 article-title: Using data-independent, high-resolution mass spectrometry in protein biomarker research: perspectives and clinical applications publication-title: Proteomics Clin Appl doi: 10.1002/prca.201400117 – volume: 15 start-page: 1088 year: 2010 ident: 10.1016/j.schres.2019.05.002_bb0210 article-title: Global proteomic profiling reveals altered proteomic signature in schizophrenia serum publication-title: Mol. Psychiatry doi: 10.1038/mp.2009.54 – volume: 158 start-page: 75 year: 2008 ident: 10.1016/j.schres.2019.05.002_bb0065 article-title: Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder publication-title: Psychiatry Res. doi: 10.1016/j.psychres.2007.05.008 – volume: 51 start-page: 555 year: 2010 ident: 10.1016/j.schres.2019.05.002_bb0080 article-title: Apolipoproteins in the brain: implications for neurological and psychiatric disorders publication-title: Clin Lipidol doi: 10.2217/clp.10.37 – volume: 47 start-page: 122 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0095 article-title: Elevated serum ApoE levels are associated with bacterial infections in pediatric patients publication-title: J Microbiol Immunol Infect doi: 10.1016/j.jmii.2013.05.010 – volume: 6 start-page: e897 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0045 article-title: Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers publication-title: Transl. Psychiatry doi: 10.1038/tp.2016.170 – ident: 10.1016/j.schres.2019.05.002_bb0195 – volume: 57 start-page: 1053 year: 2000 ident: 10.1016/j.schres.2019.05.002_bb0310 article-title: Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.57.11.1053 – volume: 19 start-page: 1143 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0115 article-title: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.110 – volume: 1001 start-page: 90 year: 1989 ident: 10.1016/j.schres.2019.05.002_bb0140 article-title: Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2760(89)90311-1 – volume: 54 start-page: 616 year: 2003 ident: 10.1016/j.schres.2019.05.002_bb0060 article-title: Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia publication-title: Biol. Psychiatry doi: 10.1016/S0006-3223(03)00075-1 – volume: 290 start-page: 28977 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0110 article-title: Complement factor H binds to human serum apolipoprotein E and mediates complement regulation on high density lipoprotein particles publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.669226 – volume: 76 start-page: 43 year: 2012 ident: 10.1016/j.schres.2019.05.002_bb0150 article-title: Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls publication-title: J. Proteome doi: 10.1016/j.jprot.2012.05.027 – volume: 49 start-page: 1782 year: 2008 ident: 10.1016/j.schres.2019.05.002_bb0215 article-title: Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors publication-title: J. Lipid Res. doi: 10.1194/jlr.M800172-JLR200 – volume: 129 start-page: 108 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0360 article-title: mapDIA: preprocessing and statistical analysis of quantitative proteomics data from data independent acquisition mass spectrometry publication-title: J. Proteome doi: 10.1016/j.jprot.2015.09.013 – volume: 57 start-page: 289 issue: 1 year: 1995 ident: 10.1016/j.schres.2019.05.002_bb8000 article-title: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing publication-title: J R Stat Soc Ser B Methodol doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 41 start-page: 419 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0295 article-title: Towards a psychosis risk blood diagnostic for persons experiencing high-risk symptoms: preliminary results from the NAPLS project publication-title: Schizophr. Bull. doi: 10.1093/schbul/sbu099 – year: 2017 ident: 10.1016/j.schres.2019.05.002_bb0025 article-title: Prefrontal fatty acid composition in schizophrenia and bipolar disorder: association with reelin expression publication-title: Schizophr. Res. – volume: 90 start-page: 353 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0155 article-title: Novel plasma biomarker surrogating cerebral amyloid deposition publication-title: Proc Jpn Acad Ser B Phys Biol Sci doi: 10.2183/pjab.90.353 – volume: 11 start-page: 786 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0230 article-title: Quantitative variability of 342 plasma proteins in a human twin population publication-title: Mol. Syst. Biol. doi: 10.15252/msb.20145728 – volume: 98 start-page: 4066 year: 2001 ident: 10.1016/j.schres.2019.05.002_bb0365 article-title: Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.071056198 – volume: 28 start-page: 654 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0400 article-title: Mass spectrum analysis of serum biomarker proteins from patients with schizophrenia publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.3084 – volume: 169 start-page: 355 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0105 article-title: No association between ApoE and schizophrenia: evidence of systematic review and updated meta-analysis publication-title: Schizophr. Res. doi: 10.1016/j.schres.2015.08.031 – volume: 13 start-page: 211 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0255 article-title: Biomarkers and clinical staging in psychiatry publication-title: World Psychiatry doi: 10.1002/wps.20144 – volume: 44 start-page: 1615 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0175 article-title: Psychotic experiences in a mental health clinic sample: implications for suicidality, multimorbidity and functioning publication-title: Psychol. Med. doi: 10.1017/S0033291713002122 – volume: 10 start-page: 799 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0145 article-title: Plasma proteins predict conversion to dementia from prodromal disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2014.05.1749 – volume: 201 start-page: 26 year: 2012 ident: 10.1016/j.schres.2019.05.002_bb0165 article-title: Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies publication-title: Br. J. Psychiatry doi: 10.1192/bjp.bp.111.101543 – volume: 9 start-page: 10 year: 2009 ident: 10.1016/j.schres.2019.05.002_bb0375 article-title: Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells publication-title: BMC Pharmacol. doi: 10.1186/1471-2210-9-10 – volume: 78 start-page: 3571 year: 2006 ident: 10.1016/j.schres.2019.05.002_bb0390 article-title: Altered levels of acute phase proteins in the plasma of patients with schizophrenia publication-title: Anal. Chem. doi: 10.1021/ac051916x – volume: 8 year: 2013 ident: 10.1016/j.schres.2019.05.002_bb0315 article-title: Distinct molecular phenotypes in male and female schizophrenia patients publication-title: PLoS One doi: 10.1371/journal.pone.0078729 – volume: 43 start-page: 57 year: 2017 ident: 10.1016/j.schres.2019.05.002_bb0005 article-title: The role of cognition and social functioning as predictors in the transition to psychosis for youth with attenuated psychotic symptoms publication-title: Schizophr. Bull. doi: 10.1093/schbul/sbw152 – volume: 170 start-page: 742 year: 2013 ident: 10.1016/j.schres.2019.05.002_bb0395 article-title: Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2013.12060768 – volume: 5 start-page: e601 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0035 article-title: Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.91 – volume: 203 start-page: 101 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0325 article-title: Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2016.05.053 – volume: 13 start-page: 1141 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0330 article-title: Blood biomarker discovery in drug-free schizophrenia: the contributionof proteomics and multiplex immunoassays publication-title: Expert Rev Proteomics doi: 10.1080/14789450.2016.1252262 – volume: 63 start-page: 287 year: 2009 ident: 10.1016/j.schres.2019.05.002_bb0185 article-title: The role of apolipoprotein E in Alzheimer's disease publication-title: Neuron doi: 10.1016/j.neuron.2009.06.026 – volume: 19 start-page: 445 year: 1998 ident: 10.1016/j.schres.2019.05.002_bb0240 article-title: The apolipoprotein E epsilon 4 allele is associated with blunting of ketamine-induced psychosis in schizophrenia - a preliminary report publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(98)00031-1 – volume: 13 start-page: 841 year: 2017 ident: 10.1016/j.schres.2019.05.002_bb0290 article-title: Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2017.06.2266 – volume: 60 start-page: Pl115 year: 1997 ident: 10.1016/j.schres.2019.05.002_bb0340 article-title: The putative blood-brain barrier transporter for the beta-amyloid binding protein apolipoprotein J is saturated at physiological concentrations publication-title: Life Sci. doi: 10.1016/S0024-3205(96)00685-6 – volume: 181 start-page: 363 year: 2002 ident: 10.1016/j.schres.2019.05.002_bb0050 article-title: Stress and the progression of the developmental hypothesis of schizophrenia publication-title: Br. J. Psychiatry doi: 10.1192/bjp.181.5.363 – volume: 44 start-page: 297 year: 2018 ident: 10.1016/j.schres.2019.05.002_bb0090 article-title: Blood-based protein changes in childhood are associated with increased risk for later psychotic disorder: evidence from a nested case-control study of the ALSPAC longitudinal birth cohort publication-title: Schizophr. Bull. doi: 10.1093/schbul/sbx075 – volume: 13 start-page: 184 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0170 article-title: Psychotic experiences as a predictor of the natural course of suicidal ideation: a Swedish cohort study publication-title: World Psychiatry doi: 10.1002/wps.20131 – volume: 273 start-page: 17483 year: 1998 ident: 10.1016/j.schres.2019.05.002_bb0125 article-title: Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.28.17483 – volume: 19 start-page: 317 year: 2014 ident: 10.1016/j.schres.2019.05.002_bb0345 article-title: Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.7 – volume: 169 start-page: 13 year: 2001 ident: 10.1016/j.schres.2019.05.002_bb0100 article-title: Impairment of the blood-nerve and blood-brain barriers in apolipoprotein E knockout mice publication-title: Exp. Neurol. doi: 10.1006/exnr.2001.7631 – volume: 8 start-page: 2664 year: 2012 ident: 10.1016/j.schres.2019.05.002_bb0220 article-title: Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia publication-title: Mol. BioSyst. doi: 10.1039/c2mb25158b – volume: 5 start-page: e663 year: 2015 ident: 10.1016/j.schres.2019.05.002_bb0085 article-title: Reduced protein synthesis in schizophrenia patient-derived olfactory cells publication-title: Transl. Psychiatry doi: 10.1038/tp.2015.119 – volume: 170 start-page: 550 year: 2013 ident: 10.1016/j.schres.2019.05.002_bb0275 article-title: Defective processing speed and nonclinical psychotic experiences in children: longitudinal analyses in a large birth cohort publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2012.12060792 – volume: 255 start-page: 145 year: 2016 ident: 10.1016/j.schres.2019.05.002_bb0320 article-title: Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: a review publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2016.10.037
SSID	ssj0001507
Score	2.3062832
Snippet	Apolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode psychosis and... AbstractApolipoproteins, which play important roles in lipid metabolism, innate immunity and synaptic signalling, have been implicated in first episode...
SourceID	unpaywall proquest pubmed crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	141
SubjectTerms	Adolescent ALSPAC ApoE Apolipoprotein Apolipoproteins - blood Apolipoproteins E - blood Child Chromatography, High Pressure Liquid Delusions - blood Delusions - physiopathology Disease Progression Enzyme-Linked Immunosorbent Assay Female Hallucinations - blood Hallucinations - physiopathology Humans Male Outcome Prognosis Proteomics Psychiatric/Mental Health Psychotic experience
SummonAdditionalLinks	– databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBbp5tD2kLb0tekDFXqst5a9suXcTEgIpQmBdGF7EnrCpou92F5C-gf6tzPjx7K0gWxvNtZIlmc8-kaaByGftRDG6WkWCA-2yTTWJsh0qgPvmecuC60xGI18fpGczabf5ny-R74MsTBlZTDhQ4XlQfpoKmCKw02u5itoWTTVH5H9BI-TRmR_dnGZ_2zT6cFIAN3bQ2SexgGs7NkQKde6c4GtCPYr-nJlk619lHtWon-R5lPyeF2s1O2NWi63Vp_TZ-R8eO_O6eTXZN3oifn9V0rHXSf2nBz0MJTmndy8IHuueEn-5KvyhGLAecsuuqip6rnnLMUdWwpwka5wi61usTYtPe3juBaGuk3a5Jpi2AoFXUVZRJuyuxJHdChi2j3H3vLvV5f5MdWLCrrHcr1V84rMTk9-HJ8FfaGGwHCWNIEXYarc1CvlY58xr5wFHZqqWInIasMTFXEdMpuakFsWWc-4NVEkPNiCwoFeeU1GRVm4t4RGLPHoeupDpwDJeWEBMoFVZplRoJzDMYkHpknTZzHHYhpLObirXcuO1RJZLUMugdVjEmyoVl0Wjwfa80Ee5BChCjpVwjLzAF16H52re8VQSybrSIbyCgUW5RXwM3QWz7cpe-zTYZodxvw0CKwE1YDnPapw5RoaRW26NSHiMXnTSfJm9jH6lgKWHJPJRrR3-jSH_0vwjjzBu87F-T0ZNdXafQAg1-iP_f97B3YpRok priority: 102 providerName: Unpaywall
Title	ApoE elevation is associated with the persistence of psychotic experiences from age 12 to age 18: Evidence from the ALSPAC birth cohort
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S092099641930163X https://www.clinicalkey.es/playcontent/1-s2.0-S092099641930163X https://dx.doi.org/10.1016/j.schres.2019.05.002 https://www.ncbi.nlm.nih.gov/pubmed/31080155 https://www.proquest.com/docview/2231964883 https://orca.cardiff.ac.uk/id/eprint/123027/
UnpaywallVersion	submittedVersion
Volume	209
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1573-2509 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001507 issn: 1573-2509 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1573-2509 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001507 issn: 1573-2509 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1573-2509 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001507 issn: 1573-2509 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection 2013 customDbUrl: eissn: 1573-2509 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001507 issn: 1573-2509 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1573-2509 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001507 issn: 1573-2509 databaseCode: AKRWK dateStart: 19880101 isFulltext: true providerName: Library Specific Holdings
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9swEBbL9tD2UFr6SrddVOjVieWn3JsJu6SvsLANpCch6wFegm1ih9LLXvu3O2PLacou7NJTEkeSZc1o9I38zYiQDwXnyhRR5nELvkkUFsrLirTwrGU2NpmvlcJo5G_LZLGKPq_j9RGZj7EwSKt0tn-w6b21dldmbjRnTVnOLv0Mwz6TCCAI4JZwjRHsUYK0vun1X5oHAp4-3x50BUuP4XM9xwscSHBqkeCVTQ82V25Znm7Cz8fk4a5q5K-fcrM5WJLOn5InDkvSfOjuM3Jkqufkd97UZxSjxvsxp2VLpROB0RS3XSlgPtrgPlnbA2ZaW-qCsUpFzT73cUsx9oSCwaEsoF09fOMf6XgS6fA_tpZ_vbzI57Qot9A8nrm77V6Q1fnZ9_nCc6cteCpmSedZ7qfSRFZKG9qMWWk0GMJUhpIHulBxIoO48JlOlR9rFmjLYq2CgFtw6LgB4_CSHFd1ZV4TGrDEIn_U-kYCHLNcA-4B10ozJcHC-hMSjoMslEtFjidibMTIObsSg2gEikb4sQDRTIi3r9UMqTjuKB-P8hNjmCkYRgFrxR310tvqmdbN7lYw0QbCFzc08LDmP0p8j3u-HxVMwPzGlzayMvUOCgV9zjTOwwl5NWje_ulDJIgCIJyQ6V4V7zU0b_67oyfkEf4aCMtvyXG33Zl3AMu64rSfd6fkQf7py2IJn6vlRf7jD0XjOS4
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb5wwELbSzSHtoWrV16YvV-qVLAYMpje0SrRpNqtKSaS9WcYPiWgFaGFV9Rfkb3cMBm2VSIl6Q8CA8Yw_f2Nmxgh9zxmTOo9SjxnwTaIwl16aJ7lnDDFUp76S0mYjX67ixU30c03XB2g-5MLYsEqH_T2md2jtzsxcb87qophd-alN-4wjoCDAW8L1M3QYUcDkCTrMzi8WqxGQLefpSu5Ba6zAkEHXhXmBDwl-rY3xSk_21lcemKHuM9AX6GhX1uLPb7HZ7M1KZ6_QS0cncda3-DU60OUbdJfV1Sm2ieNdt-OiwcJpQStsV14x0D5c26WypuPMuDLY5WMVEuux_HGDbfoJBszBJMBt1R-xH3jYjLS_bp-WLa9-ZXOcF1t4vN12d9u-RTdnp9fzhec2XPAkJXHrGeYnQkdGCBOalBihFWBhIkLBApVLGouA5j5RifSpIoEyhCoZBMyAT8c04MM7NCmrUn9AOCCxsSGkxtcCGJlhCqgPeFeKSAEg609ROHQyl64aud0UY8OHsLNb3quGW9Vwn3JQzRR5o1TdV-N45H466I8PmaaAjRymi0fkkofkdOMGeMMJbwLu83tGuC_5jx0_4Z3fBgPjMMTtfxtR6moHNwVd2TTGwil631ve-PWhjREFTjhFJ6MpPqlrjv-7oV_R0eL6csmX56uLj-i5vdLHL39Ck3a705-BpbX5FzcK_wL-hjop
linkToUnpaywall	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBbp5tD2kLb0tekDFXqst5a9suXcTEgIpQmBdGF7EnrCpou92F5C-gf6tzPjx7K0gWxvNtZIlmc8-kaaByGftRDG6WkWCA-2yTTWJsh0qgPvmecuC60xGI18fpGczabf5ny-R74MsTBlZTDhQ4XlQfpoKmCKw02u5itoWTTVH5H9BI-TRmR_dnGZ_2zT6cFIAN3bQ2SexgGs7NkQKde6c4GtCPYr-nJlk619lHtWon-R5lPyeF2s1O2NWi63Vp_TZ-R8eO_O6eTXZN3oifn9V0rHXSf2nBz0MJTmndy8IHuueEn-5KvyhGLAecsuuqip6rnnLMUdWwpwka5wi61usTYtPe3juBaGuk3a5Jpi2AoFXUVZRJuyuxJHdChi2j3H3vLvV5f5MdWLCrrHcr1V84rMTk9-HJ8FfaGGwHCWNIEXYarc1CvlY58xr5wFHZqqWInIasMTFXEdMpuakFsWWc-4NVEkPNiCwoFeeU1GRVm4t4RGLPHoeupDpwDJeWEBMoFVZplRoJzDMYkHpknTZzHHYhpLObirXcuO1RJZLUMugdVjEmyoVl0Wjwfa80Ee5BChCjpVwjLzAF16H52re8VQSybrSIbyCgUW5RXwM3QWz7cpe-zTYZodxvw0CKwE1YDnPapw5RoaRW26NSHiMXnTSfJm9jH6lgKWHJPJRrR3-jSH_0vwjjzBu87F-T0ZNdXafQAg1-iP_f97B3YpRok
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ApoE+elevation+is+associated+with+the+persistence+of+psychotic+experiences+from+age+12+to+age+18%3A+Evidence+from+the+ALSPAC+birth+cohort&rft.jtitle=Schizophrenia+research&rft.au=Sabherwal%2C+Sophie&rft.au=F%C3%B6cking%2C+Melanie&rft.au=English%2C+Jane+A&rft.au=Fitzsimons%2C+Stephen&rft.date=2019-07-01&rft.issn=1573-2509&rft.eissn=1573-2509&rft.volume=209&rft.spage=141&rft_id=info:doi/10.1016%2Fj.schres.2019.05.002&rft.externalDBID=NO_FULL_TEXT
thumbnail_m	http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F09209964%2FS0920996419X00067%2Fcov150h.gif